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1. 发明公开

EP4355420A1 IRRADIATION TARGETS FOR THE PRODUCTION OF RADIOISOTOPES AND DEBUNDLING TOOL FOR DISASSEMBLY THEREOF 审中-实审
公开(公告)号：EP4355420A1
公开(公告)日：2024-04-24
申请号：EP22825925.5
申请日：2022-06-17
申请人： BWXT Isotope Technology Group, Inc.
发明人： LOGUE, Evan, Thomas
IPC分类号： A61N5/10 , G21G1/12 , A61K51/00
CPC分类号： H05H6/00 , G21G1/06

2. 发明授权

EP3991184B1 METHOD FOR PRODUCING 225ACTINIUM FROM 226RADIUM 有权
公开(公告)号：EP3991184B1
公开(公告)日：2024-01-03
申请号：EP20733813.8
申请日：2020-06-22
发明人： MALMBECK, Rikard , CACIUFFO, Roberto , BANIK, Nidhu Lal
IPC分类号： G21G1/10 , G21G1/12

3. 发明公开

EP3988687A1 METHOD FOR PRODUCING 226RA TARGET, METHOD FOR PRODUCING 225AC, AND ELECTRODEPOSITION LIQUID FOR PRODUCTION OF 226RA TARGET 审中-实审
公开(公告)号：EP3988687A1
公开(公告)日：2022-04-27
申请号：EP20827092.6
申请日：2020-06-18
申请人： Nihon Medi-Physics Co., Ltd
发明人： KAJISHIRO, Ikuo , YANO, Shinya , ICHINOSE, Jun
IPC分类号： C25D3/54 , C22B26/20 , C22B60/02 , G21G1/10 , G21G1/12 , G21K5/08
摘要： One embodiment of the present invention relates to a production method of a 226 Ra target, a production method of 225 Ac, or an electrodeposition solution for producing a 226 Ra target, and the production method of a 226 Ra target includes an electrodeposition step of electrodepositing a 226 Ra-containing substance on a substrate by using an electrodeposition solution that contains 226 Ra ions and a pH buffer.

4. 发明授权

EP2250649B1 RADIOISOTOPE PRODUCTION AND TREATMENT OF SOLUTION OF TARGET MATERIAL 有权
标题翻译：放射性同位素的制造与处理靶材料溶液
公开(公告)号：EP2250649B1
公开(公告)日：2012-05-09
申请号：EP09707442.1
申请日：2009-02-03
申请人： The Curators Of The University Of Missouri
发明人： GAHL, John, M. , FLAGG, Michael, A.
IPC分类号： G21G1/12 , G21G1/08
CPC分类号： G21G1/12 , G21G1/08
摘要： The invention provides methods for the production of radioisotopes or for the treatment of nuclear waste. In methods of the invention, a solution of heavy water and target material including fissile material present in subcritical amounts is provided in a shielded irradiation vessel. Bremsstrahlung photons are introduced into the solution, and have an energy sufficient to generate photoneutrons by interacting with the nucleus of the deuterons present in the heavy water and the resulting photoneutrons in turn cause fission of the fissile material. The bremmsstrahlung photons can be generated with an electron beam (37) and an x-ray converter (32). Devices of the invention can be small and generate radioisotopes on site, such as at medical facilities and industrial facilities. Solution can be recycled for continued use after recovery of products.

