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1. 发明公开

EP3286300A1 ISOLATION OF BONA FIDE PANCREATIC PROGENITOR CELLS 有权
公开(公告)号：EP3286300A1
公开(公告)日：2018-02-28
申请号：EP16721712
申请日：2016-04-21
申请人： UNIV COPENHAGEN
发明人： AMERI JACQUELINE , SEMB HENRIK
IPC分类号： C12N5/071 , C12N5/00
CPC分类号： C12N5/0678 , C12N5/0081 , C12N5/0676 , C12N2501/50 , C12N2501/58 , C12N2501/585 , C12N2506/02
摘要： The present invention relates to a method for isolating bona fide pancreatic progenitor cells and to cell populations enriched for bona fide pancreatic progenitor cells.

2. 发明公开

EP1242577A1 PROCESS FOR EX VIVO FORMATION OF MAMMALIAN BONE AND USES THEREOF 有权
标题翻译：对于离体形成过程的动物骨方法及其用途
公开(公告)号：EP1242577A1
公开(公告)日：2002-09-25
申请号：EP00988458.6
申请日：2000-12-27
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF MICHIGAN
发明人： LONG, Michael, W. , KALE, Sujata
IPC分类号： C12N5/00 , C12N5/06 , C12N5/08 , C12N5/10 , A61K35/32 , G01N33/50
CPC分类号： G01N33/5044 , A61K35/12 , C12N5/0654 , C12N2500/14 , C12N2501/105 , C12N2501/15 , C12N2501/165 , C12N2501/585 , C12N2503/00 , C12N2503/02 , C12N2510/00 , G01N33/5008 , G01N33/5026 , G01N33/5073
摘要： The present invention concerns methods for the ex vivo formation of mammalian bone and subsequent uses of the bone. A critical and distinguishing feature of the present invention are defined tissue culture conditions and factors resulting in the formation of bone cell spheroids. The invention also provides for methods of implanting into subjects the ex vivo formed bone. Also described are methods for genetically altering the bone cell spheroids to affect bone formation, identification of candidate modulators of bone formation, and identification of genes involved in bone formation.

3. 发明公开

EP3029061A1 MESENCHYMAL STEM CELLS, COMPOSITIONS, AND METHODS FOR TREATMENT OF CARDIAC TISSUE DAMAGE 失效
标题翻译： MESENCHYMALE STAMMZELLEN，ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VONHERZGEWEBESCHÄDEN
公开(公告)号：EP3029061A1
公开(公告)日：2016-06-08
申请号：EP15200119.4
申请日：2009-06-18
申请人： The Texas A&M University System
发明人： PROCKOP, Darwin, J. , LEE, Ryang, Hwa
IPC分类号： C07K14/525 , C12N5/077 , C12N5/0775
CPC分类号： C07K14/525 , C12N5/0663 , C12N2501/25 , C12N2501/585
摘要： The present invention provides compositions comprising mesenchymal stem cells (MSCs), and methods for their novel use in the repair of cardiac damage and treatment of inflammatory diseases. The invention also provides methods for using TSG-6 protein that is secreted by MSCs under certain conditions, for repair of cardiac damage and inflammatory disease. The compositions of the invention may be particularly useful in restoring cardiac function following cardiac damage, including, but not limited to, myocardial infarction, as well as in reducing symptoms of inflammatory disease.
摘要翻译：本发明提供了包含间充质干细胞（MSC）的组合物，以及它们用于修复心脏损伤和治疗炎症性疾病的新方法。本发明还提供了在某些条件下使用由MSC分泌的TSG-6蛋白质用于修复心脏损伤和炎性疾病的方法。本发明的组合物可以特别用于恢复心脏损伤后的心脏功能，包括但不限于心肌梗塞，以及减少炎性疾病的症状。

4. 发明公开

EP2179032A1 METHOD FOR PREPARING CELLS FOR ENGRAFTMENT 审中-公开
标题翻译：工艺用于细胞植入的制备
公开(公告)号：EP2179032A1
公开(公告)日：2010-04-28
申请号：EP08787244.6
申请日：2008-08-14
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： BLANC-BRUDE, Olivier , BONNEFOY, Arnaud
IPC分类号： C12N5/06 , A61K38/39
CPC分类号： A61K38/39 , C12N5/0663 , C12N2501/585 , C12N2533/54 , C12N2533/56
摘要： The present invention relates to an in vitro method for preparing progenitor cells having an increased adhesivity, wherein progenitor cells are contacted with an agonist of the CD47/IAP receptor thereby yielding progenitor cells presenting an increased adhesivity.

