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1. 发明公开

EP3368100A1 APPARATUS FOR THE REGIONAL COAGULATION OF THE BLOOD 审中-公开
公开(公告)号：EP3368100A1
公开(公告)日：2018-09-05
申请号：EP16815630.5
申请日：2016-10-27
申请人： O2 Group SA
发明人： FONTANA, Michele
IPC分类号： A61M1/36
CPC分类号： A61M1/3672 , A61M1/3675 , A61M2205/055 , A61M2205/75
摘要： An apparatus for the regional anticoagulation of the blood, usable for reducing the amount of Ca++ ions in the blood which have to receive a treatment in a circuit for the treatment of blood comprising an inlet conduit (1) for the blood collected from the patient, a device for the treatment of the blood (9), an outlet conduit for returning the treated blood to the patient; the apparatus is characterized in that it comprises a membrane (60) made of a material selectively permeable to Ca++ ions.

2. 发明授权

EP1511525B1 A CARTRIDGE FOR ELECTROHEMODIALYSIS 有权
标题翻译：电渗析装置
公开(公告)号：EP1511525B1
公开(公告)日：2012-06-27
申请号：EP02795474.2
申请日：2002-11-19
申请人： Dizayn Teknik Plastik Boru ve Elemanlari San. Ve Tic A.S.
发明人： Degim, Y. Tuncer , Dundaroz, Rusen , Denli, Metin , Ilbasmis, Sibel , Oczelikay, A. Tanju , Degin, Zelihagül
IPC分类号： A61M1/16 , B01D61/42 , B01D57/02
CPC分类号： A61M1/16 , A61M1/28 , A61M1/287 , A61M2205/055 , B01D57/02 , B01D61/42
摘要： The scope of the invention is to apply an electric current or to use a kind of iontophoresis system with the hemodialysis cartridge and system (the proposed method is also applicable to peritoneal or other similar methods) to remove unwanted molecules from blood, plasma or serum or other body fluids and to increase the effectiveness of the process. This cartridge can be used for patients with uremia and cartridge fixed to the conventional hemodialysis machine and additionally the electric current applied to the electrodes placed in to the cartridge or electrode connectors placed to the conventional cartridge. When the system activated, the molecules in the blood or other body fluid migrates to the hemodialysis solution. Charged ions or uncharged molecules move together with electroosmotic flow. The sterilized electrodes preferably made by Ag/AgC1 to prevent pH changing effect. Other apparatus can also be used for providing an electropotential gradient.
摘要翻译：本发明的范围是在血液透析盒和系统（所提出的方法也适用于腹膜或其他类似方法）上施加电流或使用一种离子电渗疗法系统以从血液，血浆或血清中去除不需要的分子或其他体液，并提高过程的有效性。该药筒可以用于尿毒症患者和固定在常规血液透析机上的药筒，另外还可以将电流施加到放置在常规药筒上的药筒或电极连接器中的电极上。当系统激活时，血液或其他体液中的分子迁移到血液透析溶液。带电离子或不带电分子随着电渗流一起移动。灭菌电极优选由Ag / AgCl制成以防止pH变化效应。其他装置也可以用于提供电位梯度。

3. 发明公开

EP3094343A4 RAPID ACTION INSULIN FORMULATIONS AND PHARMACEUTICAL DELIVERY SYSTEMS 审中-公开
公开(公告)号：EP3094343A4
公开(公告)日：2017-10-18
申请号：EP15735454
申请日：2015-01-13
申请人： THERMALIN DIABETES LLC
发明人： JOSEPH JEFFREY I , BERENSON RICHARD WILLIAM , FRANK BRUCE , WEISS MICHAEL A , HATTIER THOMAS , DUBÉ GREGORY , CHEN ZHIQIANG
IPC分类号： A61K38/28 , A61K36/05 , A61K36/23 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/36 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/0021 , A61K36/05 , A61K36/23 , A61K45/06 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/36 , A61M5/142 , A61M5/1723 , A61M25/02 , A61M37/0092 , A61M2025/0253 , A61M2037/0007 , A61M2205/055 , A61M2205/35 , A61M2205/50 , A61M2205/502 , A61M2230/201 , A61N1/0448 , A61N1/327 , A61N7/00 , A61K2300/00
摘要： The present invention provides rapid-acting insulin and insulin analog formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogs, as well as other active agents. Methods of using the insulin and insulin analog formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.

