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92. 发明专利

JPH02101018A IMPROVEMENT RELATING TO ORGANIC COMPOUND 失效
公开(公告)号：JPH02101018A
公开(公告)日：1990-04-12
申请号：JP25468188
申请日：1988-10-07
申请人： ISUCHI NATSUIYONAALES PERU RO , SANDOZ AG
发明人： ARETSUSANDORO EMU JIANNI
IPC分类号： A61K38/00 , A61P7/00 , A61P35/00 , A61P43/00
摘要： PURPOSE: To treat with a cell-injuring agent and with GM-CSM, simultaneously taking out peripheral blood and marrow, and subsequently reinjecting the blood or leukocytes obtained from the blood together with the marrow to stimulate the reproduction of the marrow. CONSTITUTION: A high dose (properly 6-7g/m ) of a medicine injuring cells but allowing stem cells (e.g. cyclophosphamide) is administered, and GM-CSF is subsequently administered at a daily dose of 6-24μg/kg for 10-14 days. When marrows are actively proliferated and when stem cell precursors are contained in peripheral blood (properly when the number of leukocytes exceeds 1000/μ liter and when the number of platelets exceeds 100000/μliter), the marrow and a prescribed volume of the peripheral blood or leukocytes obtained from the peripheral blood are taken out. The marrow is sufficiently removed by a chemotherapy or radiotherapy, and the marrow and the peripheral blood or leukocytes obtained from the blood are subsequently reinjected 3-24hrs later. If necessary, GM-CSF is continuously administered until the reproduction of the marrow occurs.

93. 发明专利

JPH0249067A BASIC COMPOUND CONTAINING NO SULFONIC ACID GROUP 失效
公开(公告)号：JPH0249067A
公开(公告)日：1990-02-19
申请号：JP11284789
申请日：1989-05-06
申请人： SANDOZ AG
发明人： HERUMUUTO ANTON MOZEERU , ROORAN WARUDO
IPC分类号： C09B44/08 , C07D401/12 , C07D401/14 , C09B29/42 , C09B35/031 , C09B35/039 , C09B43/16 , C09B45/14

94. 发明专利

JPH0220264A LOW CHOLESTEROL EGG PRODUCT 失效
公开(公告)号：JPH0220264A
公开(公告)日：1990-01-23
申请号：JP13028889
申请日：1989-05-25
申请人： SANDOZ AG
发明人： YUUJIN AARU MARII , POORIN EMU ORUSON , JIEISON EICHI YANGU
IPC分类号： A23L15/00
摘要： PURPOSE: To obtain an egg product having flavor and texture of a whole egg and having low cholesterol amt. by compounding an egg white and food gum into a yolk in a smaller amt. than that in a whole egg, controlling the mixture to specified pH and then pasteurizing. CONSTITUTION: An egg white and food gum are compounded into a smaller amt. of a yolk than that in a whole egg and the pH of the egg component is controlled to obtain 6.35 to 7.8 pH of the finish product. Further, each component or mixture of these are pasteurized to produce an egg product with a low cholesterol content. By compounding food gum, the flavor and texture of a whole egg can be maintained even when about 90wt.% of the yolk in a whole egg is replaced by an egg white. As for the food gum, κ-carrageenan, ι-carrageenan or a mixture of these and food gum such as carob bean gum and fine crystalline cellulose can be used.

95. 发明专利

JPH026690A SURFACE SIZE OF PAPER STRUCTURE 失效
公开(公告)号：JPH026690A
公开(公告)日：1990-01-10
申请号：JP7071789
申请日：1989-03-24
申请人： SANDOZ AG
发明人： SEODORU RANGU
IPC分类号： D21H19/10 , D21H17/12 , D21H17/24
摘要： PURPOSE: To effectively obtain a high-grade paper in a high yield from reusable waste paper by treating a surface-flat structure made of paper stuff with a sizing composition containing chitosan and a specified complex as sizing active components. CONSTITUTION: A surface-flat structure having at least 60 g/m weight (e.g. cardboard, board or the like) is obtained using wood fibers, reusable waste paper or the like, as raw materials. (A) Chitosan preferably having a molecular weight of 5×10 -5×10 protonated with hydrochloric acid, acetic acid or the like and (B) a (12-22C fatty acid)-Cr (III) complex obtained by allowing a 12-22C fatty acid to react with basic chromium chloride in alcohol are blended in a weight ratio A:B of 1:0.2 to 1:5 (the component A shows weight before protonation). The blend is adjusted to pH 3-6, applied to the surface of the structure by 0.005-0.3 g/m with an air knife or the like and dried to obtain the objective paper.

97. 发明专利

JPH021126B2 失效
公开(公告)号：JPH021126B2
公开(公告)日：1990-01-10
申请号：JP15937680
申请日：1980-11-11
申请人： SANDOZ AG
发明人： FUORUKAA HARUTOMAN , KAARUUHAINTSU OTSUTO , RUUDOITSUHI PATSUTO
IPC分类号： A61K31/48 , A61K9/00 , A61K9/08 , A61K47/10 , A61K47/16 , A61K47/18 , A61K47/22 , A61K47/36 , C07D519/02

99. 发明专利

JPH01279834A NOVEL USE OF 4-(3-PHOSPHONO- 2-PROPENYL)-2-PIPERAZINE CARBOXYLATE 失效
公开(公告)号：JPH01279834A
公开(公告)日：1989-11-10
申请号：JP5946789
申请日：1989-03-10
申请人： SANDOZ AG
发明人： AANORUDO KIISU DEIKUSON , JIYURIAN EI GUREI
IPC分类号： A61K31/675 , A61P25/04 , A61P25/06 , A61P25/20 , A61P25/24 , A61P25/26 , C07F9/6509
摘要： PURPOSE: To use a [R-(E)]-4(3-phosphono-2-propenyl)-2-piperazinecarboxylic acid compound for treating diseases characterized by impulsive diminution and/or social withdrawal, insomnia or megrim. CONSTITUTION: This medicinal composition for treating diseases characterized by the above-mentioned symptoms contains as active ingredient [R-(E)]-4(3- phosphono-2-propenyl)-2-piperazinecarboxylic acid, its hydrate, or medicinally permissible salt thereof. The daily dose of the active ingredient is normally about 0.3-3mg/kg, or about 5-800mg/kg for large-sized mammals such as human in one to four portions.

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