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1. 发明授权

EP2975133B1 MICROCHANNEL DEVICE AND METHOD PERTAINING THERETO 有权
标题翻译：微通道装置及其方法
公开(公告)号：EP2975133B1
公开(公告)日：2018-01-17
申请号：EP14763586.6
申请日：2014-02-24
申请人： University of Tsukuba
发明人： FUKUDA, Junji , SUZUKI, Hiroaki , YAMAGISHI, Anna , ENOMOTO, Junko , YOKOKAWA, Masatoshi
IPC分类号： C12Q1/02 , C12M1/00 , C12M3/00 , C12Q3/00
CPC分类号： B01L3/502784 , B01F3/0803 , B01F5/0085 , B01F13/0061 , B01F13/0069 , B01F13/0071 , B01F13/0072 , B01L3/0293 , B01L3/5027 , B01L3/502792 , B01L2200/0605 , B01L2300/088 , C12M23/16 , G01N1/38
摘要： Provided are a microchannel device for realizing an effective manipulation of a tiny amount of liquid and a method relating thereto . A microchannel device (1) includes: an upstream channel portion (10) configured to allow an upstream liquid plug and a gas to flow therethrough; a downstream channel portion (20) configured to allow a downstream liquid plug and a gas to flow therethrough; a liquid holding portion (30) provided between a downstream end portion of the upstream channel portion and an upstream end portion of the downstream channel portion, the liquid holding portion being configured to hold a main liquid plug therein; and a gas bypass channel portion (40) provided so as to bypass the liquid holding portion from the downstream end portion of the upstream channel portion to the upstream end portion of the downstream channel portion, the gas bypass channel portion being configured to allow the gas to flow therethrough in a state in which the liquid holding portion holds the main liquid plug.

2. 发明公开

EP3207980A1 FLUID MIXING DEVICE 审中-公开
标题翻译：流体混合装置
公开(公告)号：EP3207980A1
公开(公告)日：2017-08-23
申请号：EP15851470.3
申请日：2015-08-21
申请人： Alps Electric Co., Ltd.
发明人： SAMESHIMA, Kenichiro
IPC分类号： B01F5/00
CPC分类号： B01F13/0061 , B01F5/0603 , B01F5/0641 , B01F13/0059 , B01F2215/0034 , B01F2215/0037 , B01L3/502 , B01L2200/16 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887
摘要： To provide a fluid mixing device in which it is possible to greatly increase the mixing rate of a plurality of fluids without changing the installation area.
A fluid mixing device is provided with a plurality of flow channel units 20a to 20g disposed to be divided in a plurality of layers. Each of the flow channel units has an inflow port, an outflow port, and a plurality of branch flow channels making the inflow port and the outflow port communicate with each other. The flow channel units located in different layers are connected to each other at the inflow port and the outflow port between the flow channel units, thereby configuring a three-dimensional flow channel 4 as a whole. When the direction from the inflow port to the outflow path of each flow channel unit is set to be a flow direction in the flow channel unit, the flow directions intersect each other between the respective layers.
摘要翻译：为了提供一种流体混合装置，其中可以在不改变安装区域的情况下显着提高多种流体的混合速率。流体混合装置具备多个流路单元20a〜20g，该多个流路单元20a〜20g被分割成多层。每个流道单元具有流入端口，流出端口以及使流入端口和流出端口彼此连通的多个分支流道。位于不同层的流道单元在流道单元之间的流入口和流出口处彼此连接，由此构成整体的三维流道4。在将流路单元的从流入口到流出路径的方向作为流路单元内的流动方向的情况下，流动方向在各层之间交叉。

3. 发明公开

EP3066190A4 MICROFLUIDIC DEVICES, AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译： MIKROFLUIDISCHE VORRICHTUNGEN SOWIE VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON
公开(公告)号：EP3066190A4
公开(公告)日：2017-07-05
申请号：EP14859826
申请日：2014-11-05
申请人： BECTON DICKINSON CO
发明人： BORNHEIMER SCOTT JOSEPH , SUGARMAN JEFFREY , HUANG WEI , GOLDBERG EDWARD MICHAEL , TAN MING
IPC分类号： B01L3/00 , B01F5/06 , B01F13/00 , G01N33/558
CPC分类号： G01N33/558 , B01F5/0691 , B01F13/0059 , B01F13/0061 , B01F2215/0431 , B01L3/5023 , B01L3/502746 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/086
摘要： The present disclosure provides methods and systems for assaying a sample. A microfluidic device to perform an assay of a sample (e.g., biological sample) is described having a sample application site, a porous component and a flow channel. The porous component provides for uniform dissolution of a reagent and mixing of the sample and reagent without filtering the sample.
摘要翻译：本公开提供了用于测定样品的方法和系统。描述了用于执行样本（例如，生物样本）的分析的微流体装置，其具有样本施加位置，多孔组件和流动通道。多孔组分提供试剂的均匀溶解以及样品和试剂的混合而不过滤样品。

