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1. 发明授权

EP2956136B1 D-FAGOMINE FOR PREVENTING THE ONSET OF AUTOIMMUNE DISEASES 有权
公开(公告)号：EP2956136B1
公开(公告)日：2018-11-21
申请号：EP14704342.6
申请日：2014-02-13
申请人： Pumarola Segura, Sergio
发明人： PUMAROLA SEGURA, Sergio , ANTOLIN MATÉ, María, Carmen , LLOPIS PAGÉS, Marta , CALVO TORRAS, Maria, de los Angeles
IPC分类号： A61K31/445 , A61K31/7008 , A61K31/7048 , A61K36/605 , A61K36/70 , A61K36/815 , A61K36/77 , A61K36/48 , A61K36/04 , A23L33/105 , A61P37/04 , A61P43/00
CPC分类号： C07H5/06 , A23L33/105 , A61K31/445 , A61K31/7008 , A61K31/7048 , A61K36/48 , A61K36/605 , A61K36/70 , A61K36/77 , A61K36/815 , A61K2300/00
摘要： The present invention belongs to the field of nutraceuticals or functional agents with immunostimulating capacity for triggering mechanisms of the innate immune response at a mucosal level. More specifically, it refers to the use of the compound D-fagomine as immunostimulating agent of the innate immune response in the mucosa and for the prevention or prophylaxis of inflammatory processes or diseases associated with an overactivation of the humoral immune response. The invention also relates to a composition comprising D-fagomine for the above referenced application.

2. 发明公开

EP3247461A1 COMPOSITION FOR LYMPH DRAINAGE 有权
标题翻译：淋巴液的组成
公开(公告)号：EP3247461A1
公开(公告)日：2017-11-29
申请号：EP16705577.1
申请日：2016-01-04
申请人： Aboca S.p.A. Società Agricola
发明人： MERCATI, Valentino , MAIDECCHI, Anna
IPC分类号： A61P3/04 , A61K36/896 , A61K36/28 , A61K36/288 , A61K36/53 , A61K36/70 , A61P13/00
CPC分类号： A61K36/896 , A61K9/0019 , A61K9/0053 , A61K9/14 , A61K9/20 , A61K9/48 , A61K36/28 , A61K36/288 , A61K36/53 , A61K36/70 , A61K47/46
摘要： The present invention relates to a mixture of active ingredients consisting of Taraxacum officinalis, Fagopyrum esculentum, Ruscus aculeatus, Solidago virgaurea and Orthosiphon stamineus or extracts of said plants or from said plants and extracts thereof, a composition comprising such a mixture, and uses thereof.

3. 发明公开

EP3078382A1 MEDICINE FOR PROTECTING THE LIVER, REMOVING TOXINS, REDUCING BLOOD LIPIDS AND REDUCING BLOOD SUGAR AND USE THEREOF 审中-公开
标题翻译：药肝的对废水毒素，要降低血脂，血糖和使用还原其保护
公开(公告)号：EP3078382A1
公开(公告)日：2016-10-12
申请号：EP15722345.4
申请日：2015-03-10
申请人： Zhao, Junhong
发明人： Zhao, Junhong
IPC分类号： A61K36/8945 , A61K36/428 , A61K36/48 , A61K36/489 , A61K36/70 , A61P3/10 , A61P3/06 , A61P1/16
CPC分类号： A61K36/428 , A61K36/48 , A61K36/489 , A61K36/70 , A61K36/8945 , A61K2300/00
摘要： The present invention provides a drug showing liver protection, detoxification, lipid-lowering and hypoglycemic properties and use thereof, which is a formulation prepared from a starting material comprising, in parts by weight, 10-35 parts of the root of Trichosanthes cucumeroides (Ser.) Maxim, 5-20 parts of the root of Radix Sophorae Flavescentis, 15-30 parts of Tartary Buckwheat, 15-25 parts of the root of Rhizoma Dioscorea, 10-35 parts of the root of Kudzu Vine and 10-25 parts of pollen. It is useful in the manufacturing of a medicament for treating liver diseases, in the manufacturing of a medicament for treating hyperlipidemia or in the manufacturing of a medicament for treating diabetes. The drug of the present invention takes advantages of the medicinal properties of the root of Trichosanthes cucumeroides (Ser.) Maxim and the root of Radix Sophorae Flavescentis, to achieve liver-clearing and cholagogue effects, and a therapeutical effect on jaundice and chronic hepatitis, in combination with the spleen-nourishing, Qi-regulating, pathogenic wind-dispelling and phlegm-eliminating properties of Tartary Buckwheat, the spleen-nourishing, appetizing, deficiency restoring properties of the root of Rhizoma Dioscorea, the deficient heat clearing and alcoholism relieving properties of the root of Kudzu Vine, and the thirst relieving and jaundice clearing properties of pollen. Thus, liver protection, detoxification, lipid-lowering and hypoglycemic effects can be achieved by the drug of the present invention. The drug of the present invention further provides the following advantages: its raw materials can be obtained from abundant sources; its formulation can be prepared using conventional processes, through simple procedures, and at a low cost; it is much worthy of promotion and application, and has a promising market prospect and a vast space for development.
摘要翻译：本发明提供了一种药物显示保肝，解毒，降脂和降血糖特性，并使用它们，所有这些是从起始材料制备的制剂，其包含，（按重量份计，10-35份的栝楼根cucumeroides丝氨酸。）马克西姆，5-20份苦参的根部，15-30份苦荞麦的，15-25份羌活薯蓣的根部，10-35份葛根和10-25份的根部的花粉。它是用于治疗肝脏疾病，在制造用于治疗治疗高脂血症或在制备用于治疗糖尿病的药物中的制造的药物中是有用的。本发明的药物为（序列）马克西姆和苦参的根部的栝cucumeroides根的药性的优势，实现肝清算和利胆影响，以及对黄疸和慢性肝炎治疗作用，与脾滋养，齐调节的组合，风邪-消解和苦荞麦，脾-滋补，开胃，缺乏恢复羌活薯蓣，不足的热交换的根部的性质的化痰消除性能和酒精中毒缓解性质葛根的根部，和口渴的减轻黄疸和清除花粉的性质。因此，保护肝脏，解毒，降脂和降血糖作用，可以通过本发明的药物来实现的。本发明的药物还提供了以下优点：其原料可以从丰富的来源中获得; 其制剂可以使用常规的方法来制备，通过简单的程序，并且以较低的成本; 这是很值得推广和应用，并具有广阔的市场前景和广阔的发展空间。

