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1. 发明公开

EP2070919A1 SPIROQUINONE COMPOUND AND PHARMACEUTICAL COMPOSITION 有权
标题翻译： SPIROCHINONVERBINDUNG UND PHARMAZEUTISCHE ZUSAMMENSETZUNG
公开(公告)号：EP2070919A1
公开(公告)日：2009-06-17
申请号：EP07832277.3
申请日：2007-11-21
申请人： Hykes Laboratories LLC
发明人： YOKOYAMA, Shinji , KANAZAWA, Hashime , AOTSUKA, Tomoji
IPC分类号： C07D339/06 , A61K31/381 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/16 , A61P9/00 , A61P9/10 , A61P13/12 , A61P19/08 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： C07D339/06
摘要： A novel spiroquinone derivative having a high ABCA1 stabilization effect and being useful for prophylactic and/or therapeutic agents for various diseases developing hypo-high density lipoproteinemia is obtained. The novel spiroquinone derivative is a compound represented by the following formula:

wherein R 1a , R 1b , R 1c and R each represents a hydrogen atom, a halogen atom, an alkyl group which may have a substituent, or an alkoxy group which may have a substituent, and R 2a and R 2b each represents a hydrogen atom, or an alkyl group which may have a substituent (e.g., a carboxyl group, an alkoxycarbonyl group, a carbamoyl group, and an N-substituted carbamoyl group), the groups R 2a and R 2b may bond together to form a hydrocarbon ring with an adjacent carbon atom, provided that compounds in which all of the groups R 1a , R 1b , R 1c and R 1d are t-butyl groups, and both of the groups R 2a and R 2b are hydrogen atoms or both of the groups R 2a and R 2b are methyl groups are excluded; or a pharmacologically acceptable salt thereof.
摘要翻译：获得具有高ABCA1稳定作用并可用于预防和/或治疗各种发展低密度脂蛋白血症的疾病的新型螺醌衍生物。新的螺醌衍生物是下式表示的化合物：其中R 1a，R 1b，R 1c和R各自表示氢原子，卤素原子，可以具有取代基的烷基或可具有取代基的烷氧基取代基，R 2a和R 2b各自表示氢原子或可以具有取代基的烷基（例如羧基，烷氧基羰基，氨基甲酰基和N-取代氨基甲酰基），基团 R 2a和R 2b可以键合在一起形成具有相邻碳原子的烃环，条件是其中所有基团R 1a，R 1b，R 1c和R 1d都是叔丁基的化合物，以及两个基团 R 2a和R 2b是氢原子，或者R 2a和R 2b基团都是甲基; 或其药理学上可接受的盐。

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