4. 发明公开

EP3207980A4 FLUID MIXING DEVICE 审中-公开
公开(公告)号：EP3207980A4
公开(公告)日：2018-07-04
申请号：EP15851470
申请日：2015-08-21
申请人： ALPS ELECTRIC CO LTD
发明人： SAMESHIMA KENICHIRO
IPC分类号： B01F5/00 , B01F5/06 , B01F13/00 , B01L3/00
CPC分类号： B01F13/0061 , B01F5/0603 , B01F5/0641 , B01F13/0059 , B01F2215/0034 , B01F2215/0037 , B01L3/502 , B01L2200/16 , B01L2300/0864 , B01L2300/0867 , B01L2300/0887
摘要： To provide a fluid mixing device in which it is possible to greatly increase the mixing rate of a plurality of fluids without changing the installation area. A fluid mixing device is provided with a plurality of flow channel units 20a to 20g disposed to be divided in a plurality of layers. Each of the flow channel units has an inflow port, an outflow port, and a plurality of branch flow channels making the inflow port and the outflow port communicate with each other. The flow channel units located in different layers are connected to each other at the inflow port and the outflow port between the flow channel units, thereby configuring a three-dimensional flow channel 4 as a whole. When the direction from the inflow port to the outflow path of each flow channel unit is set to be a flow direction in the flow channel unit, the flow directions intersect each other between the respective layers.

5. 发明公开

EP3000528A1 Microfluidic device for the generation of combinatorial samples 有权
标题翻译： on。。chen。。。。。。。。。。chen chen chen。chen。
公开(公告)号：EP3000528A1
公开(公告)日：2016-03-30
申请号：EP14186463.7
申请日：2014-09-25
申请人： European Molecular Biology Laboratory
发明人： MERTEN, Christoph , UTHARALA, Ramesh , EICHER, Dominic
IPC分类号： B01L3/00 , B01F5/04 , B01F13/00 , B01F3/08
CPC分类号： B01J19/0046 , B01F3/0807 , B01F5/0471 , B01F13/0059 , B01F13/0061 , B01F2215/0037 , B01J2219/00389 , B01J2219/00418 , B01J2219/00547 , B01J2219/00599 , B01J2219/00743 , B01L3/502715 , B01L3/502738 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0867 , B01L2300/0883
摘要： The present disclosure relates to a microfluidic device and a method allowing the generating and screening of combinatorial samples. A microfluidic device for producing droplets of at least one sample into an immiscible phase is provided, the device comprising a droplet maker connecting an immiscible phase channel and a sample channel having at least one sample inlet connected to at least one sample inlet channel injecting the at least one sample into the sample channel, wherein the injection of the at least one sample is controlled by at least one sample valve, so that the at least one sample flows either towards a sample waste outlet or into the at least one sample inlet channel, wherein different sample inlet channel of the at least one sample inlet channel have the same hydrodynamic resistance resulting from the length, height and width of each sample inlet channel upstream of the droplet maker.
摘要翻译：本公开涉及微流体装置和允许生成和筛选组合样品的方法。提供了一种用于将至少一个样品的液滴产生到不混溶相中的微流体装置，该装置包括连接不混溶相通道和样品通道的液滴制造器，该液滴制造器具有连接至少一个样品入口通道的至少一个样品入口，至少一个样品进入样品通道，其中所述至少一个样品的注射由至少一个样品阀控制，使得所述至少一个样品流向样品废物出口或至少一个样品入口通道，其中至少一个样品入口通道的不同样品入口通道具有由液滴制造器上游的每个样品入口通道的长度，高度和宽度产生的相同的流体动力学阻力。