5. 发明公开

EP2421006A1 Method for producing isotopes, in particular method for producing radioisotopes by means of gamma-beam irradiation 审中-公开
标题翻译：的方法，用于生产同位素，特别是通过γ射线的装置，用于产生放射性同位素的方法
公开(公告)号：EP2421006A1
公开(公告)日：2012-02-22
申请号：EP10186576.4
申请日：2010-10-05
申请人： Ludwig-Maximilians-Universität München , INSTITUT MAX VON LAUE - PAUL LANGEVIN
发明人： Habs, Dietrich , Köster, Ulli
IPC分类号： G21G1/12
CPC分类号： G21G1/12
摘要： The invention relates to a method for producing a radionuclide product B. The method comprises the following steps: Providing a target (6) comprising an amount of a nuclide A, providing a γ beam (5) and irradiating the target (6) by the γ beam (5) and thereby transmuting at least a portion of the amount of the nuclide A into the product B. Providing the target (6) comprises selecting a nuclide A, such that A is transmutable into product B by a γ induced nuclear reaction. Moreover, providing the γ beam (5) comprises providing a γ beam by Compton backscattering of laser light (2) from an electron beam (1).
摘要翻译：本发明涉及一种用于制造放射性核素产品B的方法，包括以下步骤： - 提供一个目标（6）包括一个核素A的量的，提供了一个³梁（5）和照射所述目标（6）由 ³光束（5）并从而嬗变至少一个到产品B.提供目标核素A的量的部分（6）包括选择一个核素甲搜索做了诱导核反应一³是transmutable到产品B ，更上方，提供³光束（5）包括从电子束（1）的激光（2）的康普顿背散射提供³光束。

6. 发明公开

EP2177232A2 Activation and production of radiolabeled particles 审中-公开
标题翻译： Aktivierung und Herstellung von radioaktiv markierten Partikeln
公开(公告)号：EP2177232A2
公开(公告)日：2010-04-21
申请号：EP09179303.4
申请日：2004-02-27
申请人： The European Atomic Energy Community (EURATOM), represented by the European Commission
发明人： Magill, Joseph , Galy, Jean , Apostolidis, Christos , Somers, Joseph , Jehenson, Philippe
IPC分类号： A61K41/00 , A61K51/12 , G21G1/12 , G21H5/02
CPC分类号： G21G1/12 , A61K41/00 , A61K41/0023 , A61K51/1244 , A61K51/1251 , G21H5/02
摘要： A method for activating particles for internal radiopharmaceutical use, said particles comprising precursor nuclides to be activated, is disclosed. The method comprises:
directing a high-intensity laser beam (10) onto converting means (12) to produce an irradiating field of protons; and
irradiating said particles comprising precursor nuclides (18) in said irradiating field of protons to activate said precursor nuclides, thereby obtaining radiolabeled particles.
摘要翻译：公开了一种用于激活用于内部放射性药物用途的颗粒的方法，所述颗粒包含待活化的前体核素。该方法包括：将高强度激光束（10）引导到转换装置（12）上以产生质子的照射场; 并将包含前体核素（18）的所述粒子照射在所述质子辐射场中以活化所述前体核素，由此获得放射性标记的颗粒。

7. 发明公开

EP1453063A1 Method for producing actinium-225 审中-公开
标题翻译： Verfahren zum Herstellen von Actinium-225
公开(公告)号：EP1453063A1
公开(公告)日：2004-09-01
申请号：EP03100507.7
申请日：2003-02-28
申请人： EURATOM
发明人： Magill, Joseph , Galy, Jean , Apostolidis, Christos , Jehenson, Philippe
IPC分类号： G21G1/10 , G21G1/12
CPC分类号： G21G1/12 , G21G1/10
摘要： A method for producing Actinium-225 comprises directing a high-intensity laser beam onto a converting means to produce an irradiating field, and irradiating a target of radium-226 in this irradiating field. The irradiating field may comprise high-energy photons or protons, to induce nuclear reactions in the target of Ra-226.
摘要翻译：制造锕-225的方法包括将高强度激光束引导到转换装置上以产生照射场，并在该照射场中照射镭-226的靶。辐射场可以包含高能光子或质子，以在Ra-226的靶中诱导核反应。

8. 发明公开

EP1156492A3 Apparatus for transmuting nitrogen 14 into carbon 14 审中-公开
标题翻译：一种用于在碳-14氮-14的嬗变
公开(公告)号：EP1156492A3
公开(公告)日：2004-06-30
申请号：EP01304325.2
申请日：2001-05-15
申请人： Beckwith, Robert Wallace , Craig, Andrew Pettit
发明人： Beckwith, Robert Wallace , Craig, Andrew Pettit
IPC分类号： G21G1/12 , G21K1/00
CPC分类号： G21G1/12
摘要： Nitrogen 14 is fed by pressure differentials in a continuous process in which atoms are held in fixed magnetic positions while electromagnetic energy converts protons into neutrons thus transmuting nitrogen 14 into carbon 14.

