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1. 发明专利

JPH0597664A DRY SYRUP OF BIFEMELANE HYDROCHLORIDE 失效
公开(公告)号：JPH0597664A
公开(公告)日：1993-04-20
申请号：JP26399791
申请日：1991-10-11
申请人： MITSUBISHI CHEM IND
发明人： NOMURA TATSUO , IZUMIDA YOSHIRO
IPC分类号： A61K9/50 , A61K31/135 , A61K47/12 , A61K47/32 , A61K47/38 , A61K47/44 , A61P25/28
摘要： PURPOSE:To obtain a dry syrup capable of reducing bitter taste of bifemelane hydrochloride and administering in a state suspended in water. CONSTITUTION:The objective dry syrup in which fine powder containing bifemelane hydrochloride and flavor is coated with wax and further coated with a water-insoluble coating agent.

2. 发明专利

JPH0429929A SOLID DRUG COMPOSITION 失效
公开(公告)号：JPH0429929A
公开(公告)日：1992-01-31
申请号：JP13461790
申请日：1990-05-24
申请人： MITSUBISHI CHEM IND
发明人： SUNAHARA MASAKI , NOMURA TATSUO
IPC分类号： A61K9/20 , A61K31/47 , A61K47/12
摘要： PURPOSE:To obtain the subject solid drug composition capable of preparing a tablet having an excellent visual appearance by blending a quinolopyran-4-on-2- carboxylate or its tautomer as a therapeutic agent for antiallergic asthma with a weakly acidic substance. CONSTITUTION:A weekly acidic substance (e.g. adipic acid or succinic acid) is blended with a quinopyran-4-on-2-carboxylate of the formula (R -R are H, 1-5C alkyl, 1-5C alkoxy, benzyloxy, halogen, alkoxycarbonyl, aryl, or two of these are alkoxy and mutually bonded to form 1-3C alkylenedioxy; R is 5-6C alcohol residue selected from H, 3-methyl-1-butyl, 2-methyl-1-butyl, 2,2-dimethyl-1- propyl, 2-pentyl, etc., or its tautomer to obtain the objective solid drug composition capable of preparing a tablet having an excellent visual appearance.

3. 发明专利

JPS5430164A 22AMINOMETHYLL55PHENYLOXAZOLES AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS 失效
公开(公告)号：JPS5430164A
公开(公告)日：1979-03-06
申请号：JP9591777
申请日：1977-08-10
申请人： NIPPON SHINYAKU CO LTD , MITSUBISHI CHEM IND
发明人： INOUE SHIYOU , OOHATA KATSUYA , TSUTSUI TOSHIAKI , NOMURA TATSUO
IPC分类号： C07D263/32
摘要： PURPOSE:2-Aminomethyl-5-phenyloxazoles of formula I: (R1 is phenyl or halophenyl group; R2 is H, 1-3C alkyl, 2-6C hydroxyalkyl, 3-10C alkoxyalkyl, 1-5C alkyl group substituted by a 4-8C cyclic ether; R3 is 2-6C hydroxyalkyl,3-10C alkoxyalkyl,1-5C alkyl group substituted by a 4-8C cyclic ether) and their pharmaceutically acceptable acid salts.

4. 发明专利

JPS5430163A 22AMINOMETHYLL55PHENYLOXAZOLES AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID SALTS 失效
公开(公告)号：JPS5430163A
公开(公告)日：1979-03-06
申请号：JP9591677
申请日：1977-08-10
申请人： NIPPON SHINYAKU CO LTD , MITSUBISHI CHEM IND
发明人： INOUE SHIYOU , OOHATA KATSUYA , TSUTSUI TOSHIAKI , NOMURA TATSUO
IPC分类号： C07D263/32
摘要： PURPOSE:2-Aminomethyl-5-phenyloxazoles of formula I: [R1 is phenyl, halophenyl, or methoxyphenyl group; R2 and R3 are H, 3-10C cycloalkyl groups, or may form 3-7C alkylene which may be substituted by a 1-5C alkyl group (except when R1 is phenyl or halophenyl group, and R2 and R3 are H at the same time)].

5. 发明专利

JPS52105185A 22*44*22HYDROXYETHYL**11PIPERADINYLMETHYL**55PHENYLLOXAZOLES AND PHAR MCOLOGICALLY ACCEPTABLE ACID SALTS 失效
公开(公告)号：JPS52105185A
公开(公告)日：1977-09-03
申请号：JP2032876
申请日：1976-02-26
申请人： NIPPON SHINYAKU CO LTD , MITSUBISHI CHEM IND
发明人： INOUE SHIYOU , OOHATA KATSUYA , TSUTSUI TOSHIAKI , NOMURA TATSUO
IPC分类号： C07D263/32 , A61K31/495 , A61K31/496 , A61P25/04 , A61P29/00 , C07D295/14 , C07D413/06
摘要： PURPOSE:2-[4-(2-Hydroxyethyl)-1-piperadinylmethyl]-5-phenyloxazoles and their acid salts I(R1 is phenyl or halophenyl), e.g. 2-[4-(2-hydroxyethyl)piperazinylmethyl]-5-(4-chlorophenyl)-oxazole.hyd rochloride.

