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1. 发明公开

EP4357351A1 TRAP1 INHIBITOR AND USE THEREOF 审中-公开
公开(公告)号：EP4357351A1
公开(公告)日：2024-04-24
申请号：EP22825110.4
申请日：2022-01-24
申请人： Smartin Bio Inc. , Ulsan National Institute of Science and Technology (UNIST)
发明人： KANG, Byoung Heon , KIM, So-Yeon , YOON, Nam Gu
IPC分类号： C07F9/54 , A61K31/662 , A61K31/675 , A61P35/00 , A61K31/665 , A61P27/02
CPC分类号： A61K31/662 , A61K31/665 , A61K31/675 , A61P27/02 , A61P35/00 , C07F9/54
摘要： The present application provides a compound that inhibits TRAP1 or a pharmaceutically acceptable salt thereof. In this case, the compound or the pharmaceutically acceptable salt thereof can inhibit the binding between TRAP1 and the client protein. In addition, the present application provides: a pharmaceutical composition for the treatment of cancer or ocular disease comprising a compound that inhibits TRAP1 or a pharmaceutically acceptable salt thereof; and use thereof.

3. 发明授权

EP1658262B1 VERFAHREN ZUR HERSTELLUNG IONISCHER FLÜSSIGKEITEN, IONISCHER FESTSTOFFE ODER GEMISCHE DERSELBEN 有权转让
标题翻译：用于生产离子液体，离子型固体或其混合物
公开(公告)号：EP1658262B1
公开(公告)日：2013-02-20
申请号：EP04764280.6
申请日：2004-08-19
申请人： proionic Production of Ionic Substances GmbH & Co KG
发明人： KALB, Roland
IPC分类号： C07C211/62 , C07F9/54 , C07C209/68 , C07C381/12
CPC分类号： C07C211/62 , C07C381/12 , C07F9/54 , C10N2220/04

4. 发明公开

EP2295440A1 Nouveaux liquides ioniques à base d'anions thiophosphate et leurs préprations 有权
标题翻译： Auf Thiophosphatanionen basierende neuartige ionischeFlüssigkeiten，und ihre Herstellung
公开(公告)号：EP2295440A1
公开(公告)日：2011-03-16
申请号：EP10290391.1
申请日：2010-07-13
申请人： IFP Energies Nouvelles
发明人： Delfort, Bruno , Morvan, Didier , Vallee, Christophe , Olivier-Bourbigou, Hélène , Pellier, Emmanuel
IPC分类号： C07F9/165 , C08B1/00
CPC分类号： C07F9/11 , C07D233/58 , C07F9/094 , C07F9/12 , C07F9/1653 , C07F9/17 , C07F9/18 , C07F9/54
摘要： L'invention décrit un liquide ionique associant un cation organique Q + à un anion thiophosphate, répondant à l'une des formules suivantes :

dans lesquelles R a et R b identiques ou différents, représentent des radicaux hydrocarbyles ayant de 1 à 30 atomes de carbone.
摘要翻译：具有硫代磷酸盐阴离子的有机阳离子的离子液体（I）是新的。（（R1aO-P（-OR1b）（= O）-S - >）（Q +>））（1a）或（（C1 +））的离子液体（I）具有硫代磷酸盐阴离子的有机阳离子（Q + （R1aO-P（-OR1b）（= S）-O - >）（Q +））（1b）是新的。 R1a，R1b：任选取代的1-30C烃基，优选任选饱和的烷基，环烷基或芳基，芳基或芳烷基（其中R1a和R1b的全部或部分氢任选被杂原子如卤代取代），其中烃基任选地携带一个或多个-CO 2R，-C（O）R，-OR，-C（O）NRRaa，-C（O）N（R）NRaaRbb，-NRRaa，-SR，-S（O ）R，-S（O）2 R，-SO 3 N，-CN，-N（R）P（O）R a R aaa，-PR R aa-，-P（O）R aaa，-P（OR） P（O）（OR）（ORaa）; 和R，Raa，Rbb：H或1-30C烃基。独立要求包括：（一）的准备工作。

5. 发明授权

EP1294676B1 NEUE KOMPOSITIONEN FÜR DIE STABILISIERUNG VON NUKLEINSÄUREN IN BIOLOGISCHEN MATERIALIEN 有权
标题翻译：新成分用于生物材料抗滑NUCLEIC
公开(公告)号：EP1294676B1
公开(公告)日：2007-10-03
申请号：EP01947306.5
申请日：2001-05-22
申请人： QIAGEN GmbH
发明人： HOLLÄNDER, Vera , WYRICH, Ralph , OELMÜLLER, Uwe
IPC分类号： C07C211/62 , C07C211/63 , C07C211/64 , C07F9/54 , C11D3/00 , C12N15/10
CPC分类号： C12N15/1003 , C07C211/62 , C07C211/63 , C07C211/64 , C07F9/54
摘要： The invention relates to novel compositions for isolating and/or stabilising nucleic acids in material of a biological origin. Said compositions comprise a cationic compound of general formula Y R1R2R3R4 X' as an essential constituent; wherein Y can represent nitrogen or phosphorus; R1, R2, R and R4 can independently represent an unbranched or branched C1-C20 alkyl radical and/or a C6-C20 aryl radical and a C6-C26 aralkyl radical; and X' can represent an anion pertaining to an inorganic or organic, monobasic or polybasic acid.

