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1. 发明公开

EP4351705A1 SYSTEM FOR NEUROSTIMULATION APPLICATIONS 审中-实审
公开(公告)号：EP4351705A1
公开(公告)日：2024-04-17
申请号：EP22732268.2
申请日：2022-06-10
申请人： Innervia Bioelectronics SLU
发明人： BAKKER, Jurriaan , DONEGA, Matteo , RODRIGUEZ, Elisa
IPC分类号： A61N1/05 , A61N1/372 , A61N1/375 , A61N1/36 , A61B5/374 , A61B5/377 , A61B5/053 , A61B5/00
CPC分类号： A61B5/263 , A61B5/293 , A61N1/0534 , A61N1/0531 , A61N1/37514 , A61N1/3614 , A61N1/36139 , A61N1/36167 , A61N1/36178

2. 发明公开

EP4351703A1 SYSTEM FOR NEUROMODULATION APPLICATIONS 审中-实审
公开(公告)号：EP4351703A1
公开(公告)日：2024-04-17
申请号：EP22732266.6
申请日：2022-06-10
申请人： INBRAIN Neuroelectronics SL
发明人： BAKKER, Jurriaan , DONEGA, Matteo , RODRIQUEZ, Elisa , VAN SCHUYLENBERGH, Koenraad F.
IPC分类号： A61N1/05 , A61N1/372 , A61N1/375 , A61B5/374 , A61B5/377 , A61N1/36 , A61B5/053 , A61B5/00
CPC分类号： A61B5/263 , A61B5/293 , A61N1/0534 , A61N1/0531 , A61N1/37514 , A61N1/3614 , A61N1/36139 , A61N1/36167 , A61N1/36178

3. 发明公开

EP3389768A1 HIGH DUTY CYCLE ELECTRICAL STIMULATION THERAPY 有权
公开(公告)号：EP3389768A1
公开(公告)日：2018-10-24
申请号：EP16820528.4
申请日：2016-12-15
申请人： Medtronic, Inc.
发明人： JOHANEK, Lisa M.
IPC分类号： A61N1/36
CPC分类号： A61N1/36167 , A61N1/3606 , A61N1/36071 , A61N1/36171 , A61N1/36175 , A61N1/36178
摘要： In some examples, a medical device is configured to deliver high dose electrical stimulation therapy to a patient by at least generating and delivering an electrical stimulation signal having a relatively high duty cycle, and a stimulation intensity less than a perception or paresthesia threshold intensity level for the patient. The pulses of the electrical stimulation signal may each have a relatively low amplitude, but due at least in part to a relatively high number of pulses per unit of time, a dose of the electrical stimulation may be high enough to elicit a therapeutic response from the patient.

4. 发明公开

EP3316959A1 METHODS OF SENSING CROSS-FREQUENCY COUPLING AND NEUROMODULATION 有权
标题翻译：检测交叉频率耦合和神经调节的方法
公开(公告)号：EP3316959A1
公开(公告)日：2018-05-09
申请号：EP16817313.6
申请日：2016-06-30
申请人： Ridder, Dirk, De
发明人： Ridder, Dirk, De
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36135 , A61B5/0031 , A61B5/04012 , A61B5/0478 , A61B5/048 , A61B5/128 , A61B5/4836 , A61B5/6868 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082 , A61N1/36167
摘要： Representative embodiments are directed to detecting neurological activity in a patient. The detection of neurological activity includes identifying cross-frequency coupling and determining whether the cross-frequency coupling is physiological or pathological. When pathological cross-frequency coupling is detected, neurostimulation of one or more sites is applied. In some embodiments, an implantable pulse generator is adapted to analyze neural activity for pathological cross-frequency coupling and to provide electrical stimulation in response to the detected pathological cross-frequency coupling.

5. 发明授权

EP3088041B1 IMPLANTABLE DEVICE FOR EVALUATING AUTONOMIC CARDIOVASCULAR DRIVE IN A PATIENT SUFFERING FROM CHRONIC CARDIAC DYSFUNCTION 有权
标题翻译：用于评估患有慢性心功能不全患者的自主心血管驱动装置的可植入装置
公开(公告)号：EP3088041B1
公开(公告)日：2018-03-14
申请号：EP16168072.3
申请日：2012-12-06
申请人： Cyberonics, Inc.
发明人： LIBBUS, Imad , AMURTHUR, Badri , KENKNIGHT, Bruce, H
IPC分类号： A61B5/024 , A61N1/36 , A61N1/05 , A61B5/00 , A61B5/02
CPC分类号： A61N1/36167 , A61B5/02 , A61B5/02438 , A61B5/4836 , A61B5/686 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： An implantable device (11) for evaluating autonomic cardiovascular drive, comprising: an implantable neurostimulator (12) comprising a pulse generator configured to deliver electrical therapeutic stimulation tuned to restore autonomic balance through continuously-cycling, intermittent and periodic electrical pulses delivered in a manner that results in creation and propagation (in both afferent and efferent directions) of action potentials within neuronal fibers comprising a cervical vagus nerve (15, 16, 61) of a patient (10) in continuous alternating cycles of stimuli application and stimuli inhibition (90) and configured to deliver the electrical therapeutic stimulation according to stored stimulation parameters comprising the pulse width falling within the range of 100 to 250 µsec, the output current (96) falling within the range of 0.02 to 50 mA, and the signal frequency (93) at least being 10 Hz; a cervical vagus nerve stimulation therapy lead (13) electrically coupled to the pulse generator and terminated by a at least one electrode through which the therapeutic electrical stimulation is delivered to the patient's cervical vagus nerve (15, 16, 61).

