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1. 发明授权

EP2571528B1 BRAS AUTORÉACTIFS ET PRODROGUES LES COMPRENANT 有权
标题翻译：自反应的武器和包括他们的产品
公开(公告)号：EP2571528B1
公开(公告)日：2018-01-31
申请号：EP11724800.5
申请日：2011-05-18
申请人： Centre National de la Recherche Scientifique , Université De Poitiers
发明人： PAPOT, Sébastien , THOMAS, Mickaël
IPC分类号： A61K47/54 , A61K47/55 , C07C205/22 , C07D475/04 , C07H15/252 , C07H15/203 , A61P35/00
CPC分类号： A61K47/549 , A61K47/551 , C07C205/22 , C07D475/04 , C07H15/203 , C07H15/252

2. 发明公开

EP2001823A1 NITRIERUNG AKTIVIERTER AROMATEN IN MIKROREAKTOREN 审中-公开
标题翻译：微反应器中活性炭硝化芳烃
公开(公告)号：EP2001823A1
公开(公告)日：2008-12-17
申请号：EP06706213.3
申请日：2006-01-12
申请人： Lonza AG
发明人： ROBERGE, Dominique , DUCRY, Laurent
IPC分类号： C07B43/02 , B01J19/00 , C07C201/08 , C07C205/22 , C07C205/23
CPC分类号： C07C201/08 , B01J19/0093 , B01J2219/0086 , B01J2219/00984 , C07C205/23 , C07C205/22 , C07C205/25 , C07C205/37 , C07C205/59 , C07C205/60
摘要： The invention relates to the nitration of aromatic or heteroaromatic compounds, wherein an activated aromatic or heteroaromatic compound and a nitrating agent, in the presence, if desired, of a solvent, are mixed intensely in a microreactor, and wherein the proportion of the nitrating agent to the activated aromatic or heteroaromatic compound, the concentration of nitrating agent in the reaction mixture, and the temperature are selected at levels such that the nitration begins autocatalytically, and wherein the nitration product is obtained after leaving the microreactor and, if desired, after an after-reaction time outside the microreactor.

4. 发明公开

EP1519911A1 PROCEDE DE PREPARATION D'UN NITROPHENOL 审中-公开
标题翻译：程序DE制备D'NITROPHENOL
公开(公告)号：EP1519911A1
公开(公告)日：2005-04-06
申请号：EP03763942.4
申请日：2003-07-09
申请人： RHODIA CHIMIE
发明人： FACHE, Eric , RIGHINI, Sébastien
IPC分类号： C07C205/22
CPC分类号： C07C201/16 , C07C205/22
摘要： The invention relates to a method of preparing a high-purity nitrophenol and, more specifically, p-nitrophenol from a nitrohalobenzene. The inventive method comprises the following steps: (a) hydrolysis of a nitrohalobenzene compound by reacting said compound with a base; (b) acidification in order to produce the nitrophenol compound from the salt thereof by means of an acid treatment; (c) crystallisation of the nitrophenol compound obtained; and (d) separation of the product obtained. The invention is characterised in that it also comprises at least the following steps: (e) concentration of the reaction medium after hydrolysis (a) and before acidification (b); and (f) liquid/liquid decantation after acidification (b) and before crystallisation (c), which is intended to eliminate the water phase obtained after acidification (b).
摘要翻译：本发明涉及由硝基卤代苯制备高纯度硝基苯酚，更具体而言，制备对硝基苯酚的方法。本发明方法包括以下步骤：（a）通过使所述化合物与碱反应来水解硝基卤代苯化合物; （b）酸化以便通过酸处理由其盐产生硝基苯酚化合物; （c）所得硝基酚化合物的结晶; 和（d）分离所得产物。本发明的特征在于其还包括至少以下步骤：（e）在水解（a）之后和酸化（b）之前浓缩反应介质; 和（f）酸化后（b）和结晶前（c）液体/液体倾析，其目的是消除酸化后得到的水相（b）。

5. 发明公开

EP1409446A1 METHOD FOR THE NITRATION OF PHENOLIC COMPOUNDS 审中-公开
标题翻译：氮化酚类化合物的方法
公开(公告)号：EP1409446A1
公开(公告)日：2004-04-21
申请号：EP02747586.2
申请日：2002-07-22
申请人： Portela & CA SA
发明人： LEARMONTH, David Alexander
IPC分类号： C07C201/08 , C07C205/60 , C07C205/45 , C07C205/44 , C07C205/22
CPC分类号： A61K31/06 , C07C201/08 , C07C201/12 , C07C205/22 , C07C205/26 , C07C205/43 , C07C205/44 , C07C205/60 , C07C205/45
摘要： A method for the regioselective ortho-directed nitration of phenolic compounds useful for the preparation of ortho-nitro-phenols according to formula (I) is described.