6. 发明公开

EP1778705A1 PHOSPHONIUM IONIC LIQUIDS AS RECYCLABLE SOLVENTS FOR SOLUTION PHASE CHEMISTRY 审中-公开
标题翻译：离子PHOSPHONIUMFLÜSSIGKEITEN可回收溶剂液相化学
公开(公告)号：EP1778705A1
公开(公告)日：2007-05-02
申请号：EP05764254.8
申请日：2005-07-15
申请人： SIMON FRASER UNIVERSITY
发明人： CLYBURNE, Jason , RAMNIAL, Taramatee
IPC分类号： C07F9/54
CPC分类号： C07F9/54 , Y02P20/542 , Y02P20/582
摘要： This application relates to the use of phosphonium-based ionic liquids as recyclable solvents for solution phase chemistry. The ionic liquids may be used, for example, as solvents for reactions involving Grignard reagents, hydridic reagents, metallic and non-metallic reducing agents, and strong bases, including nucleophilic carbenes and Wittig reagents. In one embodiment the invention may comprise homogeneous mixtures of strong bases/nucleophiles/reducing agents and tetrahydrocarbylphosphonium salt ionic liquids. The invention also relates to chemical processes that may proceed in either minimally flammable solvent, or a complete absence of flammable solvent, including systems containing strong reducing agents such as alkali and alkaline metals or metal and non-metal hydrides. Methods for generating anions and nucleophililic carbenes (imidazol-2-ylidenes) (and complexes derived from them) in phosphonium-based ionic liquids are also described. The invention demonstrates the feasibility of using phosphonium-based ionic liquids as a reliable reaction media for a wide variety of basic reagents. The problems associated with C-H activation in imidazolium-based ionic liquids by highly reactive bases are not observed for phosphonium-based ionic liquids.

7. 发明授权

EP0971854B1 NOUVEAUX MATERIAUX UTILES EN TANT QUE SOLUTES ELECTROLYTIQUES 有权
标题翻译：新电解增溶物合适的材料
公开(公告)号：EP0971854B1
公开(公告)日：2006-11-29
申请号：EP99903554.6
申请日：1999-02-03
申请人： ACEP INC. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Université de Montréal
发明人： MICHOT, Christophe , ARMAND, Michel , GAUTHIER, Michel , RAVET, Nathalie
IPC分类号： C01B21/086 , C01B21/097 , C07C211/63 , C07C211/64 , C07C381/12 , C07D213/20 , C07D213/26 , C07D233/58 , C07F9/54 , C08F136/14 , H01M10/40 , H01M6/16
CPC分类号： C07C211/63 , C07C45/46 , C07C45/72 , C07C211/64 , C07C317/04 , C07C317/12 , C07C381/00 , C07D213/20 , C07D213/74 , C07D231/12 , C07D233/56 , C07D249/08 , C07D311/82 , C07D339/06 , C07F9/54 , H01G9/038 , H01G9/20 , H01G9/2004 , H01G11/62 , H01M4/13 , H01M4/505 , H01M4/525 , H01M4/58 , H01M4/5825 , H01M4/587 , H01M4/60 , H01M4/602 , H01M4/624 , H01M6/164 , H01M6/166 , H01M6/168 , H01M6/181 , H01M8/1048 , H01M10/052 , H01M10/0525 , H01M10/0565 , H01M10/0566 , H01M10/0568 , H01M10/0569 , H01M10/36 , H01M2300/0022 , H01M2300/0082 , Y02E10/542 , Y02E60/122 , Y02E60/13
摘要： The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, O, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FX?1O)N-(OX2¿F) wherein X?1 and X2¿ are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.

