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1. 发明授权

EP3342415B1 STRUCTURE AND USE OF 5' PHOSPHATE OLIGONUCLEOTIDES 有权
公开(公告)号：EP3342415B1
公开(公告)日：2022-01-26
申请号：EP17194752.6
申请日：2007-08-08
发明人： HORNUNG, Veit , HARTMANN, Gunther
IPC分类号： A61K31/7115 , A61P37/04 , A61P31/12 , A61P31/04 , A61P35/00 , A61P37/06 , A61P37/08 , C07H21/00 , C12N15/117 , A61K45/06 , A61K31/7105 , A61P25/00 , A61P31/00 , A61P33/00 , A61P37/00 , A61P37/02 , A61P43/00

2. 发明公开

EP3723767A1 6'-SIALYLLACTOSE FOR USE IN THE TREATMENT OF HEARING LOSS 审中-公开
公开(公告)号：EP3723767A1
公开(公告)日：2020-10-21
申请号：EP18815669.9
申请日：2018-12-07
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn
发明人： NEUMANN, Harald , KLAUS, Christine
IPC分类号： A61K31/7016 , A61K31/702 , A23L33/125 , A61P27/16

3. 发明授权

EP3045536B1 5' TRIPHOSPHATE OLIGONUCLEOTIDE WITH BLUNT END AND USES THEREOF 有权
公开(公告)号：EP3045536B1
公开(公告)日：2019-07-10
申请号：EP15190442.2
申请日：2008-05-21
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn
发明人： Hartmann, Gunther , Schlee, Martin
IPC分类号： C12N15/117 , C07H21/00 , A61K31/7105 , A61K31/7115 , A61K31/713

4. 发明授权

EP2762052B1 A method of operating a household appliance, and a household appliance, in particular a dishwasher 审中-公开
公开(公告)号：EP2762052B1
公开(公告)日：2018-12-26
申请号：EP13153747.4
申请日：2013-02-01
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn
发明人： Stamminger, Rainer , Boeker, Peter , Gilleßen, Claudia
IPC分类号： A47L15/42 , G01N33/00
CPC分类号： A47L15/4276 , A47L2401/30 , A47L2501/26 , A47L2501/34 , D06F35/008 , G01N33/0031 , G01N33/004
摘要： In a method of operating a household appliance, in particular a dishwasher, the presence of (unpleasant) odours due to decomposition of organic materials is determined by using two different sensors, responsive to different chemical substances occurring upon decomposition of organic material, wherein the sensors do in particular apply different working principles of measurement (e.g. different physical principles). A first pre-determined criterion (S12) is applied to first measurement signals obtained (S10) from the first sensor, and a second pre-determined criterion (S18) is applied to measurement signals (12, 12') obtained (S16) by the second sensor. If both criteria are fulfilled, this is an indication of unpleasant odours, and a signal is output (an action is initiated, S24).

5. 发明公开

EP3382034A1 GENE EXPRESSION ANALYSIS BY MEANS OF GENERATING A CIRCULARIZED SINGLE STRANDED CDNA LIBRARY 审中-公开
公开(公告)号：EP3382034A1
公开(公告)日：2018-10-03
申请号：EP17164230.9
申请日：2017-03-31
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn
发明人： HORNUNG, Veit , SCHMID-BURGK, Jonathan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q2521/107 , C12Q2525/191 , C12Q2525/307 , C12Q2527/137
摘要： The present invention is directed to methods and kits for analysis of nucleic acid samples. The methods of the invention comprise the steps of a) providing nucleic acid; b) transcribing the nucleic acid to form single-stranded DNA having at its 3'-end a ddATP, ddCTP, ddGTP, or ddTTP nucleotide or a dATP, dCTP, dGTP, or dTTP nucleotide comprising a modified 3'-moiety by contacting the nucleic acid with a DNA polymerase, a primer and a mixture of (a) dNTPs and (b) at least one ddNTP or at least one dNTP comprising the modified 3'-moiety under conditions that allow the generation of the DNA, wherein the primer comprises a target-complementary region and optionally wherein the amounts of dNTPs are essentially equimolar; c) degrading the non-elongated primer; d) optionally purifying the DNA; e) contacting the DNA with a 3' to 5' exonuclease to remove the ddATP, ddCTP, ddGTP or ddTTP nucleotide or the dATP, dCTP, dGTP, or dTTP nucleotide comprising the modified 3'-moiety; f)i) contacting the DNA with a ssDNA ligase to circularize the DNA; or f)ii) contacting the DNA with (1) a linker molecule comprising a nucleic acid portion; and (2) a DNA ligase to ligate the DNA to the linker molecule; g) optionally amplifying the DNA; h) optionally quantifying the DNA by qPCR; and i) sequencing the DNA. The kits comprise the components necessary to perform the methods of the invention.

