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1. 发明授权

EP3582826B1 DRUG INFUSION DEVICE 有权转让
公开(公告)号：EP3582826B1
公开(公告)日：2022-10-19
申请号：EP18707579.1
申请日：2018-02-14
发明人： HOCHMAN, Mark, N. , INKROTE, Nathan, J. , BOYER, Robert, D. , MULLINS, Maureen, A.
IPC分类号： A61M5/145 , A61M5/42

2. 发明授权

EP1670522B1 DRUG INFUSION DEVICE WITH TISSUE IDENTIFICATION USING PRESSURE SENSING 有权
标题翻译：利用组织鉴定药物输注装置使用压力检测
公开(公告)号：EP1670522B1
公开(公告)日：2009-11-11
申请号：EP04783761.2
申请日：2004-09-13
申请人： Milestone Scientific, Inc.
发明人： HOCHMAN, Mark, N.
IPC分类号： A61M37/00 , A61M5/145 , A61M5/48
CPC分类号： A61M5/1456 , A61B17/3478 , A61B2090/064 , A61M5/16854 , A61M2205/3344
摘要： An automatic injection device includes a drive mechanism and a sensor used to determine an internal characteristic such as a force or internal pressure generated during an injection process. This characteristic is then used as a control parameter by a microprocessor or controller to determine the exit pressure of the fluid expelled by the device. This exit pressure is then used to identify the kind of tissue in which the injection is being introduced.

3. 发明公开

EP3618917A1 METHOD AND APPARATUS FOR PERFORMING A PERIPHERAL NERVE BLOCK 有权转让
公开(公告)号：EP3618917A1
公开(公告)日：2020-03-11
申请号：EP18729820.3
申请日：2018-05-04
申请人： Milestone Scientific, Inc.
发明人： HOCHMAN, Mark, N. , CHOQUET, Olivier
IPC分类号： A61N1/05 , A61N1/36 , A61M5/48 , A61M5/168

4. 发明公开

EP3419501A1 DEVICE AND METHOD FOR IDENTIFICATION OF A TARGET REGION 审中-公开
公开(公告)号：EP3419501A1
公开(公告)日：2019-01-02
申请号：EP16819735.8
申请日：2016-11-28
申请人： Milestone Scientific, Inc.
发明人： HOCHMAN, Mark N.
IPC分类号： A61B5/00 , A61B17/34

5. 发明授权

EP3009164B1 COMPUTER CONTROLLED DRUG DELIVERY SYSTEM WITH DYNAMIC PRESSURE SENSING 有权
标题翻译：具有动态压力感测的电脑控制药物输送系统
公开(公告)号：EP3009164B1
公开(公告)日：2017-08-02
申请号：EP15192531.0
申请日：2007-04-19
申请人： Milestone Scientific Inc.
发明人： HOCHMAN, Mark
IPC分类号： A61M31/00 , A61M5/48
CPC分类号： A61M5/48 , A61C1/0015 , A61C19/08 , A61M5/24 , A61M5/46 , A61M2005/2407 , A61M2005/2488 , A61M2205/3344 , A61M2205/581 , A61M2205/582

6. 发明公开

EP3009164A1 COMPUTER CONTROLLED DRUG DELIVERY SYSTEM WITH DYNAMIC PRESSURE SENSING 有权
标题翻译：麻醉药物研究与开发研究中心动物研究所DRUCKERFASSUNG ARZNEIMITTELABGABESYSTEM MIT DYNAMISCHER DRUCKERFASSUNG
公开(公告)号：EP3009164A1
公开(公告)日：2016-04-20
申请号：EP15192531.0
申请日：2007-04-19
申请人： Milestone Scientific Inc.
发明人： HOCHMAN, Mark
IPC分类号： A61M31/00 , A61M5/48
CPC分类号： A61M5/48 , A61C1/0015 , A61C19/08 , A61M5/24 , A61M5/46 , A61M2005/2407 , A61M2005/2488 , A61M2205/3344 , A61M2205/581 , A61M2205/582
摘要： An apparatus and method for a controlled injection of a drug into a selected tissue of a subject by a practitioner, uses a drive unit for supplying the drug and a handpiece to be held and guided by the practitioner, connected to the drive unit for receiving the drug. The handpiece holds an injection needle to be inserted into the selected tissue by the practitioner for passing the drug to the selected tissue at an instantaneous and absolute pressure that varies as a function of the type of tissue and the placement of the needle. A pressure sensor senses this instantaneous pressure and a feedback mechanism supplies a perceptible audible, visual or other signal to the practitioner that indicates when the instantaneous pressure has reached a minimum desired pressure, the practitioner thus being informed that the correct placement and dosage has been attained.
摘要翻译：用于由从业者将药物受控地注射到被选择的组织中的装置和方法使用连接到驱动单元的用于供应药物的驱动单元和由从业者保持和引导的手持件，用于接收药物。所述手持件保持注射针，以由所述从业者将所述药物插入所选择的组织中，所述注射针以随所述组织的类型和所述针的位置而变化的瞬时绝对压力将所述药物递送至所选择的组织。压力传感器感测到这种瞬时压力，并且反馈机构向实践者提供可察觉的可听见的视觉或其他信号，该信号指示瞬时压力何时达到最小期望压力，从业者被告知正确的放置和剂量已经达到。