6. 发明公开

EP2996809A2 RAPID PRODUCTION OF DROPLETS 审中-公开
标题翻译： SCHNELLE HERSTELLUNG VON TROPFEN
公开(公告)号：EP2996809A2
公开(公告)日：2016-03-23
申请号：EP14730349.9
申请日：2014-05-14
申请人： President and Fellows of Harvard College
发明人： WEITZ, David, A. , AMSTAD, Esther
IPC分类号： B01L3/00 , B01L3/02
CPC分类号： F17D1/20 , B01F3/0807 , B01F5/0478 , B01F13/0059 , B01F13/0061 , B01F2215/0431 , B01L3/0241 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , F15D1/02
摘要： The present invention generally relates to the production of fluidic droplets. Certain aspects of the invention are generally directed to systems and methods for creating droplets by flowing a fluid from a first channel to a second channel through a plurality of side channels. The fluid exiting the side channels into the second channel may form a plurality of droplets, and in some embodiments, at very high droplet production rates. In addition, in some aspects, double or higher-order multiple emulsions may also be formed. In some embodiments, this may be achieved by forming multiple emulsions through a direct, synchronized production method and/or through the formation of a single emulsion that is collected and re-injected into a second microfluidic device to form double emulsions.
摘要翻译：本发明一般涉及流体液滴的生产。本发明的某些方面一般涉及用于通过使多个侧面通道将流体从第一通道流向第二通道来产生液滴的系统和方法。离开侧通道进入第二通道的流体可以形成多个液滴，并且在一些实施例中，以非常高的液滴产生速率。此外，在一些方面，也可以形成双重或更高级的多重乳液。在一些实施方案中，这可以通过直接的，同步的生产方法形成多个乳液和/或通过形成单个乳液来实现，所述乳液被收集并重新注射到第二微流体装置中以形成双重乳液。

7. 发明公开

EP3389837A1 DISPOSITIF ET PROCÉDÉ POUR RÉALISER UNE ÉMULSION EN CONTINU DE DEUX LIQUIDES IMMISCIBLES 审中-公开
公开(公告)号：EP3389837A1
公开(公告)日：2018-10-24
申请号：EP16825521.4
申请日：2016-12-15
申请人： Université de Nantes , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人： BELLETTRE, Jérôme , BELKADI, Arab , MONTILLET, Agnès
IPC分类号： B01F5/02 , B01F5/06 , B01F13/00 , B01F3/08
CPC分类号： B01F3/0807 , B01F5/0256 , B01F5/0648 , B01F5/0651 , B01F5/0653 , B01F13/0061
摘要： The invention relates to a device (1) for carrying out continuous emulsion of two immiscible fluids. Said device has: a first microsystem (2) including at least two micro-channels (23, 24) for intake of each fluid, of different respective cross sections S1 and S2, which are offset and face each other along a central intake axis A; at least two micro-channels (25, 26) for output of the emulsion from said device (1) once said emulsion is formed; and an area (27) where the intake and output micro-channels intersect, said area being capable of generating an interface between the fluids and forming a pre-emulsion flowing in the output micro-channels until the emulsion is complete. The device (1) also includes at least one singularity (31, 32, 33, 34, 35, 36) capable of destabilizing the interfaces between the fluids in the pre-emulsion. The invention also relates to a method for carrying out continuous emulsion of two immiscible liquids, said method implementing the device (1) according to the invention.

8. 发明公开

EP3066190A1 MICROFLUIDIC DEVICES, AND METHODS OF MAKING AND USING THE SAME 有权
标题翻译：维多利亚州VORRICHTUNGEN SOWIE VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON
公开(公告)号：EP3066190A1
公开(公告)日：2016-09-14
申请号：EP14859826.1
申请日：2014-11-05
申请人： Becton, Dickinson and Company
发明人： BORNHEIMER, Scott Joseph , SUGARMAN, Jeffrey , HUANG, Wei , GOLDBERG, Edward Michael , TAN, Ming
IPC分类号： C12M1/24 , G01N35/08
CPC分类号： G01N33/558 , B01F5/0691 , B01F13/0059 , B01F13/0061 , B01F2215/0431 , B01L3/5023 , B01L3/502746 , B01L2200/16 , B01L2300/0816 , B01L2400/0406 , B01L2400/086
摘要： The present disclosure provides methods and systems for assaying a sample. A microfluidic device to perform an assay of a sample (e.g., biological sample) is described having a sample application site, a porous component and a flow channel. The porous component provides for uniform dissolution of a reagent and mixing of the sample and reagent without filtering the sample.
摘要翻译：本公开提供了用于测定样品的方法和系统。描述了用于进行样品（例如生物样品）测定的微流体装置，其具有样品施加位点，多孔组分和流动通道。多孔组分提供试剂的均匀溶解和样品和试剂的混合而不过滤样品。

