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1. 发明授权

EP2991968B1 COMPOUNDS AND METHODS OF TREATING INFECTIONS 有权
公开(公告)号：EP2991968B1
公开(公告)日：2021-11-10
申请号：EP14791590.4
申请日：2014-05-01
发明人： PAGE, Stephen , GARG, Sanjay , KEENAN, Martine , MCCLUSKEY, Adam , STEVENS, Andrew
IPC分类号： C07C279/02 , C07C241/04 , C07C281/08 , C07C337/08 , C07C281/18 , C07C249/14 , C07D407/12 , C07D403/12 , C07D409/12 , C07D401/12 , C07C275/68 , A61K31/4045 , A61K31/155 , A61K31/4192 , A61K31/341 , A61K31/381 , A61K31/498 , A61K31/44 , A61K31/12 , A61P31/04

3. 发明公开

EP2986590A4 NOVEL CURING AGENTS AND DEGRADABLE POLYMERS AND COMPOSITES BASED THEREON 审中-公开
标题翻译：基于此的新型硬化剂和可降解聚合物及复合材料
公开(公告)号：EP2986590A4
公开(公告)日：2016-11-16
申请号：EP14785785
申请日：2014-04-18
申请人： ADESSO ADVANCED MATERIALS WUXI CO LTD
发明人： QIN BING , LI XIN , LIANG BO
IPC分类号： C07C217/84 , C07C201/12 , C07C213/02 , C07C241/02 , C07C241/04 , C07C243/28 , C07C243/38 , C08G59/50 , C08J5/24 , C08J11/16 , C08J11/26 , C08J11/28 , C08K7/06 , C08L63/00
CPC分类号： C07C243/38 , C07C201/12 , C07C213/02 , C07C217/84 , C07C241/02 , C07C243/28 , C08G59/1477 , C08G59/50 , C08J5/24 , C08J11/16 , C08J11/26 , C08K7/06 , Y02W30/705 , Y02W30/706
摘要： The present invention provides, among others, compounds of Formula (I) or a salt thereof, methods for making these compounds, degradable polymers and reinforced composites made therefrom, and methods for degrading and/or recycling the degradable polymers and reinforced composites.

4. 发明授权

EP2088185B1 Diesel fuel composition 有权
标题翻译： Dieselkraftstoffzusammensetzung
公开(公告)号：EP2088185B1
公开(公告)日：2011-11-02
申请号：EP09160925.5
申请日：2007-07-03
申请人： Infineum International Limited
发明人： Breakspear, Angella Priscilla, Dr. , Caprotti, Rinaldo , Thomson, Russell Martin
IPC分类号： C10L1/238 , C10L1/226 , C10L10/18 , C10L10/02 , F02M61/18 , F02M65/00 , F02B77/04 , C08F8/30 , C07C241/04
CPC分类号： F02M65/008 , C07D207/323 , C07D259/00 , C10L1/221 , C10L1/226 , C10L1/2381 , C10L1/2383 , C10L10/02 , C10L10/04 , C10L10/06 , C10L10/18 , F02M43/00 , F02M2200/06

5. 发明授权

EP1887074B1 Method and use for the prevention of fuel injector deposits 有权
标题翻译：一种用于防止沉积物的燃料喷射器的方法和应用
公开(公告)号：EP1887074B1
公开(公告)日：2011-09-14
申请号：EP07111678.4
申请日：2007-07-03
申请人： Infineum International Limited
发明人： Brekspear, Angela Priscilla, Dr. , Caprotti, Rinaldo , Thomson, Russell Martin
IPC分类号： C10L1/238 , C10L1/226 , C10L10/18 , C10L10/02 , F02M61/18 , F02M65/00 , F02B77/04 , C08F8/30 , C07C241/04
CPC分类号： F02M65/008 , C07D207/323 , C07D259/00 , C10L1/221 , C10L1/226 , C10L1/2381 , C10L1/2383 , C10L10/02 , C10L10/04 , C10L10/06 , C10L10/18 , F02M43/00 , F02M2200/06

6. 发明公开

EP1910303A2 PROCESS FOR SYNTHESIZING A SUBSTITUTED PYRAZOLE 审中-公开
标题翻译：方法合成取代的吡唑
公开(公告)号：EP1910303A2
公开(公告)日：2008-04-16
申请号：EP06800239.3
申请日：2006-07-21
申请人： Merck & Co., Inc.
发明人： TAN, Lushi , MCWILLIAMS, James Christopher , HARTNER, Frederick, W. , YOSHIKAWA, Naoki , LI, Wenji
IPC分类号： C07D231/12 , C07C281/02 , C07C241/04 , C07C241/02
CPC分类号： C07D231/12 , C07C241/02 , C07C241/04 , C07C281/02 , C07C243/18 , C07C243/24
摘要： The present application relates to a process for the synthesis of the compound of formula 1. The compound of formula I is a glucagon receptor antagonist and is useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