5. 发明公开

EP2117582A2 PERIOSTIN INDUCES PROLIFERATION OF CARDIOMYOCYTES AND PROMOTES CARDIAC REGENERATION 失效
标题翻译：骨膜确保心肌细胞的增殖和促进心脏的再生
公开(公告)号：EP2117582A2
公开(公告)日：2009-11-18
申请号：EP08713899.6
申请日：2008-01-22
申请人： Children's Medical Center Corporation
发明人： KUHN, Bernhard
IPC分类号： A61K38/18
CPC分类号： C12N5/0657 , A61K38/1709 , C12N2501/585 , C12N2501/998
摘要： The present invention provides compositions and methods for increasing proliferation, increasing cell cycle activity, and/or proliferation of postmitotic mammalian differentiated cardiomyocytes. The invention can be used to slow, reduce, or prevent the onset of cardiac damage caused by, for example, myocardial ischemia, hypoxia, stroke, or myocardial infarction in vivo. In addition, the methods and compositions of the invention can be used to enhance proliferation of differentiated cardiomyocytes in vitro and/or ex vivo, which can then be used in tissue grafting.

6. 发明公开

EP2071020A2 Tissue Implant 审中-公开
标题翻译： Gewebeimplantat
公开(公告)号：EP2071020A2
公开(公告)日：2009-06-17
申请号：EP08018661.2
申请日：2001-07-30
申请人： Smith&Nephew PLC
发明人： Archer, Charles William , Dowthwaite, gary Paul , Thomson, Brian Mark , Smith, Mark Fredrick
IPC分类号： C12N5/06
CPC分类号： A61L27/3817 , A61F2/30756 , A61F2002/30766 , A61K35/12 , A61L27/3852 , A61L2430/06 , C12N5/0068 , C12N5/0655 , C12N5/0662 , C12N5/0697 , C12N2501/15 , C12N2501/39 , C12N2501/42 , C12N2501/585 , C12N2502/1317 , C12N2502/1358 , C12N2502/1394 , C12N2509/00 , C12N2533/50 , C12N2533/52
摘要： The invention relates to a medicament and method of treating cartilage defect. The invention also relates to an implant for treating cartilage defect.
摘要翻译：本发明涉及治疗软骨缺损的药物和方法。本发明还涉及一种用于治疗软骨缺损的植入物。

7. 发明授权

EP1307541B1 TISSUE IMPLANT FOR CARTILAGE REPAIR 有权
标题翻译： GEWE工厂进行恢复软骨的
公开(公告)号：EP1307541B1
公开(公告)日：2009-01-14
申请号：EP01953258.9
申请日：2001-07-30
申请人： Smith & Nephew PLC
发明人： THOMSON, Brian Mark , SMITH, Mark Frederick , ARCHER, Charles William , DOWNTHWAITE, Gary Paul
IPC分类号： C12N5/06 , A61L27/38 , A61L24/10
CPC分类号： A61L27/3817 , A61F2/30756 , A61F2002/30766 , A61K35/12 , A61L27/3852 , A61L2430/06 , C12N5/0068 , C12N5/0655 , C12N5/0662 , C12N5/0697 , C12N2501/15 , C12N2501/39 , C12N2501/42 , C12N2501/585 , C12N2502/1317 , C12N2502/1358 , C12N2502/1394 , C12N2509/00 , C12N2533/50 , C12N2533/52
摘要： The invention relates to a medicament and method of treating cartilage defect. The invention also relates to an implant for treating cartilage defect.

8. 发明公开

EP0994185A3 Method for culturing Langerhans islets cells 有权
标题翻译：用于培养胰岛细胞的方法
公开(公告)号：EP0994185A3
公开(公告)日：2001-07-25
申请号：EP99308203.1
申请日：1999-10-18
申请人： Yoon, Tai-Wook
发明人： Yoon, Tai-Wook
IPC分类号： C12N5/08 , C12N5/06
CPC分类号： C12N5/0676 , A61K35/12 , C12N2500/25 , C12N2500/38 , C12N2500/90 , C12N2501/105 , C12N2501/11 , C12N2501/12 , C12N2501/13 , C12N2501/135 , C12N2501/39 , C12N2501/585 , C12N2501/70 , C12N2509/00
摘要： A method for culturing Langerhans islets to obtain an amount sufficient for transplant and autotransplant is disclosed. The islets are cultured in a culture serum (rat/human) medium which is supplemented with radical scavengers, growth factors, a matrix material, nerve growth factor, cell migrating/scattering factors and anti-integrin β1 antibody at proper the time during the culturing process. The medium is supplemented with radical scavengers and growth factors for the first time and then further supplemented with matrix material, radical scavengers, nerve growth factor and the growth factors around 12-24 hours after culturing. Thereafter, supplemented with growth factors, cell migrating/scattering factors and anti-integrin β1 antibody at 4-5 days into the culturing process. The culturing process is conduced for an extended period of time, so that any latent red blood cells are eliminated from the islet culture. The islets then continue to proliferate to produce an amount of islets which is sufficient for transplantation into a diabetic patient, including a human, to provide extended normoglycaemia and islet regeneration to fully treat diabetes mellitus without the growth of fibroblasts.

