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1. 发明公开

EP1771419A1 PREPARATION OF NOVEL SUBSTITUTED HALOARENE COMPOUNDS 审中-公开
标题翻译：新型取代的卤代烯烃化合物的制备
公开(公告)号：EP1771419A1
公开(公告)日：2007-04-11
申请号：EP05759742.9
申请日：2005-07-07
申请人： Pfizer Products Inc.
发明人： RUTHERFORD, Jennifer Lea , HAWKINS, Joel Michael
IPC分类号： C07D213/61 , C07C25/02 , C07C2/00
CPC分类号： C07C29/40 , C07C2601/08 , C07C2601/14 , C07D213/61 , C07C33/46 , C07C33/44 , C07C31/125
摘要： This invention relates to a new process for the preparation of novel substituted haloarene compounds of the formula I or IV: respectively, wherein R1, R2, R3, R4, R5, X, and Y are as defined herein, that comprises a novel and efficient selective mono-lithiation of a dihaloarene of the formula II or V: respectively, by an organo-lithium compound in the presence of a carbonyl reactant of the formula III: wherein R1 and R2 are as defined herein. In the process of the instant invention, the newly formed lithiated haloarene is sequentially quenched in situ by the carbonyl reactant to form said substituted haloarene. The process is suitable for batch or continuous flow systems. The substituted haloarenes produced by the process of the present invention are useful intermediates in the preparation of N-aryl or N-heteroaryl substituted pharmaceutically active compounds that include selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors useful in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT1 agonist or antagonist is indicated.
摘要翻译：本发明涉及分别制备式I或IV的新型取代卤代芳烃化合物的新方法，其中R 1，R 2，R 3，R 4，R 5，X和Y如本文所定义，其包含新颖且有效在式III的羰基反应物存在下，通过有机锂化合物分别选择性地将式II或V的二卤芳烃单锂化：其中R 1和R 2如本文所定义。在本发明的方法中，新形成的锂化卤代芳烃通过羰基反应物原位依次猝灭以形成所述取代的卤代芳烃。该工艺适用于批量或连续流动系统。由本发明方法制备的取代卤代芳烃是制备N-芳基或N-杂芳基取代的药物活性化合物的有用中间体，其包括选择性拮抗剂，反向激动剂和血清素1（5-HT1）受体的部分激动剂，其可用于治疗或预防抑郁症，焦虑症，强迫症（OCD）和表明5-HT1激动剂或拮抗剂的其它疾病。

2. 发明公开

EP1449860A1 NOVEL FLUOROPOLYMER, RESIST COMPOSITIONS CONTAINING THE SAME, AND NOVEL FLUOROMONOMERS 审中-公开
标题翻译：新的含氟聚合物，含抗蚀剂组合物NEW含氟
公开(公告)号：EP1449860A1
公开(公告)日：2004-08-25
申请号：EP02772966.4
申请日：2002-10-02
申请人： Daikin Industries, Ltd.
发明人： ARAKI, Takayuki, c/o Daikin Industries, Ltd. , ISHIKAWA, Takuji, c/o Daikin Industries, Ltd. , KOH, Meiten, c/o Daikin Industries, Ltd.
IPC分类号： C08F214/18 , C07C33/44 , C07C57/56 , C07C35/48
CPC分类号： C07C25/13 , C07C25/18 , C07C25/22 , C07C31/38 , C07C33/423 , C07C33/44 , C07C35/52 , C07C43/313 , C07C45/63 , C07C49/167 , C07C2601/08 , C07C2602/42 , C07F9/5407 , C07F9/5435 , C07F9/5442 , C07F9/5449 , C07F9/5456 , C07F9/591 , C08F8/00 , C08F214/18 , C08F214/186 , C08F2800/10 , C08F2800/20 , G03F7/0045 , G03F7/0046 , G03F7/0382 , G03F7/0392 , G03F7/0395 , Y02P20/55 , Y10S430/106 , Y10S430/108 , C08F214/265 , C08F232/04 , C08F234/00 , C08F220/22
摘要： There is provided a fluorine-containing copolymer having an aliphatic monocyclic structure in the polymer trunk chain which has a number average molecular weight of from 500 to 1,000,000 and is represented by the formula (Ma):

