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1. 发明公开

EP4272000A2 LINKER STRUCTURES WITH MINIMAL SCAR FOR ENZYMATIC SYNTHESIS 审中-实审
公开(公告)号：EP4272000A2
公开(公告)日：2023-11-08
申请号：EP21881340.0
申请日：2021-12-09
申请人： Microsoft Technology Licensing LLC
发明人： NGUYEN, Bichlien, Hoang , SMITH, Jake
IPC分类号： G01N33/547

2. 发明公开

EP4111200A1 MÉTHODE D'IDENTIFICATION DE COMPOSÉS UTILES POUR LE TRAITEMENT D'UN CANCER 审中-公开
公开(公告)号：EP4111200A1
公开(公告)日：2023-01-04
申请号：EP21714639.8
申请日：2021-02-26
申请人： Université Paris-Saclay , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Institut Gustave-Roussy
发明人： BRENNER, Catherine , MODJTAHEDI, Nazanine
IPC分类号： G01N33/547 , G01N33/68 , G01N33/574 , C07K14/47 , C12N9/02 , C07K19/00

3. 发明公开

EP3289357A1 QUANTITATION OF FUNCTIONAL GROUPS ON SOLID SUPPORTS 有权
标题翻译：功能群在固体支持物上的定量
公开(公告)号：EP3289357A1
公开(公告)日：2018-03-07
申请号：EP16762498.0
申请日：2016-03-10
申请人： Siemens Healthcare Diagnostics Inc.
发明人： LIN, Spencer , REAMER, Christopher , SPEARS, Ryan
IPC分类号： G01N33/53 , G01N33/543 , G01N33/547
CPC分类号： G01N33/531 , G01N33/52 , G01N33/536 , G01N33/54306 , G01N33/54353
摘要： Processes for quantifying an amount of functional groups immobilized on a solid support are described herein. The processes allow for determining whether sufficient functional groups are provided on a solid support for the attachment of a first binding pair member for the detection of a target analyte.

4. 发明公开

EP3224260A1 LIGHT-ACTIVATED TWO-COMPONENT PROTEIN BINDING MATRIX 审中-公开
标题翻译：活化的双组分蛋白质结合基质
公开(公告)号：EP3224260A1
公开(公告)日：2017-10-04
申请号：EP15854188.8
申请日：2015-10-29
申请人： National University of Singapore
发明人： DRUM, Chester Lee
IPC分类号： C07D491/107 , C07D209/12 , C07D209/18 , C07K1/22 , C07K7/06 , C07K7/08 , G01N33/547
CPC分类号： C07D209/12 , C07D209/18 , C07D491/107 , C07K1/22 , C07K7/06 , C07K7/08 , G01N33/547
摘要： A binding pair for chromatographic separation or purification of a molecule of interest, where one binding member of the pair is an isomerizable organic molecule and the other binding member of the pair is an isomer-specific affinity agent bound to a molecule of interest. The binding pair associates and disassociates upon exposure to a binding agent, such as using light, decreased intensity of light, darkness, heat, stress, ions, an isomerizable affinity agent, change in pH, or a combination thereof.
摘要翻译：用于色谱分离或纯化目标分子的结合对，其中对中的一个结合成员是可异构化的有机分子，并且该对中的另一个结合成员是与目标分子结合的异构体特异性亲和试剂。当暴露于结合剂时，例如使用光，降低的光强度，黑暗度，热量，应激，离子，可异构亲和剂，pH变化或其组合，结合对结合并解离。

5. 发明公开

EP2874724A4 AFFINITY SUPPORT AND METHOD FOR TRAPPING SUBSTANCE USING THE SAME 有权转让
标题翻译：亲和载体和方法检测物质的THAT
公开(公告)号：EP2874724A4
公开(公告)日：2016-04-06
申请号：EP13820377
申请日：2013-06-03
申请人： CAPON DANIEL J
发明人： CAPON DANIEL J
IPC分类号： B01D15/08 , B01D15/38 , B01J20/32 , G01N33/547
CPC分类号： C07K14/4711 , B01D15/34 , B01D15/3804 , B01D15/3809 , B01D15/3847 , B01J20/289 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3274 , G01N33/54353 , G01N33/6896 , G01N2333/4703 , H01J49/0027 , H01J49/164

