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1. 发明授权

EP1749885B1 Infectious and attenuated bovine viral diarrhea virus vaccine 有权
标题翻译：传染病和衰减Rinderdiarrhoeviren疫苗
公开(公告)号：EP1749885B1
公开(公告)日：2012-12-05
申请号：EP06011790.0
申请日：2002-09-05
申请人： Boehringer Ingelheim Vetmedica GmbH
发明人： Elbers, Knut , Fetzer, Christiane , von Freyburg, Martina , Meyers, Gregor
IPC分类号： C12N7/04 , A61K39/12 , C07K14/18
CPC分类号： C12N7/00 , A61K2039/5254 , C07K14/005 , C12N2770/24022 , C12N2770/24061 , C12N2770/24321 , C12N2770/24322 , C12N2770/24361

2. 发明公开

EP1973565A2 MARKED BOVINE VIRAL DIARRHEA VIRUS VACCINES 有权
标题翻译： MARKED牛病毒性腹泻病毒
公开(公告)号：EP1973565A2
公开(公告)日：2008-10-01
申请号：EP06821006.1
申请日：2006-11-24
申请人： Pfizer Products Incorporated
发明人： HUANG, Chichi , SHEPPARD, Michael G. , CAO, Xuemei , ZYBARTH, Gabriele
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/525 , A61K2039/55 , A61K2039/552 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
摘要： The present invention is directed to a bovine viral diarrhea virus comprising at least one helicase domain amino acid mutation wherein the mutation in the NS3 domain results in a loss of recognition by a monoclonal antibody raised against wild-type NS3 but wherein viral RNA replication and the generation of infectious virus is retained. The present invention is useful, for example, to produce a marked bovine viral diarrhea virus vaccine or to differentiate between vaccinated and infected or unvaccinated animals.

3. 发明公开

EP1948229A2 COMBINATION VACCINE COMPRISING AN ATTENUATED BOVINE VIRAL DIARRHEA VIRUS 审中-公开
标题翻译： WITH A炖牛病毒性腹泻病毒联合疫苗
公开(公告)号：EP1948229A2
公开(公告)日：2008-07-30
申请号：EP06850760.7
申请日：2006-11-15
申请人： Boehringer Ingelheim Vetmedica GmbH
发明人： MEYERS, Gregor , KNITTEL, Jeff , ELBERS, Knut , TREMBLAY, Rob , JONES, Craig , LISCHEWSKI, Axel
IPC分类号： A61K39/00 , C12N7/00
CPC分类号： C07K14/005 , A61K39/0225 , A61K39/12 , A61K39/155 , A61K39/265 , A61K2039/521 , A61K2039/5254 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/16022 , C12N2710/16734 , C12N2760/18022 , C12N2760/18522 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
摘要： The present invention relates to combination vaccines for the prophylaxis and treatment of microbiological infections in cattle which comprise an attenuated bovine viral diarrhea virus (BVDV) for the the prophylaxis and treatment of BVDV caused infections, and a further immunological active component for the prophylaxis and treatment of microbiological infections other than BVDV.

4. 发明公开

EP1013757A3 Attenuated forms of bovine viral diarrhea virus 审中-公开
标题翻译： Rinderdiarrhöevirus的减毒形式
公开(公告)号：EP1013757A3
公开(公告)日：2002-03-06
申请号：EP99308866.5
申请日：1999-11-08
申请人： Pfizer Products Inc.
发明人： Cao, Xuemei , Sheppard, Michael George
IPC分类号： C12N7/04 , C12N7/02 , C12N15/40 , C12N5/10 , C12N15/85 , C07K16/10 , A61K39/15 , A61K31/505
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
摘要： The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the N pro protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.

