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1. 发明公开

EP4058427A1 TUCARESOL DERIVATIVES AND USES THEREOF 审中-实审
公开(公告)号：EP4058427A1
公开(公告)日：2022-09-21
申请号：EP20887291.1
申请日：2020-11-09
申请人： Beyondspring Pharmaceuticals Inc.
发明人： HE, Chengjiang , HUANG, Lan , TONRA, James, R.
IPC分类号： C07C233/87 , C07C233/83 , C07C249/08 , C07C251/48 , C07C319/12 , C07C319/20 , C07C321/14 , C07C41/18 , C07C43/23 , C07D207/09 , C07D209/20 , C07D233/64 , C07H15/203 , C07H5/04 , C07K16/28 , A61K31/496 , A61K31/7034 , A61K39/395 , A61P35/00

2. 发明授权

EP3649104B1 PROCESS FOR PRODUCING LONG CHAIN AMINO ACIDS AND DIBASIC ACIDS 有权
公开(公告)号：EP3649104B1
公开(公告)日：2021-12-15
申请号：EP18827967.3
申请日：2018-06-22
发明人： HU, Songzhou
IPC分类号： C07C227/04 , C07C231/10 , C07C249/08 , C07C51/06 , C07C209/62 , C07C227/20

4. 发明授权

EP2970075B1 OXIMATION OF KA OIL BY-PRODUCT 有权转让
公开(公告)号：EP2970075B1
公开(公告)日：2019-02-20
申请号：EP14773007.1
申请日：2014-03-12
申请人： AdvanSix Resins & Chemicals LLC
发明人： KWEEDER, James A. , LEVY, Alan B.
IPC分类号： C07C35/08 , C07C49/403 , C07C251/44 , C07C29/88 , C07C45/85 , C07C249/08 , C07C249/14

5. 发明授权

EP2440678B1 METHOD AND APPARATUS FOR REGENERATION OF EXTRACTION SOLUTION IN METAL EXTRACTION PROCESSES 有权
公开(公告)号：EP2440678B1
公开(公告)日：2018-07-18
申请号：EP10785790.6
申请日：2010-05-26
申请人： OUTOTEC (FINLAND) OY
发明人： PAATERO, Erkki , JYRKKÄ, Kai , VIROLAINEN, Sami
IPC分类号： C22B3/30 , C22B3/16 , B01D11/04 , C07C249/08 , B01F7/00 , C22B3/24 , C22B3/42
CPC分类号： C22B3/0004 , B01D15/02 , B01D21/00 , B01F7/00441 , B01F7/24 , B01F13/1013 , B01F13/1016 , C07C249/08 , C07C249/14 , C22B3/0005 , C22B3/0017 , C22B3/0032 , C22B3/02 , C22B15/0084 , C22B15/0089 , Y02P10/234 , Y02P10/236 , C07C251/48
摘要： The invention relates to a method and apparatus for restoring the extractive potential of organic hydroxyoxime-based extraction solution used in the recovery of metals by liquid-liquid extraction. The method is two-stage, in which an aqueous solution of hydroxylamine or some hydroxylamine compound is used in the reaction stage, and the removal of the undesirable compounds generated in the reaction occurs in the second stage by adsorption purification. The reaction stage and the adsorptive stage are carried out in a mixing tank.

6. 发明公开

EP3318550A4 METHOD FOR PREPARING BENZOIC ACID AMIDE COMPOUND 有权
公开(公告)号：EP3318550A4
公开(公告)日：2018-06-06
申请号：EP16818140
申请日：2016-06-03
申请人： AMOREPACIFIC CORP
发明人： JOO YUNG HYUP , BAEK HEUNG SOO , KIM YONG JIN , SHIN HONG-JU , LEE JOHN HWAN
IPC分类号： C07C231/02 , C07C213/02 , C07C217/58 , C07C235/60 , C07C249/08 , C07C251/48
CPC分类号： C07C231/02 , C07C213/02 , C07C249/08 , C07C2603/74 , C07C235/60 , C07C217/58 , C07C251/48
摘要： The present invention relates to a method for preparing a benzoic acid amide compound in a high yield by presenting a novel method for preparing a benzyl amine compound to be used as a reactant and delimiting the reaction condition of each step by using the same, and the method is economically advantageous since mass production is possible.