- (M1) - (M2a) - (N) - (Ma)

in which
the structural unit M1 is a structural unit derived from an ethylenic monomer having 2 or 3 carbon atoms and at least one fluorine atom, the structural unit M2a is at least one structural unit which introduces an aliphatic monocyclic structure in the polymer trunk chain and is represented by the formula (a):
wherein R 1 is at least one hydrocarbon group selected from the group consisting of a divalent hydrocarbon group having 1 to 8 carbon atoms and constituting a ring which may be further substituted with a hydrocarbon group or a fluorine-containing alkyl group and a divalent hydrocarbon group having ether bond which has the sum of carbon atoms and oxygen atoms of 2 to 8, constitutes a ring and may be further substituted with a hydrocarbon group or a fluorine-containing alkyl group; R 2 is an alkylene group which has 1 to 3 carbon atoms and constitutes a ring; R 3 and R 4 are the same or different and each is a divalent alkylene group which has 1 or 2 carbon atoms and constitutes a ring; n1, n2 and n3 are the same or different and each is 0 or 1, the structural unit N is a structural unit derived from a monomer copolymerizable with the monomers to introduce the structural units M1 and M2a, and
the structural units M1, M2a and N are contained in amounts of from 1 to 99 % by mole, from 1 to 99 % by mole and from 0 to 98 % by mole, respectively. The fluorine-containing polymer possesses excellent dry etching resistance and transparency in a vacuum ultraviolet region.

3. 发明公开

EP0630361A4 PALLADIUM CATALYZED ALKYLATIVE CYCLIZATION USEFUL IN SYNTHESIS OF VITAMIN D AND ANALOGUES. 失效
标题翻译：钯催化的烷基化环化使用含维生素D及其类似物的合成适用于您。
公开(公告)号：EP0630361A4
公开(公告)日：1995-08-23
申请号：EP93904940
申请日：1993-02-05
申请人： UNIV LELAND STANFORD JUNIOR
发明人： TROST BARRY M , DUMAS JACQUES
IPC分类号： B01J31/18 , B01J31/24 , C07B37/04 , C07B37/10 , C07B61/00 , C07C2/86 , C07C13/465 , C07C17/26 , C07C17/272 , C07C22/00 , C07C23/18 , C07C29/44 , C07C33/44 , C07C35/21 , C07C41/30 , C07C43/178 , C07C401/00 , C07F7/18 , C07C13/36 , C07C13/38 , C07C403/00 , C07C403/02
CPC分类号： C07F7/1892 , C07B37/10 , C07C17/2635 , C07C22/00 , C07C33/44 , C07C35/21 , C07C401/00 , Y02P20/55
摘要： An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 where a substantially geometrically pure first precursor having structure (I), and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having structure (II), where R2 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.

4. 发明授权

EP0361827B1 Pyrazole compounds, method for production thereof, use thereof and intermediates for production thereof 失效
标题翻译：吡咯化合物，其生产方法，其用途及其生产中间体
公开(公告)号：EP0361827B1
公开(公告)日：1992-12-16
申请号：EP89309723.8
申请日：1989-09-25
申请人： SUMITOMO CHEMICAL COMPANY LIMITED
发明人： Meki, Naoto , Nishida, Kazue , Imahase, Tomotoshi , Fijimoto, Hiroaki , Mikitani, Kenichi , Takano, Hirotaka , Ogasawara, Yoriko , Tamaki, Masahiro
IPC分类号： C07D231/20 , A01N43/56 , C07D231/22 , C07D405/12 , C07D401/12 , C07D409/12 , C07D213/26 , C07D213/30 , A01N43/28 , A01N43/16 , A01N43/40
CPC分类号： C07D213/30 , C07C21/22 , C07C22/00 , C07C22/02 , C07C22/08 , C07C33/42 , C07C33/44 , C07C33/48 , C07C43/17 , C07C43/1786 , C07C239/20 , C07C323/05 , C07C323/14 , C07D213/26 , C07D231/20 , C07D231/22 , C07D401/12 , C07D405/12 , C07D409/12 , C07F7/0812

