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1. 发明授权

EP1521959B1 METHOD AND APPARATUS FOR 3-D IMAGING OF INTERNAL LIGHT SOURCES 有权转让
标题翻译： FOR 3D成像的方法和设备内的采样LOCATED LIGHT
公开(公告)号：EP1521959B1
公开(公告)日：2010-09-08
申请号：EP03764754.2
申请日：2003-07-15
申请人： Xenogen Corporation
发明人： STEARNS, Daniel, G. , RICE, Bradley, W. , CABLE, Michael, D.
IPC分类号： G01N21/76 , G01N21/64 , A61K49/00
CPC分类号： G01N21/763 , A61K49/0013 , G01B9/02004 , G01B9/0203 , G01B9/02041 , G01B11/24 , G01B11/2518 , G01N21/6456 , H04N13/204 , H04N13/25 , H04N13/271
摘要： The present invention provides systems and methods for obtaining a three-dimensional (3D) representation of one or more light sources inside a sample, such as a mammal. Mammalian tissue is a turbid medium, meaning that photons are both absorbed and scattered as they propagate through tissue. In the case where scattering is large compared with absorption, such as red to near-infrared light passing through tissue, the transport of light within the sample is described by diffusion theory. Using imaging data and computer-implemented photon diffusion models, embodiments of the present invention produce a 3D representation of the light sources inside a sample, such as a 3D location, size, and brightness of such light sources.

2. 发明公开

EP1836548A2 GRAPHICAL USER INTERFACE FOR 3-D IN-VIVO IMAGING 审中-公开
标题翻译：图形用户界面，3D图像中VIVO
公开(公告)号：EP1836548A2
公开(公告)日：2007-09-26
申请号：EP05853015.5
申请日：2005-12-01
申请人： Xenogen Corporation
发明人： RICE, Bradley, W. , CABLE, Michael, D. , MARVAR, Binoy , COQUOZ, Olivier , KUO, Chaincy
IPC分类号： G06F3/00 , G06K9/36
CPC分类号： A61B5/0059 , A61B5/7435 , A61B2503/40 , G06F3/0481 , G06F3/04815
摘要： The present invention provides a computer system and user interface that allows a user to readily view and analyze two-dimensional and three-dimensional in vivo images and imaging data. The user interface is well-suited for one or more of the following actions pertinent to in vivo light imaging: investigation and control of three-dimensional imaging data and reconstruction algorithms; control of topographic reconstruction algorithms; tomographic spectral imaging and analysis; and comparison of two-dimensional or three-dimensional imaging data obtained at different times.

3. 发明授权

EP1212429B1 LUCIFERASE EXPRESSION CASSETTES AND METHODS OF USE 有权
标题翻译：荧光素酶表达盒和它们的使用方法
公开(公告)号：EP1212429B1
公开(公告)日：2006-06-28
申请号：EP00960044.6
申请日：2000-09-07
申请人： Xenogen Corporation
发明人： FRANCIS, Kevin, P. , CONTAG, Pamela, R. , JOH, Danny, J.
IPC分类号： C12N15/53 , C12N15/64 , C12N15/85 , C12Q1/68 , C12N1/21 , A01K67/027
CPC分类号： C12N15/1051 , C12N9/0069 , C12N15/65 , C12N15/74 , C12Q1/66 , G01N33/52
摘要： The present invention relates to bacterial luciferase expression cassettes suitable for conferring bioluminescence properties on Gram-positive bacteria, cells transformed with such cassettes, and methods of making and using such cassettes.

4. 发明公开

EP0743366A1 Nachweis von Listerien mittels rekombinanter Bakteriophagen 失效转让
公开(公告)号：EP0743366A1
公开(公告)日：1996-11-20
申请号：EP96107225.3
申请日：1996-05-08
申请人： MERCK PATENT GmbH
发明人： Scherer, Siegfried, Prof. Dr. , Loessner, Martin J., Dr.
IPC分类号： C12Q1/04 , C12N7/00
CPC分类号： C12N15/86 , C12N7/00 , C12N15/77 , C12N2795/10143 , C12Q1/04
摘要： Die Erfindung betrifft ein Nachweisverfahren für Bakterien der Gattung Listeria umfassend die Schritte:

