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    • 14. 发明专利
    • Preparation of 3,5,5-trimethyl-2-cyclohexen-1-one derivative
    • 3,5,5-三甲基-2-环己基-1-酮衍生物的制备
    • JPS58198434A
    • 1983-11-18
    • JP8007182
    • 1982-05-14
    • Soda Koryo Kk
    • NAMITA TAKESHIETOU TAKEAKISUZUKI KIYONORIITOU NOBUHIKO
    • C07C67/313C07C45/00C07C45/51C07C49/603C07C49/757C07C67/00C07C69/738C07C231/00C07C231/12C07C235/78C07C253/00C07C255/31
    • PURPOSE: To prepare the titled substance in short steps, by reacting 3,5,5-trimethyl-2-cyclohexen-1-one magnesium enolate with an olefinic compound, hydrolyzing the reaction product, and if necessary, treating with an acid or a base.
      CONSTITUTION: The compound of formula III is prepared by reacting the compound of formula I (X is halogen) with the compound of formula II [R
      1 and R
      2 are H or 1W5C aliphatic hydrocarbon group; Y is -C(=0)R
      3 , -COOR
      4 or -CONR
      5 R
      6 (R
      3 , R
      5 and R
      6 are H or 1W5C aliphatic hydrocarbon group; R
      4 is 1W5C aliphatic hydrocarbon group] at a molar ratio of 1:(1W1.5) at -20W +5°C, hydrolyzing the reaction product to remove magnesium, and if necessary, treating the hydrolyzate with an acid or a base.
      EFFECT: The objective compound can be prepared in high yield with simple operation.
      USE: Flavor for food, drink, cosmetic, tobacco, etc. Intermediate of carotinoid, perfumery, pharmaceuticals, etc.
      COPYRIGHT: (C)1983,JPO&Japio
    • 目的:为了以短时间步骤制备标题物质,通过使3,5,5-三甲基-2-环己烯-1-酮镁烯醇化物与烯烃化合物反应,水解反应产物,如果需要,用酸或 基础。 结构式:式III化合物通过使式I化合物(X为卤素)与式Ⅱ化合物反应制备:[R 1和R 2]为H或1-5C脂族烃基; Y是-C(= O)R 3,-COOR 4或-CONR 5 R 6(R 3,R 5和R 6)是H或1-5C脂族基 烃基; R 4为1-5C脂肪族烃基],在-20〜+ 5℃下摩尔比为1:(1-1.5),水解反应产物以除去镁,如果需要, 使用:食品,饮料,化妆品,烟草等的中等程度的类胡萝卜素,香料,药物等的中间体。