9. 发明公开

EP0994185A2 Method for culturing Langerhans islets cells 有权
标题翻译： Verfahren zur Kultivierung von Langerhansinsel-Zellen
公开(公告)号：EP0994185A2
公开(公告)日：2000-04-19
申请号：EP99308203.1
申请日：1999-10-18
申请人： Yoon, Tai-Wook
发明人： Yoon, Tai-Wook
IPC分类号： C12N5/08
CPC分类号： C12N5/0676 , A61K35/12 , C12N2500/25 , C12N2500/38 , C12N2500/90 , C12N2501/105 , C12N2501/11 , C12N2501/12 , C12N2501/13 , C12N2501/135 , C12N2501/39 , C12N2501/585 , C12N2501/70 , C12N2509/00
摘要： A method for culturing Langerhans islets to obtain an amount sufficient for transplant and autotransplant is disclosed. The islets are cultured in a culture serum (rat/human) medium which is supplemented with radical scavengers, growth factors, a matrix material, nerve growth factor, cell migrating/scattering factors and anti-integrin β1 antibody at proper the time during the culturing process. The medium is supplemented with radical scavengers and growth factors for the first time and then further supplemented with matrix material, radical scavengers, nerve growth factor and the growth factors around 12-24 hours after culturing. Thereafter, supplemented with growth factors, cell migrating/scattering factors and anti-integrin β1 antibody at 4-5 days into the culturing process. The culturing process is conduced for an extended period of time, so that any latent red blood cells are eliminated from the islet culture. The islets then continue to proliferate to produce an amount of islets which is sufficient for transplantation into a diabetic patient, including a human, to provide extended normoglycaemia and islet regeneration to fully treat diabetes mellitus without the growth of fibroblasts.
摘要翻译：公开了一种培养朗格汉斯胰岛以获得足以进行移植和自体移植的量的方法。将胰岛培养在培养血清（大鼠/人）培养基中，其中补充有自由基清除剂，生长因子，基质材料，神经生长因子，细胞迁移/散射因子和抗整联蛋白β1抗体培养过程。培养基首先补充自由基清除剂和生长因子，然后在培养后12-24小时左右进一步补充基质材料，自由基清除剂，神经生长因子和生长因子。此后，在培养过程中4-5天，补充生长因子，细胞迁移/散射因子和抗整联蛋白β1抗体。培养过程延长了一段时间，使得任何潜伏的红细胞从胰岛培养物中消除。胰岛然后继续增殖以产生一定量的胰岛，其足以移植到糖尿病患者（包括人）中，以提供延长的血糖异常和胰岛再生以完全治疗糖尿病而无需成纤维细胞的生长。

10. 发明公开

EP0983075A1 A METHOD TO INCREASE THE SURVIVAL OF TRANSPLANTED CELLS 失效
标题翻译：方法增ÜBERLEBUNG移植细胞
公开(公告)号：EP0983075A1
公开(公告)日：2000-03-08
申请号：EP98924669.9
申请日：1998-05-25
申请人： Leadd B.V.
发明人： BRUIN, Jan, Anthonie , TERPSTRA, Onno
IPC分类号： A61K35/407 , C12N5/06 , C12N5/08 , C12Q1/00
CPC分类号： A61K35/407 , A61K35/12 , A61K38/00 , A61K2035/122 , C12N5/067 , C12N2501/585 , C12N2510/02
摘要： The invention relates to the field of transplantation, specifically to the field of transplantation of isolated cells. The invention provides a method to allow cell transplantation as a method to replace organ transplantation. Anti-integrin (poly)peptides significantly block attachment of cells to both vessel walls and tissue in an in vitro binding assay. Blocking of integrins by incubation with blocking (poly)peptides significantly decreases the number of cellular aggregates after in vivo cell transplantation, and has a significant increasing effect on cellular homing in the recipient tissue. Blocking of integrin strongly improves transplanted cell survival in the recipient tissue after transplantation.

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