(a) Bereitstellen eines mittels Rekombinationstechniken hergestellten DNA-Vektors, enthaltend ein genetisches System, umfassend DNA, die die Expression eines oder mehrerer Proteine kodiert, wobei die Proteine kein Genprodukt von Bakterien der Gattung Listeria darstellen und das Vorhandensein der Proteine durch eine Nachweisreaktion festgestellt werden kann, und wobei der DNA-Vektor die Bakterien der Gattung Listeria infiziert und dabei das genetische System in die Bakterien übertragen kann;
(b) Vermischen der Probe mit besagtem DNA-Vektor unter Bedingungen, die eine Infektion von Bakterien der Gattung Listeria durch den DNA-Vektor erlauben;
(c) Exprimieren der nachweisbaren Proteine in den Bakterien der Gattung Listeria ;
(d) Nachweis der nachweisbaren Proteine, wobei die Anwesenheit von Bakterien der Gattung Listeria nachgewiesen wird,
sowie für dieses Nachweisverfahren geeignete rekombinante DNA-Vektoren und Reagenzzusammenstellungen.
摘要翻译：检测样品中利斯特氏菌的方法包括：（a）制备重组载体，编码可检测的非利斯特氏菌标记蛋白的DNA，其中载体能够转染利斯特氏菌; （b）在转染条件下用载体培养样品，和（c）检测标记蛋白的表达。还要求的是：（1）重组李斯特氏菌噬菌体，其选自形态学A1型的肌病毒。整合到其基因组中的荧光素酶基因，和（2）可以通过extn获得的分离的DNA。从（1）的噬菌体。

5. 发明授权

EP1141359B1 NON-INVASIVE EVALUATION OF PHYSIOLOGICAL RESPONSE IN A MAMMAL 有权
标题翻译：不流血确定生理反应在哺乳动物
公开(公告)号：EP1141359B1
公开(公告)日：2006-10-04
申请号：EP99967380.9
申请日：1999-12-16
申请人： Xenogen Corporation
发明人： CONTAG, Pamela, R. , ZHANG, Ning
IPC分类号： C12N15/85 , A61K49/00 , A01K67/027
CPC分类号： C12N15/85 , A01K67/0271 , A01K67/0275 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , A01K2267/0393 , C12N15/8509
摘要： The present invention relates to panels of reporter expression cassettes and the generation of transgenic non-human animals, wherein said reporter expression cassettes have selected control elements operable linked to reporter genes. The invention includes methods of use thereof for the identification and characterization of the effects of compounds administered to the live transgenic non-human animals.

6. 发明授权

EP1478423B1 MULTIPLE OUTPUT ANESTHESIA SYSTEM 有权
标题翻译：具有多个输出的麻醉系统
公开(公告)号：EP1478423B1
公开(公告)日：2006-07-26
申请号：EP03713630.6
申请日：2003-02-19
申请人： Xenogen Corporation
发明人： DALGETTY, Richard, George , BATES, Brian, Robert , NELSON, Michael, Bo
IPC分类号： A61M16/01
CPC分类号： A22B3/005 , A01K1/031 , A22B3/00 , A61D7/04 , A61M16/104 , A61M16/18 , A61M16/202 , A61M16/209 , A61M2016/0039
摘要： The present invention provides improved anesthesia delivery systems that consistently and reliably deliver anesthesia gas to multiple gas outlets. The systems are particularly useful for anesthetizing multiple mammals and living specimens to be imaged by a low-light level imaging system. The anesthesia delivery systems are suitable for use with conventional oxygen sources, and convert the high pressures associated with a conventional oxygen source to lower pressures suitable for use with small mammals and suitable for combination with an anesthesia gas at low flow rates. The systems include an anesthesia gas source that combines anesthesia gas with the oxygen. The combination of anesthesia gas and oxygen is supplied to one or more multiple outlets.

7. 发明公开

EP1643902A2 MULTI-MODE INTERNAL IMAGING 有权转让
标题翻译：内部多模式图像演示
公开(公告)号：EP1643902A2
公开(公告)日：2006-04-12
申请号：EP04756529.6
申请日：2004-06-30
申请人： Xenogen Corporation
发明人： CABLE, Michael, D. , RICE, Bradley, W. , NILSON, David
IPC分类号： A61B5/05
CPC分类号： G01N21/76 , A61B5/0035 , A61B5/0059 , A61B5/0077 , A61B6/032 , A61B6/037 , A61B6/4417 , A61B6/5247 , A61B8/13 , A61B8/4416 , G01N21/6456 , G01N35/0099 , G01T1/1603 , G01T1/1648 , G01T1/2985
摘要： The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.