5. 发明公开

EP0418690A3 Verfahren zur Herstellung von Ironen 失效
标题翻译：制备铁的过程
公开(公告)号：EP0418690A3
公开(公告)日：1992-02-12
申请号：EP90117367.4
申请日：1990-09-10
申请人： GIVAUDAN-ROURE (INTERNATIONAL) S.A.
发明人： Fráter, Georg, Dr. , Helmlinger, Daniel, Dr.
IPC分类号： C07C403/16 , C07C45/67 , C07C49/21 , C07C45/51 , C07C33/05 , C07C33/44 , C07C29/58
CPC分类号： C07C403/16 , C07C33/05 , C07C33/44 , C07C45/513 , C07C45/67 , C07C49/21 , C07C2601/02 , C07C2601/16
摘要： Die Erfindung betrifft ein Verfahren zur Herstellung von α- und β-Iron, also den Verbindungen der Formel I, sowie neue Zwischenprodukte dieser Synthese.
摘要翻译：本发明涉及制备α-和β-铁的方法，也就是说式I的化合物，以及该合成中的新型中间体。 ... ...

6. 发明授权

EP0083335B1 Chirale, optisch aktive Verbindungen, Verfahren zu ihrer Herstellung und Verwendung dieser Verbindungen für den Schutz funktioneller -OH, -SH, -NH-Gruppen, zur Racemattrennung, zur Herstellung optisch aktiver Imidoesterhydrochloride sowie optisch aktiver Ester, zur Herstellung optisch angereicherter Alkohole und zur Herstellung optisch aktiver Verbindungen durch asymmetrische Induktion 失效
标题翻译：光学有效的化合物，其制备和使用这些化合物在保护功能性-OH，-SH，-NH-基团，在分离反应中，在制备光学活性的活性氯化氢和光学活性酯的过程中，在制备光学富集醇和通过不对称诱导制备光学活性化合物
公开(公告)号：EP0083335B1
公开(公告)日：1987-08-12
申请号：EP82890185.0
申请日：1982-12-17
申请人： Noe, Christian, Dipl.-Ing. Dr.
发明人： Noe, Christian, Dipl.-Ing. Dr.
IPC分类号： C07D307/93 , C07D311/94 , C07B57/00
CPC分类号： C07D311/94 , C07B2200/07 , C07C29/92 , C07C209/88 , C07C253/34 , C07C257/06 , C07C319/12 , C07C319/28 , C07C2602/10 , C07D307/93 , Y02P20/55 , C07C35/36 , C07C33/20 , C07C33/44 , C07C255/36 , C07C211/27 , C07C323/52 , C07C321/10

7. 发明授权

EP1061070B1 Process for the preparation of ED-71 有权
标题翻译：一种用于ED-71的制备方法
公开(公告)号：EP1061070B1
公开(公告)日：2008-07-16
申请号：EP99905280.6
申请日：1999-02-23
申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人： HATAKEYAMA, Susumi , WATANABE, Hiroyoshi , KAWASE, Akira
IPC分类号： C07C401/00 , C07C35/32 , C07C49/443 , C07C43/178 , C07C33/44 , C07F7/18 , A61K31/59
CPC分类号： C07C401/00 , C07C33/44 , C07C35/32 , C07C2601/14 , C07C2602/24 , C07F7/1856 , Y02P20/55
摘要： Vitamin D derivatives having general formula (1) which are hydroxylated at the 24-position and considered as one of metabolites of physiologically active vitamin D derivatives substituted at the 2β-position wherein R1, R2, R3 and R4 are the same or different and each represents hydrogen or a protective group; X and Y represent each H or OR5, provided that Y is OR5 when X is H, and Y is H when X is OR5 (wherein R5 represents hydrogen or a protective group, or R1 and R5 may together form a vicinal-diol protective group); synthesis intermediates useful in synthesizing these vitamin D derivatives; and medicinal compositions containing these vitamin D derivatives.

