专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP4335857A1 METHOD FOR PURIFYING SUCRALOSE-6-ETHYL ESTER 审中-公开
公开(公告)号：EP4335857A1
公开(公告)日：2024-03-13
申请号：EP21939686.8
申请日：2021-05-07
申请人： Anhui Jinhe Industrial Co., Ltd.
发明人： ZHENG, Xuelian , WANG, Dong , CHEN, Yongle
IPC分类号： C07H13/04 , C07H1/06
摘要： Disclosed in the present disclosure is a purification method for sucralose-6-ethyl ester, and the method comprises: a secondary water boiling step: taking a sucralose-6-ethyl ester mother liquor, which has been subjected to boiling with water and a negative pressure treatment, adding a predetermined proportion of water to the sucralose-6-ethyl ester mother liquor, fully stirring and heating for boiling with water, and after stirring and boiling with water for a predetermined time, carrying out solid-liquid separation to obtain a secondary water-boiled mother liquor in which sucralose-6-ethyl ester is dissolved; a phase separating extraction step: leaving the secondary water-boiled mother liquor to stand for phase separation, taking the separated upper phase, extracting with an alkane extractant at a predetermined temperature, and removing residual white oil in the upper phase; a recrystallizing purification step: evaporating a lower-layer effluent obtained from extraction, so as to obtain a solid, and purifying the solid by means of recrystallization to obtain sucralose-6-ethyl ester; and a recycling step: separating the extracted upper-layer effluent, recovering the alkane extractant, and circulating the alkane extractant for use in the phase separation and extraction step. The method is simple, efficient and of low cost, and can effectively remove trace white oil and improve the purity of sucralose-6-ethyl ester.

2. 发明公开

EP4286393A1 NOVEL METHOD FOR PRODUCING ANTIBODY-IMMUNOSTIMULATOR CONJUGATE 审中-公开
公开(公告)号：EP4286393A1
公开(公告)日：2023-12-06
申请号：EP22746065.6
申请日：2022-01-31
申请人： Daiichi Sankyo Company, Limited
发明人： OGURA, Tomokazu , NAKAYA, Takeshi , INOUE, Hidekazu , ABE, Narumi , ABE, Yuzo , NAKAMURA, Tatsuya , YAMAMOTO, Yuko , SAKANISHI, Kohei , SAKAMOTO, Tatsuhiro , NAKANE, Satoshi
IPC分类号： C07H5/02 , C07H13/08 , C07H19/067 , C07H19/073 , C07H19/167 , C07H19/207 , C07H19/213 , C07H19/23 , C07H21/02 , C07K7/06 , C07K16/00 , C07K16/18 , C07D487/04 , A61K47/68
摘要： The purpose of the present invention is to provide a novel stereoselective method for preparing a cyclic dinucleotide derivative and a production intermediate therefor, which can be used for an antibody-immunostimulant conjugate. Also provided is a method for producing a cyclic dinucleotide-linker and an antibody-immunostimulant conjugate while using the above production method. Further provided is a method for preparing a cyclic dinucleotide derivative, the method including the step of subjecting a compound (I) and a compound (IV) to stereoselective condensation using an optically active phosphitylating agent (Rc-II) or (Sc-II).

3. 发明授权

EP3450444B1 CROCINS COMPOUNDS AND USES THEREOF 审中-实审
公开(公告)号：EP3450444B1
公开(公告)日：2023-11-15
申请号：EP17788553.0
申请日：2017-03-16
发明人： YAO, Xinsheng , YU, Yang , ZHANG, Dan , NI, Yang , BAO, Xiuqi , LI, Lin , ZANG, Caixia , GAO, Hao , ZHENG, Yuanpeng
IPC分类号： C07H13/04 , C07H13/06 , C07H1/08 , A61P25/28 , A61P25/00 , A61K31/7024

4. 发明授权

EP3119761B1 AMYLOID TARGETING AGENTS AND METHODS OF USING THE SAME 有权
公开(公告)号：EP3119761B1
公开(公告)日：2023-06-07
申请号：EP15714358.7
申请日：2015-03-19
发明人： YANG, Jerry , THEODORAKIS, Emmanuel, A. , SARRAF, Stella
IPC分类号： C07D401/14 , C07C255/58 , C07C255/59 , C07D333/22 , C07D401/04 , C07C311/35 , C07D405/04 , C07H13/00 , C07H13/04 , C07D405/10 , C07D407/10 , C07D409/04 , C07D409/10 , C07D409/14 , C07D241/04

5. 发明公开

EP4007761A1 PROCESS FOR PREPARING THE CRYSTALLINE FORM II OF SOTAGLIFLOZIN 审中-实审
公开(公告)号：EP4007761A1
公开(公告)日：2022-06-08
申请号：EP20750368.1
申请日：2020-07-31
申请人： Lexicon Pharmaceuticals, Inc.
发明人： BUREL, Bruno , CEZERAC, Jérome , DUTHEIL, Stéphane , ETIENNE, Martial , FLACHER, Richard , NOBREGA, Antonio
IPC分类号： C07H1/06 , C07H7/04 , C07H13/08 , A61P3/10

6. 发明公开

EP3990441A1 IONIZABLE LIPIDS FOR NUCLEIC ACID DELIVERY 审中-实审转让
公开(公告)号：EP3990441A1
公开(公告)日：2022-05-04
申请号：EP20835492.8
申请日：2020-06-26
申请人： Precision Nanosystems Inc
发明人： THOMAS, Anitha , JAIN, Nikita , BROWN, Andrew William
IPC分类号： C07D307/20 , A61K47/22 , A61K47/28 , A61K47/30 , A61K9/14 , C07D405/12 , C07D453/02 , C12N15/87 , C07H13/06 , C07H13/10

8. 发明公开

EP3853238A1 AMINO ACID DERIVATIVE OF GLUCOSAMINE STIMULATING EXTRACELLULAR MATRIX SYNTHESIS AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
公开(公告)号：EP3853238A1
公开(公告)日：2021-07-28
申请号：EP19790789.2
申请日：2019-09-19
申请人： Cartilago S.r.l.
发明人： SURACE, Filippo , SCANDURRA, Roberto
IPC分类号： C07H13/04 , C07K2/00 , C07K5/00 , A61K31/7008 , A61P29/00

9. 发明授权

EP2941435B1 MANNOSE-RECEPTOR SELECTIVE LYSINYLATED CATIONIC AMPHIPHILES AND A PROCESS FOR PREPARATION THEREOF 有权
公开(公告)号：EP2941435B1
公开(公告)日：2021-06-16
申请号：EP13836231.4
申请日：2013-12-27
发明人： GARU, Arup , MOKU, Gopikrishna , AGAWANE, Sachin Barad , CHAUDHURI, Arabinda
IPC分类号： C07H1/00 , C07H13/12 , C07H15/04 , C07C279/14 , A61K31/166 , A61K31/351 , A61K31/7105 , A61K31/711 , A61K9/127 , A61K47/18 , A61P37/02 , A61P37/04 , A61K45/06

10. 发明公开

EP3820564A1 THROMBIN INHIBITORS, FORMULATIONS, AND USES THEREOF 审中-公开
公开(公告)号：EP3820564A1
公开(公告)日：2021-05-19
申请号：EP19745941.5
申请日：2019-07-12
申请人： Verseon International Corporation
发明人： SHORT, Kevin Michael , ESTIARTE-MARTINEZ, Maria de los Angeles , KITA, David Ben , SIRISOMA, Nilantha Sudath
IPC分类号： A61P7/02 , C07D409/14 , A61K31/4439 , C07H13/02

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式