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11. 发明专利

JP2009022303A Stabilized sarcosine oxidase 审中-公开
标题翻译：稳定的焦磷酸氧化酶
公开(公告)号：JP2009022303A
公开(公告)日：2009-02-05
申请号：JP2008263717
申请日：2008-10-10
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KISHIMOTO TAKAHIDE , SOGABE ATSUSHI , OKA MASANORI
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/06 , C12Q1/26
摘要： PROBLEM TO BE SOLVED: To provide a sarcosine oxidase which is obtained by modifying a protein having sarcosine oxidase activity by a protein engineering method and has improved stability in a liquid state, to provide a method for producing the same, and to provide a use thereof. SOLUTION: This modified sarcosine oxidase is formed by replacing lysine at the 89 site and serine at the 213 site of an amino acid sequence described in the sequence No.1 of a sequence table with arginine and proline, respectively. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供通过蛋白质工程方法修饰具有肌氨酸氧化酶活性的蛋白质并且具有改善的液态稳定性而获得的肌氨酸氧化酶，以提供其制备方法，并提供其用途。解决方案：该修饰的肌氨酸氧化酶分别通过用精氨酸和脯氨酸替代序列表中所述的89位氨基酸序列的氨基酸序列的第89位的赖氨酸和213位的丝氨酸而形成。版权所有（C）2009，JPO＆INPIT

12. 发明专利

JP2008247839A Antioxidant comprising chalcone glycoside 审中-公开
标题翻译：抗氧化剂包含氯氰菊酯
公开(公告)号：JP2008247839A
公开(公告)日：2008-10-16
申请号：JP2007092319
申请日：2007-03-30
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： SHINDO KAZUTOSHI , KITAZAWA HIROAKI , KITAGAWA MASARU , SOGABE ATSUSHI
IPC分类号： A61K31/7034 , A23L1/30 , A61K8/60 , A61K8/97 , A61K36/00 , A61K36/28 , A61P17/00 , A61P17/18 , A61P25/00 , A61P25/28 , A61P39/06 , A61P43/00 , A61Q19/02 , A61Q19/08 , C09K15/08 , C09K15/34
摘要： PROBLEM TO BE SOLVED: To provide an antioxidant excellent in radical-eliminating action and lipid peroxidation-suppressing action, and to provide an external preparation containing the antioxidant. SOLUTION: The antioxidant comprising a chalcone glycoside and/or chalcone glycoside-containing extracts as an active ingredient and the external preparation containing the antioxidant are provided. As the chalcone glycoside-containing extracts, extracts of at least one plant selected from Cosmos plants, Dahlia plants and Chrysanthemum plants belonging to Compositae family, especially of Cosmos sulphureus Cav. are preferable. The chalcone glycoside as an antioxidant active material contained in the plants is coreopsin. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：解决问题的方法：提供一种抗自由基消除作用和脂质过氧化抑制作用优异的抗氧化剂，提供含有抗氧化剂的外用剂。解决方案：提供含有查耳酮糖苷和/或查耳酮糖苷提取物作为活性成分的抗氧化剂和含有抗氧化剂的外用制剂。作为含有查耳酮糖苷的提取物，选自属于菊科的宇宙植物，大丽花植物和菊花植物中的至少一种植物的提取物，特别是天竺葵（Cosmos sulphureus Cav。）。是优选的。植物中含有的作为抗氧化活性物质的查耳酮糖苷是核心蛋白。版权所有（C）2009，JPO＆INPIT