6. 发明公开

EP2959299A1 MULTILAYER FLUORESCENT NANOPARTICLES AND METHODS OF MAKING AND USING SAME 有权转让
标题翻译：多层荧光纳米粒子和方法体和用途及其生产
公开(公告)号：EP2959299A1
公开(公告)日：2015-12-30
申请号：EP14754877.0
申请日：2014-02-20
申请人： Cornell University
发明人： IYER, Srikant, K. , WIESNER, Ulrich, B.
IPC分类号： G01N33/58 , G01N33/50 , G01N33/52 , G01N33/547 , G01N33/551 , B32B19/00
CPC分类号： G01N33/587 , B05D5/06 , G01N33/54346 , G01N33/552 , G01N33/582
摘要： A multilayer, fluorescently responsive material (FRM)-containing nanoparticle and compositions comprising such nanoparticles. The nanoparticles can be made using a layer-by-layer deposition method. The nanoparticles can be used in imaging methods such as, for example, cellular imaging methods.

7. 发明公开

EP2707714A1 CHAPERONE INTERACTION ASSAYS AND USES THEREOF 有权转让
标题翻译：安东尼·达文的CHAPERON-INTERAKTIONSASSAY
公开(公告)号：EP2707714A1
公开(公告)日：2014-03-19
申请号：EP12782991.9
申请日：2012-05-09
申请人： Whitehead Institute For Biomedical Research
发明人： TAIPALE, Mikko , LINDQUIST, Susan
IPC分类号： G01N33/53 , G01N33/547 , G01N33/543 , G01N33/487
CPC分类号： G01N33/573 , C12Q1/485 , C12Q1/66 , G01N33/502 , G01N33/54306 , G01N33/57484 , G01N33/6845 , G01N33/6872 , G01N2500/02 , G01N2800/60
摘要： In some aspects, the invention provides methods of identifying, detecting, and/or measuring protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein-protein interactions. In some aspects, the invention provides methods of identifying and/or characterizing modulators of protein activity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some aspects, the invention provides methods for identifying and/or characterizing compounds and/or for assessing compound specificity, wherein the methods are based at least in part on measuring interaction between a chaperone and client protein. In some embodiments, a client protein is a kinase. In some embodiments, a compound is a kinase inhibitor. In some aspects, the invention provides methods of profiling kinase inhibitor specificity. In some aspects, the invention provides assay systems and/or reagents useful for performing one or more of the inventive methods. In some aspects, the invention provides newly identified targets of a variety of kinase inhibitors. In some aspect, the invention provides methods of inhibiting kinases identified herein as targets of certain kinase inhibitors. In some aspects, the invention provides methods of treating a disease, e.g., cancer, by inhibiting one or more kinase(s) newly identified as targets of certain kinase inhibitors.
摘要翻译：在一些方面，本发明提供鉴定，检测和/或测量蛋白质 - 蛋白质相互作用的方法。在一些方面，本发明提供鉴定和/或表征蛋白质 - 蛋白质相互作用的调节剂的方法。在一些方面，本发明提供鉴定和/或表征蛋白质活性调节剂的方法，其中所述方法至少部分地基于测量分子伴侣和客体蛋白质之间的相互作用。在一些方面，本发明提供用于鉴定和/或表征化合物和/或用于评估化合物特异性的方法，其中所述方法至少部分地基于测量分子伴侣和客体蛋白质之间的相互作用。在一些实施方案中，客户蛋白质是激酶。在一些实施方案中，化合物是激酶抑制剂。在一些方面，本发明提供了分析激酶抑制剂特异性的方法。在一些方面，本发明提供了用于执行本发明一种或多种方法的测定系统和/或试剂。在一些方面，本发明提供了新鉴定的各种激酶抑制剂的靶标。在一些方面，本发明提供抑制本文鉴定的激酶作为某些激酶抑制剂靶标的方法。在一些方面，本发明提供了通过抑制新鉴定为某些激酶抑制剂的靶标的一种或多种激酶来治疗疾病例如癌症的方法。