8. 发明公开

EP1415974A1 PROCESS FOR PRODUCTION OF FLUORINE-CONTAINING NORBORNENE DERIVATIVES 有权
标题翻译：用于生产含氟降冰片烯
公开(公告)号：EP1415974A1
公开(公告)日：2004-05-06
申请号：EP02746012.0
申请日：2002-07-12
申请人： Daikin Industries, Ltd.
发明人： ARAKI, Takayuki, c/o DAIKIN INDUSTRIES, LTD. , ISHIKAWA, Takuji, c/o DAIKIN INDUSTRIES, LTD. , KUME, Takuji, c/o DAIKIN INDUSTRIES, LTD. , YAMAMOTO, Akinori, c/o DAIKIN INDUSTRIES, LTD.
IPC分类号： C07C45/68 , C07C49/567 , C07C33/44 , C07C29/36 , C07C43/172 , C08F32/00 , G03F7/039
CPC分类号： G03F7/0395 , C07C33/44 , C07C43/313 , C07C45/45 , C07C49/567 , C07C61/28 , C07C69/96 , C07C2602/42 , C07C2603/86 , G03F7/0046 , G03F7/0382
摘要： There are provided a novel norbornene derivative which is a material for a chemically amplifying type photoresist for F 2 laser, possesses excellent transparency and improved dry etching resistivity and has a fluorine-containing ketone unit or fluorine-containing tertiary alcohol unit directly bonded to the norbornene backbone; a fluorine-containing polymer obtained by using the norbornene derivative as a copolymerizable monomer; and a chemically amplifying type photoresist composition comprising the fluorine-containing polymer, a photoacid generator and a solvent.

9. 发明公开

EP1331216A1 MONOMERS HAVING ELECTRON-WITHDRAWING GROUPS AND PROCESSES FOR PREPARING THE SAME 审中-公开
标题翻译： MONOMERE MIT ELEKTRONEN ABZIEHENDEN GRUPPEN UND VERFAHREN ZU IHRER HERSTELLUNG
公开(公告)号：EP1331216A1
公开(公告)日：2003-07-30
申请号：EP01983793.9
申请日：2001-10-31
申请人： Daicel Chemical Industries, Ltd.
发明人： INOUE, Keizo
IPC分类号： C07C33/44 , C07D313/06 , C07D307/77 , C07D317/42 , C07D307/30 , C07D339/06 , C08F24/00 , C08F32/00 , G03F7/039
CPC分类号： C07C41/58 , C07C33/44 , C07C35/52 , C07C41/06 , C07C41/54 , C07C41/56 , C07C43/313 , C07C43/317 , C07C49/755 , C07C2602/42 , C07C2603/74 , C07D307/30 , C07D307/93 , C07D313/10 , C07D317/42 , C07D339/06 , C08F24/00 , G03F7/0046 , G03F7/0397 , C07C43/1786 , C07C43/196
摘要： A monomer containing an electron-withdrawing group of the present invention is represented by following Formula (a), (b) or (c) :
wherein A 1 , A 2 , and A 3 are each a ring; R a , R b , R c , and R u are the same or different and are each a hydrogen atom or organic group; at least one of R s , R w and R v , at least one of R t and R w1 , and at least one of the two R w2 s are each an electron-withdrawing group, and the others are each a hydrogen atom or organic group; W 1 is a single bond or linkage group; and n denotes an integer of 2 to 25, where at least two of R a , R b , R c , R s , R t , R u , R v , R w , R w1 , R w2 , W 1 , and carbon atoms constituting ring A 1 , carbon atoms constituting ring A 2 , and carbon atoms constituting ring A 3 may be combined to form a ring, respectively. The electron-withdrawing groups in R s , R t , R v , R w , R w1 , and R w2 are, for example, groups each containing a fluorine atom. The monomer is useful as a raw material for photoresist polymeric compounds.
摘要翻译：含有本发明吸电子基团的单体由下式（a），（b）或（c）表示：其中A 1，A 2，和A 3各自为环; R a，R b，R c和R i相同或不同，各自为氢原子或有机基团; R 0和R 2中的至少一个，R 0和R 2中的至少一个，R 0和R 2， SUP> w1 <！ - SIPO - >，并且两个R 2 w 2中的至少一个各自为吸电子基团，其余各自为氢原子或有机基团; W 1是单键或连接基团; n表示2〜25的整数，其中R a，R b，R b，R c，R i，R b， R ，R ，R ，R，V，R，W，W， W 2，W 1和构成环A 1的碳原子，构成环A 2的碳原子，并且构成环A 3的碳原子可以分别组合形成环。 R“，”R“，”R“，”R“，”R“和”R“中的吸电子基团， w1，w2，...，w2都是例如各自含有氟原子的基团。该单体可用作光致抗蚀剂聚合物的原料。