7. 发明公开

EP1915190A2 DRUG INFUSION DEVICE FOR NEURAL AXIAL AND PERIPHERAL NERVE TISSUE IDENTIFICATION USING EXIT PRESSURE SENSING 审中-公开
标题翻译：于检测药物输注装置和周围神经的神经AXLE面料具有输出压力检测
公开(公告)号：EP1915190A2
公开(公告)日：2008-04-30
申请号：EP06788598.8
申请日：2006-07-26
申请人： Milestone Scientific, Inc.
发明人： HOCHMAN, Mark
IPC分类号： A61M31/00
CPC分类号： A61M5/1723 , A61M5/1456 , A61M5/16854 , A61M2205/332 , A61M2205/3344
摘要： An automatic injection device includes a drive mechanism and a sensor used determine an internal characteristic such as a force or internal pressure generated during an injection process. This characteristic is then used as a control parameter by a microprocessor or controller to determine the exit pressure of the fluid expelled by the device. This exit pressure is then used to identify the kind of tissue in which the injection being introduced.

8. 发明公开

EP3582826A1 DRUG INFUSION DEVICE 有权转让
公开(公告)号：EP3582826A1
公开(公告)日：2019-12-25
申请号：EP18707579.1
申请日：2018-02-14
申请人： Milestone Scientific, Inc.
发明人： HOCHMAN, Mark, N. , INKROTE, Nathan, J. , BOYER, Robert, D. , MULLINS, Maureen, A.
IPC分类号： A61M5/145 , A61M5/42

9. 发明公开

EP2869869A4 DRUG INFUSION WITH PRESSURE SENSING AND NON-CONTINUOUS FLOW WITH INDENTIFICATION OF AND INJECTION INTO FLUID-FILLED ANATOMIC SPACES 有权
标题翻译：药物输注压力传感及识别与充液解剖空间，在这种不连续的流动注射
公开(公告)号：EP2869869A4
公开(公告)日：2016-03-23
申请号：EP13813314
申请日：2013-06-11
申请人： MILESTONE SCIENTIFIC INC
发明人： HOCHMAN MARK N
IPC分类号： A61M5/00 , A61B5/00 , A61B5/03 , A61M5/168 , A61M19/00
CPC分类号： A61M5/168 , A61B5/032 , A61F9/0008 , A61M19/00 , A61M2205/581 , A61M2205/583
摘要： An automatic injection apparatus uses non-continuous fluid-flow of drugs to identify an intended injection site and includes a drive mechanism, a sensor and a controller for establishing fluid flow and pressure and preventing fluid flow until the pressure drops below a predetermined threshold. The pressure threshold is determined based on an internal pressure generated during an injection and more fluid will not flow until it drops below a predetermined pressure. An injection is performed to establish an initial pressure threshhold and then to stop the fluid flow into a patient until the pressure drops below a predetermined pressure which allows fluid flow to resume, thus identifying a fluid filled tissue space. The initial pressure threshold is used as a control parameter to a microprocessor below which controls the rate of injection. Fluid flows below certain pressures are also used to identify a specific location within the body during injections.
摘要翻译：自动注射装置使用的药物的非连续的流体流动，以确定在预期注射部位和包括驱动机构，一个传感器和用于建立流体流动和压力，并防止流体流，直到压力下降到低于预定阈值的控制器。基于对一个注入和多个流体不会流动，直到它下降到低于预定压力期间产生的内部压力的压力阈值被确定的开采。一种注射执行在初始压力门限，建立和然后停止流体流动到患者体内，直到压力下降到低于预定的压力，其允许流体流以恢复，从而识别一个充满液体的组织的空间。初始压力阈值被用作控制参数到低于其控制注入速率的微处理器。因此在下文中的某些压力流体流被用于在注射过程来识别所述主体内的特定位置。

10. 发明公开

EP2869869A1 DRUG INFUSION WITH PRESSURE SENSING AND NON-CONTINUOUS FLOW WITH INDENTIFICATION OF AND INJECTION INTO FLUID-FILLED ANATOMIC SPACES 有权
标题翻译：药物输注压力传感及识别与充液解剖空间，在这种不连续的流动注射
公开(公告)号：EP2869869A1
公开(公告)日：2015-05-13
申请号：EP13813314.5
申请日：2013-06-11
申请人： Milestone Scientific, Inc.
发明人： HOCHMAN, Mark, N.
IPC分类号： A61M5/00
CPC分类号： A61M5/168 , A61B5/032 , A61F9/0008 , A61M19/00 , A61M2205/581 , A61M2205/583 , G06F19/00 , G16H20/17
摘要： An automatic injection apparatus uses non-continuous fluid-flow of drugs to identify an intended injection site and includes a drive mechanism, a sensor and a controller for establishing fluid flow and pressure and preventing fluid flow until the pressure drops below a predetermined threshold. The pressure threshold is determined based on an internal pressure generated during an injection and more fluid will not flow until it drops below a predetermined pressure. An injection is performed to establish an initial pressure threshhold and then to stop the fluid flow into a patient until the pressure drops below a predetermined pressure which allows fluid flow to resume, thus identifying a fluid filled tissue space. The initial pressure threshold is used as a control parameter to a microprocessor below which controls the rate of injection. Fluid flows below certain pressures are also used to identify a specific location within the body during injections.

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