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11. 发明专利

JPS5871887A CELL FUSION PROCESS 失效
公开(公告)号：JPS5871887A
公开(公告)日：1983-04-28
申请号：JP16895381
申请日：1981-10-22
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： YOSHII FUMIO , KAETSU ISAO
IPC分类号： C12N15/02 , C12N5/10 , C12N5/12
摘要： PURPOSE:To carry out the cell fusion in high efficiency, preventing the deactivation of the cells, by using a mono(meth)acrylate or di(meth)acrylate as a cell fusion agent and a water-soluble polymer as a protecting agent. CONSTITUTION:Fusion of cells of the same kind of different kinds of animals or vegetables is carried out by using (A) a mono(meth)acrylate or di(meth) acrylate of formulaI-IV (n is integer of >=10), preferably methoxypolyethylene glycol methacrylate of formulaIwherein n is 23 or 50 as a cell fusion agent and (B) a water-soluble polymer such as polyvinyl pyrrolidone, polyacrylamide, poly- DL-alanine, etc. as a protecting agent. The amounts of the cell fusion agent and the protecting agent are 40-50wt% and 5-10wt%, respectively.

12. 发明专利

JPS57108010A PREPARATION OF SLOW-RELEASING COMPOSITE 失效
公开(公告)号：JPS57108010A
公开(公告)日：1982-07-05
申请号：JP18443480
申请日：1980-12-25
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： ASANO MASAHARU , YOSHIDA MASARU , KAETSU ISAO
IPC分类号： A61K9/00 , A61K9/70 , A61K47/32 , A61K47/34 , A61K47/42
摘要： PURPOSE:To obtain the titled composite, by dissolving a synthetic polymer and N-carboxyamino acid anhydride (NCA) in an organic solvent, adding a physiologically active substance to the solution before, during, or after the polymerization of the solution in the presence of an NCA-polymerization catalyst, and forming the polymer to the desired shape. CONSTITUTION:1pt.wt. of a synthetic polymer (e.g. polycarbonate) and 0.1-20pts. of N-carboxyamino acid anhydride (NCA) are dissolved in 10-50pts. of an organic solvent (e.g. dichloromethane). The solution is added with 0.01-1.0mol%, based on NCA, of an NCA-polymerization catalyst, and then with 1-200pts. of a physiologically active substance before, during or after the polymerization. The polymer is formed to desired shape, and the organic solvent is removed to obtain the slow-releasing composite. The composite has longer slow-releasing period than the composite containing a polypeptide as only carrier, and has excellent physical properties such as strength, hardness, etc. As an alternative method, the composite can be obtained by dissolving a synthetic polymer and a polypeptide in an organic solvent, and carrying out the similar operations.

13. 发明专利

JPS57106614A PREPARATION OF PROLONGED RELEASE TYPE COMPOSITE 失效
公开(公告)号：JPS57106614A
公开(公告)日：1982-07-02
申请号：JP18153080
申请日：1980-12-22
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： ASANO MASAHARU , YOSHIDA MASARU , KAETSU ISAO
IPC分类号： A61K47/42 , A61K9/22
摘要： PURPOSE:To obtain a prolonged release type composite having improved prolonged release properties and the desired shape, by mixing a powdery polypeptid with a powdery physiologically active substance, and treating the resultant mixture under pressure. CONSTITUTION:A powdery polypeptide, e.g. poly-alanine or polyglycine, is mixed with a physiologically active substance, e.g. beomycin drochloride, growth hormone, or antihistaminic agent, and the resultant mixture is then treated under a pressure of 50-20,000kg/cm to give the aimed prolonged release type composite of desired shape. According to the method, the polypeptide becomes a film in appearance, and the physiologically active substance is uniformly dispersed and covered with the film-like polypeptide to give the prolonged release type composite having a long duration of drug effects. The two components must be finely pulverized prior to the mixing thereof, e.g. by a method of pulverizing the components in a forzen state at -190 deg.C (liquid nitrogen temperature).