6. 发明授权

EP0293718B1 Substituierte Aminophenyl-carbamate 失效
标题翻译：取代的氨基苯甲酸
公开(公告)号：EP0293718B1
公开(公告)日：1993-02-03
申请号：EP88108239.0
申请日：1988-05-24
申请人： BAYER AG
发明人： Krüger, Bernd-Wieland, Dr. , Sasse, Klaus, Dr. , Heitkämper, Peter, Dr. , König, Klaus, Dr. , Brandes, Wilhelm, Dr. , Hänssler, Gerd, Dr. , Marhold, Albrecht, Dr.
IPC分类号： C07C273/08 , C07C275/30 , C07D319/06 , C07C215/76 , C07C205/22 , A01N47/22 , A01N47/20 , A01N47/30
CPC分类号： C07D307/08 , C07C205/26 , C07C205/37 , C07C275/34 , C07D319/06

7. 发明公开

EP2440511A1 PROCÉDÉ D' HYDROXYLATION DE COMPOSÉS ARYLES HALOGÉNÉS 审中-公开
标题翻译：羟化卤代芳基化合物的方法
公开(公告)号：EP2440511A1
公开(公告)日：2012-04-18
申请号：EP10737971.1
申请日：2010-06-08
申请人： Centre National de la Recherche Scientifique (C.N.R.S)
发明人： TAILLEFER, Marc , TLILI, Anis , MONNIER, Florian , XIA, Ning
IPC分类号： C07C37/02 , C07B41/02 , C07C41/26 , C07C45/64 , C07C205/22 , C07C39/27 , C07C39/04 , C07C49/825 , C07C255/53 , C07C253/30 , C07C201/12
CPC分类号： C07C37/02 , C07B41/02 , C07C41/26 , C07C45/64 , C07C201/12 , C07C253/30 , C07C39/07 , C07C39/14 , C07C39/04 , C07C39/15 , C07C39/27 , C07C39/28 , C07C43/23 , C07C49/825 , C07C255/53 , C07C205/22
摘要： The present invention relates to a method for the hydroxylation of halogen aryl compounds carried out at a temperature lower than 200°C in the presence of a catalytic system including a copper-based catalyst and a ligand L according to reaction scheme Formula (A), in which: R is selected from the groups having an acceptor inductive effect and the groups having a donor mesomer effect; M is selected from alkaline or alkaline-earth cations; X is a halogen atom; r is between 0 and 5; and the ligand L is selected from compounds having formula I.

8. 发明公开

EP2144866A1 PROCEDE DE PREPARATION DU 2-(N-BUTYL)-5-NITROBENZOFURANE 审中-公开
标题翻译：用于生产2-（正丁基）-5-硝基苯并呋喃
公开(公告)号：EP2144866A1
公开(公告)日：2010-01-20
申请号：EP08787910.2
申请日：2008-04-04
申请人： Finorga
发明人： DURAND, Thierry , DIOUF, Ousmanne , LEMEUNE, Stéphane , MARCOUX, Jean-François , HENRYON, Vivien , MONBRUN, Jérôme , DELAMARE, Madeleine
IPC分类号： C07C205/22 , C07D307/79
CPC分类号： C07D307/79 , C07C201/12 , C07C205/22 , C07C205/37
摘要： The invention relates to a method for preparing 2-(n-butyl)-5-nitrobenzofuran from 1-halogeno-4-nitrobenzene, characterised in that it comprises reacting the 1-hexen-3-ol, then subjecting the product to a Claisen rearrangement, followed by a catalytic intramolecular cyclisation.

9. 发明公开

EP1274673A1 VERFAHREN ZUR HERSTELLUNG VON 4-HYDROXY-3-NITROBIPHENYL 有权
标题翻译：用于生产4-羟基-3-硝基联苯
公开(公告)号：EP1274673A1
公开(公告)日：2003-01-15
申请号：EP01929466.9
申请日：2001-03-28
申请人： Bayer Aktiengesellschaft
发明人： BEHRE, Horst , DOCKNER, Michael , KLAUSENER, Alexander
IPC分类号： C07C205/22 , C07C201/08
CPC分类号： C07C201/08 , C07C205/22
摘要： The invention relates to a method for producing 4-hydroxy-3-nitrobiphenyl on the basis of 4-hydroxybiphenyl by highly selective and effective nitration in the vicinal position to the phenolic hydroxy group, whereby the azotic acid used as the nitration reagent is added to the reaction system in a specific manner.

10. 发明授权

EP0626366B1 Procédé de préparation de nitrophénols 失效
标题翻译：一种制备硝基酚过程
公开(公告)号：EP0626366B1
公开(公告)日：1998-01-14
申请号：EP94401124.6
申请日：1994-05-20
申请人： RHONE-POULENC CHIMIE
发明人： Metivier, Pascal , Bernard, Laurent
IPC分类号： C07C205/22 , C07C207/04 , C07C205/37 , C07C205/26 , C07C201/10
CPC分类号： C07C201/00 , C07C201/08 , C07C205/22 , C07C207/04

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