4. 发明公开

EP2956136A1 D-FAGOMINE FOR THE CONTROL OF INFLAMMATORY PROCESSES RELATED TO AN OVERACTIVATION OF THE HUMORAL IMMUNE RESPONSE 有权
标题翻译： D-桑叶生物碱进行战斗炎症进程与反应体液免疫的激活连接
公开(公告)号：EP2956136A1
公开(公告)日：2015-12-23
申请号：EP14704342.6
申请日：2014-02-13
申请人： Pumarola Segura, Sergio
发明人： PUMAROLA SEGURA, Sergio , ANTOLIN MATÉ, María, Carmen , LLOPIS PAGÉS, Marta , CALVO TORRAS, Maria, de los Angeles
IPC分类号： A61K31/445 , A23L1/305 , A61K36/605 , A61K36/70 , A61K36/815 , A61K36/77 , A61K36/48 , A61K31/7048 , A61K36/04 , A61P37/04 , A61P43/00
CPC分类号： C07H5/06 , A23L33/105 , A61K31/445 , A61K31/7008 , A61K31/7048 , A61K36/48 , A61K36/605 , A61K36/70 , A61K36/77 , A61K36/815 , A61K2300/00
摘要： The present invention belongs to the field of nutraceuticals or functional agents with immunostimulating capacity for triggering mechanisms of the innate immune response at a mucosal level. More specifically, it refers to the use of the compound D-fagomine as immunostimulating agent of the innate immune response in the mucosa and for the prevention or prophylaxis of inflammatory processes or diseases associated with an overactivation of the humoral immune response. The invention also relates to a composition comprising D-fagomine for the above referenced application.
摘要翻译：本发明属于营养制品或功能性剂领域具有用于触发在粘膜水平的先天免疫应答的免疫刺激机制的能力。更具体地，它指的是使用该化合物D-桑叶生物碱如在粘膜中的先天免疫应答的免疫刺激剂的以及用于与所述的体液免疫应答的过度活化有关的炎症过程或疾病的预防或预防。因此，本发明涉及包含D-桑叶生物碱用于上述参考申请的组合物。

