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11. 发明专利

JPH1036406A GALACTOSYL-CYCLOISOMALTO OLIGOSACCHARIDE AND ITS MANUFACTURE 失效
公开(公告)号：JPH1036406A
公开(公告)日：1998-02-10
申请号：JP18787896
申请日：1996-07-17
申请人： OSAKA CITY , KIKKOMAN CORP
发明人： KITAHATA SUMIO , TOBE KOUICHIROU , KITAO SATORU
IPC分类号： C12P19/18 , C08B37/16
摘要： PROBLEM TO BE SOLVED: To provide a galactosyl-cycloisomalt oligosaccharide which is widely applicable not only to medicinal field but also to food, cosmetics, chemical fields, etc., and its manufacturing method. SOLUTION: A galactosyl-cycloisomalt oligosaccharide is manufactured by the act of a galactosyl group transfer enzyme to a galactosyl-cycloisomalt oligosaccharide which is obtd. by combining a galactosyl group to a hydroxyl group of glucosyl group of cycloisomalt oligosaccharide ring by α or β bond and a mixture of a galactosyl saccharide compound and a cycloisomalt oligosaccharide.

12. 发明专利

JPH09157156A BATH ARTICLE 失效
公开(公告)号：JPH09157156A
公开(公告)日：1997-06-17
申请号：JP33566295
申请日：1995-12-01
申请人： KIKKOMAN CORP
发明人： MATSUURA MASARU , OBATA AKIO , TOBE KOUICHIROU
IPC分类号： C07H17/07 , A61K8/00 , A61K8/60 , A61K8/96 , A61K31/70 , A61K31/7042 , A61K31/7048 , A61K36/48 , A61P17/00 , A61Q19/00 , A61Q19/10 , A61K7/50 , A61K7/00 , A61K7/48 , A61K35/78
摘要： PROBLEM TO BE SOLVED: To obtain a bath article containing an isoflavone derivative. SOLUTION: This bath article contains an isoflavone derivative, especially a malonylisoflavone glycoside in an amount of 1-100mg per liter of the bath article. The malonylisoflavone glycoside is obtained e.g. by immersing defatted soybeans as a raw material in 45-65 deg.C water controlled to a pH of 7.5-9 with sodium hydroxide, etc., for 2-4hr, controlling the obtained extraction solution to a pH of approximately 4.3 with hydrochloric acid to precipitate proteins contained in the extraction solution, bringing the supernatant into contact with an adsorbent, eluting the adsorbed malonylflavone glycoside with an alcohol aqueous solution, etc., subjecting the eluate to a vacuum concentration treatment, etc., and subsequently drying the concentrate into the dry powder. The alcohol or alkaline alcohol aqueous solution containing the malonylisoflavone glycoside, its vacuum concentration solution or its dry powder is compounded with various kinds of base materials, a perfume and a coloring matter to obtain the bath article. The bath article gives increased moisture, smoothness and heat-insulating effect to skin, after a bath containing the bath article is taken. The bath article further gives a refreshing feeling after the bath is taken, and has effects for preventing the dry touch and itching of the skin.

13. 发明专利

JPH03172197A REAGENT FOR MEASURING ALPHA-AMYLASE ACTIVITY AND METHOD FOR MEASURING ALPHA-AMYLASE ACTIVITY 失效
公开(公告)号：JPH03172197A
公开(公告)日：1991-07-25
申请号：JP30904289
申请日：1989-11-30
申请人： DAIICHI PURE CHEMICALS CO LTD , KIKKOMAN CORP , SEISHIN SEIYAKU KK
发明人： SAITO KAZUNORI , KUROSAWA KAORU , TOKUTAKE SHOICHI , OGUMA TETSUYA , TOBE KOUICHIROU , SHIMIZU TOSHIYUKI
IPC分类号： C12Q1/40
摘要： PURPOSE:To measure the title activity for diagnosing pancreatitis in a short time by adding a maltooligoside derivative, in which non-reductive end is protected and a substance capable of optically detecting is bound to a reductive end, and a conjugated enzyme to a sample and optically measuring an isolated substance. CONSTITUTION:A maltooligoside derivative (e.g. 2-chloro-4-nitrophenyl=4 ,6 -O- benzilidene-beta-D-maltopentaoxide) in which a non-reductive end is modified with a protective group and substance capable of detecting by alpha- or beta-glucoside bond is bound to a reductive end and beta-amylase used as one of conjugated enzyme ingredients are added to alpha-amylase-containing sample to carry out enzymatic reaction and an isolated optically detectable substance (e.g. 2-chloro-4- nitrophenol) is determined to measure alpha-amylase.