9. 发明公开

EP2975133A1 MICROCHANNEL DEVICE AND METHOD PERTAINING THERETO 有权
标题翻译：密克罗尼西亚维多利亚州VERFAHRENDAFÜR
公开(公告)号：EP2975133A1
公开(公告)日：2016-01-20
申请号：EP14763586.6
申请日：2014-02-24
申请人： University of Tsukuba
发明人： FUKUDA, Junji , SUZUKI, Hiroaki , YAMAGISHI, Anna , ENOMOTO, Junko , YOKOKAWA, Masatoshi
IPC分类号： C12Q1/02 , C12M1/00 , C12M3/00 , C12Q3/00
CPC分类号： B01L3/502784 , B01F3/0803 , B01F5/0085 , B01F13/0061 , B01F13/0069 , B01F13/0071 , B01F13/0072 , B01L3/0293 , B01L3/5027 , B01L3/502792 , B01L2200/0605 , B01L2300/088 , C12M23/16 , G01N1/38
摘要： Provided are a microchannel device for realizing an effective manipulation of a tiny amount of liquid and a method relating thereto . A microchannel device (1) includes: an upstream channel portion (10) configured to allow an upstream liquid plug and a gas to flow therethrough; a downstream channel portion (20) configured to allow a downstream liquid plug and a gas to flow therethrough; a liquid holding portion (30) provided between a downstream end portion of the upstream channel portion and an upstream end portion of the downstream channel portion, the liquid holding portion being configured to hold a main liquid plug therein; and a gas bypass channel portion (40) provided so as to bypass the liquid holding portion from the downstream end portion of the upstream channel portion to the upstream end portion of the downstream channel portion, the gas bypass channel portion being configured to allow the gas to flow therethrough in a state in which the liquid holding portion holds the main liquid plug.
摘要翻译：提供了一种用于实现微量液体的有效操作的微通道装置和与其相关的方法。微通道装置（1）包括：上游通道部分（10），其构造成允许上游液体塞和气体流过其中; 下游通道部分（20），其构造成允许下游液体塞和气体流过其中; 设置在所述上游通道部分的下游端部分与所述下游通道部分的上游端部分之间的液体保持部分，所述液体保持部分被配置为将主液体塞塞在其中; 以及气体旁通流路部（40），其设置成从所述上游流路部的下游端部向所述下游流路部的上游侧端部旁通所述液体保持部，所述气体旁通流路部构成为，在液体保持部保持主液塞的状态下流过。

10. 发明公开

EP2431091A1 TUBULAR FLOW TYPE REACTOR 审中-公开
标题翻译： ROHRFÖRMIGERDURCHFLUSSREAKTOR
公开(公告)号：EP2431091A1
公开(公告)日：2012-03-21
申请号：EP10764211.8
申请日：2010-03-24
申请人： Nisso Engineering Co., Ltd.
发明人： KOBAYASHI, Eiichiro , FUKUZAWA, Norihira
IPC分类号： B01J19/24 , B01F5/00 , F28D7/10
CPC分类号： B01F13/0061 , B01F5/0068 , B01F15/0203 , B01F15/024 , B01F15/066 , B01J4/001 , B01J19/006 , B01J19/0093 , B01J19/02 , B01J19/244 , B01J2219/00081 , B01J2219/00094 , B01J2219/00164 , B01J2219/00765 , B01J2219/00797 , B01J2219/00822 , B01J2219/00833 , B01J2219/0086 , B01J2219/00873 , B01J2219/00889 , B01J2219/00894 , B01J2219/0286 , B01J2219/029 , B01J2219/0295
摘要： A tubular flow type reactor comprising: (1) inflow channels for respective inflow of at least two kinds of fluids to be used in a reaction, (2) an outer tube having a lumen that is capable of merging the fluids and of distributing the merged fluids for the reaction, (3) an outflow channel for outflow of a reaction product from the outer tube, and (4) an inner tube disposed in the lumen of the outer tube, wherein an annular flow channel is formed between the outer tube and the inner tube, and the inflow channels are connected to the outer tube along the direction tangential to the internal circumference of the outer tube in such a manner that the lumens of the inflow channels communicate with the lumen of the outer tube, i.e., the annular flow channel.
摘要翻译：一种管状流式反应器，包括：（1）用于反应中使用的至少两种流体的相应流入的流入通道，（2）具有能够合并流体的内腔和分配合并的流体的外管用于反应的流体，（3）用于从外管流出反应产物的流出通道，和（4）设置在外管内腔中的内管，其中在外管和内管和流入通道沿着与外管的内圆周相切的方向连接到外管，使得流入通道的内腔与外管的内腔连通，即环形流通道。

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