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1. 发明公开

EP4450646A2 METHOD FOR INVESTIGATING MOLECULES SUCH AS NUCLEIC ACIDS 审中-公开
公开(公告)号：EP4450646A2
公开(公告)日：2024-10-23
申请号：EP24187116.9
申请日：2018-06-21
申请人： Lightcast Discovery Ltd
发明人： FRAYLING, Cameron Alexander , CUNHA, Pedro , ISAAC, Thomas Henry
IPC分类号： C12Q1/6869
CPC分类号： B01L3/502792 , C12Q1/6869 , B01L2200/067320130101 , B01L2300/086420130101 , B01L2300/088720130101 , B01L2300/08920130101 , B01L2300/16120130101 , B01L2300/16520130101 , B01L2300/16820130101 , B01L2400/042720130101
摘要： A method for carrying out a chemical transformation of a target molecule immobilised at a given location on a solid support is provided. The method is characterised by the steps of (a) generating a stream of microdroplets each comprised of a medium capable of causing the chemical transformation to occur; (b) contacting each microdroplet in turn with the target molecule at the given location and for a given period of time under conditions where the chemical transformation can occur, wherein the method further comprising the step of synchronising the microdroplets flow over the particle; (c) at the end of the given period removing the microdroplet from the given location; wherein the microdroplets are caused to move over a surface chemically modified to have areas of locally increased level of wettability and wherein such an increase in wettability is used to mediate the wetting of the microdroplet around the target molecule; and wherein the electrowetting or optically-mediated electrowetting effects are used to locally modify the wettability of a region of the surface around the particle.

2. 发明授权

EP4180122B1 SUBSTRATE, MICROFLUIDIC DEVICE, DRIVING METHOD AND MANUFACTURING METHOD 有权转让
公开(公告)号：EP4180122B1
公开(公告)日：2024-10-23
申请号：EP20966626.2
申请日：2020-12-25
IPC分类号： B01L3/00
CPC分类号： G01N1/38 , B01L3/502792 , B01L2200/1620130101 , B01L2200/14720130101 , B01L2300/182720130101 , B01L3/502707 , B01L2400/042720130101 , B01L2200/060520130101 , B01L2300/16120130101

3. 发明公开

EP4453923A1 HIGH VOLTAGE DRIVING USING TOP PLANE SWITCHING 失效
公开(公告)号：EP4453923A1
公开(公告)日：2024-10-30
申请号：EP22912486.2
申请日：2022-12-22
申请人： Nuclera Ltd
发明人： ZHITOMIRSKY, David , PAOLINI, Richard, J., Jr. , CROUNSE, Ken , TELFER, Stephen, J. , LATTES, Analisa , HOOGEBOOM, Chris , BISHOP, Seth, J.
IPC分类号： G09G3/34 , G02B26/00 , B01L3/00
CPC分类号： B01L3/502792 , B01L2200/067320130101 , B01L2300/064520130101 , B01L2400/042720130101 , G02B26/005

4. 发明公开

EP4390394A3 DROPLET INTERFACES IN ELECTRO-WETTING DEVICES 审中-实审
公开(公告)号：EP4390394A3
公开(公告)日：2024-09-25
申请号：EP24168406.7
申请日：2018-12-21
申请人： Oxford Nanopore Technologies PLC
发明人： HOLDEN, Matthew , WHITE, James , HERON, Andrew, John , CLARKE, James, Anthony , HYDE, Jason, Robert , HADWEN, Benjamin, James , ANDERSON, Sally
IPC分类号： B01L3/00 , G01N33/487
CPC分类号： B01L3/502792 , G01N33/48721 , G01N33/48728 , B01L2300/064520130101 , B01L2300/16520130101 , B01L2400/042720130101
摘要： An electro-wetting device for taking measurements across a droplet interface comprises: a first substrate supporting an array of actuation electrodes; an insulator layer covering said actuation electrodes and having a hydrophobic surface; and a second substrate supporting at least one set of at least two sensor electrodes. The electro-wetting device receives a fluid medium disposed between the substrates, in which droplets of liquid are suspended in the fluid medium. The actuation electrodes receive actuation signals for electro-wetting, moving, and/or modifying the shape of the droplets to form a system of droplets having a droplet interface between droplets. The sensor electrodes make electrical contact with respective droplets in the system of droplets.

5. 发明公开

EP4413362A1 COAGULATION ASSAYS FOR A POINT-OF-CARE PLATFORM 审中-实审
公开(公告)号：EP4413362A1
公开(公告)日：2024-08-14
申请号：EP22879334.5
申请日：2022-10-07
申请人： Baebies, Inc.
发明人： BASMAJIAN, Michael A. , BOSO, Michael , SRINIVASAN, Vijay , PAMULA, Vamsee
IPC分类号： G01N33/49 , G01N33/483 , G01N33/487
CPC分类号： G01N33/4905 , B01L3/502792 , B01L2400/042720130101 , B01L2200/1620130101

