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1. 发明公开

EP3143131A4 ASSAYS AND COMPOUNDS TO TREAT KIDNEY DISEASES 审中-公开
标题翻译：测试VERBINDUNGEN ZUR BEHANDLUNG VON NIERENERKRANKUNGEN
公开(公告)号：EP3143131A4
公开(公告)日：2017-10-04
申请号：EP15792210
申请日：2015-05-08
申请人： UNIV RUSH MEDICAL CENTER
发明人： GUPTA VINEET , REISER JOCHEN
IPC分类号： C12N5/071 , C07D239/12 , C12Q1/68
CPC分类号： G01N33/502 , A61K31/352 , A61K31/4409 , A61K31/4418 , A61K31/472 , A61K31/4745 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/52 , A61K31/55 , C12N5/0686 , C12N2503/02 , G01N33/5023 , G01N33/5026 , G01N33/5032 , G01N2500/10 , G02B21/0028
摘要： Methods of treating kidney disease and protecting podocytes from injury are provided. Methods of screening agents for the treatment of kidney disease are also provided. In addition, methods of identifying structural or functional defects in a patient's podocytes and methods of identifying kidney disease causing agents in a patient's biological sample are also provided.
摘要翻译：提供了治疗肾病和保护足细胞免受损伤的方法。还提供了用于治疗肾病的筛选剂的方法。此外，还提供了鉴定患者足细胞中的结构或功能缺陷的方法以及鉴定患者生物样品中的肾病致病因子的方法。

2. 发明公开

EP2217945A4 SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) SYSTEM FOR CARDIAC IMAGING 无效
标题翻译：电化学计算机 SPECT系统FÜRDIE HERZBILDGEBUNG
公开(公告)号：EP2217945A4
公开(公告)日：2017-03-01
申请号：EP08754595
申请日：2008-05-21
申请人： UNIV RUSH MEDICAL CENTER
发明人： CHANG WEI
IPC分类号： G01T1/166 , G01T1/164
CPC分类号： G01T1/1642 , A61B6/037 , G01T1/1648

3. 发明公开

EP2970871A4 PSEUDOMONAS EXOTOXINS FOR CANCER TREATMENT 审中-公开
标题翻译：假单胞菌外毒素用于癌症治疗
公开(公告)号：EP2970871A4
公开(公告)日：2016-08-31
申请号：EP14768741
申请日：2014-03-10
申请人： UNIV RUSH MEDICAL CENTER
发明人： KAUFMAN HOWARD , RUBY CARL , SHAFIKHANI SASHA
IPC分类号： C12N1/21 , A61P35/00
CPC分类号： C12N15/86 , A61K38/164 , A61K38/45 , A61K45/06 , C07K14/21 , C12N9/1048 , C12N2710/24143

4. 发明公开

EP1841463A4 METHODS AND COMPOSITIONS FOR TREATING, INHIBITING AND REVERSING DISORDERS OF THE INTERVERTEBRAL DISC 有权
标题翻译：方法和组合物用于治疗，抑制和腰椎疾患倒车
公开(公告)号：EP1841463A4
公开(公告)日：2008-08-27
申请号：EP06733663
申请日：2006-01-11
申请人： UNIV RUSH MEDICAL CENTER , ANGES MG INC
发明人： MASUDA KOICHI , GEMBA TAKEFUMI
IPC分类号： C12N15/00 , A61K48/00 , C07H21/04 , C12N15/63
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/315

5. 发明公开

EP1737435A4 FLUID COMPOSITION USED TO SIMULATE HUMAN SYNOVIAL FLUID 审中-公开
标题翻译：液体组成仿真人体滑液
公开(公告)号：EP1737435A4
公开(公告)日：2008-06-11
申请号：EP05713464
申请日：2005-02-11
申请人： UNIV RUSH MEDICAL CENTER
发明人： SCHWENKE THORSTEN
IPC分类号： A61K35/16 , A61K31/00 , A61P43/00
CPC分类号： A61K35/16 , A61K31/195 , A61K31/7034 , A61K2300/00
摘要： An artificial synovial fluid comprising a serum, a chelator, and a buffer is provided. In particular embodiments, the artificial synovial fluid may further comprise an antibiotic. The artificial synovial fluid is generally used in tribological testing of medical device implants such as artificial joints. Methods of using and making the artificial synovial fluid are also provided.

6. 发明公开

EP3194025A4 METHODS FOR PREVENTING OR TREATING OSTEOARTHRITIS 无效
公开(公告)号：EP3194025A4
公开(公告)日：2018-05-23
申请号：EP15842375
申请日：2015-09-14
申请人： UNIV RUSH MEDICAL CENTER
发明人： CHAN DEVA , LI JUN , PLAAS ANNA H K , PREDESCU DANIEL , SANDY JOHN D
IPC分类号： A61K31/4412 , A61K31/196 , A61K31/235 , A61K31/4439 , A61K31/506 , A61K31/52 , A61K31/551 , A61K39/00 , A61P19/02
CPC分类号： A61K31/4375 , A61K31/192 , A61K31/196 , A61K31/4412 , A61K31/4439 , A61K31/52 , A61K31/55 , A61K31/551 , A61K2123/00
摘要： One aspect of the invention provides a method for treating or preventing the development of osteoarthritis by administering to a subject in need of such treatment a composition including a therapeutically effective amount of an anti-fibrotic agent. In various embodiments, the anti-fibrotic agent is 5-methyl-1-phenylpyridin-2-one, tranilast, gamma-glutamyl transpeptidase inhibitor, fasudil, CC-930, T-5524, rosiglitazone, tocilizumab, E5564, TAK-242, GKT136901 or bosentan.

