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1. 发明公开

EP3984989A1 IBUPROFEN ESTER PRODRUG, PHARMACEUTICAL COMPOSITION AND PREPARATION METHOD AND USE 审中-实审
公开(公告)号：EP3984989A1
公开(公告)日：2022-04-20
申请号：EP21824460.6
申请日：2021-06-28
申请人： Nanjing Heron Pharmaceutical Science and Technology Co., Ltd.
发明人： YE, Hai , MIN, Tao , LV, Tian , ZHOU, Wenliang , CHEN, Xingran , FENG, Yunqing , MO, Meiling , WANG, Jialin
IPC分类号： C07C69/96 , C07C68/06 , C07C68/00 , A61P19/02 , A61P29/00 , A61P25/04 , A61K31/265 , A61K31/192
摘要： Provided is an ibuprofen ester prodrug represented by Structural Formula (1), a racemate, stereoisomer or pharmaceutically acceptable salt or solvate thereof, or a solvate of a pharmaceutically acceptable salt thereof. Further provided are a method for preparing the compound, a pharmaceutical composition containing the compound, and an application of the compound in preparation of nonsteroidal anti-inflammatory drugs. The pharmaceutical composition containing the ibuprofen ester prodrug may be prepared into fat emulsion injection preparations. The ibuprofen ester prodrug has good stability and good pharmacokinetic properties and overcomes the problems of ibuprofen such as a short half-life, poor stability, irritation, and incompatibility.

2. 发明授权

EP3394023B1 METHODS FOR CONVERTING FLUORINATED COMPOUNDS 有权
公开(公告)号：EP3394023B1
公开(公告)日：2021-10-13
申请号：EP16871761.9
申请日：2016-12-12
发明人： HIRSCHBERG, Markus E. , HINTZER, Klaus , QIU, Zai-Ming , RÖSCHENTHALER, Gerd-Volker , PAJKERT, Romana , TVERDOMED, Sergey
IPC分类号： C07C51/58 , C07C53/50 , C07C67/00 , C07C67/14 , C07C68/00 , C07C69/96 , C07C45/42 , C07C51/00 , C07C51/04 , C07C59/135

3. 发明公开

EP3649277A1 ELEKTROCHEMISCHES VERFAHREN ZUR HERSTELLUNG VON ARYLALKYLCARBONATEN ODER DIARYLCARBONATEN 审中-公开
公开(公告)号：EP3649277A1
公开(公告)日：2020-05-13
申请号：EP18735288.5
申请日：2018-06-29
申请人： Covestro Deutschland AG
发明人： TRIEU, Vinh , EIDEN, Stefanie , KAUBITZSCH, Dana , RUESTA ALVAREZ, Jimena , KOPER, Marc , FIGUEIREDO, Marta , HEIJL, Jan , MEINE, Niklas
IPC分类号： C25B3/10 , C25B3/02 , C25B11/03 , C07C68/00 , C08G64/00

4. 发明授权

EP3038747B1 TRANSESTERIFICATION OF AROMATIC ALCOHOLS USING A HETEROGENEOUS CATALYST 有权转让
公开(公告)号：EP3038747B1
公开(公告)日：2020-04-08
申请号：EP14762199.9
申请日：2014-08-29
申请人： SABIC Global Technologies B.V.
发明人： RAMACHANDRAN NAIR, Balamurali Krishna , MAMEDOV, Edouard , LAWYER-HARVEY, Pamela , KULKARNI, Neeta , BANKE, Jonathan
IPC分类号： B01J23/885 , B01J23/28 , B01J23/847 , B01J23/22 , B01J23/89 , B01J27/199 , C07C68/00 , C07C68/06 , C07C69/96