14. 发明专利

JP2003221356A METHOD FOR STABILIZING NARINGENIN CHALCONE AND/OR DERIVATIVE THEREOF 审中-公开
公开(公告)号：JP2003221356A
公开(公告)日：2003-08-05
申请号：JP2002020817
申请日：2002-01-30
申请人： KIKKOMAN CORP
发明人： YAMAMOTO DAICHI , KANAMORI TOMOKO , IZUMI TORU , TOBE KOUICHIROU , OBATA AKIO
IPC分类号： C07C45/86 , C07C45/79 , C07C49/835
摘要： PROBLEM TO BE SOLVED: To provide a method for stably manufacturing naringenin chalcone and/or a derivative thereof stably. SOLUTION: A cyclodextrin, in particular, γ-cyclodextrin is added and mixed in an aqueous solution containing naringenin chalcone and/or a derivative thereof. Thus, the naringenin chalcone can be manufactured stably. Also, after adding the cyclodextrin, by stirring the aqueous solution containing the naringenin chalcone to increase the opportunity of physical contact of the naringenin chalcone with the cyclodextrin, effect on stabilizing the naringenin chalcone is raised. COPYRIGHT: (C)2003,JPO

15. 发明专利

JP2002125619A LYCOPENE COMPOSITION, METHOD OF PRODUCING THE SAME AND USE THEREOF 失效
公开(公告)号：JP2002125619A
公开(公告)日：2002-05-08
申请号：JP2000331960
申请日：2000-10-31
申请人： KIKKOMAN CORP , NIPPON DELMONTE CORP
发明人： SANO ATSUSHI , TOKUTAKE SHOICHI , TOBE KOUICHIROU , KAWARAGI MASAJI , WAKAYAMA TADAAKI , ISHIMURA EIJI
IPC分类号： A23G3/00 , A23G3/34 , A23G3/36 , A23L2/02 , A23L2/52 , A23L2/68 , A23L2/72 , A23L19/00 , A23L33/155 , A61K8/02 , A61K8/30 , A61K8/31 , A61K31/01 , A61P3/02 , A23L1/30 , A23K1/16 , A23L1/212 , A23L1/303 , A61K7/00
摘要： PROBLEM TO BE SOLVED: To provide a lycopene composition of high lycopene content having high safety, a method of producing the same and use thereof in health food, food additives, medicines, cosmetics and animal feed. SOLUTION: A lycopene composition that includes lycopene in an amount of >=9 wt.% on the anhydrous basis and is perfectly free from other residual solvent than ethanol which is used in the production process. This lycopene composition is prepared by subjecting tomato treated product to centrifugation, microfiltration and ethanol fractionation and drying and pulverizing the resultant lycopene-including liquid, washing the powder with 30-100 vol.% ethanol, then removing the solvent. The lycopene composition is useful as a starting material for health food, food product, food additive, medicine, cosmetic or animal feed.

16. 发明专利

JP2002003487A METHOD FOR PRODUCING ISOFLAVONE COMPOUND 失效
公开(公告)号：JP2002003487A
公开(公告)日：2002-01-09
申请号：JP2000184802
申请日：2000-06-20
申请人： KIKKOMAN CORP
发明人： IZUMI TORU , TOBE KOUICHIROU , KASAI KOICHI , OKADA KIYOSHI , OBATA AKIO
IPC分类号： C07D311/36
摘要： PROBLEM TO BE SOLVED: To efficiently produce an isoflavone compound from a soy sauce cake. SOLUTION: The soy sauce cake heat-treated at >=105 deg.C is extracted with alkaline water and the resultant extract liquid is brought into contact with an adsorbent to adsorb the isoflavone compound in the extract liquid. The compound is then eluted with alkaline water and precipitated under acidic conditions to obtain the isoflavone compound.

