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    • 5. 发明专利
    • Mite antigen rice
    • 空值
    • JP5263477B2
    • 2013-08-14
    • JP2007266864
    • 2007-10-12
    • 独立行政法人農業生物資源研究所
    • 文雄 高岩一矢 鈴木麗軍 楊
    • C12N15/09A01H1/00A01H5/00A23L1/305A61K36/899A61P37/08C07K19/00C12N5/10
    • C12N15/8258A23L33/18A61K36/899A61K2039/517C07K14/43531
    • An objective of the present invention is to provide methods for accumulating in rice seeds a partial peptide of a mite antigen protein comprising several T cell epitopes, or a mite antigen peptide that has been modified to not form a conformation to be recognized as an antigen, and plants which have accumulated these peptides. To achieve the above objective, the present inventors have tried to generate seeds (rice) of rice plants that have accumulated mite antigen peptide variants. As a result, the present inventors developed genetically modified rice plants which express and accumulate these mite antigen peptide variants, and demonstrated their effect on asthma, in particular, by orally feeding mice with these variants to induce immunological tolerance, thereby completing the present invention.
    • 本发明的目的是提供一种用于在水稻种子中堆积包含若干T细胞表位的螨抗原蛋白的部分肽或经修饰以形成未被认定为抗原构象的螨抗原肽的方法, 和已经积累了这些肽的植物。 为了实现上述目的,本发明人试图产生具有积累的螨抗原肽变体的水稻植物的种子(水稻)。 结果,本发明人开发了表达和积累这些螨抗原肽变体的转基因水稻植物,并且证明了其对哮喘的作用,特别是通过口服给予这些变体的小鼠以诱导免疫耐受性,从而完成了本发明。