5. 发明公开

EP3097074A1 PROCÉDÉ DE SYNTHÈSE DE CARBONATE DE DIMÉTHYLE 有权转让
标题翻译： VERFAHREN ZUR SYNTHESE VON DIMETHYLCARBONAT
公开(公告)号：EP3097074A1
公开(公告)日：2016-11-30
申请号：EP15700694.1
申请日：2015-01-19
申请人： Charabot SA , Institut National Polytechnique de Toulouse , Institut National De La Recherche Agronomique
发明人： MOULOUNGUI, Zéphirin , MARUEJOULS, Christophe , LAVOINE-HANNEGUELLE, Sophie
IPC分类号： C07C68/00
CPC分类号： C07C68/00 , B01J23/06 , B01J27/053 , B01J27/128 , B01J27/135 , B01J27/138 , B01J35/0006 , B01J37/04 , B01J37/08 , C07C69/96
摘要： The invention relates to a method for synthesising dimethyl carbonate from methanol and urea, in which a saline ureic medium is used that comprises at least one inorganic salt selected from the group made up of zinc (Zn) (II) chloride, tin (Sn) chlorides and iron (Fe) (III) chloride, characterised in that: methanol, in the presence of a catalytic composition, is placed in contact with said saline ureic medium that is at least partially liquid at a temperature referred to as synthesis temperature, which is higher than 140°C, such that reaction vapours are produced; the reaction vapours are condensed, and a condensate of said reaction vapours is collected, comprising dimethyl carbonate; the method is carried out at atmospheric pressure. The invention also relates to a method for enriching and purifying dimethyl carbonate.
摘要翻译：一种从甲醇和尿素合成碳酸二甲酯的方法，其中使用盐水介质，其包含至少一种选自氯化锌（Zn）（II），氯化锡（Sn）和氯化铁（iron） Fe）（III），其特征在于：在催化组合物存在下，将甲醇与盐水脲介质接触，所述盐溶液介质在被称为合成温度的温度下至少部分为液体，其高于140 从而产生反应蒸气; 反应蒸气冷凝，收集反应蒸气的缩合物，包括碳酸二甲酯; 该方法在大气压下进行。还描述了用于富集和纯化碳酸二甲酯的方法。

6. 发明公开

EP2930165A4 METHOD FOR PRODUCING CARBONATE COMPOUND 有权转让
标题翻译：制造方法的碳酸酯化合物
公开(公告)号：EP2930165A4
公开(公告)日：2016-07-20
申请号：EP13860942
申请日：2013-12-04
申请人： ASAHI GLASS CO LTD
发明人： OKAMOTO HIDEKAZU , FUJIMORI ATSUSHI , OKAZOE TAKASHI
IPC分类号： C07C68/00 , C07B61/00 , C07C69/96
CPC分类号： C07C68/00 , C07C69/96
摘要： The present invention relates to a production process capable of selectively producing various kinds of carbonate compounds without restraint in high yields without using toxic compounds such as phosgene and crown ethers, without producing corrosive gases such as hydrogen chloride as a by-product, and without necessity of removing the chloroform as a by-product by distillation, and to a method for producing a carbonate compound, containing reacting compound (1) with a compound having an OH group in the presence of a metal salt and 0.2 to 4.0 mol of compound (2) per mol of the metal salt to obtain a carbonate compound, in which m is an integer of 1-10, Q is an alkylene group having 1 to 4 carbon atoms, etc, and R 10 and R 11 are alkyl groups having 1 to 5 carbon atoms, etc.

7. 发明授权

EP2121563B1 PROCESS FOR MANUFACTURING DIMETHYL CARBONATE 有权
标题翻译：用于生产二甲基
公开(公告)号：EP2121563B1
公开(公告)日：2016-05-04
申请号：EP08710068.1
申请日：2008-02-15
申请人： SABIC Global Technologies B.V.
发明人： VIC FERNANDEZ, Ignacio
IPC分类号： C07C68/00 , C07C68/06 , C07C69/96
CPC分类号： C07C68/06 , C07C68/005 , C07C69/96