6. 发明专利

JPS5297964A 22AMINOMETHYLL55PHENYLOXAZOLES AND PHARMACOLOGICALLY ACCEPTABLE ACID S ALTS 失效
公开(公告)号：JPS5297964A
公开(公告)日：1977-08-17
申请号：JP1419476
申请日：1976-02-12
申请人： NIPPON SHINYAKU CO LTD , MITSUBISHI CHEM IND
发明人： INOUE SHIYOU , OOHATA KATSUYA , TSUTSUI TOSHIAKI , NOMURA TATSUO
IPC分类号： C07D263/32 , A61K31/42 , A61K31/421 , A61P25/04 , A61P29/00
摘要： PURPOSE:2-Aminomethyl-5-phenyloxazoles and its acid salts I(R1 is phenyl or halophenyl; R2 and R3 are H or 1-10C alkyl), e.g. 2-methylaminomethyl-5-phenyloxazole.

7. 发明专利

JPH06157325A CHOLESTEROL DEPRESSING AGENT FOR ORAL ADMINISTRATION 失效
公开(公告)号：JPH06157325A
公开(公告)日：1994-06-03
申请号：JP32015592
申请日：1992-11-30
申请人： MITSUBISHI CHEM IND
发明人： NOMURA TATSUO
IPC分类号： A61K31/785 , A61K47/38 , A61P3/06
摘要： PURPOSE:To provide a cholesterol depressing agent for oral administration stable even under humidified condition and having excellent abrasion resistance. CONSTITUTION:The cholesterol depressing agent for oral administration is prepared by coating a tablet composed mainly of an anion exchange resin with a coating agent containing a cellulosic compound such as hydroxypropyl cellulose.

8. 发明专利

JPH04342523A PRODUCTION OF WAX COATED PREPARATION 失效
公开(公告)号：JPH04342523A
公开(公告)日：1992-11-30
申请号：JP14378691
申请日：1991-05-20
申请人： MITSUBISHI CHEM IND
发明人： NOMURA TATSUO , IZUMIDA YOSHIRO
IPC分类号： A61K9/16 , A61K9/50 , A61K47/10 , A61K47/12 , A61K47/14
摘要： PURPOSE:To coat fine particles by dissolving a wax-containing coating raw material in a solvent under heating, spraying the solution at a specific temperature upon the surface of particles to become a core substance and rapidly depositing the coating raw material on the surface of the particles. CONSTITUTION:A coating raw material containing at least one or more wax such as fatty acid, higher alcohol or fatty acid glycerol ester is dissolved in a solvent such as methanol or ethanol under heating, the coating solution is sprayed upon a core substance (preferably tens microns to 5mm) while moving or rolling the substance at

9. 发明专利

JPH0413627A ORAL CHOLESTEROL LOWERING AGENT 失效
公开(公告)号：JPH0413627A
公开(公告)日：1992-01-17
申请号：JP11370490
申请日：1990-04-27
申请人： MITSUBISHI CHEM IND
发明人： NOMURA TATSUO , HAMADA YUJI , KURIHARA YUKIO , IZUMIDA YOSHIRO
IPC分类号： A61K45/08 , A61K31/785 , A61P3/06
摘要： PURPOSE:To obtain an oral cholesterol lowering agent containing a strongly basic anionic resin having an imidazolinium salt as a functional group and hydrophobic substance, having good internal use feeling and being stable at ambient temperature. CONSTITUTION:Imidazoles expressed by formula I (R1 is H, 1-17C alkyl or 6-8C aryl; R2 and R3 are H or 1-3C alkyl) are polymerized with a halomethyloxirane, e.g. epichlorohydrin, expressed by formula II (X is halogen; R4 is H or methyl) at substantial equivalent and the resultant high polymer quaternary salt is reacted with a prescribed amount of compound expressed by formula II at 40-60 deg.C and subjected to alkali treatment and then heated to provide a strongly basic anionic resin containing an imidazolinium salt as a functional group. The resin is granulated into proper grain size and the resin grains are blended with a hydrophobic substance such as higher fatty acid, higher alcohol or hydrocarbon of 1-20g based on the resin. In the pharmaceutical preparation process, a stable preparation reduced in hygroscopic property can be obtained by controlling water content to 3-16wt.%, especially 5-13wt.%.

10. 发明专利

JPH02286621A ORAL CHOLESTEROL LOWERING AGENT 失效
公开(公告)号：JPH02286621A
公开(公告)日：1990-11-26
申请号：JP10473489
申请日：1989-04-26
申请人： MITSUBISHI CHEM IND
发明人： NOMURA TATSUO , IZUMIDA YOSHIRO
IPC分类号： A61K31/785 , A61P3/06
摘要： PURPOSE:To obtain a readily administrable oral cholesterol lowering agent, containing an anion exchange resin, hydrophobic substance and binder and stable at ambient temperature. CONSTITUTION:The objective tablet obtained by mixing an anion exchange resin with a small amount of a hydrophobic substance and a binder, adding and mixing water or a binding solution so as to contain 3-16%, preferably 5-12% water therein, further adding a flow improving agent, etc., and tableting the resultant mixture. A highly fatty acid, metal salt or glycerol ester thereof, higher alcohol, etc., are used as the hydrophobic substance and the amount thereof blended is preferably 3-10% based on the weight of the total pharmaceutical. Hydroxypropyl cellulose, PVA, polyvinylpyrrolidone, alpha-starch, arginine, dextrin, etc., are used as the binder and the amount thereof blended is preferably 3-15% based on the weight of the total pharmaceutical.

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