8. 发明授权

EP1534755B1 GENERATION OF SURFACE COATING DIVERSITY 有权
标题翻译：生产表面包覆分歧
公开(公告)号：EP1534755B1
公开(公告)日：2011-10-12
申请号：EP03718551.9
申请日：2003-05-09
申请人： Bio-Layer Pty Limited
发明人： BARDEN, Michael, C , KAMBOURIS, Peter, A
IPC分类号： C07K17/02 , C07K17/06 , C09D135/06 , G01N33/547
CPC分类号： B01D61/18 , B01D67/0093 , B01D69/02 , B01D71/34 , B01D2323/38 , B01J19/0046 , B01J2219/00315 , B01J2219/005 , B01J2219/00527 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/0072 , B01J2219/00736 , C07K17/02 , C08F259/08 , C08F261/06 , C08F291/00 , C08F293/005 , C08L51/003 , C08L53/00 , C09D151/003 , C09D153/00 , C40B40/04 , C40B50/14 , C40B50/18 , C08L2666/02
摘要： The present invention relates to a surface discovery system comprising chemical compositions and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. This surface discovery platform is built upon a fundamental chemical unit referred to as a synthon. Each synthon comprises at least three elements: a chemical backbone coating on the solid substrate that comprises a passive (P) constituent and an active (A) constituent; a spacer unit (S) separating the backbone from a functional group; and a functional group (F). Variation of these synthon elements allows generation of large libraries surface coatings with a broad range of molecular and macroscopic properties. Further the spectrum of surfaces provided by the invention permits optimization of the wide range of solid-phase applications that involve surface immobilization of molecules.

9. 发明公开

EP2359138A1 IMMOBILIZATION SUBSTRATE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：固定化及其制造方法
公开(公告)号：EP2359138A1
公开(公告)日：2011-08-24
申请号：EP09830496.7
申请日：2009-12-04
申请人： FUJIFILM Corporation , The University of Tokyo
发明人： MINAMI, Koichi , TSUZUKI, Hirohiko , UEDA, Hiroshi , IHARA, Masaki
IPC分类号： G01N33/543 , C07K19/00 , G01N33/547
CPC分类号： G01N33/54353
摘要： An antibody-fragment-immobilizing substrate includes a substrate and at least one set of antibody fragments, wherein antibody fragments of each set include at least two types of separate antibody fragments, the at least two types of separate antibody fragments include at least one type of labeled antibody fragment having a labeled site labeled with a luminescent substance and at least one type of acceptor antibody fragment having an acceptor site for accepting emission from the labeled antibody fragment, and the at least one type of labeled antibody fragment and the at least one type of acceptor antibody fragment are capable of cooperatively recognizing one type of antigen in combination and are independently immobilized on the substrate in a positional relationship that allows each of the antibody fragments in one set to bind to the same antigen.

10. 发明公开

EP2302078A1 Microbubbles for affinity separation 有权
标题翻译： Mikrobläschenzur Konzentration mittelsAffinitätstrennung
公开(公告)号：EP2302078A1
公开(公告)日：2011-03-30
申请号：EP10190637.8
申请日：2005-11-03
申请人： Iris Molecular Diagnostics, Inc.
发明人： Adams, Thomas , Jablonski, Edward
IPC分类号： C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/543 , G01N33/552 , G01N33/544 , G01N33/547 , G01N33/546 , G01N33/537 , G01N33/531 , G01N33/20
CPC分类号： G01N33/54313 , G01N33/552 , G01N2333/765 , Y10T436/25375
摘要： The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule. Particularly, the invention provides protein microbubbles coated with an affinity molecule. In addition, the invention provides glass microbubbles coated with an affinity molecule. Methods of using the microbubbles of the invention for isolating analytes and cells are specifically provided.
摘要翻译：本发明涉及基于用亲和分子包被的微泡进行亲和分离，亲和纯化和亲和测定的方法，组合物和试剂盒。特别地，本发明提供涂覆有亲和分子的蛋白质微泡。此外，本发明提供涂覆有亲和分子的玻璃微泡。具体提供了使用本发明微泡分离分析物和细胞的方法。

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