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    • 5. 发明公开
    • Flush syringe having anti-reflux stopper
    • SpülspritzemitRückflussverhinderndemStopfen
    • EP2347780A1
    • 2011-07-27
    • EP11163245.1
    • 2004-09-03
    • Becton, Dickinson and Company
    • Alheidt, Thomas A.Timko, James John
    • A61M5/315A61M25/00
    • A61M5/31511A61M2005/31523
    • An I.V. flush syringe (20) assembly includes a barrel (22) having an inside surface (32) defining a chamber (33) for retaining fluid, an open proximal end (28) and a distal end (30) including a distal wall (31) with an elongate tip (36) extending distally therefrom having a passageway (38) therethrough in fluid communication with the chamber (33). A plunger (24) having an elongate body portion (25) and a stopper (54) slidably positioned in fluid-tight engagement with the inside surface (32) of the barrel (22) is provided. Anti-reflux structure for controlling stopper deflection when fluid has been delivered from the chamber (33) and the stopper (54) is in contact with the distal wall (31) is provided. The anti-reflux structure includes the stopper (54) having a conically shaped distal surface (59) and the inside surface (32) of the barrel (22) and the distal wall (31) being conically shaped (35) wherein the total included angle A of the inside surface (32) of the barrel (22) at the distal wall (31) is greater than the total included angle B of the distal surface (59) of the stopper (54) by at least 6°.
    • 一个 冲洗注射器(20)组件包括具有限定用于保持流体的室(33)的内表面(32)的桶(22),包括远侧壁(31)的开放近端(28)和远端(30) 其中从其向远侧延伸的细长尖端(36)具有通过其与腔室(33)流体连通的通道(38)。 提供具有细长主体部分(25)和可滑动地定位成与筒体(22)的内表面(32)流体密封接合的止动件的柱塞(24)。 提供了当从腔室(33)和止挡器(54)输送流体与远侧壁(31)接触时用于控制止挡器偏转的防回流结构。 防回流结构包括具有圆锥形远端表面(59)和筒体(22)的内表面(32)和远端壁(31)是圆锥形(35)的塞子(54),其中总计包括 远端壁(31)处的筒体(22)的内表面(32)的角度A大于塞子(54)的远端表面(59)的总包角度至少为6°。
    • 10. 发明公开
    • DRUG DELIVERY DEVICE WITH THREADED HOUSING AND PISTON, AND METHOD FOR MANUFACTURING THE SAME
    • WITH其制造螺纹住房和活塞和方法的药物供应设备
    • EP3164180A1
    • 2017-05-10
    • EP15731985.6
    • 2015-07-01
    • SANOFI
    • MARSH, WilliamMORRIS, Anthony Paul
    • A61M5/315
    • A61M5/31553A61M5/20A61M5/31515A61M5/31541A61M5/31561A61M5/31583A61M5/31585A61M2005/202A61M2005/3126A61M2005/31523A61M2005/3154A61M2205/581A61M2205/582A61M2205/583A61M2207/00B29C45/2618B29C45/44
    • The present invention is generally directed to a drug delivery device for selecting and dispensing a number of user variable doses of a medicament. The device comprises a housing (10) having a tubular portion (12) with an inner thread, a piston rod (30) having a threaded portion (31) and a distal end, and a bearing (140) having a distal face and a proximal face. The bearing (140) comprises a retaining stem (142) protruding from the proximal face. The piston rod (30) comprises a distal portion having an outer diameter which is smaller than the inner diameter of the inner thread of the tubular portion (12) and comprising at its distal end at least one retaining clip (33, 33′) engaging the retaining stem (142). The axial length of the tubular portion (12) is smaller than or equal to the axial distance between the proximal face of the bearing disc (141) and the distal end of the threaded portion (31) of the piston rod (30). During manufacturing of the device, the retaining clip (33, 33′) engages the retaining stem (142) prior to the inner thread of the tubular portion (12) engages with the threaded portion (31) of the piston rod (30).
    • 本发明是针对一种药物递送装置,用于选择和分配多个用户可变剂量的药物中的基因的反弹。 该装置包括具有与所述内螺纹的管状部分(12)和具有远端面和一螺纹部分(31)和一个远端,以及一个轴承(140)的壳体(10),活塞杆(30) 近端面。 所述轴承(140)包括一个保持杆(142)从近端面突出。 活塞杆(30)包括具有外径的远侧部分的所有比所述管状部分(12)的内螺纹的内径小,并在其远端包括至少一个保持夹(33,33“)接合 所述保持杆(142)。 筒状部(12)的轴向长度小于或等于所述支承盘(141)和所述活塞杆(30)的螺纹部分(31)的远端的近端面之间的轴向距离。 在制造过程中该装置的,所述保持夹(33,33“)接合所述保持杆(142)之前,所述管状部(12)与活塞杆(30)的螺纹部分(31)接合的内螺纹。