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1. 发明公开

EP4382606A1 NUCLEIC ACID STRUCTURE UTILIZING SNARE 审中-实审
公开(公告)号：EP4382606A1
公开(公告)日：2024-06-12
申请号：EP22853204.0
申请日：2022-08-05
申请人： Kao Corporation
发明人： SAYAMA, Keimon , SUGANUMA,Takaya , HORI, Satoshi , KUBO, Shun , YAMAMOTO, Masaki , FUKAGAWA, Satoko , ISHIKAWA, Junko
IPC分类号： C12N15/12 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/12 , A61K39/35 , A61K48/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P35/00 , A61P37/04 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/47 , C12N15/63
CPC分类号： Y02A50/30 , A61K31/7088 , A61K35/76 , A61K39/00 , A61K48/00 , A61P35/00 , A61P37/02 , A61P37/04 , A61P43/00 , C07K14/435 , C12N15/62 , C12N15/85 , A61K39/02 , A61K39/35 , A61P37/08 , A61K39/12 , A61K39/002 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/02 , A61P37/06 , C07K14/47 , C12N15/63
摘要： Provided is a nucleic acid structure which enhances an antigen-specific immune response. The nucleic acid structure comprises a polynucleotide encoding a SNARE protein, a polynucleotide encoding a proprotein convertase recognition sequence, and a polynucleotide encoding an antigen, wherein the polynucleotide encoding a SNARE protein and the polynucleotide encoding an antigen are linked via the polynucleotide encoding a proprotein convertase recognition sequence.

2. 发明公开

EP3849590A1 ANTI-PARASITIC IMMUNOLOGICAL COMPOSITIONS 审中-公开
公开(公告)号：EP3849590A1
公开(公告)日：2021-07-21
申请号：EP19859519.1
申请日：2019-09-13
申请人： Prommune, Inc. , Board of Regents of the University of Nebraska
发明人： DAVIS, Paul , AL-MURRANI, Samer
IPC分类号： A61K38/17 , A61K39/002 , A61K39/005 , A61K39/008 , A61K39/012 , A61K39/015

3. 发明授权

EP2988776B1 NOVEL VACCINES AGAINST APICOMPLEXAN PATHOGENS 审中-公开
公开(公告)号：EP2988776B1
公开(公告)日：2018-12-26
申请号：EP14719741.2
申请日：2014-04-24
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： BOES, Alexander , SPIEGEL, Holger , GÜVEN, Edgü , BEISS, Veronique , SACK, Markus , REIMANN, Andreas , FISCHER, Rainer
IPC分类号： A61K39/002 , A61K39/015 , C12N15/62
CPC分类号： C07K14/445 , A61K39/002 , A61K39/015 , C07K2319/00 , C07K2319/40 , C12N15/62 , Y02A50/412
摘要： The technology provided herein generally relates to novel fusion proteins suitable as human and/or animal vaccines against parasites or pathogens of the phylum Apicomplexa. In particular, the present disclosure relates to novel fusion proteins as a basis for vaccines against Plasmodium parasites, including P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. Nucleic acid molecules encoding said fusion proteins, vectors, host cells containing the nucleic acids and methods for preparation and producing such fusion proteins; antibodies induced or generated by the use of said fusion proteins or said nucleic acid molecules encoding said fusion proteins and the use of such antibodies or recombinant derivatives for passive immunotherapy; methods for producing such fusion proteins; compositions and methods for using such fusion proteins for the prevention and treatment of malaria are also encompassed by the present disclosure.

4. 发明公开

EP3368070A1 NEOSPORA VACCINE COMPOSITION 有权
公开(公告)号：EP3368070A1
公开(公告)日：2018-09-05
申请号：EP16795246.4
申请日：2016-10-28
申请人： Universidad Complutense De Madrid
发明人： REGIDOR CERRILLO, Javier , ARRANZ SOLÍS, David , COLLANTES FERNÁNDEZ, Esther , ÁLVAREZ GARCÍA, Gema , ORTEGA MORA, Luis Miguel
IPC分类号： A61K39/002 , C07K14/435 , C07K14/44
CPC分类号： A61K39/012 , A61K39/002 , A61K2039/552 , A61K2039/55577 , A61K2039/70 , A61P33/02 , C07K14/44 , Y02A50/412
摘要： The present invention relates to new protein compositions, methods for producing said protein compositions, pharmaceutical compositions comprising said protein compositions and methods for treating infections caused by Neospora caninum. In particular, the present invention relates to a protein composition comprising the proteins specified in Table A in an amount of at least about 2 times (fold change) higher than the same protein present in the whole tachyzoite, as calculated by quantitative label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS).