7. 发明公开

EP3220906A4 COMPOSITIONS AND METHODS FOR TREATING LYSOSOMAL DISORDERS 有权
公开(公告)号：EP3220906A4
公开(公告)日：2018-04-25
申请号：EP15861122
申请日：2015-11-16
申请人： UNIV RUSH MEDICAL CENTER
发明人： PAHAN KALIPADA
IPC分类号： A61K31/19 , A61K31/07 , A61K31/192 , A61K31/203 , A61K31/216 , A61K31/22 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/48 , A61K31/505 , A61K31/616 , A61K45/06 , A61P25/28
CPC分类号： A61K31/616 , A61K31/07 , A61K31/192 , A61K31/203 , A61K31/216 , A61K31/22 , A61K31/222 , A61K31/366 , A61K31/40 , A61K31/404 , A61K31/47 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： One aspect of the invention provides a method for treatment of a lysosomal storage disorder. The method may include administering to a subject in need of such treatment a composition including a therapeutically effective amount of an agent that mediates upregulation of Transcription Factor EB. In one embodiment, the composition includes a fibrate, such as gemfibrozil or fenofibrate. In another embodiment, the composition also includes all-trans retinoic acid or vitamin A.

8. 发明公开

EP3183206A4 FOOD/BEVERAGE VENDING MACHINE WITH ADJUSTABLE DELIVERY DELAYS 审中-公开
公开(公告)号：EP3183206A4
公开(公告)日：2018-01-10
申请号：EP15833276
申请日：2015-08-20
申请人： UNIV RUSH MEDICAL CENTER
发明人： APPELHANS BRADLEY M
IPC分类号： B67D1/08 , G07F9/00 , G07F9/02 , G07F11/16 , G07F13/06 , G07F17/00
CPC分类号： G07F17/0021 , G07F9/006 , G07F9/02 , G07F9/023 , G07F11/16 , G07F13/065 , G07F17/0064
摘要： A method and system for encouraging the selection of healthy products with a vending machine are provided. The method includes providing a vending machine that displays an inventory of products. Each product of the inventory of products includes a dispensing countdown time displayed on the vending machine. The method also includes receiving a first customer selection of a first product from the inventory of products, where the first product has a first dispensing countdown time. Additionally, the method includes actuating a countdown timer to count down to zero seconds from the first dispensing countdown time. The method also includes dispensing the first product once the countdown timer reaches zero seconds. The first product is only dispensed if a customer does not select a second product having a second dispensing countdown time before the first dispensing countdown time counts down to zero seconds.

9. 发明公开

EP2748608A4 LUNG CANCER TESTS 无效
标题翻译：肺癌试验
公开(公告)号：EP2748608A4
公开(公告)日：2016-07-20
申请号：EP11835150
申请日：2011-10-20
申请人： UNIV RUSH MEDICAL CENTER
发明人： BORGIA JEFFREY A
IPC分类号： G01N33/574 , C12Q1/68 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6884 , C12Q1/6886 , C12Q2600/158 , G01N33/57423

10. 发明公开

EP3080299A4 BIOMARKERS OF RAPID PROGRESSION IN ADVANCED NON-SMALL CELL LUNG CANCER 有权
标题翻译： BIOMARKERFÜRSCHNELLES FORTSCHREITEN VON ERWEITERTEM NICHT-KLEINZELLIGEM LUNGENKREBS
公开(公告)号：EP3080299A4
公开(公告)日：2017-06-21
申请号：EP14869355
申请日：2014-12-08
申请人： UNIV RUSH MEDICAL CENTER
发明人： BORGIA JEFFREY A , BASU SANJIB
IPC分类号： G01N33/574
CPC分类号： G01N33/57423
摘要： Methods and kits for identifying rapidly progressing lung cancer in a subject are provided. The method includes obtaining a biological sample from the subject and assaying a level of a biomarker in a biomarker panel in the biological sample where the panel includes at least one biomarker selected from Table I or Table II. The method further includes determining with the subject is treatment naïve or has received at least one treatment; and comparing the level of the biomarker in the subject's sample to a cutoff value listed in Table I for treatment naïve subjects or Table II for previously treated subjects. The method further includes determining whether the subject's level is above or below the cutoff value to determine whether the subject has rapidly progressing lung cancer.
摘要翻译：提供了用于鉴定受试者中快速进展的肺癌的方法和试剂盒。该方法包括获得来自受试者的生物样品并测定生物样品中生物标志物组中的标志物的水平，其中该组包括选自表I或表II的至少一种生物标志物。该方法进一步包括确定对象未接受治疗或已接受至少一种治疗; 并将受试者样品中的生物标志物的水平与表I中针对治疗初始受试者或表II针对之前治疗的受试者列出的截断值进行比较。该方法还包括确定受试者的水平是高于还是低于截止值以确定受试者是否具有快速进展的肺癌。

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