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1. 发明专利

JPS62174014A RADIATION SENSITIZATION BY COBALT (III) OR IRON (III) COMPLEX 失效
公开(公告)号：JPS62174014A
公开(公告)日：1987-07-30
申请号：JP25280486
申请日：1986-10-23
申请人： JOHNSON MASSEY INC , DANAAFUAABAA KIYANSAA INST INC
发明人： ABRAMS MICHAEL J , TEICHER BEVERLY A
IPC分类号： A61K31/28 , A61K33/24 , A61K33/26 , A61P35/00 , C07F15/02 , C07F15/04
摘要： The present invention relates to radiosensitization and, more particularly, to rendering hypoxic cells more sensitive to being killed by X-rays or other forms of irradiation. In particular, the invention is directed to a pharmaceutical composition containing a radio-sensitizing amount of Co (III) or Fe (III) coordination compound selected from the group consisting of: …… (1) compounds having the formula:… [CoNnX6-n] (1)… where n has a value of 3 or 4;… N is an uncharged nitrogen donor atom that is contained in a ligand;… X represents an anionic ligand; and… Y represents the charge on the complex; … (2) compounds having the formula:… (CoA2X D) (2)… where A represents a bidentate or tetradentate negative ligand containing N or O donor atoms:… X and D represent the same or different monodentate ligands; and… Y represents a positive or negative charge on the complex; … (3) compounds having the formula:… [CoZ3] (3)… where Z represents a chelating mononegative ligand; and … (4) Compounds of the formula:… [Fe TT ] (4)… where T and T , which may be the same or different, represent mono-negative tridentate ligands. …… The invention also includes a method for rendering hypoxic cells more sensitive to irradiation which comprises subjecting the cells to treatment using the Co (III) or Fe (III) coordination compounds defined above.

2. 发明专利

JPS62105046A METHOD OF DETECTING ACTIVATED T CELL 失效
公开(公告)号：JPS62105046A
公开(公告)日：1987-05-15
申请号：JP25810886
申请日：1986-10-29
申请人： DANAAFUAABAA KIYANSAA INST INC
发明人： ERISU ERU REINHAATSU , ANDORESU ARUKOBUERU , MAIKERU JIEI UEISU
IPC分类号： G01N33/53 , G01N33/50 , G01N33/569

3. 发明专利

JPS6128000A Human nk cell dissoluble monoclonal antibody 失效
标题翻译：人NK细胞分离单克隆抗体
公开(公告)号：JPS6128000A
公开(公告)日：1986-02-07
申请号：JP8735485
申请日：1985-04-23
申请人： Danaafuaabaa Kiyansaa Inst Inc
发明人： TEIERII ERUSAN , JIEROOMU RITSUTSU , SUCHIAATO EFU SHIYUROSUMAN
IPC分类号： A61K39/395 , A61K38/00 , A61P37/00 , A61P37/06 , C07K14/005 , C07K14/195 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C12N5/00 , C12N5/06 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12Q1/04 , C12R1/91 , G01N33/53 , G01N33/574 , G01N33/577
CPC分类号： C07K16/28 , A61K38/00 , Y10S436/821 , Y10S530/864

4. 发明专利

JPS60115584A CHAIN PROLONGED ANALOGUE OF METHOTREXATE AND AMINOPTERIN 失效
公开(公告)号：JPS60115584A
公开(公告)日：1985-06-22
申请号：JP16947384
申请日：1984-08-15
申请人： DANAAFUAABAA KIYANSAA INST INC
发明人： ANDORE ROSOUSUKI
IPC分类号： A61K31/505 , A61K31/519 , A61P29/00 , A61P35/00 , A61P35/02 , C07D475/08

5. 发明专利

JPS60214799A Monoclonal antibody 失效
公开(公告)号：JPS60214799A
公开(公告)日：1985-10-28
申请号：JP26098484
申请日：1984-12-12
申请人： Danaafuaabaa Kiyansaa Inst Inc
发明人： SAMIYUERU DEII BAANARU
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12Q1/04 , C12R1/91 , G01N33/577
CPC分类号： C07K16/3023 , A61K38/00 , Y10S436/813 , Y10S436/821 , Y10S530/864

6. 发明专利

JPS6078983A CYSTEINOIC ACID OR HOMOCYSTEINOIC ACID ANALOG OF METHOTREXATE AND AMINOPTERIN 失效
公开(公告)号：JPS6078983A
公开(公告)日：1985-05-04
申请号：JP18292284
申请日：1984-09-03
申请人： DANAAFUAABAA KIYANSAA INST INC
发明人： ANDORE ROSOUSUKI
IPC分类号： A61K31/505 , A61K31/519 , A61P35/00 , A61P35/02 , C07D475/08

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