6. 发明公开

EP3360549A1 SMALL MOLECULE THERAPEUTICS FOR TREATING METACHROMATIC LEUKODYSTROPHY 审中-公开
公开(公告)号：EP3360549A1
公开(公告)日：2018-08-15
申请号：EP17156089.9
申请日：2017-02-14
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn
发明人： Gieselmann, Volkmar , König, Gabriele Maria , Eckhardt, Matthias , Hufendiek, Peter , Zech, Isabell
IPC分类号： A61K31/34 , A61K31/7042 , A61P25/28
CPC分类号： A61K31/7042 , A61K31/34
摘要： The present invention pertains to a novel treatment of pathologies caused by an increased synthesis or accumulation of sulfolipids such as sulfatide. The invention provides compounds isolated from Epicoccum nigrum strains 749 and 800, which were identified as inhibitors of Sulfotransferase, an enzyme catalyzing the generation of sulfatide. Sulfatides accumulate in the central nervous system (CNS) and lead to a degeneration of white matter. The present invention therefore preferably provides new therapeutic options for treating such diseases by administration of Epicoccum nigrum derived compounds. Further provided are pharmaceutical compositions comprising these compounds.

7. 发明公开

EP3356549A1 EXOSOMAL MICRORNA IN SERUM AS AN INDICATOR FOR THE ACTIVATION OF BROWN AND BEIGE FAT TISSUE (BAT) 有权
公开(公告)号：EP3356549A1
公开(公告)日：2018-08-08
申请号：EP16775185.8
申请日：2016-09-27
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn , Maastricht University
发明人： PFEIFER, Alexander , BUYEL, Joschka , CHEN, Yong , VAN MARKEN LICHTENBELT, Wouter
IPC分类号： C12Q1/68
摘要： The present invention relates to methods for detecting activation of a brown/beige fat cell or brown/beige adipose tissue (BAT) in a biological sample taken from a mammal to be diagnosed, comprising measuring the amount of miR-92 in said sample. The invention furthermore relates to diagnostic and clinical applications of the methods of the invention.

8. 发明公开

EP3172326A1 IMPROVED STRAINS OF AGROBACTERIUM TUMEFACIENS FOR TRANSFERRING DNA INTO PLANTS 审中-公开
标题翻译：农杆菌转化菌株用于将DNA转入植物的改良菌株
公开(公告)号：EP3172326A1
公开(公告)日：2017-05-31
申请号：EP15741171.1
申请日：2015-07-21
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn
发明人： ÜLKER, Bekir , BERSON, Tobias
IPC分类号： C12N15/82
CPC分类号： C12N15/743 , C12N15/8205
摘要： The present invention relates to Agrobacterium tumefaciens strains that comprise at least one deletion/mutation in a sequence selected from the group of IS426 copy I, IS426 copy II, the OriT -like sequence, and the border-like sequences, and their uses in safer and improved transformation procedures for cells.
摘要翻译：本发明涉及根癌土壤杆菌菌株，其在选自IS426拷贝I，IS426拷贝II，OriT样序列和边界样序列的序列中包含至少一个缺失/突变，以及它们在更安全并改进了细胞的转化程序。