4. 发明公开

EP1951337A4 EXTRACORPOREAL BLOOD CLEANING 有权
标题翻译： EXTRAKORPORALE BLUTREINIGUNG
公开(公告)号：EP1951337A4
公开(公告)日：2013-11-13
申请号：EP06799812
申请日：2006-09-25
申请人： GAMBRO LUNDIA AB
发明人： STERNBY JAN , WIESLANDER ANDERS , KJELLSTRAND PER , LINDEN TORBJOERN
IPC分类号： A61M1/34 , A61M1/16 , A61M1/36
CPC分类号： A61M1/3472 , A61M1/3479 , A61M1/3482 , A61M1/3486 , A61M1/3686 , A61M1/3687 , A61M1/369 , A61M2205/055 , A61M2205/058
摘要： An apparatus (100) for extracorporeal blood cleaning includes a separation unit (110), at least two processing branches (120; 130) and a mixing unit (140). The separation unit (110) receives 5 incoming blood (B A) and divides off a first fraction (fC) from this blood. The first fraction (fC) contains predominantly blood cells. The separation unit (110) also divides off at least one second fraction (fP), which contains predominantly blood plasma. A first processing branch (120) processes the first fraction (fC) according to a first cleaning process, in which cell-bound substances are removed from the blood cells. As a result, a first cleaned fraction (fC c) containing washed blood cells is produced. A second processing branch (130) processes the second fraction (fP) according to a second cleaning process in which toxins bound on proteins within the plasma and/or toxins dissolved in 15 the plasma are removed, and a second cleaned fraction (fP c) is produced. The second cleaning process is different from the first cleaning process. Thereby each process can be tailored for the requirements of the respective fraction (fC, fP). The mixing unit 20 (140) receives the first and second cleaned fractions (fC c, fP c, combines these fractions (fC c, fP c, and outputs cleaned whole blood (BV).

5. 发明公开

EP1511525A1 A CARTRIDGE FOR ELECTROHEMODIALYSIS 有权
标题翻译：用卡ELEKTROHÄMODIALYSE
公开(公告)号：EP1511525A1
公开(公告)日：2005-03-09
申请号：EP02795474.2
申请日：2002-11-19
申请人： Degim, Y. Tuncer , Dundaroz, Rusen , Denli, Metin , Ilbasmis, Sibel , Ozcelikay, A. Tanju , Degim, Zelihagül
发明人： Degim, Y. Tuncer , Dundaroz, Rusen , Denli, Metin , Ilbasmis, Sibel , Ozcelikay, A. Tanju , Degim, Zelihagül
IPC分类号： A61M1/16 , B01D61/42 , B01D57/02
CPC分类号： A61M1/16 , A61M1/28 , A61M1/287 , A61M2205/055 , B01D57/02 , B01D61/42
摘要： The scope of the invention is to apply an electric current or to use a kind of iontophoresis system with the hemodialysis cartridge and system (the proposed method is also applicable to peritoneal or other similar methods) to remove unwanted molecules from blood, plasma or serum or other body fluids and to increase the effectiveness of the process. This cartridge can be used for patients with uremia and cartridge fixed to the conventional hemodialysis machine and additionally the electric current applied to the electrodes placed in to the cartridge or electrode connectors placed to the conventional cartridge. When the system activated, the molecules in the blood or other body fluid migrates to the hemodialysis solution. Charged ions or uncharged molecules move together with electroosmotic flow. The sterilized electrodes preferably made by Ag/AgC1 to prevent pH changing effect. Other apparatus can also be used for providing an electropotential gradient.

6. 发明授权

EP1951337B1 EXTRACORPOREAL BLOOD CLEANING 有权
公开(公告)号：EP1951337B1
公开(公告)日：2018-08-01
申请号：EP06799812.0
申请日：2006-09-25
申请人： Gambro Lundia AB
发明人： STERNBY, Jan , WIESLANDER, Anders , KJELLSTRAND, Per , LINDÉN, Torbjörn
IPC分类号： A61M1/34 , A61M1/16 , A61M1/36
CPC分类号： A61M1/3472 , A61M1/3479 , A61M1/3482 , A61M1/3486 , A61M1/3686 , A61M1/3687 , A61M1/369 , A61M2205/055 , A61M2205/058
摘要： An apparatus (100) for extracorporeal blood cleaning includes a separation unit (110), at least two processing branches (120; 130) and a mixing unit (140). The separation unit (110) receives 5 incoming blood (B A) and divides off a first fraction (fC) from this blood. The first fraction (fC) contains predominantly blood cells. The separation unit (110) also divides off at least one second fraction (fP), which contains predominantly blood plasma. A first processing branch (120) processes the first fraction (fC) according to a first cleaning process, in which cell-bound substances are removed from the blood cells. As a result, a first cleaned fraction (fC c) containing washed blood cells is produced. A second processing branch (130) processes the second fraction (fP) according to a second cleaning process in which toxins bound on proteins within the plasma and/or toxins dissolved in 15 the plasma are removed, and a second cleaned fraction (fP c) is produced. The second cleaning process is different from the first cleaning process. Thereby each process can be tailored for the requirements of the respective fraction (fC, fP). The mixing unit 20 (140) receives the first and second cleaned fractions (fC c, fP c, combines these fractions (fC c, fP c, and outputs cleaned whole blood (BV).