6. 发明公开

EP4374963A1 ELECTROWETTING APPARATUS AND METHOD OF OPERATING THE SAME 审中-公开
公开(公告)号：EP4374963A1
公开(公告)日：2024-05-29
申请号：EP22209197.7
申请日：2022-11-23
申请人： Koninklijke Philips N.V.
发明人： PELSSERS, Eduard Gerard Marie , MOONEN, Emma
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L2300/16120130101 , B01L2400/042720130101 , B01L2300/064520130101
摘要： Provided is an electrowetting apparatus (100) suitable for transporting sweat droplets (124). The electrowetting apparatus comprises a plurality of electrodes (102) arranged to define a transportation path (104) along which the sweat droplets are transportable. An electrowetting transport control circuit (106) charges and discharges the plurality of electrodes in sequence along the transportation path to enable the sweat droplets to be transported along the transportation path. A sensing circuit (134) provides, via connection of the sensing circuit with at least one electrode (126) of the plurality of electrodes, an electrical signal indicative of droplet presence on the transportation path. A switch (140) enables switching between the electrowetting transport control circuit being connected to and disconnected from the at least one electrode whose connection with the sensing circuit enables the sensing circuit to provide the electrical signal. The capability to disconnect such electrode(s) from the electrowetting transport control circuit assists to alleviate noise from the latter interfering with droplet presence detection. Following the sensing circuit providing the electrical signal, the at least one electrode can be reconnected to the electrowetting transport control circuit to enable sweat droplet transportation via the at least one electrode to resume. Further provided is a method of operating such an electrowetting apparatus, and related computer program.

7. 发明公开

EP4336168A3 DEVICE AND METHOD FOR MICRODROPLET DETECTION OF CELLS 审中-实审
公开(公告)号：EP4336168A3
公开(公告)日：2024-05-29
申请号：EP24154515.1
申请日：2019-11-08
申请人： Lightcast Discovery Ltd
发明人： ISAAC, Tom , FRAYLING, Cameron
IPC分类号： B01L3/00 , C12M1/00 , C12M1/12 , G01N15/14 , G01N15/10 , G01N15/1492 , G01N33/48
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L3/502784 , B01L2200/065220130101 , B01L2300/065420130101 , B01L2300/086420130101 , B01L2300/086720130101 , B01L2400/042720130101 , C12M25/01 , C12M47/04 , G01N15/1484 , G01N15/1456 , G01N2015/148120130101 , G01N2015/10320240101 , G01N15/1492
摘要： A method for using a device for manipulating and/or determining one or more characteristics of cells or micro-bead contained within a biological sample is provided. The device comprises: a sorting component configured to separate cell-containing or micro-bead containing microdroplets from empty ones into a population of cell-containing or micro-bead containing first microdroplets; a microdroplet manipulation component configured to manipulate the first microdroplets in a first zone configured to arrange the first microdroplets into an array for optical inspection and a second zone located within or adjacent the first zone and configured to detect merged microdroplets in one or more detection windows; and an optical detection system configured to detect an optical signal from the microdroplets via the one or more detection windows and to analyse the contents of each microdroplet to determine one or more characteristics of a cell or micro-bead contained in that microdroplet. The method comprises the steps of: creating from the biological sample aqueous first microdroplets in an immiscible carrier fluid, at least some of which are believed to contain cells of a particular cell type; moving the first microdroplets along a pathway using real or virtual electrodes to at least one microdroplet-merging location; merging reporter system containing microdroplets into the first microdroplets to produce merged microdroplets; analyzing the contents of each merged microdroplet with an optical detection system and detecting an optical signal characteristic of an interaction between the cell or micro-bead and the reporter system.

8. 发明公开

EP4370248A1 A METHOD OF FORMING ARRAYS OF DROPLETS 审中-实审
公开(公告)号：EP4370248A1
公开(公告)日：2024-05-22
申请号：EP22743544.3
申请日：2022-07-14
申请人： Nuclera Ltd
发明人： ZHITOMIRSKY, David , SLOMINSKI, Luke M. , PAOLINI. JR., Richard J. , WAEBER, Andreas Michael , HORKA, Michal Jan , KALSI, Sumit , MCINROY, Gordon Ross
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L3/50273 , B01L2400/042720130101 , B01L2300/081620130101 , B01L2300/064520130101 , B01L3/502792 , B01L2300/16120130101

9. 发明授权

EP3641934B1 MICRODROPLET MANIPULATION DEVICE 有权转让
公开(公告)号：EP3641934B1
公开(公告)日：2024-09-25
申请号：EP18732778.8
申请日：2018-06-21
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L2200/067320130101 , B01L2300/086420130101 , B01L2300/088720130101 , B01L2300/08920130101 , B01L2300/16120130101 , B01L2300/16520130101 , B01L2300/16820130101 , B01L2400/042720130101 , B01L3/50273

10. 发明公开

EP4426487A1 DIFFUSIONAL MICROFLUIDICS 审中-实审
公开(公告)号：EP4426487A1
公开(公告)日：2024-09-11
申请号：EP22802237.2
申请日：2022-11-07
申请人： Nuclera Ltd
发明人： KALSI, Sumit , MCINROY, Gordon Ross , PAOLINI. JR., Richard J. , SLOMINSKI, Luke M. , ZANZOTTO, Andrea
IPC分类号： B01L3/00 , G01N21/00
CPC分类号： B01L3/502792 , B01L2400/042720130101 , B01L2200/069420130101 , G01N21/6428

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