5. 发明公开

EP2953641A4 GROUP A STREPTOCOCCAL M-RELATED PROTEINS AND METHODS OF USE 审中-公开
标题翻译： A组链球菌M-相关蛋白及其使用方法
公开(公告)号：EP2953641A4
公开(公告)日：2016-11-16
申请号：EP14749611
申请日：2014-02-11
申请人： UNIV TENNESSEE RES FOUNDATION
发明人： DALE JAMES B , COURTNEY HARRY S
IPC分类号： A61K39/02 , A61K39/002 , A61K39/09
CPC分类号： C07K14/315 , A61K38/164 , A61K39/092 , A61K2039/55505 , A61K2039/58 , A61K2039/6081 , A61K2039/70 , C07K2319/00
摘要： Immunogenic group A streptococcus M-related polypeptides and peptides and immunogenic compositions comprising these M-related polypeptides and peptides are provided herein that evoke cross-opsonic and cross-protective anti-GAS and anti-SDSE antibodies in animals. Also provided are preparations comprising immunogenic compositions that comprise M-related polypeptides, peptides, or fusion proteins and that further comprise at least one additional group A streptococcus immunogen, such as an M peptide or Spa peptide.

6. 发明公开

EP2988776A1 NOVEL VACCINES AGAINST APICOMPLEXAN PATHOGENS 审中-公开
标题翻译： NEUARTIGE IMPFSTOFFE GEGEN APICOMPLEXA-KRANKHEITSERREGER
公开(公告)号：EP2988776A1
公开(公告)日：2016-03-02
申请号：EP14719741.2
申请日：2014-04-24
申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
发明人： BOES, Alexander , SPIEGEL, Holger , GÜVEN, Edgü , BEISS, Veronique , SACK, Markus , REIMANN, Andreas , FISCHER, Rainer
IPC分类号： A61K39/002 , A61K39/015 , C12N15/62
CPC分类号： C07K14/445 , A61K39/002 , A61K39/015 , C07K2319/00 , C07K2319/40 , C12N15/62 , Y02A50/412
摘要： The technology provided herein generally relates to novel fusion proteins suitable as human and/or animal vaccines against parasites or pathogens of the phylum Apicomplexa. In particular, the present disclosure relates to novel fusion proteins as a basis for vaccines against Plasmodium parasites, including P. falciparum, P. vivax, P. malariae, P. ovale and P. knowlesi. Nucleic acid molecules encoding said fusion proteins, vectors, host cells containing the nucleic acids and methods for preparation and producing such fusion proteins; antibodies induced or generated by the use of said fusion proteins or said nucleic acid molecules encoding said fusion proteins and the use of such antibodies or recombinant derivatives for passive immunotherapy; methods for producing such fusion proteins; compositions and methods for using such fusion proteins for the prevention and treatment of malaria are also encompassed by the present disclosure.
摘要翻译：本文提供的技术通常涉及适用于针对Apicomplexa门的寄生虫或病原体的人和/或动物疫苗的新型融合蛋白。特别地，本公开内容涉及新颖的融合蛋白作为针对疟原虫寄生虫的疫苗的基础，包括恶性疟原虫，间日疟原虫，马鞭草，疟原虫和know know属。编码所述融合蛋白的核酸分子，载体，含有核酸的宿主细胞和用于制备和产生此类融合蛋白的方法; 通过使用所述融合蛋白或编码所述融合蛋白的所述核酸分子诱导或产生的抗体以及所述抗体或重组衍生物用于被动免疫治疗的用途; 生产这种融合蛋白的方法; 用于预防和治疗疟疾的这种融合蛋白的组合物和方法也包括在本公开中。

7. 发明公开

EP2819665A1 PROTEASE INHIBITORS FOR TREATING TRICHOMONAS GALLINAE INFECTIONS 有权
标题翻译：蛋白酶抑制剂的感染滴虫鸡皮的治疗
公开(公告)号：EP2819665A1
公开(公告)日：2015-01-07
申请号：EP13706564.5
申请日：2013-03-01
申请人： Veterinärmedizinische Universität Wien
发明人： HESS, Michael , BILIC, Ivana , ABDEL-FATTAH ABDEL-MAGEED AMIN, Aziza
IPC分类号： A61K31/18 , A61K31/336 , A61K39/002 , A61K39/39 , A61P33/02
CPC分类号： A61K31/18 , A61K31/336 , A61K39/002 , A61K2039/53 , A61K2039/552
摘要： Disclosed is the use of protease inhibitors for use in the treatment of a Trichomonas gallinae infection of an animal, selected from the orders Galliformes, Passeriformes, Psittaciformes, Columbiformes and Falconiformes.