13. 发明专利

JP2008239547A Plant-derived activator and extracellular matrix production promoter 有权
标题翻译：植物衍生的激活剂和细胞基质生产促进剂
公开(公告)号：JP2008239547A
公开(公告)日：2008-10-09
申请号：JP2007082260
申请日：2007-03-27
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KASUKABE YOSHIHISA , SUZUKI MICHIKO , SOGABE ATSUSHI
IPC分类号： A61K8/97 , A23L1/30 , A61K8/41 , A61K31/132 , A61K36/00 , A61K36/48 , A61K36/899 , A61P17/14 , A61P17/16 , A61P43/00 , A61Q7/00 , A61Q17/04 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To solve a problem that although various animal-derived or plant-derived activators have been found, such a sufficient and stable effect as to be actually usable in terms of industry is not achieved, and to provide a plant-derived activator or extracellular matrix production promoter having an excellent activation or extracellular matrix production promotion effect on cells. SOLUTION: The activator or extracellular matrix production promoter comprises a plant extract containing a polyamine as an active ingredient. A method for using the activator or extracellular matrix production promoter as a cosmetic, a quasi-medicine (skin care preparation, bath medicine, hair grower etc.), a food and beverage or a medicine comprising it as an active ingredient is provided. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了解决虽然已经发现了各种动物来源或植物来源的活化剂，但是没有实现如实际上可用于工业方面的足够和稳定的效果，并且提供一种植物来源的活化剂或细胞外基质产生促进剂，对细胞具有优异的活化或细胞外基质产生促进作用。解决方案：活化剂或细胞外基质产生促进剂包含含有多胺作为活性成分的植物提取物。提供了使用活化剂或细胞外基质产生促进剂作为化妆品，准医药（护肤品，浴药，头发种植者等），食品和饮料或其中含有它作为活性成分的药物的方法。版权所有（C）2009，JPO＆INPIT

14. 发明专利

JP2008187902A Method for producing deacylated product of glycolipid type biosurfactant 有权
标题翻译：生产GLYCOLIPID型生物交换剂脱水产物的方法
公开(公告)号：JP2008187902A
公开(公告)日：2008-08-21
申请号：JP2007022445
申请日：2007-01-31
申请人： National Institute Of Advanced Industrial & Technology , Toyobo Co Ltd , 東洋紡績株式会社 , 独立行政法人産業技術総合研究所
发明人： KITAGAWA MASARU , YAMAMOTO SHUHEI , SUZUKI MICHIKO , SOGABE ATSUSHI , KITAMOTO MASARU , MORITA TOMOTAKE , IMURA TOMOHIRO , FUKUOKA TOKUMA
IPC分类号： C12P19/02 , C07H15/04
摘要： PROBLEM TO BE SOLVED: To provide a method for producing a biosurfactant, such as glycolipid, having high biodegradability and low toxicity and which is environmentally friendly and has improved water solubility in order to attempt wide spreadof the biosurfactant in the food industry, cosmetic industry, medicalindustry, chemical industry, and environmental field, or the like.
SOLUTION: The method for producing a deacylated product of a glycolipid type biosurfactant comprises regioselectively cleaving the acyl group of a glycolipid type biosurfactant by using a hydrolase.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了提供一种生产生物降解性和低毒性的生物表面活性剂如脂肪酸的生物表面活性剂的方法，其是环境友好的并且为了尝试在食品工业中生物表面活性剂的广泛扩散而具有改善的水溶性，化妆品工业，医疗工业，化学工业和环境领域等。解决方案：用于制备糖脂型生物表面活性剂的脱酰基化产物的方法包括通过使用水解酶区域选择性地切割糖脂型生物表面活性剂的酰基。版权所有（C）2008，JPO＆INPIT

15. 发明专利

JP2008079600A Method for producing mannosyl erythritol lipid 有权
标题翻译：生产曼尼列酮脂质体的方法
公开(公告)号：JP2008079600A
公开(公告)日：2008-04-10
申请号：JP2006331073
申请日：2006-12-07
申请人： National Institute Of Advanced Industrial & Technology , Toyobo Co Ltd , Tsuru Gakuen , 学校法人鶴学園 , 東洋紡績株式会社 , 独立行政法人産業技術総合研究所
发明人： MORITA TOMOTAKE , KONISHI MASAO , FUKUOKA TOKUMA , IMURA TOMOHIRO , KITAMOTO MASARU , KADOKAWA KOJI , KITAGAWA MASARU , SOGABE ATSUSHI
IPC分类号： C12N1/14 , C07H15/04 , C12N15/09 , C12P19/44
摘要： PROBLEM TO BE SOLVED: To provide a microbial strain capable of efficiently producing MEL-C which is difficult to produce in a mass and a method for efficiently producing mannosyl erythritol lipid composed mainly of MEL-C by using the microbial strain.
SOLUTION: The invention provides a microbial strain having a ribosome RNA gene containing a base sequence having ≥95% homology with the base sequence shown by the sequence number 1, having high MEL-C productivity and belonging to the genus Pseudozyma, and a method for producing mannosyl erythritol lipid by culturing the microbial strain in a medium containing oil-and-fat and separating produced mannosyl erythritol lipid composed mainly of MEL-C from the culture product.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：待解决的问题：提供能够有效地生产质量难以产生的MEL-C的微生物菌株和通过使用微生物菌株有效地制备主要由MEL-C组成的甘露糖基赤藓糖醇脂质的方法。解决方案：本发明提供一种具有核糖体RNA基因的微生物菌株，其含有与序列号1所示的碱基序列具有≥95％同源性的碱基序列，具有高MEL-C生产力并属于假酶属的碱基序列，以及通过在含有油脂的培养基中培养微生物菌株并从培养产物中分离产生的主要由MEL-C组成的甘露糖基赤藓糖醇脂质来制备甘露糖基赤藓糖醇脂质的方法。版权所有（C）2008，JPO＆INPIT