5. 发明公开

EP2744504A1 VERFAHREN ZUR HERSTELLUNG VON TROCKENEXTRAKTEN 有权
公开(公告)号：EP2744504A1
公开(公告)日：2014-06-25
申请号：EP12762228.0
申请日：2012-08-20
申请人： Bionorica SE
发明人： POPP, Michael
IPC分类号： A61K36/185 , A61K36/515 , A61K36/70 , A61K36/85 , A61P11/12 , A61P31/00
CPC分类号： A61K36/85 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/35 , A61K36/515 , A61K36/70 , A61K2236/33 , A61K2300/00
摘要： The invention relates to a method for producing dry extracts of plants and to pharmaceutical preparations containing the same, more particularly phytopharmaceuticals, which contain at least one ethanolic/aqueous extract of a plant (drug), the plants being selected from the group consisting of:
Rumicis herba ;
Verbena officinalis ;
Sambucus nigra ;
Primula veris ; and
Gentiana lutea and mixtures thereof. The invention further relates to a pharmaceutical for treating inflammatory and/or infectious diseases of the nose and throat area and/or the nasal sinuses, as well as the use thereof.
摘要翻译：本发明涉及一种用于生产植物的干燥提取物的方法和含有该植物的药物制剂的方法，更特别是含有至少一种植物（药物）的乙醇/水提取物的植物药物，所述植物选自：罗米is 马鞭草黑曲霉樱草属和龙胆草及其混合物。本发明还涉及用于治疗鼻部和喉部区域和/或鼻窦炎症和/或感染性疾病的药物及其用途。

6. 发明公开

EP2004207A1 WIRKSTOFFFRAKTIONEN FÜR FORMULIERUNGEN ZUR THERAPIE UND PRÄVENTION VON ENTZÜNDLICHEN ERKRANKUNGEN 审中-公开
标题翻译：活性基团，用于治疗和炎性疾病的预防制剂
公开(公告)号：EP2004207A1
公开(公告)日：2008-12-24
申请号：EP07722137.2
申请日：2007-03-30
申请人： Hochschule Anhalt (FH) , ESA Patentverwertungsagentur Sachsen-Anhalt GmbH
发明人： KABRODT, Kathrin , SCHELLENBERG, Ingo , LENDECKEL, Uwe , WOLKE, Carmen
IPC分类号： A61K36/70
CPC分类号： A61K36/70 , A61K36/708
摘要： The invention relates to antioxidant substance fractions produced from Rheum species for formulations for the therapy and prophylaxis of inflammatory or autoimmune diseases and/or diseases with disturbed keratinocyte proliferation. The active substance fractions are obtained by extraction of the dried and ground root samples with methanol, the aqueous phase so produced is liberated from lipophilic accompanying substances while completely removing the methanol, the purified aqueous phase is extracted by shaking with ethyl acetate, the resulting aqueous phase and the combined ethyl acetate phase are processed separately, separated by column chromatography to give a limited number of active substance fractions and the active substance fractions from the aqueous phase and from the ethyl acetate phase having the same spectrum of constituents are each combined.

7. 发明公开

EP3560506A1 PHARMACEUTICAL COMPOSITION COMPRISING INDIGO PULVERATA LEVIS EXTRACT OR FRACTION THEREOF AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING INFLAMMATORY BOWEL DISEASE 审中-公开
公开(公告)号：EP3560506A1
公开(公告)日：2019-10-30
申请号：EP17883777.9
申请日：2017-12-20
申请人： Seoul National University Hospital , Dong-A ST Co., Ltd.
发明人： CHO, Young Woong , SON, Mi Won , CHOI, Sang Zin , CHOI, Song Hyen , JEONG, Jin Seok , SONG, In Sung , KIM, Nayoung
IPC分类号： A61K36/70 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition comprising an Indigo Pulverata Levis extract or a fraction thereof as an effective ingredient for preventing or treating inflammatory bowel disease. Exhibiting the effect of reducing the activity and expression of inflammatory activation markers and alleviating the disease activity index of inflammatory bowel disease, an Indigo Pulverata Levis extract or a fraction thereof according to the present invention may be useful as an agent for preventing and treating inflammatory bowel disease.

8. 发明公开

EP3437648A1 METHOD FOR PRODUCING NEPODIN-RICH EXTRACT OF RUMEX PLANT AND NEPODIN-RICH EXTRACT OF RUMEX PLANT 审中-公开
公开(公告)号：EP3437648A1
公开(公告)日：2019-02-06
申请号：EP17773859.8
申请日：2017-02-21
申请人： Okinawa Research Center Co. Ltd. , University of The Ryukyus
发明人： WOO, Je-Tae , TERUYA, Yuto , SASAKI, Kozue , TERUYA, Toshiaki , YAMANO, Aki , SUEYOSHI, Kosuke , YAMADA, Miki
IPC分类号： A61K36/70 , A61K31/12
摘要： An objective of the present invention is to provide a method for producing a nepodin-containing extract containing a high concentration of nepodin with less contaminants present therein thereby being able to be readily carried out on an industrial scale, when compared to the conventional techniques. The objective is solved by A method for producing a nepodin-containing Rumex plant extract, the method comprising the following steps (1) to (5):
(1) a step of subjecting a Rumex plant to an extraction treatment using a nepodin-dissolving solvent to obtain a crude Rumex plant extract;
(2) a step of subjecting the crude Rumex plant extract to a water-adding treatment and/or concentration treatment to obtain a solid crude Rumex plant extract;
(3) a step of subjecting the solid crude Rumex plant extract to a weak alkali treatment to obtain a weak alkali insoluble product;
(4) a step of subjecting the weak alkali insoluble product to a strong alkali treatment to obtain a strong alkali soluble product; and
(5) a step of subjecting the strong alkali soluble product to a neutralization treatment to obtain the nepodin-containing Rumex plant extract.