8. 发明公开

EP2930165A1 METHOD FOR PRODUCING CARBONATE COMPOUND 有权转让
标题翻译： VERFAHREN ZUR HERSTELLUNG EINER CARBONATVERBINDUNG
公开(公告)号：EP2930165A1
公开(公告)日：2015-10-14
申请号：EP13860942.5
申请日：2013-12-04
申请人： Asahi Glass Company, Limited
发明人： OKAMOTO, Hidekazu , FUJIMORI, Atsushi , OKAZOE, Takashi
IPC分类号： C07C68/00 , C07C69/96 , C07B61/00
CPC分类号： C07C68/00 , C07C69/96
摘要： The present invention relates to a production process capable of selectively producing various kinds of carbonate compounds without restraint in high yields without using toxic compounds such as phosgene and crown ethers, without producing corrosive gases such as hydrogen chloride as a by-product, and without necessity of removing the chloroform as a by-product by distillation, and to a method for producing a carbonate compound, containing reacting compound (1) with a compound having an OH group in the presence of a metal salt and 0.2 to 4.0 mol of compound (2) per mol of the metal salt to obtain a carbonate compound, in which m is an integer of 1-10, Q is an alkylene group having 1 to 4 carbon atoms, etc, and R 10 and R 11 are alkyl groups having 1 to 5 carbon atoms, etc.
摘要翻译：本发明涉及能够不产生诸如光气和冠醚之类的有毒化合物而不产生腐蚀性气体如氯化氢作为副产物而以高产率选择性地生产各种碳酸酯化合物的生产方法，并且不需要通过蒸馏除去作为副产物的氯仿，以及在金属盐存在下含有反应化合物（1）与具有OH基的化合物的碳酸酯化合物的制造方法以及0.2〜4.0摩尔的化合物（ 2），得到碳原子数为1〜10的整数的碳酸酯化合物，Q为碳原子数1〜4的亚烷基等，R 10和R 11为1个至5个碳原子等

9. 发明公开

EP2700629A4 METHOD FOR PREPARING DIALKYL CARBONATE 审中-公开
标题翻译：用于生产二烷基
公开(公告)号：EP2700629A4
公开(公告)日：2014-09-24
申请号：EP12774514
申请日：2012-04-20
申请人： RES INST IND SCIENCE & TECH
发明人： BAIK JOON HYUN , KOH JAE CHEON , KIM KYONG TAE , KOH DONG JUN , SA YOUNG SAM , KIM YUN MIN , KIM CHUL UNG
IPC分类号： C07C68/00 , C07C69/96
CPC分类号： C07C68/00 , Y02P20/582 , C07C69/96

10. 发明公开

EP2513126A1 BIMETALLISCHE KOMPLEXE UND IHRE VERWENDUNG IN DER DIARYLCARBONATHERSTELLUNG 有权
标题翻译：双金属络合物与它们在碳酸二
公开(公告)号：EP2513126A1
公开(公告)日：2012-10-24
申请号：EP10792885.5
申请日：2010-12-09
申请人： Bayer Intellectual Property GmbH
发明人： GÜRTLER, Christoph , MÜLLER, Thomas Ernst , OOMS, Pieter , RECHNER, Johann , RISSE, Friedhelm , PROKOFIEVA, Angelina , DORO, Franco , KÖHLER, Burkhard , LEITNER, Walter , WOLF, Aurel
IPC分类号： C07F15/00 , C07F1/08 , C07C68/00 , C08G64/36
CPC分类号： C07F15/0066 , C07C68/005 , C07C69/96
摘要： The invention relates to bimetallic complexes, wherein the ligand comprises a salophene unit complexing copper, manganese, or cobalt, and a phenanthroline unit complexing palladium, and both systems are linked by a conjugated system. The invention further relates to the use of said bimetallic complexes as catalysts for oxidizing carbonylization of aromatic hydroxy compounds into diaryl carbonates, to a method for producing diaryl carbonates by means of the bimetallic complex as a catalyst, and to diaryl carbonates produced by means of oxidizing carbonylization of aromatic hydroxy compounds using the bimetallic complexes according to the invention as catalysts.

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