5. 发明授权

EP2382307B1 RECOMBINANT CLASSICAL SWINE FEVER VIRUS (CSFV) COMPRISING A MODIFIED E2 PROTEIN AND METHODS FOR GENERATING SAID RECOMBINANT CSFV. 有权
标题翻译：重组古典猪瘟病毒（CSFV）与修饰E2蛋白和方法用于生产重组CSFVS的
公开(公告)号：EP2382307B1
公开(公告)日：2015-07-15
申请号：EP09775363.6
申请日：2009-12-23
申请人： Intervet International B.V.
发明人： KORTEKAAS, Jeroen Alexander , VLOET, Rianka Petronella Maria
IPC分类号： C12N7/04 , C07K14/18 , A61K39/12 , G01N33/569
CPC分类号： C12N7/00 , C07K14/005 , C12N2770/24322 , C12N2770/24361 , G01N33/56983

6. 发明授权

EP2023953B1 A NOVEL VIRULENCE DETERMINANT WITHIN THE E2 STRUCTURAL GLYCOPROTEIN OF CLASSICAL SWINE FEVER VIRUS 有权
标题翻译：新型毒力结构E2糖古典猪瘟病毒
公开(公告)号：EP2023953B1
公开(公告)日：2014-11-19
申请号：EP07797826.0
申请日：2007-05-29
申请人： The United States of America, as represented by the Secretary of Agriculture
发明人： BORCA, Manuel, V. , RISATTI, Guillermo, R.
IPC分类号： A61K39/12 , A61K39/00 , C12Q1/68 , C12N15/09
CPC分类号： A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361

7. 发明公开

EP2202298A1 Recombinant classical swine fever virus (CSFV) comprising a modified E2 protein and methods for generating said recombinant CSFV 审中-公开
标题翻译：猪瘟（CSF）与经修饰的E2蛋白和方法用于产生重组病毒，所述猪瘟病毒
公开(公告)号：EP2202298A1
公开(公告)日：2010-06-30
申请号：EP08172874.3
申请日：2008-12-23
申请人： Stichting Dienst Landbouwkundig Onderzoek
发明人： The designation of the inventor has not yet been filed
IPC分类号： C12N7/04 , C07K14/18 , A61K39/12 , G01N33/569
CPC分类号： C12N7/00 , C07K14/005 , C12N2770/24322 , C12N2770/24361 , G01N33/56983
摘要： The invention relates to a recombinant classical swine fever virus (CSFV). A preferred recombinant CSFV comprises a deletion of at least one amino acid in a "TAVSPTTLR" domain of the E2 protein. The invention further relates to a vaccine comprising the recombinant CSFV, a method for generating a recombinant CSFV, and use of a recombinant CSFV.
摘要翻译：本发明涉及一种重组猪瘟病毒（CSFV）。优选的重组CSFV包含缺失至少一个氨基酸的在E2蛋白的“TAVSPTTLR”域。本发明还涉及到一种疫苗，包含所述重组CSFV，产生重组CSFV的方法，以及一种重组CSFV的用途。

