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1. 发明公开

EP2010474A1 VERFAHREN ZUR HERSTELLUNG VON MUMBAISTATIN-DERIVATEN 审中-公开
公开(公告)号：EP2010474A1
公开(公告)日：2009-01-07
申请号：EP07723811.1
申请日：2007-03-30
申请人： Sanofi-Aventis
发明人： SCHWINK, Lothar , SCHMALZ, Günther , SUCUNZA, David , VELDER, Janna , DEMBKOWSKI, Daniel
IPC分类号： C07C65/40 , C07C65/17 , C07C15/28
CPC分类号： C07C67/343 , C07C67/307 , C07C67/31 , C07C67/313 , C07C69/95 , C07C2603/24 , C07D313/20
摘要： The current invention relates to a production method for mumbaistatin derivatives (I), wherein the basic framework of the anthraquinone is built up by means of a Diels-Alder reaction and the central methylene bridge is built up by means of a transitional metal catalyzed reaction, and to the intermediates used in this method.
摘要翻译：本发明涉及一种通过狄氏 - 阿尔德反应和中间亚甲基桥通过过渡金属催化反应构成蒽醌骨架的方法，以及本方法中使用的中间体。

2. 发明公开

EP1254100A1 CALIXARENES AND THEIR USE AS LUBRICANT ADDITIVES 审中-公开
标题翻译：杯芳烃及其作为润滑油添加剂
公开(公告)号：EP1254100A1
公开(公告)日：2002-11-06
申请号：EP00988965.0
申请日：2000-12-11
申请人： BP OIL INTERNATIONAL LIMITED
发明人： TAYLOR, Spencer Edwin , WILSON, Michael John
IPC分类号： C07C65/17 , C07C69/94 , C10L1/18 , C10M145/20 , C10M129/54 , C10M129/76 , C10M159/22
CPC分类号： C10M159/22 , B01D17/045 , B01D17/047 , C07C65/17 , C07C69/94 , C10L1/1981 , C10L10/04 , C10L10/08 , C10M145/20 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10M2209/101 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/106
摘要： A cyclic compound comprising m units of formula (Ia) and n units of formula (Ib) joined together to form a ring, wherein Y and Y are divalent bridging groups which may be the same or different in each unit; R is H or (C1-C6) alkyl or is a metal or ammonium cation; R is H or (C1-C60) alkyl or OH group; j is 1 or 2; R is hydrogen, a hydrocarbyl or a hetero-substituted hydrocarbyl group; each of R , R and R , which may be the same or different, is hydroxyl, hydrogen, hydrocarbyl or hetero-substituted hydrocarbyl, with the provisos that i) at least one of R , R , R is hydroxyl, and m + n is 4 to 20, m is 1-8 and n is at least 3, and ii) in formula Ia at least one OH group is in the meta or para position to the COOR group and/or at least one R group is OH.

4. 发明公开

EP1513793A1 NOVEL LIGANDS THAT ARE INHIBITORS OF THE RAR RECEPTORS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS 有权转让
标题翻译：对于RAR受体的新的配基作为抑制剂，其制造方法相同，它们在人类药物及化妆品
公开(公告)号：EP1513793A1
公开(公告)日：2005-03-16
申请号：EP03755947.3
申请日：2003-05-27
申请人： Galderma Research & Development, S.N.C.
发明人： BIADATTI, Thibaud , COLLETTE, Pascal
IPC分类号： C07C65/36 , C07C65/40 , C07C65/17 , C07C65/19 , C07C65/26 , C07C65/28 , C07D213/79 , C07C335/06 , C07D405/06 , A61K31/19 , A61K7/48 , A61K7/00 , A61P17/00 , A61P19/00
CPC分类号： C07C65/17 , C07C65/19 , C07C65/26 , C07C65/28 , C07C65/36 , C07C65/40 , C07D213/30 , C07D213/50 , C07D213/80 , C07D295/096 , C07D295/112 , C07D295/15
摘要： The invention relates to novel biaryl compounds corresponding to the general formula (I) below: and to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternatively in cosmetic compositions.