6. 发明授权

EP2209518B1 ONSET-MITIGATING HIGH-FREQUENCY NERVE BLOCK 有权
标题翻译：开始减少高频神经块
公开(公告)号：EP2209518B1
公开(公告)日：2018-02-21
申请号：EP08844728.9
申请日：2008-10-28
申请人： Case Western Reserve University
发明人： KILGORE, Kevin, L. , BHADRA, Niloy
IPC分类号： A61N1/36 , A61N1/32 , A61N1/20
CPC分类号： A61N1/36171 , A61N1/0551 , A61N1/20 , A61N1/205 , A61N1/32 , A61N1/36057 , A61N1/36067 , A61N1/36071 , A61N1/36103 , A61N1/3615 , A61N1/36167
摘要： A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The method may also include applying a direct current (DC) to the axon, increasing the amplitude of the DC over time to a predetermined amplitude, applying the HFAC, and then decreasing the DC. The method may also include temporarily reducing the amplitude of the HFAC to permit the transmission of signals through the axon and subsequently increasing the amplitude to block transmission without triggering an onset response. The method may also include temporarily applying an unbalanced charge to the nerve and then balancing the charge over time.

7. 发明授权

EP3078395B1 ARBITRARY WAVEFORM GENERATOR AND NEURAL STIMULATION APPLICATION 有权
标题翻译：任意波形发生器与神经刺激应用
公开(公告)号：EP3078395B1
公开(公告)日：2017-12-27
申请号：EP16167230.8
申请日：2012-04-10
申请人： NUVECTRA CORPORATION
发明人： TRIER, Stephen , WEISGARBER, Jeffrey A. , POLEFKO, Richard J.
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/36071 , A61N1/36125 , A61N1/3615 , A61N1/36167 , A61N1/36175 , A61N1/3625 , A61N1/37235 , G06F1/0328
摘要： A device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy.

8. 发明公开

EP3197545A1 SYSTEMS AND METHODS FOR PROVIDING THERAPY USING ELECTRICAL STIMULATION TO DISRUPT NEURONAL ACTIVITY 有权
标题翻译：用于使用电刺激来破坏神经元活动的用于提供治疗的系统和方法
公开(公告)号：EP3197545A1
公开(公告)日：2017-08-02
申请号：EP15775547.1
申请日：2015-09-22
申请人： Boston Scientific Neuromodulation Corporation
发明人： MOFFITT, Michael, A. , CARCIERI, Stephen
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/36021 , A61N1/36139 , A61N1/36167 , A61N1/36185
摘要： A transcutaneous electrical-stimulation system includes a transcutaneous control module including a processor. The transcutaneous control module provides electrical-stimulation signals to electrode sets electrically-coupled to the transcutaneous control module. A first electrode set is electrically-coupled to the transcutaneous control module and is placed along patient skin over a first stimulation location. The first electrode set generates a first effective electric field suitable for transcutaneous stimulation of patient tissue at the first stimulation location. A second electrode set is electrically-coupled to the transcutaneous control module and is placed along patient skin over a second stimulation location. The second electrode set generates a second effective electric field suitable for stimulating patient tissue at the second stimulation location. The second effective electric field is time-delayed from the first effective electric field such that the second effective electric field is out of phase with the first effective electric field.
摘要翻译：经皮电刺激系统包括包含处理器的经皮控制模块。经皮控制模块将电刺激信号提供给与经皮控制模块电耦合的电极组。第一电极组电耦合到经皮控制模块并且沿着患者皮肤放置在第一刺激位置上。第一电极组产生适合于在第一刺激位置经皮刺激患者组织的第一有效电场。第二电极组电耦合到经皮控制模块并且沿患者皮肤放置在第二刺激位置上。第二电极组产生适合于在第二刺激位置刺激患者组织的第二有效电场。第二有效电场从第一有效电场延时，使得第二有效电场与第一有效电场异相。

9. 发明授权

EP3002036B1 NEUROSTIMULATION SYSTEM WITH CONTROL USING EVOKED RESPONSES 有权
标题翻译：带有控制的神经调节系统使用感知响应
公开(公告)号：EP3002036B1
公开(公告)日：2017-07-26
申请号：EP15193595.4
申请日：2011-06-09
申请人： Cardiac Pacemakers, Inc.
发明人： HINCAPIE ORDONEZ, Juan Gabriel , TERNES, David J. , HAMANN, Jason J. , RUBLE, Stephen
IPC分类号： A61N1/36 , A61B5/04
CPC分类号： A61N1/36139 , A61B5/04001 , A61B5/4041 , A61B5/4047 , A61B5/4058 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36135 , A61N1/36167

10. 发明公开

EP3078395A1 ARBITRARY WAVEFORM GENERATOR AND NEURAL STIMULATION APPLICATION 有权
标题翻译：威尔逊公司在戴尔神经病学中发现
公开(公告)号：EP3078395A1
公开(公告)日：2016-10-12
申请号：EP16167230.8
申请日：2012-04-10
申请人： NUVECTRA CORPORATION
发明人： TRIER, Stephen , WEISGARBER, Jeffrey A. , POLEFKO, Richard J.
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/36071 , A61N1/36125 , A61N1/3615 , A61N1/36167 , A61N1/36175 , A61N1/3625 , A61N1/37235 , G06F1/0328
摘要： A device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy.
摘要翻译：用于产生可用于产生用于医疗目的的刺激脉冲（例如脊髓刺激治疗）的期望形状的任意波形的装置和/或系统。

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