8. 发明公开

EP1598408A1 A polymer for a photochromic compound matrix, and a matrix comprising the said polymer 审中-公开
标题翻译：聚合物聚合物聚合物
公开(公告)号：EP1598408A1
公开(公告)日：2005-11-23
申请号：EP04076489.6
申请日：2004-05-19
申请人： Kim, Gyongtae
发明人： Kim, Gyongtae , Cho, Joung Hyun , Shon, Dong Woo , Choi, Hong Young , Ryu, Jae Jun , Park, Jae Seok
IPC分类号： C09K9/02 , C08F20/34 , C08F30/02 , C07F9/54
CPC分类号： C09K9/02 , C07F9/54 , C09K2211/1425
摘要： The present invention provides a polymer of Formula (4) or (5) as manufactured by polymerizing alkylmethacrylate of the formula (1) or its salt with 2-metacroxyethyl triammonium chloride of Formula (2) or vinyl monomer of phosphonium salt of the formula (3), and further provides a photochromic polymer matrix manufactured by blending the said polymer as the supporter with a known photochromic organic compound. Further, the present invention enables a glass or a mirror, of which the transmittance and/or the reflectance can be adjusted, to be manufactured by coating it with the said photochromic polymer matrix in a given thickness.
In the case of the glass manufactured by using the matrix of the present invention, it can be used in the field requiring adjustment the transmittance of light depending upon a weather condition, including a building or a car glass, a sunroof and the like. In the case of the mirror manufactured so, it can be applied to a rear-view mirror and a side view mirror for a vehicle and the like.
摘要翻译：本发明提供通过使式（1）的甲基丙烯酸烷基酯或其盐与式（2）的2-甲基乙基氯化铵或式（2）的鏻盐的乙烯基单体聚合而制备的式（4）或（5）的聚合物， 3），并且还提供通过将所述聚合物作为载体与已知的光致变色有机化合物共混制造的光致变色聚合物基体。此外，本发明能够通过用给定厚度的所述光致变色聚合物基质涂布来制造可以调节透射率和/或反射率的玻璃或反射镜。在通过使用本发明的基体制造的玻璃的情况下，可以在需要调节根据包括建筑物或汽车玻璃，天窗和天花板在内的天气条件下的光的透射率的领域中使用类似。在制造的反射镜的情况下，可以将其应用于车辆的后视镜和侧视镜等。

9. 发明公开

EP1575705A2 PROCESS FOR THE RECOVERY OF PHOSPHORUS AND IODINE CONTAINING CATALYST COMPONENTS 审中-公开
标题翻译：中回收磷和IOD含催化剂成分
公开(公告)号：EP1575705A2
公开(公告)日：2005-09-21
申请号：EP03814182.6
申请日：2003-12-18
申请人： EASTMAN CHEMICAL COMPANY
发明人： KANEL, Jeffrey, Scott , OKRASINSKI, Stanley, John
IPC分类号： B01J31/24 , B01J31/40 , C07F9/50 , C07C51/12
CPC分类号： B01J31/0231 , B01J31/0239 , B01J31/0271 , B01J31/04 , B01J31/20 , B01J31/24 , B01J31/2404 , B01J31/4053 , B01J2231/34 , B01J2531/64 , C07F9/025 , C07F9/5095 , C07F9/54 , Y02P20/584
摘要： Disclosed is a process for the recovery of phosphorus and/or iodine containing catalyst components, present as an organophosphorus compound such as trihydrocarbylphosphine compounds and tetrahydro carbylphosphonium compounds, from a solution of at least one such organophosphorus compound in an organic solvent by the steps comprising (1) converting the organophosphorus compound to an iodide complex of a organophosphonium compound which is insoluble in the organic solvent; and (2) separating the insoluble iodide complex of the organophosphonium compound from the solution. The process also results in the recovery of iodine values present in the solution.

10. 发明授权

EP1047701B1 MITOCHONDRIALLY TARGETED ANTIOXIDANTS 有权
标题翻译：线粒体靶向抗氧化剂
公开(公告)号：EP1047701B1
公开(公告)日：2005-05-25
申请号：EP98961702.2
申请日：1998-11-25
申请人： ANTIPODEAN BIOTECHNOLOGY LIMITED
发明人： MURPHY, Michael, Patrick , SMITH, Robin, A., J.
IPC分类号： C07F9/54 , C07F9/655 , C07F9/572 , A61K31/66 , A61K31/665 , A61K31/675 , A61K47/48
CPC分类号： C07F9/65522 , A61K47/54 , A61K47/543 , C07F9/54 , C07F9/5722
摘要： The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph3) XR.Z where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.
摘要翻译：本发明提供了线粒体靶向的抗氧化剂化合物。本发明的化合物包含与抗氧化剂部分共价偶联的亲脂性阳离子。在优选的实施方案中，亲脂性阳离子是三苯基鏻阳离子，并且该化合物具有式P（Ph3）+ XR.Z-，其中X是连接基团，Z是阴离子，R是抗氧化剂部分。还提供了含有线粒体靶向抗氧化剂化合物的药物组合物，以及治疗或预防将从减少的氧化应激中受益的患者的方法，其包括施用本发明化合物的步骤。

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