9. 发明公开

EP2893935A1 Pharmazeutische Zusammensetzung zur Behandlung von Borreliose 审中-公开
公开(公告)号：EP2893935A1
公开(公告)日：2015-07-15
申请号：EP14197338.8
申请日：2014-12-11
申请人： Andres-Fischer, Wolfgang
发明人： Andres-Fischer, Wolfgang
IPC分类号： A61K36/74 , A61K36/23 , A61K36/28 , A61K36/48 , A61P31/00 , A61P31/04 , A61K36/185 , A61K36/70 , A61K36/704
CPC分类号： A61K31/675 , A61K31/194 , A61K31/197 , A61K31/385 , A61K31/593 , A61K31/714 , A61K31/728 , A61K35/612 , A61K36/185 , A61K36/23 , A61K36/28 , A61K36/48 , A61K36/64 , A61K36/70 , A61K36/704 , A61K36/74 , A61K38/39 , A61K47/12 , A61K47/14 , A61K47/22 , Y02A50/401 , A61K2300/00
摘要： Die vorliegende Erfindung stellt eine Zusammensetzung zur Verwendung in der Behandlung der Borreliose bereit, sowie ein Kit, das die Zusammensetzung umfasst. Die erfindungsgemäße Zusammensetzung umfasst vier Gruppen an Bestandteilen, wobei Gruppe A) 1000 - 5000 mg Katzenkralle, 1000 - 3000 mg Krillöl oder Kalamarinöl oder Kombinationen davon, 200 - 600 mg Magnesium Malat, 3000 - 5000 mg Ester C, 100 - 300 mg Alpha-Liponsäure, 25 - 75 mg Pyridoxal-5-phosphat (Vitamin B6), 6000 - 14000 IU Cholecalciferol (Vitamin D3), 2000 - 4000 mg He Shou Wu, 1200 - 2500 mg Rotklee Tee, 10 - 50 ml Petersiliensaft umfasst, Gruppe B) 2000 - 4000 mg Monolaurin, 400 - 800 mg N-Acetylcystein, 100 - 300 mg Hyaluronsäure mit BioCell Kollagen II und 1 - 7 Tropfen Karde Wurzel, Gruppe C) 10 - 70 Tropfen Spilanthes Acmella umfasst und Gruppe D) 500 - 1500 µg Cyanocobalamin (Vitamin B 12) umfasst. Die Zusammensetzung und das Kit eignen sich zur Verwendung in der Behandlung von Borreliose, wobei die Bestanteile der Gruppe A) einmal täglich verabreicht werden, die der Gruppe B) zweimal täglich, das der Gruppe C) dreimal täglich und das der Gruppe D) alle 14 Tage.
摘要翻译：本发明提供了用于治疗硼酸血症的组合物和试剂盒。组合物包括四组组分，组A）组分1000-5000 mg Cat's Claw，1000-3000 mgs磷虾油或Kalamarine油或其组合，200-600 mgs苹果酸镁，3000-5000 mgs C，100 -300毫克α-硫辛酸，25-75毫克磷酸二肟基（维生素B6），6000-14000 IU胆钙化醇（维生素D3），2000-4000毫克何守武，1200-2500毫克紫色三叶草茶，10- 50毫升荷兰芹，B组）2000-4000毫克单硫酸，400-800毫克N-乙酰半胱氨酸，100-300毫克透明质酸与BioCell胶原II，1-5滴Teasel根，C组）10-70滴Spilanthes Acmella和D组）500-1500微克氰钴胺（维生素B12）。该组合物和试剂盒适用于治疗硼复性，其中A组的成分每日一次，B组每日一次，C组每日两次，C组每日三次， D组）每14天。

10. 发明授权

EP2744504B1 VERFAHREN ZUR HERSTELLUNG VON TROCKENEXTRAKTEN 有权
标题翻译：用于生产干提取物
公开(公告)号：EP2744504B1
公开(公告)日：2015-06-10
申请号：EP12762228.0
申请日：2012-08-20
申请人： Bionorica SE
发明人： POPP, Michael
IPC分类号： A61K36/185 , A61K36/515 , A61K36/70 , A61K36/85 , A61P11/12 , A61P31/00
CPC分类号： A61K36/85 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/35 , A61K36/515 , A61K36/70 , A61K2236/33 , A61K2300/00

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