5. 发明授权

EP0954517B1 SALICYCLIC CALIXARENES AND THEIR USE AS LUBRICANT ADDITIVES 有权
标题翻译：水杨酸杯芳烃及其作为润滑油添加剂
公开(公告)号：EP0954517B1
公开(公告)日：2003-02-05
申请号：EP98952930.0
申请日：1998-11-12
申请人： LUBRIZOL ADIBIS HOLDINGS (UK) LIMITED
发明人： MORETON, David, John
IPC分类号： C07C65/17 , C07C69/94 , C10M129/54 , C10M129/76 , C10M159/22 , C10M159/12 , C10L1/18
CPC分类号： C07C69/94 , C07C65/17 , C07C2603/00 , C07C2603/92 , C10L1/143 , C10L1/1616 , C10L1/1981 , C10L1/1985 , C10L1/238 , C10L1/2383 , C10L1/2481 , C10L10/06 , C10L10/08 , C10M129/54 , C10M133/56 , C10M145/18 , C10M159/12 , C10M159/22 , C10M165/00 , C10M2207/028 , C10M2207/262 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10M2215/086 , C10M2215/28 , C10M2217/042 , C10M2217/043 , C10M2219/089 , C10M2227/00 , C10N2240/10 , C10N2240/101 , C10N2240/104 , C10N2240/105 , C10N2240/106
摘要： This invention relates to a cyclic compound comprising m units of formula (Ia)and n units of the formula (Ib)joined together to form a ring, wherein each Y is a divalent bridging group which may be the same or different in each unit; R0 is H or an alkyl group of 1 to 6 carbon atoms; R5 is H or an alkyl group of 1 to 60 carbon atoms; j is 1 or 2; R3 is hydrogen, a hydrocarbyl or a hetero-substituted hydorcarbyl group; either R1 is hydroxy and R2 and R4 are independently either hydrogen, hydrocarbyl or hetero-substituted hydrocarbyl, or R2 and R4 are hydroxyl and R1 is either hydrogen, hydrocarbyl or hetero-substituted hydrocarbyl; m is from 1 to 8; n is at least 3, and m +n is 4 to 20. This invention also relates to metal salts of the foregoing compound, especially overbased metal salts. The invention also relates to additive compositions, finished lubricating oil compositions and fuel compositions containing the foregoing compound or metal salt thereof. The invention also relates to a process for making the foregoing compound and salts thereof.

6. 发明公开

EP1237840A1 SALICYLIC CALIXARENES AND THEIR USE AS LUBRICANT ADDITIVES 审中-公开
标题翻译：食品安全监督管理委员会（IHRE VERWENDUNG ALS SCHMIERSTOFFADDITIVE）
公开(公告)号：EP1237840A1
公开(公告)日：2002-09-11
申请号：EP00981476.5
申请日：2000-12-11
申请人： BP OIL INTERNATIONAL LIMITED
发明人： Taylor, Spencer Edwin
IPC分类号： C07C65/17 , C07C69/94 , C10L1/18 , C10M145/20 , C10M129/54 , C10M129/76 , C10M159/22
CPC分类号： C10M159/22 , B01D17/045 , B01D17/047 , C07C65/17 , C07C69/94 , C07C2603/92 , C10L1/143 , C10L1/1981 , C10M145/20 , C10M2209/101 , C10M2227/09 , C10N2210/01 , C10N2240/10 , C10N2240/101 , C10N2240/102 , C10N2240/103 , C10N2240/104 , C10N2240/106
摘要： A cyclic compound comprising m units of formula Ia and n units of formula (Ib) joined together to form a ring, wherein Y is a divalent bridging group which may be the same or different in each unit; R is H, a C1-C6 alkyl or a metal or ammonium cation; R is H or a C1-C60 alkyl; and j is 1 or 2; R is hydrogen, a hydrocarbyl or a hetero-substituted hydrocarbyl group; each of R , R and R , which may be the same or different, is hydroxyl, hydrogen, hydrocarbyl or hetero-substituted hydrocarbyl, with the proviso that at least one of R , R , R is hydroxyl, and m + n is 4 to 20, m is 1-8 and n is at least 3; and with the proviso that at least one of the conditions a) to e) below is satisfied: (a) the cyclic compound comprises at least one formula (Ia) unit in the form of a carboxylate anion, (b) the caclic compound comprises at least one formula (Ia) unit in the form of an alkaline earth metal or alkali metal carboxylate salt, (c) the cyclic compound comprises at least 2 units of formula (Ia) (d) the cyclic compound comprises an m + n value of 5 to 11, and (e) the cyclic compound is in the substantial absence of linear species comprising formula (Ia) and (Ib) units and/or the substantial absence of compounds of the formula (IIa) and (IIb) below: (IIa) (IIb).
摘要翻译：包含m个单元的式Ia和n个式（Ib）单元的环状化合物连接在一起形成环，其中Y是每个单元可以相同或不同的二价桥连基团; R 0是H，C 1 -C 6烷基或金属或铵阳离子; R 5是H或C 1 -C 60烷基; j为1或2; R 3是氢，烃基或杂取代的烃基; R 1，R 2和R 4各自可以相同或不同，是羟基，氢，烃基或杂取代的烃基，条件是R 1， R 2，R 4为羟基，m + n为4〜20，m为1-8，n为3以上。并且条件是满足以下条件a）至e）中的至少一个：（a）环状化合物包含至少一种羧酸根阴离子形式的式（Ia）单元，（b）所述化合物包括至少一种碱土金属或碱金属羧酸盐形式的式（Ia）单元，（c）环状化合物包含至少2个式（Ia）单元（d），该环状化合物包括m + n值（e）环状化合物基本上不存在包含式（Ia）和（Ib）单元的线性物质和/或基本上不存在下式（IIa）和（IIb）的化合物：（IIa）（IIb）。

