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1. 发明公开

EP2823065A1 METHODS AND COMPOSITIONS RELATING TO DIAGNOSING AND TREATING RECEPTOR TYROSINE KINASE RELATED CANCERS 审中-公开
标题翻译：方法和组合物与癌症有关的受体酪氨酸激酶的诊断与治疗
公开(公告)号：EP2823065A1
公开(公告)日：2015-01-14
申请号：EP13758525.3
申请日：2013-03-08
申请人： Insight Genetics, Inc.
发明人： HOUT, David , HANDSHOE, John
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： Disclosed are methods and compositions for detecting the presence of a cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR), real time polymerase chain reaction, and multiplex polymerase chain reaction techniques to detect fusions, over- expression, truncation, and nucleic acid variation of
RET and
DEPDC1 in cancers.

2. 发明公开

EP2823065A4 METHODS AND COMPOSITIONS RELATING TO DIAGNOSING AND TREATING RECEPTOR TYROSINE KINASE RELATED CANCERS 审中-公开
标题翻译：方法和组合物与癌症有关的受体酪氨酸激酶的诊断与治疗
公开(公告)号：EP2823065A4
公开(公告)日：2016-03-02
申请号：EP13758525
申请日：2013-03-08
申请人： INSIGHT GENETICS INC
发明人： HOUT DAVID , HANDSHOE JOHN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： Disclosed are methods and compositions for detecting the presence of a cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR), real time polymerase chain reaction, and multiplex polymerase chain reaction techniques to detect fusions, over-expression, truncation, and nucleic acid variation of RET and DEPDC1 in cancers.
摘要翻译：本发明公开了一种用于检测癌症的存在在受试者和离开唱的对于相同的治疗的功效的方法和组合物。盘游离缺失方法使用逆转录聚合酶链反应（RT-PCR），实时聚合酶链反应和多重聚合酶链式反应技术来检测融合体，过表达，截短，以及在癌症RET和DEPDC1核酸变异。

3. 发明公开

EP2432900A4 METHODS AND COMPOSITIONS RELATING TO FUSIONS OF ALK FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：与ALK融合有关的方法和组合物用于癌症的诊断和治疗
公开(公告)号：EP2432900A4
公开(公告)日：2012-11-21
申请号：EP10775673
申请日：2010-05-17
申请人： INSIGHT GENETICS INC
发明人： NICKOLS JOSH , DAHLHAUSER ERIC , HAUT DAVID , NORMAN KIM
IPC分类号： C12Q1/68 , C08B3/00 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Disclosed are methods and compositions for detecting the presence of an anaplastic lymphoma kinase (ALK) related cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR) and multiplex polymerase chain reaction techniques as well as Template Exchange Extension Reaction (TEER) to detect the presence of point mutations, truncations, or fusions of anaplastic lymphoma kinase (ALK).

4. 发明公开

EP2152915A2 METHODS OF SCREENING NUCLEIC ACIDS FOR SINGLE NUCLEOTIDE VARIATIONS 审中-公开
标题翻译：筛选单核苷酸变异的核酸的方法
公开(公告)号：EP2152915A2
公开(公告)日：2010-02-17
申请号：EP08754474.8
申请日：2008-05-14
申请人： Insight Genetics, Inc.
发明人： DAHLHAUSER, Eric, B.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6834 , C12Q2535/125 , C12Q2525/125 , C12Q2521/319 , C12Q2521/101
摘要： Disclosed are methods and compositions for detecting variation in nucleic acids. The disclosed method compares the sequence of a nucleic acid of interest with the sequence of a reference nucleic acid to sensitively identify variations between the sequence of a nucleic acid of interest and the sequence of a reference nucleic acid. The disclosed method generally involves excision and replacement of selected nucleotides in nucleic acid strands hybridized to other strands. In the method, if the excised nucleotide was mismatched with the nucleotide in the other, hybridized strand, then the replacement nucleotide will not be mismatched. If the excised nucleotide was not mismatched with the nucleotide in the other, hybridized strand, then the excised nucleotide is not replaced. This difference allows detection of variation in the nucleic acid of interest. In some forms of the method, by replacing excised nucleotides with nuclease-resistant nucleotides, strands in which excised nucleotides are replaced will be resistant to nuclease digestion while strands in which excised nucleotides are not replaced will be sensitive to nuclease digestion. By exposing the hybridizing nucleic acids to nuclease following replacement of excised nucleotides, the strands in which excised nucleotides are not replaced can be destroyed by the nuclease while strands in which excised nucleotides are replaced can be preserved. The remaining strands can then be detected and whether the strand survived nuclease digestion can be noted. Strands that survive nuclease digestion are indicative of the presence of variation in the nucleic acid of interest.
摘要翻译：公开了用于检测核酸变异的方法和组合物。所公开的方法将感兴趣的核酸的序列与参考核酸的序列进行比较以灵敏地鉴定感兴趣的核酸的序列与参考核酸的序列之间的变化。所公开的方法通常包括切除和置换与其他链杂交的核酸链中的选定核苷酸。在该方法中，如果切下的核苷酸与另一杂交链中的核苷酸错配，则替换的核苷酸不会错配。如果切除的核苷酸不与另一条杂交链中的核苷酸错配，则切除的核苷酸不被替换。这种差异允许检测感兴趣的核酸的变异。在该方法的一些形式中，通过用核酸酶抗性核苷酸置换被切除的核苷酸，其中被切除的核苷酸被置换的链将对核酸酶消化有抗性，而其中被切除的核苷酸不被置换的链将对核酸酶消化敏感。通过在交换的核苷酸置换后将杂交核酸暴露于核酸酶，其中被切除的核苷酸不被置换的链可被核酸酶破坏，而被置换的核苷酸置换的链可被保存。然后可以检测到剩余的链，并且可以注意到链是否存在核酸酶消化。存活核酸酶消化的链表明目标核酸存在变异。