17. 发明专利

JP2001204486A METHOD FOR PRODUCING ISOFLAVONE AGLYCONE-CONTAINING COMPOSITION 失效
公开(公告)号：JP2001204486A
公开(公告)日：2001-07-31
申请号：JP2000020393
申请日：2000-01-28
申请人： KIKKOMAN CORP
发明人： OBATA AKIO , MANAKA TATSUO , TOBE KOUICHIROU , IZUMI TORU , SAITO MINORU , KIKUCHI MAMORU
IPC分类号： C12P17/06
摘要： PROBLEM TO BE SOLVED: To provide a method for producing at a good recovery rate by a simple operation a composition containing soybean isoflavone aglycone composed mainly of soybean genistein. SOLUTION: A soybean protein raw material, soybean protein raw material extract or a soybean protein raw material by-product is subjected to enzymatic hydrolysis with an enzymatic agent having both of protease activity and β- glucosidase activity in order to make proteins derived from soybean be water-soluble and also to convert isoflavone glycosides into isoflavone aglycons. The water-soluble components are removed by being washed with water and then the water-insoluble components are recovered. The recovery rate is especially improved by adding 1-50% of an organic solvent to the enzymatic reaction solution.

18. 发明专利

JP2000325039A ANTI-ARTERIOSCLEROTIC FOOD 失效
公开(公告)号：JP2000325039A
公开(公告)日：2000-11-28
申请号：JP14262999
申请日：1999-05-24
申请人： KIKKOMAN CORP
发明人： YAMAKOSHI JUN , SAITO MINORU , OBATA AKIO , IZUMI TORU , TOBE KOUICHIROU
IPC分类号： A23G3/34 , A23G3/00 , A23L1/30 , A23L2/52 , A23L2/56 , A61K31/00 , A61K31/35 , A61K31/352 , A61K36/00 , A61K36/48 , A61K36/87 , A61P9/00 , A61P9/10
摘要： PROBLEM TO BE SOLVED: To obtain the subject food more effective even if taken in small amounts. SOLUTION: This food is obtained by incorporating an original food with proanthocyanidin and isoflavone, wherein, in particular, the proanthocyanidin to be used is grape seed extract, and the isoflavone to be used soy sauce cake extract. Thus, the objective anti-arteriosclerotic composition effective even if taken in small amounts can be afforded.

19. 发明专利

JP2000302797A EXTRACTION OF ACTEOSIDE 失效
公开(公告)号：JP2000302797A
公开(公告)日：2000-10-31
申请号：JP11496899
申请日：1999-04-22
申请人： KIKKOMAN CORP
发明人： WATANABE JUN , KASAI KOICHI , KANEGAE RYOTA , ARIGA TOSHIAKI , TOBE KOUICHIROU
IPC分类号： C07H15/18 , A61K31/00 , A61K31/70 , A61K31/7028 , A61K36/18 , A61P3/00 , A61P3/10 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To provide a method for efficiently extracting acteoside. SOLUTION: Acteoside is extracted from a plant raw material of the genus Piper of the family Piperaceae such as Piper aduncum. For example, Piper aduncum, Piper nigrum, Piper betle, Piper kadsura, Piper longum, Piper methysticum, Piper retrofractum, etc., may be cited as the plant of the genus Piper of the family Piperaceae. In order to extract acteoside, any part of the plant raw material may be used and, for example, the terrestrial part of Piper aduncum is especially preferable with respect to content.

20. 发明专利

JPH0390095A DEOXIMALTOOLIGOCIDE DERIVATIVE, ALPHA-AMYLASE ACTIVATING REAGENT CONTAINING SAME DERIVATIVE AS ACTIVE INGREDIENT AND DETERMINATION OF ALPHA-AMYLASE ACTIVITY USING SAME REAGENT 失效
公开(公告)号：JPH0390095A
公开(公告)日：1991-04-16
申请号：JP22484589
申请日：1989-08-31
申请人： KIKKOMAN CORP
发明人： TOKUTAKE SHOICHI , OGUMA TETSUYA , TOBE KOUICHIROU , KIKUCHI MAMORU , MIZUSAWA KIYOSHI , YAMATSUGU NOBUYUKI
IPC分类号： C12P19/14 , C07H15/203 , C07H15/26 , C08B31/08 , C12Q1/40
摘要： NEW MATERIAL:A compound expressed by formula I (R is aromatic chromophoric group; n is 2-6). EXAMPLE:2-chloro-4-nitrophenyl-6 -deoxy-beta-D-maltopentaoside. USE:Used as a reagent for alpha-amylase activation. PREPARATION:6-deoxycyclodextrin expressed by formula II (n is 4-6) is affected with cyclodextrinase to afford a reacted solution containing a mixture of 6- deoxymaltooligosaccharide expressed by formula III (one of X is H and other n+1 pieces are OH) having 6-deoxyglucose residues at various positions as principal ingredient.

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