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    • 3. 发明专利
    • Method for searching differentiated maturity inhibitor for fat cell and/or fat accumulation inhibitor
    • 搜索FAT细胞和/或脂肪蓄积抑制剂的差异成熟抑制剂的方法
    • JP2013036797A
    • 2013-02-21
    • JP2011171659
    • 2011-08-05
    • Kao Corp花王株式会社
    • URANO SATOMIMORI SHINOBUMURASE TAKATOSHI
    • G01N33/50A61K45/00A61P3/06C07K14/78C12Q1/02C12Q1/68G01N33/15
    • PROBLEM TO BE SOLVED: To provide a method for searching a differentiated maturity inhibitor for fat cells, or a fat accumulation inhibitor being effective on systematic or local body fat reduction.SOLUTION: The method for searching a differentiated maturity inhibitor for fat cells and/or a fat accumulation inhibitor is characterized in evaluating a laminin signal inhibition activity by a test substance in the fat cell. The laminin signal inhibition activity may be an activity for inhibiting the bond of laminin and laminin receptor, the laminin signal inhibition activity may be an activity for inhibiting the expression of laminin and laminin receptor, or the laminin signal inhibition activity may be an activity for inhibiting intracellular signal transduction caused by the laminin.
    • 要解决的问题:提供一种用于搜索脂肪细胞的分化成熟抑制剂的方法,或对系统或局部体内脂肪减少有效的脂肪蓄积抑制剂。 解决方案:用于搜索脂肪细胞和/或脂肪蓄积抑制剂的分化成熟抑制剂的方法的特征在于通过脂肪细胞中的测试物质评价层粘连蛋白信号抑制活性。 层粘连蛋白信号抑制活性可以是抑制层粘连蛋白和层粘连蛋白受体结合的活性,层粘连蛋白信号抑制活性可以是抑制层粘连蛋白和层粘连蛋白受体表达的活性,或者层粘连蛋白信号抑制活性可以是抑制 由层粘连蛋白引起的细胞内信号转导。 版权所有(C)2013,JPO&INPIT