16. 发明专利

JP2008044857A Ameliorating agent for skin roughening 审中-公开
标题翻译：用于皮肤粗化的美容剂
公开(公告)号：JP2008044857A
公开(公告)日：2008-02-28
申请号：JP2006219379
申请日：2006-08-11
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KITAGAWA MASARU , SUZUKI MICHIKO , YAMAMOTO SHUHEI , SOGABE ATSUSHI
IPC分类号： A61K8/60 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To find out a humectant actions and ceramide substitution effects as new functions in a biosurfactant such as an environmentally friendly glycolipid having high degradability and low toxicity and to provide a material utilizing the functions.
SOLUTION: A cosmetic material and an ameliorating agent for skin roughening characterized as comprising a triacyl derivative of a glycolipid type biosurfactant which is a triacyl derivative of MEL (mannosyl erythritol lipid) or MML (mannosyl mannitol lipid) as an active ingredient are provided.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：发现作为生物表面活性剂的新功能的湿润作用和神经酰胺替代效应，例如具有高降解性和低毒性的环境友好的糖脂，并提供利用该功能的材料。解决方案：用于皮肤粗糙化的化妆品材料和改善剂，其特征在于包含作为活性成分的作为MEL（甘露糖基赤藓糖醇脂质）或MML（甘露糖基甘露醇脂质）的三酰基衍生物的糖脂型生物表面活性剂的三酰基衍生物是提供。版权所有（C）2008，JPO＆INPIT

17. 发明专利

JP2007195453A Glycerol kinase variant 有权
标题翻译：甘油激酶变体
公开(公告)号：JP2007195453A
公开(公告)日：2007-08-09
申请号：JP2006017630
申请日：2006-01-26
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KISHIMOTO TAKAHIDE , SOGABE ATSUSHI , HATTA TAKASHI , INAGAKI KENJI
IPC分类号： C12N9/12 , C12N15/09
摘要： PROBLEM TO BE SOLVED: To obtain a glycerol kinase having high thermostability and high resistance to a preservative and to use the enzyme for quantifications of neutral fat and glycerol.
SOLUTION: The variant protein is a variant protein in which a cysteine residue in an amino acid sequence constituting a parent protein having glycerol kinase activity is substituted with another amino acid.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：获得具有高耐热性和对防腐剂的高抗性的甘油激酶，并使用该酶用于定量中性脂肪和甘油。解决方案：变体蛋白是其中构成具有甘油激酶活性的亲本蛋白的氨基酸序列中的半胱氨酸残基被另一个氨基酸取代的变体蛋白质。版权所有（C）2007，JPO＆INPIT

