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    • 6. 发明公开
    • Process for the preparation of biocidal compounds
    • Verfahren zur Herstellung von bioziden Verbindungen。
    • EP0518439A2
    • 1992-12-16
    • EP92201692.8
    • 1992-06-10
    • SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.
    • Wood, William Wakefield
    • C07C291/08
    • C07C291/08
    • A process for the preparation of a compound of general formula

         wherein X represents a cyano group, a group -COOH or a salt, ester or amido derivative thereof, R¹ represents a hydrogen atom or an optionally substituted alkyl group, R² represents an optionally substituted alkyl or phenyl group, Z represents an alkyl group or a halogen atom and n represents 0, 1, 2, 3 or 4, the process comprising reacting a compound of general formula

         with a first reactant capable of both dehydrating the amide group of said compound of general formula IV, to form a group X wherein X represents a cyano group, and reacting with the carboxy group of said compound of general formula IV to form a group with which a compound of general formula R¹R²NH may react; subsequently reacting the resulting compound with a compound of general formula R¹R²NH to form a compound of general formula III wherein X represents a cyano group; and optionally derivatising that compound to form other compounds of general formula III, is disclosed.
    • 制备通式的化合物的方法,其中X表示氰基,-COOH或其盐,酯或酰氨基衍生物,R 1表示氢原子或任选取代的烷基, R 2表示任选取代的烷基或苯基,Z表示烷基或卤素原子,n表示0,1,2,3或4,所述方法包括使通式的化合物与第一 能够使所述通式IV化合物的酰胺基脱水的反应物形成基团X,其中X表示氰基,并与所述通式IV化合物的羧基反应形成基团,其中化合物 通式R 1 R 2 NH可以反应; 随后使所得化合物与通式R 1 R 2 NH的化合物反应以形成通式III的化合物,其中X表示氰基; 并且可选地衍生化该化合物以形成其它通式III的化合物。