7. 发明公开

EP3094343A2 RAPID ACTION INSULIN FORMULATIONS AND PHARMACEUTICAL DELIVERY SYSTEMS 审中-公开
标题翻译：维生素MIT SCHNELLER WIRKUNG UND PHARMAZEUCHESCHES VERABREICHUNGSSYSTEM
公开(公告)号：EP3094343A2
公开(公告)日：2016-11-23
申请号：EP15735454.9
申请日：2015-01-13
申请人： Thermalin Diabetes, LLC
发明人： JOSEPH, Jeffrey, I. , BERENSON, Richard, William , FRANK, Bruce , WEISS, Michael, A. , HATTIER, Thomas , DUBÉ, Gregory , CHEN, Zhiqiang
IPC分类号： A61K38/28 , A61K38/00
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/0021 , A61K36/05 , A61K36/23 , A61K45/06 , A61K47/12 , A61K47/183 , A61K47/20 , A61K47/36 , A61M5/142 , A61M5/1723 , A61M25/02 , A61M37/0092 , A61M2025/0253 , A61M2037/0007 , A61M2205/055 , A61M2205/35 , A61M2205/50 , A61M2205/502 , A61M2230/201 , A61N1/0448 , A61N1/327 , A61N7/00 , A61K2300/00
摘要： The present invention provides rapid-acting insulin and insulin analog formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogs, as well as other active agents. Methods of using the insulin and insulin analog formulations as well as the insulin delivery devices for treating subjects with diabetes mellitus are also provided.
摘要翻译：本发明提供速效胰岛素和胰岛素类似物制剂。本发明进一步提供了允许快速吸收胰岛素和胰岛素类似物以及其它活性剂的递送装置，特别是输注装置。还提供了使用胰岛素和胰岛素类似物制剂以及用于治疗患有糖尿病的胰岛素递送装置的方法。

8. 发明公开

EP1951337A1 EXTRACORPOREAL BLOOD CLEANING 有权
标题翻译：体外血液净化
公开(公告)号：EP1951337A1
公开(公告)日：2008-08-06
申请号：EP06799812.0
申请日：2006-09-25
申请人： Gambro Lundia AB
发明人： STERNBY, Jan , WIESLANDER, Anders , KJELLSTRAND, Per , LINDÉN, Torbjörn
IPC分类号： A61M1/34 , A61M1/16 , A61M1/36
CPC分类号： A61M1/3472 , A61M1/3479 , A61M1/3482 , A61M1/3486 , A61M1/3686 , A61M1/3687 , A61M1/369 , A61M2205/055 , A61M2205/058
摘要： An apparatus (100) for extracorporeal blood cleaning includes a separation unit (110), at least two processing branches (120; 130) and a mixing unit (140). The separation unit (110) receives 5 incoming blood (B A ) and divides off a first fraction (f C ) from this blood. The first fraction (f C ) contains predominantly blood cells. The separation unit (110) also divides off at least one second fraction (f P ) , which contains predominantly blood plasma. A first processing branch (120) processes the first fraction (f C ) accor- 10 d i n g to a first cleaning process, in which cell-bound substances are removed from the blood cells. As a result, a first cleaned fraction (f C c ) containing washed blood cells is produced. A second processing branch (130) processes the second fraction (f P ) according to a second cleaning process in which toxins bound on proteins within the plasma and/or toxins dissolved in 15 the plasma are removed, and a second cleaned fraction (f P c ) is produced. The second cleaning process is different from the first cleaning process. Thereby each process can be tailored for the requirements of the respective fraction (f C , f P ) . The mixing unit 20 (140) receives the first and second cleaned fractions (f C c , f P c ) , combines these fractions (f C c , f P c ) , and outputs cleaned whole blood (B V ).

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