10. 发明公开

EP0854147A3 Tripodale Cyclopentadienderivate und deren Verwendung 失效
标题翻译：三脚架环戊二烯衍生物及其应用
公开(公告)号：EP0854147A3
公开(公告)日：1999-03-03
申请号：EP98100436.9
申请日：1998-01-13
申请人： BASF AKTIENGESELLSCHAFT
发明人： Huttner, Gottfried, Prof. Dr. , Vogelgesang, Joachim , Winterhalter, Ute , Antelmann, Björn, Dr.
IPC分类号： C07F7/00
CPC分类号： B01J31/18 , B01J31/2204 , B01J31/2295 , B01J31/24 , B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/0258 , B01J2531/40 , B01J2531/64 , B01J2531/72 , B01J2531/80 , B01J2531/842 , C07B2200/07 , C07C17/093 , C07C29/44 , C07C309/66 , C07C2601/10 , C07F9/5018 , C07F9/5027 , C07F9/5045 , C07F9/65683 , C07F17/00 , C07F17/02 , C07C22/02 , C07C33/44
摘要： Tripodale Cyclopentadienderivate der allgemeinen Formel (I)
worin
E gleich oder verschieden ist und für -N(R) (R), -P(R) (R), -As(R) (R), -Sb(R) (R), -OR, -SR, -SeR, -TeR, wobei R gleich oder verschieden ist und Wasserstoff- einen C 1 - bis C 20 -kohlenstofforganischen oder C 1 - bis C 30 -siliciumorganischen Rest bedeutet, oder E für eine Abgangsgruppe X steht und R 1 , R 2 , R 3 , R 4 , R 5 , R 6 gleich oder verschieden ist und Wasserstoff einen C 1 - bis C 2O - kohlenstofforganischen oder C 1 - bis C 3O -siliciumorganischen Rest bedeutet, Z für den Cyclopentadienylrest oder eine substituierte Cyclopentadienylstruktureinheit steht und T Wasserstoff einen C 1 - bis C 20 -kohlenstofforganischen oder C 1 - bis C 30 -siliciumorganischen Rest bedeutet oder für eine Gruppe E-Y- steht, worin E für -N(R) (R), -P(R) (R), -As(R) (R), -Sb(R) (R), -OR, -SR, -SeR, -TeR oder eine Abgangsgruppe X steht, wobei R gleich oder verschieden ist und Wasserstoff einen C 1 - bis C 2O -kohlenstofforganischen oder C 1 - bis C 3O -siliciumorganischen Rest bedeutet und worin Y eine C 1 - bis C 2O -organische Gruppe ist, die E mit C 1 verbindet.

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