8. 发明公开

EP1478916A2 FLUORESCENCE ILLUMINATION ASSEMBLY FOR AN IMAGING APPARATUS 有权
标题翻译：光管照明系统及治理设备的图像
公开(公告)号：EP1478916A2
公开(公告)日：2004-11-24
申请号：EP03713577.9
申请日：2003-02-21
申请人： Xenogen Corporation
发明人： NILSON, David , RICE, Brad , TROY, Tamara
IPC分类号： G01N21/64 , G02B6/38
CPC分类号： G01N21/6456 , A01K1/031 , A61M16/104 , A61M16/18 , A61M16/202 , A61M2016/0039 , G01N2021/6463 , G01N2021/6484
摘要： A fluorescence imaging assembly including an imaging apparatus having an enclosure wall defining a view port into a light-tight imaging compartment thereof. A specimen platform is positioned in the imaging compartment having a support surface facing toward the view port. An illumination assembly includes a light source and a frame disposed in the imaging compartment. The illumination assembly is positioned proximate to and substantially peripherally encircling the view port. A bundle of fiber optic strands extends into the imaging compartment wherein proximal ends of the strands are in optical communication with the light source and distal ends thereof terminate at the frame to emit a conical directional beam of light onto the specimen platform. The distal ends of the fiber optic strands are sufficiently spaced peripherally about the view port such that the plurality of directional beams collectively illuminate the specimen platform in a substantially uniform manner.

9. 发明公开

EP1409973A2 ABSOLUTE INTENSITY DETERMINATION FOR A LIGHT SOURCE IN LOW LEVEL LIGHT IMAGING SYSTEMS 有权
标题翻译：绝对强度测量为微光图象系统的光源
公开(公告)号：EP1409973A2
公开(公告)日：2004-04-21
申请号：EP02742268.2
申请日：2002-06-20
申请人： Xenogen Corporation
发明人： NELSON, Michael, Bo , RICE, Bradley , BATES, Brian, Roberts , BEEMAN, Barton, V. , CABLE, Michael, D.
IPC分类号： G01J1/42
CPC分类号： G01J1/08 , G01N21/278
摘要： The invention describes systems and methods to obtain and present imaging data in absolute units. The systems and methods convert relative image data produced by a camera to absolute light intensity data using a compensation factor. The compensation factor accommodates for hardware and specific imaging conditions in the imaging system that variably affect camera output. The present invention determines the compensation factor based on assessing the output of the camera against a known light source for a specific set of imaging conditions in the imaging system. The compensation factor is then stored in memory corresponding to the specific set of imaging conditions. Upon subsequent imaging with the set of imaging conditions, the corresponding compensation factor is called from memory and applied to the camera output. A compensation factor may be determined and stored for each hardware state and imaging condition available to the imaging system.

10. 发明公开

EP1402243A2 METHOD AND APPARATUS FOR DETERMINING TARGET DEPTH, BRIGHTNESS AND SIZE WITHIN A BODY REGION 有权
标题翻译：方法和设备的目标深度BRIGHT和规模于一体的检测
公开(公告)号：EP1402243A2
公开(公告)日：2004-03-31
申请号：EP02731879.9
申请日：2002-05-17
申请人： Xenogen Corporation
发明人： RICE, Bradley, W. , STEARNS, Daniel, G. , TROY, Tamara, L.
IPC分类号： G01N21/47 , G01N21/64
CPC分类号： G01N21/6456 , G01N21/4795 , G01N21/6428
摘要： A method of investigating the location and size of a light-emitting source in a subject is disclosed. In practicing the method, one first obtains a light intensity profile by measuring, from a first perspective with a photodetector device, photons which (i) originate from the light-emitting source, (ii) travel through turbid biological tissue of the subject, and (iii) are emitted from a first surface region of interest of the subject. The light-intensity profile is matched against with a parameter-based biophotonic function, to estimate function parameters such as depth and size. The parameters so determined are refined using data other than the first measured light intensity profile, to obtain an approximate depth and size of the source in the subject. Also disclosed is an apparatus for carrying out the method.

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