8. 发明公开

EP2687227A4 IMMUNOGENIC COMPOSITION FOR IMMUNE SYSTEM MODULATION AND USE THEREOF, METHOD FOR TREATING AND PREVENTING DISEASES, METHOD FOR INDUCING CELL REGENERATION AND METHOD FOR RESTORING IMMUNE RESPONSE 有权
标题翻译：免疫原性组合物免疫系统的治疗和预防传染病调制和使用方法，方法，以确保细胞的再生和方法恢复的免疫反应
公开(公告)号：EP2687227A4
公开(公告)日：2014-10-01
申请号：EP12757249
申请日：2012-03-19
申请人： NOWILL ALEXANDRE EDUARDO
发明人： NOWILL ALEXANDRE EDUARDO
IPC分类号： A61K39/00 , A61K39/002 , A61K39/02 , A61K39/12 , A61P37/04
CPC分类号： A61K39/245 , A61K39/0002 , A61K39/0275 , A61K39/04 , A61K39/085 , A61K39/09 , A61K39/092 , A61K39/095 , A61K39/104 , A61K39/145 , A61K39/165 , A61K2039/55533 , A61K2039/585 , A61K2039/70
摘要： Immunogenic composition for modulating the immune system and its use, method for the treatment and prevention of disease, method to induce cell regeneration and method for the renewal of the immune response.

9. 发明公开

EP2690438A1 Synthesis of diverse glycosylphosphatidylinositol glycans and glycolipids from toxoplasma gondii and their application as diagnostic markers and vaccines 审中-公开
标题翻译：弓形虫合成不同的糖基聚糖和糖脂以及其作为诊断标志物和疫苗的使用
公开(公告)号：EP2690438A1
公开(公告)日：2014-01-29
申请号：EP12177602.5
申请日：2012-07-24
申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Azzouz, Nahid , Götze, Sebastian , Seeberger, Peter H. , Silva, Daniel Varon , Tsai, Yu-Hsuan
IPC分类号： G01N33/569 , A61K31/702 , A61K39/002 , C07H3/06
CPC分类号： A61K39/002 , A61K31/702 , A61K31/7028 , C07H15/04 , C07H15/18 , C07H23/00 , G01N33/56905
摘要： The present invention relates to the synthesis of compounds derived from glycosylphosphatidylinositol (GPI) glycolipids from Toxoplasma gondii and the resulting products obtained. These synthetic compounds are suitable for diagnosis of toxoplasmosis and for use as a vaccine against diseases caused by infection with T. gondii.
摘要翻译：本发明涉及从来自弓形虫糖基（GPI）糖脂和获得的所得产物衍生的化合物的合成。这些合成化合物适合用于弓形体病的诊断和用作抗由感染弓形虫引起的疾病的疫苗。

10. 发明公开

EP2682457A1 Production and application of protozoa cultures of Histomonas meleagridis (H. meleagridis) 审中-公开
标题翻译： Herstellung und Anwendung von Protozoenkulturen aus Histomonas meleagridis（H. meleagridis）
公开(公告)号：EP2682457A1
公开(公告)日：2014-01-08
申请号：EP12174582.2
申请日：2012-07-02
申请人： Veterinärmedizinische Universität Wien
发明人： Hess, Michael , Ganas, Petra
IPC分类号： C12N1/10 , C12N1/36 , A61K35/68 , A61K39/002
CPC分类号： A61K39/002 , A61K39/00 , A61K39/0258 , C12N1/10 , C12N1/20 , C12N1/36
摘要： The invention discloses a method for producing a single bacterial strain culture of Histomonas meleagridis (H. meleagridis), the method being characterised by the following steps:
(a) providing a xenic culture of H. meleagridis comprising H. meleagridis cells with a wild type bacterial flora,
(b) treating the xenic culture with a mixture of antibiotics thereby killing the wild type bacterial flora,
(c) centrifuging and washing the H. meleagridis cells,
(d) controlling effectiveness of step (b),
(e) resuspending the washed H. meleagridis cells,
(f) adding one or more single bacterial strain(s) to the resuspended H. meleagridis cells, and
(g) culturing the one or more single bacterial strain(s) with the resuspended H. meleagridis cells so as to obtain a single bacterial strain culture of H. meleagridis.
The invention further discloses a vaccine formulation consisting of a Histomonas component consisting of an attenuated culture of Histomonas meleagridis, a bacterial component consisting of one or more cultures of a single bacterial strain, and pharmaceutically acceptable non-biological formulation compounds.
摘要翻译：本发明公开了一种用于生产嗜热Histomagasis（H. meleagridis）的单一细菌菌种培养物的方法，该方法的特征在于以下步骤：（a）提供包含具有野生型的幽门螺杆菌细胞的黑曲霉的黑色素培养物细菌菌群，（b）用抗生素混合物处理xenic培养物，从而杀死野生型细菌菌群，（c）离心和洗涤幽门螺杆菌细胞，（d）控制步骤（b）的有效性，（e）重悬（f）将一种或多种单一细菌菌株加入重悬的嗜酸性粒细胞中，和（g）用重悬的幽门螺杆菌细胞培养一种或多种单个细菌菌株从而获得H. meleagridis的单一菌株培养物。本发明还公开了一种由Histomonas组分组成的疫苗制剂，由Histomonas meleagridis的减毒培养物组成，由单一细菌菌株的一种或多种培养物组成的细菌组分和药学上可接受的非生物制剂化合物组成。

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