7. 发明授权

EP0584191B1 NOUVEAUX COMPOSES POLYCYCLIQUES AROMATIQUES ET LEUR UTILISATION EN MEDECINE HUMAINE OU VETERINAIRE ET EN COSMETIQUE 失效
标题翻译：新和多环芳香族化合物和它们在人或动物医学和化妆品
公开(公告)号：EP0584191B1
公开(公告)日：1997-08-13
申请号：EP92911015.3
申请日：1992-05-04
申请人： CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA)
发明人： CHARPENTIER, Bruno
IPC分类号： C07C65/26 , C07C65/17 , C07C63/49
CPC分类号： C07D295/192 , C07C49/84 , C07C63/49 , C07C65/17 , C07C65/26 , C07C69/00 , C07C69/007 , C07C69/88 , C07C217/18 , C07C233/65 , C07C309/65 , C07C2601/14 , C07C2603/00 , C07C2603/74 , C07D303/40 , C07D317/60
摘要： Aromatic bicyclic compounds of formula (I) where R1 is specifically -H, -CH3, -CH2OH, -OH, -CHO, -CONH2, -COOH, -COOalkyl, -SH, -S-alkyl, etc...; R2 is H; R3 is H, aryl, aralkyl or lower alkyl optionally substituted by a hydroxyl, a lower alkoxy or a -CO-R12, R12 being specifically H, lower alkyl, hydroxyl, lower alkoxy, or R2 and R3 together form a naphthalene ring with the benzene ring; R4 is a linear branched or unbranched alkyl having 1 to 15 carbon atoms or a cycloaliphatic radical; R5 represents specifically -(CH2)n-R13, -CH=CH-(CH2)n-R13, n being 0 or 1 to 6, R13 representing -COR15, monohydroxyalkyl, polyhydroxyalkyl, epoxy lower alkyl or -O-CO-R16, R15 representing specifically -OH, -Oalkyl, -Oaryl, R16 being specifically H, lower alkyl, aryl, or aralkyl; R6 and R7 are H, a halogene, lower alkyl or -OR16; and also the salts of the compounds of formula (I) in which R1 represents a carboxylic acid grouping; and the chiral analogues of the said compounds of formula (I).
摘要翻译： PCT号 PCT / FR92 / 00404秒。 371 8月22日的日期，1994秒。 102（e）中的日期1994年8月22日提交的PCT 1992年5月4日的PCT公布。号 WO92 / 19583的PCT公布。日期11月12日，式1992Aromatic双环化合物（I）CH 2 OH，-OH，-CHO，-CONH 2，-COOH，-COO烷基，-SH，S-烷基，等，， ; R2是H; R3是H，芳基，芳烷基或低级烷基任选被羟基，低级烷氧基或CO-R12，R12是特别H，低级烷基，羟基，低级烷氧基或R2和R3 substituiertem一起形成萘环与所述苯环; R 4是直链或支链的具有1至15个碳原子或脂环族基团无支链的烷基; R5 darstellt具体 - （CH 2）N-R13，-CH = CH-（CH 2）N-R13，n是0或1至6个，R13表示-COR15，单羟基，多羟基，环氧基的低级烷基或-O-CO-R16 ，R15表示具体-OH，-O烷基，-O芳基，R 16是具体地为H，低级烷基，芳基，或芳烷基; R6和R7是H，卤素，低级烷基或-OR 16; 因此式（I），其中R1 darstellt羧酸分组的化合物的盐; 和式（I）的所述化合物的手性类似物。