14. 发明专利

JPS57106610A PREPARATION OF PROLONGED RELEASE TYPE COMPOSITE 失效
公开(公告)号：JPS57106610A
公开(公告)日：1982-07-02
申请号：JP18153180
申请日：1980-12-22
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： ASANO MASAHARU , YOSHIDA MASARU , KAETSU ISAO
IPC分类号： A61K9/00 , A61K9/22 , A61K47/42
摘要： PURPOSE:To obtain a hard prolonged release type composite having a long prolonged releasing time of a physiologically active substance, by molding a system consisting of a heat denaturing protein, a mixed solution of water with an organic solvent and a physiologically active substance into a suitable shape, and heat-treating the resultant molded material. CONSTITUTION:A system consisting of 10pts.wt. heat denaturing protein, e.g. albumin, gamma-globuin or hemoglobin, with 0.01-10pts.wt. mixed solution of water with an organic solvent and 0.01-50pts.wt. physiologically active substance is molded into a suitable shape, and the resultant molded article is then heat- treated at room temperature -100 deg.C to give the aimed prolonged release type composite. The prolonged release type composite prepared by using the mixed solution of water with the organic solvent has remarkable improved prolonged releasing properties compared with that of the water alone, and improved properties such as a slight porous structure formed in the composite. The heat treatment and the light or ionizing radiation provide better effects. Preferably, the mixed solution is used in an amount of 0.5-1pt.wt. based on 1pt.wt. water.

15. 发明专利

JPS579711A PREPARATION OF PROLONGED RELEASE TYPE COMPLEX 失效
公开(公告)号：JPS579711A
公开(公告)日：1982-01-19
申请号：JP8383380
申请日：1980-06-20
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： KAETSU ISAO , ASANO MASAHARU , YOSHIDA MASARU
IPC分类号： A61K47/42 , A61K9/00
摘要： PURPOSE:To obtain a prolonged release type complex having a very long duration of drug effects, by irradiating a system consisting of a physiologically active substance and an aqueous solution of collagen with ionizing radiation, and freeze- drying the resultant system. CONSTITUTION:One or two or more physiologically active substances are brought into contact with an aqueous solution containing collagen, and if necessary the mixture is heat-treated to denature the collagen and then irradiated with ionizing radiation and freeze-dried to give a prolonged release type complex containing the physiologically active substances entrapped in the collagen matrix. A carcinostatic agnet, anti-inflammatory agent, vitaminic agent, vaccine, etc. may be cited as the physiologically active substances. The resultant complex is capable of releasing the physiologically active substances for 30 days or longer. A release type complex of multilayered structure can be prepared by repeating the preparing operations suitably.

16. 发明专利

JPS579709A PREPARATION OF PROLONGED RELEASE TYPE COMPLEX 失效
公开(公告)号：JPS579709A
公开(公告)日：1982-01-19
申请号：JP8254580
申请日：1980-06-18
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： KAETSU ISAO , ASANO MASAHARU , YOSHIDA MASARU
IPC分类号： C08F2/00 , A61K9/00 , A61K47/42 , C08F2/48 , C08F2/54
摘要： PURPOSE:To obtain a prolonged release type complex having a very long duration of drug effect, by mixing a biocompatible hydrophilic polymerizable monomer with a thermally denaturable protein and a physiologically active substance, and heat- treating and irradiating the mixture with light or ionizing radiation. CONSTITUTION:One or two or more hydrophilic polymerizable monomers containing a body fluid and/or isotonic solution are mixed with one or two or more thermally denaturable protein and one or two or more physiologically active substances, and the resultant mixture is then heat-treated to denature the protein. The resultant mixture is then irradiated with heat or ionizing radiation to polymerize the monomers, and the physiologically active substance is supported on both the denatured protein and the polymer to give a prolonged release type complex. A carcinostatic agent, hormonal or antihistaminic agent may be cited as the physiologically active substance. The resultant complex is formulated into a film, sheet or granules and can be assimilated and digested thoroughly without showing foreign body (substance) reactions to biological tissues.