7. 发明授权

EP0874806B1 PROCESS FOR PREPARATION OF HYDRAZIDES 无效
标题翻译：用于生产酰肼
公开(公告)号：EP0874806B1
公开(公告)日：2001-10-31
申请号：EP96942936.4
申请日：1996-12-19
申请人： SCHERING CORPORATION
发明人： LEONG, William , SMITH, Lyman
IPC分类号： C07C241/04
CPC分类号： C07C241/04 , Y02P20/55 , C07C243/28
摘要： A process for producing a hydrazide of formula (1.0) is disclosed. The process comprises reacting a hydrazone of formula (2.0) or (2.1), wherein said hydrazone is in toluene, with a mixture of Grignard reagents, wherein said Grignard reagents are in a suitable organic solvent; wherein: (A) Z is a suitable carbonyl protecting group; (B) R is a suitable -OH protecting group; (C) R is selected from: H, a non-enolizable alkyl, a non-enolizable substituted alkyl, aryl, substituted aryl, -S-aryl, -S-(substituted aryl), -S-alkyl, -S-(substituted alkyl), alkoxy, substituted alkoxy, aryloxy, or substituted aryloxy; (D) said mixture of Grignard reagents comprises R MgX in admixture with R MgX; (E) R is a suitable alkyl, substituted alkyl, alkenyl, alkynyl, aryl, substituted aryl, or aralkyl group capable of adding to the -C=N group of the hydrazone to produce the hydrazide; (F) R is a suitable alkyl, substituted alkyl, aryl or substituted aryl group that is more sterically hindered than said R group; (G) X is independently selected from Cl, Br or I for each Grignard reagent; (H) when said hydrazone is a compound of formula (2.0) then the reaction is conducted at a temperature of about +30 to about -40 DEG C; and (I) when said hydrazone is a compound of formula (2.1) then the reaction is conducted at a temperature of about +40 to about -20 DEG C.

8. 发明公开

EP0982292A2 Process for the preparation of monoacylhydrazines using carboxylic acids 有权
标题翻译： Verfahren zur Herstellung von Monoacyl-hydrazinen unter Verwendung vonCarbonsäuren
公开(公告)号：EP0982292A2
公开(公告)日：2000-03-01
申请号：EP99306408.8
申请日：1999-08-13
申请人： ROHM AND HAAS COMPANY
发明人： Dubuisson-Brengel, Catherine , Rayle, Heather Lynnette
IPC分类号： C07C241/04 , C07C243/24
CPC分类号： C07C241/04 , C07C243/38
摘要： This invention provides a convenient process for the preparation of monoacylhydrazines from carboxylic acids or their salts and hydrazine or substituted hydrazine in the presence of a 1,3,5-triazine substituted with at least one chloro or fluoro. The resulting monoacylhydrazine can further be converted to a diacylhydrazine by effectively either repeating the reaction or through reaction with a carboxylic acid chloride.
摘要翻译：本发明提供了在由至少一种氯或氟取代的1,3,5-三嗪存在下，从羧酸或其盐和肼或取代的肼制备单酰肼的方便方法。通过有效地重复反应或通过与羧酸氯化物反应，可以将所得的单酰基肼进一步转化为二酰肼。

9. 发明授权

EP0749421B1 SULPHONAMIDE DERIVATIVES AS ASPARTYL PROTEASE INHIBITORS 失效
标题翻译：磺胺ALS抑制剂天冬氨酰
公开(公告)号：EP0749421B1
公开(公告)日：1999-09-15
申请号：EP95911960.3
申请日：1995-02-24
申请人： VERTEX PHARMACEUTICALS INCORPORATED
发明人： TUNG, Roger, Dennis , SALITURO, Francesco, Gerald , DEININGER, David, D. , MURCKO, Mark, Andrew , NOVAK, Perry, Michael , BHISETTI, Govinda, Rao
IPC分类号： C07C311/29 , C07C311/41 , C07D307/20 , C07D319/06 , C07C241/04 , C07D493/04 , C07D211/60 , C07D317/36 , C07D241/04 , C07D277/06 , C07D213/81
CPC分类号： C07D213/30 , C07C311/29 , C07C311/41 , C07C2601/08 , C07D211/60 , C07D213/70 , C07D213/81 , C07D213/82 , C07D217/24 , C07D217/26 , C07D231/38 , C07D233/54 , C07D233/64 , C07D233/76 , C07D233/84 , C07D233/88 , C07D233/90 , C07D235/06 , C07D235/28 , C07D241/04 , C07D249/18 , C07D261/08 , C07D263/22 , C07D263/32 , C07D263/56 , C07D263/58 , C07D277/06 , C07D277/26 , C07D277/36 , C07D277/46 , C07D307/10 , C07D307/20 , C07D309/08 , C07D309/10 , C07D317/18 , C07D317/34 , C07D319/06 , C07D333/36 , C07D333/38 , C07D333/48 , C07D335/02 , C07D401/06 , C07D493/04
摘要： This invention relates to a novel class of sulfonamides that are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting aspartyl protease activity and methods for treating viral infections using the compounds and compositions of this invention.

10. 发明授权

EP0492839B1 Selective acylation of hydrazines 失效
标题翻译：肼的选择性酰化。
公开(公告)号：EP0492839B1
公开(公告)日：1995-04-12
申请号：EP91311261.1
申请日：1991-12-04
申请人： ROHM AND HAAS COMPANY
发明人： Kelly, Martha Jean
IPC分类号： C07C241/04 , C07C243/38
CPC分类号： C07C241/04 , C07C243/38

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