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    • 8. 发明公开
    • COMPOSITION AND METHODS FOR TETHERING BIOACTIVE PEPTIDES TO METAL OXIDE SURFACES
    • 用于将生物活性肽与金属氧化物表面接合的组合物和方法
    • EP3166553A1
    • 2017-05-17
    • EP15818436.6
    • 2015-07-13
    • The University of Akron
    • BECKER, MatthewTANG, Wen
    • A61F13/00A61K38/00A61K38/18
    • A61K47/10C07K7/08C07K14/51
    • In various aspects, embodiments of the present invention are directed to a series of multivalent dendrons containing a bioactive peptide domain and surface-binding catechol domains. In some embodiments, these multivalent dendrons were obtained through solid phase synthesis and have a strong binding affinity to metal oxide surfaces such as, TiO2, ZrO2, CeO2, and Fe3O4, SiO2, as well as other inorganic surfaces such as hydroxyapatite, silver, fluorapatite, calcium carbonate and gold. These catechol-bearing dendrons provide a fast and efficient method to functionalize a wide range of inorganic materials with bioactive peptides and have the potential to be used in coating orthopaedic implants and fixation devices.
    • 在各个方面,本发明的实施方案涉及一系列含有生物活性肽结构域和表面结合儿茶酚结构域的多价树突。 在一些实施方式中,这些多价树枝状结晶通过固相合成获得并且对金属氧化物表面如TiO 2,ZrO 2,CeO 2和Fe 3 O 4,SiO 2以及其他无机表面例如羟基磷灰石,银,氟磷灰石 ,碳酸钙和金。 这些含有儿茶酚的树突提供了一种快速和有效的方法来使用生物活性肽功能化各种无机材料,并且可能用于涂覆整形植入物和固定装置。