8. 发明公开

EP2023953A2 A NOVEL VIRULENCE DETERMINANT WITHIN THE E2 STRUCTURAL GLYCOPROTEIN OF CLASSICAL SWINE FEVER VIRUS 有权
标题翻译：新型毒力结构E2糖古典猪瘟病毒
公开(公告)号：EP2023953A2
公开(公告)日：2009-02-18
申请号：EP07797826.0
申请日：2007-05-29
申请人： The United States of America, as represented by the Secretary of Agriculture
发明人： BORCA, Manuel, V. , RISATTI, Guillermo, R.
IPC分类号： A61K39/12 , A61K39/00 , C12Q1/68 , C12N15/09
CPC分类号： A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2770/24322 , C12N2770/24334 , C12N2770/24361
摘要： Classical Swine Fever Virus (CSFV) E2 glycoprotein is a major inducer of neutralizing antibodies and protective immunity in swine. E2 mediates virus adsorption to the target cell, and harbors genetic determinants associated with virus virulence. CSFV E2 also contains between residues 829 and 837 a discrete epitope (TAVSPTTLR) recognized by monoclonal antibody (mAb) WH303, used to differentiate CSFV from related Pestiviruses Bovine Viral Diarrhea Virus (BVDV) and Border Disease Virus (BDV). In this report, a CSFV infectious clone of the virulent Brescia isolate (BICv) was used to progressively mutate the mAb WH303 epitope of CSFV E2 to the homologous amino acid sequence of BVDV strain NADL E2 (TSFNMDTLA). While the resulting virus mutants T1v (TSFSPTTLR), T2v (TSFNPTTLR), T3v (TSFNMTTLR) demonstrated in vitro growth characteristics similar to those of parental BICv, mutants T4v (TSFNMDTLR) and T5v (TSFNMDTLA) exhibited a 10-fold decrease in virus yield and a significant decrease in plaque size relative to parental BICv. Immunohistochemical reactivity with WH303 was lost only in T3v, T4v and T5v. Interestingly, progressive mutation of the WH303 epitope had an additive effect on attenuation for the virus in swine, with mutants T1v, T2v or T3v inducing progressively milder but invariably lethal CSF, T4v inducing only mild and transient clinical disease, and T5v inducing no disease. Swine infected with either T4v or T5v showed decreased virus replication in tonsils, draining lymph node, spleen and kidney and a significant reduction in virus shedding. Finally, T5v-infected animals were protected from clinical disease when challenged with virulent Brescia virus at 3 or 21 days post T5v inoculation. These results indicate that amino acid residues 830 to 834 of E2 are critical for virulence of CSFV in swine and that engineering at this locus may provide basis for a rationally designed live attenuated CSF vaccine.

9. 发明公开

EP1749885A2 Infectious and attenuated bovine viral diarrhea virus clones; methods for their production and use 有权
标题翻译： Impfstoff voninfektiösenund attenuierten Rinderdiarrhoeviren
公开(公告)号：EP1749885A2
公开(公告)日：2007-02-07
申请号：EP06011790.0
申请日：2002-09-05
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人： Elbers, Knut , Fetzer, Christiane , von Freyburg, Martina , Meyers, Gregor
IPC分类号： C12N7/04 , A61K39/12 , C07K14/18
CPC分类号： C12N7/00 , A61K2039/5254 , C07K14/005 , C12N2770/24022 , C12N2770/24061 , C12N2770/24321 , C12N2770/24322 , C12N2770/24361
摘要： The invention belongs to the field of animal health and in particular Bovine Viral Diarrhea Virus (BVDV). The invention provides infectious BVDV clones and methods to produce said BVDV clones. The invention further relates to methods of attenuating said clones, attenuated BVDV clones and vaccines comprising said attenuated clones.
摘要翻译：本发明属于动物健康领域，特别是牛病毒性腹泻病毒（BVDV）。本发明提供感染性BVDV克隆和产生所述BVDV克隆的方法。本发明还涉及减毒所述克隆，减毒BVDV克隆和包含所述减毒克隆的疫苗的方法。

10. 发明公开

EP1614423A2 Attenuated pestiviruses 审中-公开
标题翻译： Attenuierte Pestiviren
公开(公告)号：EP1614423A2
公开(公告)日：2006-01-11
申请号：EP05017098.4
申请日：1999-05-26
申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH
发明人： Meyers, Gregor
IPC分类号： A61K35/76 , C12N7/04 , A61K48/00 , C12Q1/70 , C12N15/55
CPC分类号： C12N9/22 , A61K35/13 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51 , A61K2039/5254 , A61K2039/53 , C07K14/005 , C12N7/00 , C12N2770/24322 , C12N2770/24361
摘要： This invention relates to attenuated pestiviruses characterised in that their enzymatic activity residing in glycoprotein E RNS is inactivated, methods of preparing, using and detecting these.
摘要翻译：本发明涉及减毒瘟病毒，其特征在于其驻留在糖蛋白E RNS中的酶活性被灭活，制备，使用和检测这些酶的方法。

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