9. 发明公开

EP1215684A4 APPARATUS FOR PRODUCING RADIOISOTOPE 审中-公开
标题翻译： VORRICHTUNG ZUR RADIOSOTOPENERZEUGUNG
公开(公告)号：EP1215684A4
公开(公告)日：2004-03-10
申请号：EP00953506
申请日：2000-08-18
申请人： HAMAMATSU PHOTONICS KK
发明人： FUJIMOTO MASATOSHI , AOSHIMA SHINICHIRO , HOSODA MAKOTO , TSUCHIYA YUTAKA
IPC分类号： G21G1/02 , G21G1/12 , G21G4/08
CPC分类号： G21G1/12 , G21G1/02
摘要： A radioisotope generating apparatus according to the present invention comprises a nuclear reaction section (30) an interior of which is retained in a vacuum; a source supply section (20) for supplying a source material R consisting of a nuclide necessary for generation of the radioisotope, to the nuclear reaction section; an optical system (10) for emitting pulse laser light toward the source material R supplied into the nuclear reaction section (30) and thereby brought into a dispersed state, thereby inducing a nuclear reaction in the source material R to generate the radioisotope; a product nucleus collecting section (40) for collecting a molecule PI having a nucleus of the radioisotope generated in the nuclear reaction section; and a radiation shielding system (50) for preventing outside leakage of radiations generated in the nuclear reaction section(30). This permits the position of a reaction field of the nuclear reaction to be fixed in a specific small region inside the nuclear reaction section, whereby the space necessary for the nuclear reaction section can be largely decreased.
摘要翻译：一种用于生产放射性同位素的装置，包括保持在真空中的核反应堆（30）原料供给装置（20），其向核反应堆供给由生成放射性同位素所需的核素构成的原料（R）一个光学系统（10），用于向分散在核反应堆（30）中的原料（R）发射激光脉冲，从而在原料（R）中发生核反应以产生放射性同位素; 收集器（40），用于收集在核反应堆中产生的含有放射性同位素核的分子P1; 和用于防止来自核反应堆（30）的辐射泄漏的辐射屏蔽系统（50）。核反应发生在一个特定的非常小的区域，因此需要核反应堆的空间更窄。

10. 发明公开

EP0198257A3 Method and apparatus for selective irradiation of biological materials 失效
标题翻译：生物材料的选择性辐射的方法和装置以及生物材料的选择性辐射装置的材料
公开(公告)号：EP0198257A3
公开(公告)日：1989-03-08
申请号：EP86103694.5
申请日：1986-03-19
申请人： Mills, Randell L.
发明人： Mills, Randell L.
IPC分类号： A61N5/10 , A61K41/00 , A61K43/00 , G21G1/12 , G21G4/08 , G21H5/00
CPC分类号： A61K41/0085 , A61K51/12 , A61K2121/00 , A61N5/10 , A61N2005/1098
摘要： The invention relates to a method and an ap- p aratus for frequency selective irradiation of biological materials and particularly tissues, cells and/or cell components of living organisms, in particular of human and animals, by irradiating a component element of the target material at the corresponding Mossbauer absorption frequency. The component radiation absorption at the Mossbauer absorption frequency is thus enhanced many times over the absorption of the surrounding material having a different Mossbauer absorption frequency. The energy thusly absorbed by the target material component is converted to and remitted as Auger electrons, which provide intranuclear radiation resulting in lethal double strand breaks in the DNA molecules of the target tissue. The irradiation is administered in frequency and material selective modes of treatment, and may be combined with conventional chemotherapeutic agents to provide a further enhanced treatment modality. Moreover, the source frequency can be adjusted to enhance the killing effect. The method of apparatus according to the present invention are useful in combination with naturally occurring or administered pharmaceutical stable isotope absorbers, having significantly reduced side effects by comparison to conventional chemotherapy or radiation therapy. The method and apparatus according to the invention can be applied for selective radiation therapy providing selective tissue damage or necrosis, in particular for cancer therapy, and for differentiating between diseased and normal tissues.

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