17. 发明专利

JPS56110052A MANUFACTURE OF UNIT SYSTEM FOR MEDICAL ANALYSIS 失效
公开(公告)号：JPS56110052A
公开(公告)日：1981-09-01
申请号：JP1290380
申请日：1980-02-05
申请人： JAPAN ATOMIC ENERGY RES INST , NIPPON KOTAI KENKYUSHO KK
发明人： KAETSU ISAO , KUMAKURA MINORU , ADACHI SHIYOUICHI , SUZUKI MIEKO
IPC分类号： C08F2/00 , A61K47/32 , C08F2/44 , C08F2/48 , G01N33/545
摘要： PURPOSE:To fix a large amount of antigen, antibody and the like on the surface of a carrier firmly without damaging the activity thereof by coating the surface of the supporting carrier with the mixture of polymeric monomer and biological active material and by applying prescribed treatment. CONSTITUTION:The mixture formed of the polymeric monomer and the biological active material is applied on the surface of the supporting carrier, a light or ionizing radiation is applied thereon to polymerize the polymeric monomer, and the biological active material is fixed on the surface of the supporting carrier. As the polymeric monomer polymeric monomer of vinyl can be used. In addition, the biological active material is used in the form of buffer solution or water solution.

18. 发明专利

JPS5639786A PREPARATION OF POLYMER COMPOSITION CONTAINING CELL OR ORGANELLE 失效
公开(公告)号：JPS5639786A
公开(公告)日：1981-04-15
申请号：JP11394179
申请日：1979-09-05
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： KAETSU ISAO , FUJIMURA TAKU , YOSHII FUMIO
IPC分类号： C08L101/00 , C08K5/00 , C12N11/04 , C12N11/08
摘要： PURPOSE:To obtain a stabilized polymer composition, by polymerizing a monomer having the supercooling property at a low temperature with light or ionizing radiation to immobilize a cell or organelle in a synthetic high polymer carrier. CONSTITUTION:A protective substance, e.g. bovine serum albumin, gelatin or sorbitol, and a monomer, e.g. hydroxyethyl acrylate or diethylene glycol dimethacrylate, or a mixture thereof having the supercooling property at a low temperature are mixed with a suspension of a cell or organelle in a buffer solution of pH7-8 containing saccharose, Trizma base and common salt. The resultant mixture is then cooled at 0 deg.C or below, preferably -20--100 deg.C, and polymerized with ultraviolet light or ionizing radiation.

19. 发明专利

JPS5639784A POLYMER COMPOSITION CONTAINING CHLOROPLAST AND ITS PREPARATION 失效
公开(公告)号：JPS5639784A
公开(公告)日：1981-04-15
申请号：JP11393979
申请日：1979-09-05
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： KAETSU ISAO , FUJIMURA TAKU , YOSHII FUMIO
IPC分类号： C08L101/00 , C08K5/00 , C08L33/00 , C08L33/02 , C08L77/00 , C12N11/04 , C12N11/08
摘要： PURPOSE:To obtain a stabilized polymer composition containing chloroplast, by polymerizing a monomer having the supercooling property at a low temperature with light or ionizing radiation to immobilize the chloroplast in a synthetic high polymer carrier. CONSTITUTION:A protective substance, e.g. bovine serum albumin, gelatin or sorbitol, and a monomer, e.g. hydroxyethyl acrylate or diethylene glycol dimethacrylate, or a mixture thereof having the supercooling property at a low temperature are mixed with a suspension of chloroplast in a buffer solution of pH 7-8 containing saccharose, Trizma base and common salt. The resultant mixture is then cooled at 0 deg.C or below, preferably -20--100 deg.C, and polymerized with ultraviolet light or ionizing radiation.

20. 发明专利

JPS5626910A PREPARATION OF SLOWWRELEASE ANTICANCER COMPLEX COMPOSITION 失效
公开(公告)号：JPS5626910A
公开(公告)日：1981-03-16
申请号：JP10299679
申请日：1979-08-13
申请人： JAPAN ATOMIC ENERGY RES INST
发明人： YOSHIDA MASARU , KAETSU ISAO
IPC分类号： C08F2/00 , A61K9/58 , A61K9/64 , A61K47/32 , C08F2/44 , C08F2/46 , C08F2/48 , C08F30/00 , C08F30/08 , C08F290/00 , C08F299/00 , C08F299/08
摘要： PURPOSE:To obtain the titled complex composition, capable of controlling release of a physiologically active material for a long period of time, by compounding a hydrolysis-condensation product of two specified silane derivatives, with an anti- cancer drug, and by irradiating light, an ionizing radiation, etc., onto the resulting compound. CONSTITUTION:(a) A vinylsilane compound of formula I or II (wherein R is a is a is OR or a

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