8. 发明授权

EP0952974B1 DERIVES BIPHENYLIQUES SUBSTITUES PAR UN RADICAL AROMATIQUE OU HETEROAROMATIQUE ET COMPOSITIONS PHARMACEUTIQUES ET COSMETIQUES LES CONTENANT 有权
标题翻译：由芳香族或杂环芳基取代的基团联苯和含有Pharmaceutische和化妆品组合物
公开(公告)号：EP0952974B1
公开(公告)日：2001-11-21
申请号：EP98942767.9
申请日：1998-08-21
申请人： Galderma Research & Development
发明人： BERNARDON, Jean-Michel , NEDONCELLE, Philippe
IPC分类号： C07C65/17 , C07C65/26 , C07C69/94 , A61K31/19 , A61K31/235
CPC分类号： C07C65/26 , C07C65/17 , C07C69/94
摘要： The invention concerns compounds of formula (I) in which: Ar represents an aromatic radical or a heteroaromatic radical optionally substituted in particular by an alkyl or a carboxylic group; R2 and R3, represent in particular H, alkyl, or R2 and R3, together form a cycle with 5 or 6 chains; R4 and R5 represent in particular H or halogen; R6 represents in particular H or lower alkyl, and the salts of the compounds of formula (I). Said compounds can be used in particular for treating dermatological diseases related to keratinization disorder, and to fight against skin ageing.

9. 发明授权

EP0658553B1 Composés aromatiques polycycliques, compositions pharmaceutiques et cosmétiques les contenant et utilisations 失效
标题翻译：多环芳族化合物，含有它们的药物和化妆品组合物及其用途的组合物
公开(公告)号：EP0658553B1
公开(公告)日：1998-11-04
申请号：EP94402553.5
申请日：1994-11-10
申请人： CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA)
发明人： Charpentier, Bruno , Bernardon, Jean-Michel
IPC分类号： C07D333/38 , C07D333/40 , C07D213/80 , C07D207/40 , C07C69/94 , C07C69/78 , C07C65/17
CPC分类号： C07D213/80 , C07C65/17 , C07C65/26 , C07C69/00 , C07C2603/00 , C07C2603/74 , C07D207/34 , C07D333/38

10. 发明授权

EP0514264B1 Composés bi-aromatiques dérivés d'un motif salicylique, leur procédé de préparation et leur utilisation en médecine humaine et vétérinaire ainsi qu'en cosmétique 失效
标题翻译：双芳族的，衍生自化合物Salizylkonfiguration化合物，其制备方法及其在人类和动物医学和化妆品中使用含有。
公开(公告)号：EP0514264B1
公开(公告)日：1995-11-15
申请号：EP92401306.3
申请日：1992-05-13
申请人： CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA)
发明人： Bernardon, Jean Michel
IPC分类号： C07C65/26 , C07C65/40 , C07C65/17 , C07C65/19
CPC分类号： C07D295/192 , C07C65/17 , C07C65/19 , C07C65/26 , C07C65/40 , C07C69/18 , C07C69/92 , C07C217/48 , C07C229/64 , C07C235/60 , C07C251/48 , C07C2602/10 , C07C2603/74

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