18. 发明专利

JP2007174957A Yeast for producing hyaluronic acid 审中-公开
标题翻译： YEAST生产HYALURONIC酸
公开(公告)号：JP2007174957A
公开(公告)日：2007-07-12
申请号：JP2005376390
申请日：2005-12-27
申请人： National Institute Of Advanced Industrial & Technology , Toyobo Co Ltd , 東洋紡績株式会社 , 独立行政法人産業技術総合研究所
发明人： YAMAMOTO SHUHEI , SOGABE ATSUSHI , SHIBATANI SHIGEO , YANAGIYA SHUSAKU , KITAZAWA HIROAKI , OGIYA SATORU , SAWARA TAKEHIKO
IPC分类号： C12N15/09 , A23L1/30 , A61K8/73 , A61K31/728 , A61P17/02 , A61P19/02 , A61P27/02 , C12N1/19 , C12P19/04
摘要： PROBLEM TO BE SOLVED: To provide a method for producing hyaluronic acid, with which hyaluronic acid is produced in an in vivo system using yeast and which is industrially advantageous with respect to safety, cost, etc., to obtain transformed yeast and an expression recombinant vector for producing hyaluronic acid. SOLUTION: The method for producing hyaluronic acid comprises: (1) a process for transforming yeast by using an expression recombinant vector containing a DNA encoding a protein having hyaluronate synthase activity under control of a promoter functioning in yeast; (2) a process for culturing a transformant obtained by transformation; and (3) a process for separating hyaluronic acid produced by the transformant. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供一种生产透明质酸的方法，在使用酵母的体内系统中产生透明质酸，并且在安全性，成本等方面在工业上有利于获得转化的酵母和用于产生透明质酸的表达重组载体。解决方案：用于生产透明质酸的方法包括：（1）通过使用含有编码具有透明质酸合成酶活性的蛋白质的DNA的表达重组载体在酵母中起启动子启动控制下来转化酵母的方法; （2）通过转化获得的转化体的培养方法; 和（3）分离由转化体产生的透明质酸的方法。版权所有（C）2007，JPO＆INPIT

19. 发明专利

JP2006304778A Plant producing udp-glcnac in high productivity 审中-公开
标题翻译：以高生产力生产UDP-GLCNAC的工厂
公开(公告)号：JP2006304778A
公开(公告)日：2006-11-09
申请号：JP2006082632
申请日：2006-03-24
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： KITAZAWA HIROAKI , SHIBATANI SHIGEO , SOGABE ATSUSHI
IPC分类号： C12N15/09 , A01H1/00 , A01H5/00 , C12N5/10 , C12P19/30
摘要： PROBLEM TO BE SOLVED: To provide a plant producing safe UDP-GlcNAc in high productivity and a method for producing UDP-GlcNAc from a plant producing an inexpensive and safe UDP-GlcNAc in high productivity by utilizing that the plant as a field of a material production is a production system having high safety and not containing infectious material to human and the plant is a low-cost production system, compared with a case using animals and microorganisms. SOLUTION: The present invention provides a transformed plant cell or a transformed plant or its descendent or organs thereof or tissues thereof producing uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) in high productivity, in which exogenous GFAT (glutamine:fructose-6-phosphoric amide transferase) gene is introduced. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供以高生产率生产安全的UDP-GlcNAc的植物，以及通过利用植物作为田地，以高生产率从生产廉价且安全的UDP-GlcNAc的植物生产UDP-GlcNAc的方法与使用动物和微生物的情况相比，材料生产的生产系统是具有高安全性并且不含人感染性材料的生产系统，并且该植物是低成本的生产系统。解决方案：本发明提供转化的植物细胞或转化植物或其后代或其器官或其组织，以高生产率制备尿苷二磷酸-N-乙酰葡糖胺（UDP-GlcNAc），其中外源GFAT（谷氨酰胺：果糖 -6-磷酰胺转移酶）基因。版权所有（C）2007，JPO＆INPIT

20. 发明专利

JP2006232807A Antioxidant containing horseradish extract 审中-公开
标题翻译：含抗氧化剂的马尾松提取物
公开(公告)号：JP2006232807A
公开(公告)日：2006-09-07
申请号：JP2005268402
申请日：2005-09-15
申请人： Toyobo Co Ltd , 東洋紡績株式会社
发明人： SUZUKI MICHIKO , KITAGAWA MASARU , SOGABE ATSUSHI
IPC分类号： A61K36/18 , A61K31/375 , A61K31/7034 , A61P39/06
摘要： PROBLEM TO BE SOLVED: To provide an antioxidant which has excellent safety and solves a problem that it is difficult to industrially stably obtain conventional natural substance-derived antioxidants in large amounts and a problem that synthetic antioxidants are shunned by consumers from the aspect of safety. SOLUTION: An extract having an anti-oxidizing action is obtained from a horseradish (Cochlearia armoracia L.) which is a cruciferous perennial plant. The antioxidant is characterized by containing the extract. COPYRIGHT: (C)2006,JPO&NCIPI

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