5. 发明公开

EP2812451A4 METHODS AND COMPOSITIONS RELATING TO FUSIONS OF ROS1 FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：方法和组合物 - 关于ROS1兼并诊断和治疗癌症
公开(公告)号：EP2812451A4
公开(公告)日：2016-01-06
申请号：EP13746869
申请日：2013-02-08
申请人： INSIGHT GENETICS INC
发明人： HOUT DAVID , HANDSHOE JOHN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158

6. 发明公开

EP2812451A2 METHODS AND COMPOSITIONS RELATING TO FUSIONS OF ROS1 FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：方法和组合物 - 关于ROS1兼并诊断和治疗癌症
公开(公告)号：EP2812451A2
公开(公告)日：2014-12-17
申请号：EP13746869.0
申请日：2013-02-08
申请人： Insight Genetics, Inc.
发明人： HOUT, David , HANDSHOE, John
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： Disclosed are methods and compositions for detecting the presence of a cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use real-time polymerase chain reaction, reverse transcription polymerase chain reaction (RT-PCR), in situ hybridization and/or multiplex polymerase chain reaction techniques to detect the presence of point mutations, truncations, or fusions of ROS1.

7. 发明授权

EP1105540B1 METHODS OF SCREENING NUCLEIC ACIDS FOR NUCLEOTIDE VARIATIONS 有权
标题翻译：方法，用于核酸的核苷酸变异的筛选
公开(公告)号：EP1105540B1
公开(公告)日：2013-03-20
申请号：EP99945120.6
申请日：1999-08-18
申请人： Insight Genetics, Inc.
发明人： DAHLHAUSER, Paul, A.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6869 , C12Q2525/186 , C12Q2521/319 , C12Q2565/125 , C12Q2563/131 , C12Q2535/125 , C12Q2535/101

8. 发明公开

EP2432900A2 METHODS AND COMPOSITIONS RELATING TO FUSIONS OF ALK FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：有关兼并ALK方法和组合物诊断和治疗癌症
公开(公告)号：EP2432900A2
公开(公告)日：2012-03-28
申请号：EP10775673.6
申请日：2010-05-17
申请人： Insight Genetics, Inc.
发明人： NICKOLS, Josh , DAHLHAUSER, Eric , HAUT, David , NORMAN, Kim
IPC分类号： C12Q1/68 , C12P19/34 , C08B3/00
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16
摘要： Disclosed are methods and compositions for detecting the presence of an anaplastic lymphoma kinase (ALK) related cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR) and multiplex polymerase chain reaction techniques as well as Template Exchange Extension Reaction (TEER) to detect the presence of point mutations, truncations, or fusions of anaplastic lymphoma kinase (ALK).

9. 发明公开

EP3137630A4 METHODS AND COMPOSITIONS RELATING TO FUSIONS OF ALK FOR DIAGNOSING AND TREATING CANCER 审中-公开
公开(公告)号：EP3137630A4
公开(公告)日：2017-11-29
申请号：EP15785965
申请日：2015-04-28
申请人： INSIGHT GENETICS INC
发明人： HOUT DAVID R , SKELTON RACHEL , HANDSHOE JOHN , LAWRENCE KASEY , SCHWEITZER BROCK
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要： Disclosed are methods and kits for detecting the presence of a cancer in a subject and assessing the efficacy of treatments for the same. The disclosed method use reverse transcription polymerase chain reaction (RT-PCR) techniques to detect the presence of point mutations, truncations, or fusions of anaplastic lymphoma kinase.

10. 发明公开

EP3137630A2 METHODS AND COMPOSITIONS RELATING TO FUSIONS OF ALK FOR DIAGNOSING AND TREATING CANCER 审中-公开
标题翻译：有关兼并ALK方法和组合物诊断和治疗癌症
公开(公告)号：EP3137630A2
公开(公告)日：2017-03-08
申请号：EP15785965.3
申请日：2015-04-28
申请人： Insight Genetics, Inc.
发明人： HOUT, David R. , SKELTON, Rachel , HANDSHOE,John , LAWRENCE, Kasey , SCHWEITZER, Brock
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158

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