9. 发明公开

EP3163302A1 SAMHD1 MODULATION FOR TREATING RESISTANCE TO CANCER THERAPY 审中-公开
标题翻译： SAMHD1-MODULATION ZUR BEHANDLUNG VON RESISTENZ GEGEN KREBSTHERAPIE
公开(公告)号：EP3163302A1
公开(公告)日：2017-05-03
申请号：EP15192494
申请日：2015-11-02
申请人： JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN , RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITÄT BONN
发明人： KEPPLER OLIVER TILL , CINATL JINDRICH , SCHNEIDER CONSTANZE , BALDAUF HANNA-MARI , SCHWARZ SARAH-MARIE , SERVE HUBERT , OELLERICH THOMAS , GEISSLINGER GERD , HORNUNG VEIT
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C12N2710/24132 , G01N2800/52
摘要： The present invention pertains to novel treatments for cancer diseases. Treatment of cancers with nucleoside analogs (NA), which specifically inhibit rapidly dividing cells, may face preexisting NA resistance or development of resistant cancer cells resulting in poor clinical prognosis. Treatment of cancers with oncolytic herpes simplex viruses (HSV) may face preexisting resistance or development of resistant cancer cells resulting in poor clinical prognosis. The invention overcomes chemotherapy resistance or resistance to oncolytic HSV by providing methods for detecting the resistance in a cancer disease based on the expression of SAM domain and HD domain-containing protein 1 (SAMHD1) in cancer cells. Furthermore provided are treatment options addressing the chemotherapy resistance such as a combination of a SAMHD1 inhibitor with a NA. Moreover, provided are treatment options addressing the resistance to oncolytic HSV such as a combination of a SAMHD1 inhibitor or depletion of SAMHD1 with an oncolytic HSV. The invention provides new medicines and companion diagnostics supporting clinical treatment decisions.
摘要翻译：本发明涉及癌症疾病的新型治疗。用特异性抑制快速分裂细胞的核苷类似物（NA）治疗癌症可能面临预先存在的NA耐药或发展抗性癌细胞，导致临床预后不良。用溶瘤性单纯疱疹病毒（HSV）治疗癌症可能面临预先存在的抗性或发展抗性癌细胞，导致临床预后不良。本发明通过提供基于SAM结构域和含HD结构域的蛋白质1（SAMHD1）在癌细胞中的表达来检测癌症疾病中的抗性的方法来克服化疗耐受性或对溶瘤性HSV的抗性。此外提供了解决化疗耐药性的治疗选择，例如SAMHD1抑制剂与NA的组合。此外，提供了治疗选择，其解决对溶瘤HSV的抗性，例如SAMHD1抑制剂或SAMHD1消耗与溶瘤HSV的组合。本发明提供支持临床治疗决定的新药物和伴侣诊断。

10. 发明公开

EP3147370A1 EXOSOMAL MICRORNA IN SERUM AS AN INDICATOR FOR THE ACTIVATION OF BROWN AND BEIGE FAT TISSUE (BAT) 审中-公开
标题翻译：血清ALS INDIKATOR中的EXOSOMALE MICRORNAFÜRAKTIVIERUNG DES BRAUN UND BEIGEN-FETTGEWEBES（BAT）
公开(公告)号：EP3147370A1
公开(公告)日：2017-03-29
申请号：EP15187038.3
申请日：2015-09-28
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn , Maastricht University
发明人： PFEIFER, Alexander , BUYEL, Joschka , van Marken Lichtenbelt, Wouter , CHEN, Yong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , A61K31/36 , C12Q1/6806 , C12Q1/686 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to methods for detecting activation of a brown/beige fat cell or brown/beige adipose tissue (BAT) in a biological sample taken from a mammal to be diagnosed, comprising measuring the amount of miR-92 in said sample. The invention furthermore relates to diagnostic and clinical applications of the methods of the invention.
摘要翻译：本发明涉及用于检测取自要诊断的哺乳动物的生物样品中的棕色/米色脂肪细胞或棕色/米色脂肪组织（BAT）的活化方法，包括测量所述样品中miR-92的量。本发明还涉及本发明方法的诊断和临床应用。

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