7. 发明公开

EP3002276A1 SHIKONIN, ALKANNIN, AND RACEMIC PARENT NUCLEUS CARBONYL OXIME DERIVATIVES AND APPLICATIONS THEREOF 失效转让
标题翻译： SHIKONIN，ALKANNIN UND RACEMISCHE MUTTERKERN-CARBONYLOXIMDERIVATE SOWIE ANWENDUNGEN DAVON
公开(公告)号：EP3002276A1
公开(公告)日：2016-04-06
申请号：EP13871854.9
申请日：2013-06-25
申请人： Shanghai Jiaotong University
发明人： LI, Shaoshun , WANG, Rubing , ZHENG, Xiaogang , ZHANG, Xu
IPC分类号： C07C251/46 , C07C249/08 , C07D213/79 , C07D213/803 , C07D333/38 , A61P35/00 , A61P35/02 , A61K31/4402 , A61K31/381 , A61K31/222 , A61K31/235 , A61K31/15
CPC分类号： C07C251/34 , A61K31/15 , A61K31/222 , C07C249/08 , C07C251/46 , C07D213/79 , C07D333/40
摘要： The present invention discloses derivatives of shikonin, alkannin and a racemic mixture thereof with hydroxyl methylation and carbonyl oximation on the parent nucleus, and their application. The derivatives of shikonin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (I) or (II); the derivatives of alkannin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (III) or (IV); the derivatives of a racemic mixture of shikonin and alkannin with hydroxyl methylation and carbonyl oximation on the parent nucleus have structural formula (V) or (VI); wherein R 1 is alkane, olefin, arene, or substituted arene comprising 1 to 6 carbon atoms; and R 2 is alkane, olefin, arene, or substituted arene comprising 1 to 6 carbon atoms or is H. The oxime derivatives of shikonin, alkannin and a racemic mixture thereof in the present invention have novel structures; and in-vitro experiments show that said derivatives of the present invention have good growth inhibitory activity against tumor cells and thus can be used in tumor treatment.
摘要翻译：本发明公开了紫草素，链烷酸及其外消旋混合物的衍生物，其在母核上具有羟基甲基化和羰基肟化及其应用。在母核上具有羟基甲基化和羰基肟化的紫草素衍生物具有结构式（I）或（II）; 具有羟基甲基化的链烷酸衍生物和母核上的羰基肟化具有结构式（III）或（IV）; 紫草素和链霉素的外消旋混合物在母核上具有羟基甲基化和羰基肟化的衍生物具有结构式（V）或（VI）; 其中R 1是含有1至6个碳原子的烷烃，烯烃，芳烃或取代的芳烃; R 2为含有1〜6个碳原子的烷烃，烯烃，芳族或取代的芳烃，或为H.本发明中紫草素，链烷烃及其外消旋混合物的肟衍生物具有新颖的结构; 并且体外实验表明，本发明的所述衍生物对肿瘤细胞具有良好的生长抑制活性，因此可用于肿瘤治疗。

8. 发明授权

EP1947056B1 Recycling system for hydroxylamine formation and oximation 失效
标题翻译：为羟胺的形成和肟化回收系统
公开(公告)号：EP1947056B1
公开(公告)日：2012-02-29
申请号：EP07024352.2
申请日：2007-12-14
申请人： China Petrochemical Development Corporation
发明人： Hwang, Jih-Dar , Cheng, Hsiu-Li , Luo, Shou-Li
IPC分类号： C01B21/14 , C07C249/08
CPC分类号： C01B21/1418

9. 发明授权

EP1193243B1 NOVEL PROCESS FOR PRODUCING BICYCLIC AMINO ALCOHOL 有权
标题翻译：新方法用于生产双环氨基醇
公开(公告)号：EP1193243B1
公开(公告)日：2008-08-13
申请号：EP00939160.8
申请日：2000-06-26
申请人： SHIONOGI & CO., LTD.
发明人： HONMA, Tsunetoshi, Shionogi & Co. Ltd. , HIRAMATSU, Yoshiharu, Shionogi & Co. Ltd. , MITSUMORI, Susumu, Shionogi & Co. Ltd.
IPC分类号： C07C67/343 , C07C69/716 , C07C213/00 , C07C215/42 , C07F7/18 , C07C249/08 , C07C251/44 , C07C45/00 , C07C49/517 , C07D333/68
CPC分类号： C07F7/1836 , C07B2200/07 , C07C67/343 , C07C213/00 , C07C213/02 , C07C215/42 , C07C249/08 , C07C2602/42 , C07D333/68 , C07D333/70 , C07F7/188 , C07C69/716 , C07C251/44 , C07C251/50
摘要： The objective bicyclic amino alcohol (IV) is produced by reacting nopinone (I) (starting material) with XCH2COOR1 (wherein X is halogeno; and R1 is alkyl) in the presence of an additive and a base to form a compound (II), converting the compound (II) into an oxime (III), and reducing the oxime (III) with aluminum hydride.

10. 发明公开

EP1947056A1 Recycling system for hydroxylamine formation and oximation 失效
标题翻译： Rückgewinnungssystemzur Bildung und Oximierung von Hydroxylamin
公开(公告)号：EP1947056A1
公开(公告)日：2008-07-23
申请号：EP07024352.2
申请日：2007-12-14
申请人： China Petrochemical Development Corporation
发明人： Hwang, Jih-Dar , Cheng, Hsiu-Li , Luo, Shou-Li
IPC分类号： C01B21/14 , C07C249/08
CPC分类号： C01B21/1418
摘要： A recycling system for hydroxylamine formation and oximation is proposed. The recycling system includes a hydroxylamine formation zone, an oximation zone, a purification zone, and an adjusting zone having a nitrate absorption tower. An inorganic process solution, used by the recycling system, partially enters the nitrate absorption tower supplementing nitrate, followed by mixing with the residual inorganic process solution, thereby reducing the loss rate of hydroxylamine in the inorganic process solution due to degradation. In addition, the organic impurities with high boiling point in the inorganic process solution can be effectively removed in the purification zone. As a result, the reduced activity or selectivity of the catalyst for hydroxylamine formation, caused by the toxic effects of these organic impurities on the catalyst, can be avoided, and hence, a high concentration of hydroxylamine can be obtained.
摘要翻译：提出了羟胺形成和肟化的回收系统。回收系统包括羟胺形成区，肟化区，净化区和具有硝酸盐吸收塔的调节区。由再循环系统使用的无机工艺溶液部分地进入硝酸盐吸收塔，补充硝酸盐，然后与剩余的无机工艺溶液混合，从而降低由于降解导致的无机工艺溶液中羟胺的损失率。此外，可以在净化区域中有效地除去无机工艺溶液中具有高沸点的有机杂质。结果，可以避免由这些有机杂质对催化剂的毒性作用引起的羟胺形成催化剂的活性降低或选择性降低，因此可以获得高浓度的羟胺。

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