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1. 发明授权

EP3517528B1 ACID ADDITION SALTS OF BENZIMIDAZOLE DERIVATIVE 有权转让
公开(公告)号：EP3517528B1
公开(公告)日：2021-09-01
申请号：EP17853411.1
申请日：2017-09-20
发明人： KIM, Eun Sun , LEE, Min Kyoung , LEE, Sung Ah , CHOI, Kwang Do , KIM, Jae Sun , YOO, Hyung Chul
IPC分类号： C07D235/06 , C07D405/12 , A61K31/4184 , A61K31/352 , A61K9/14 , A61K9/16 , A61K9/20

2. 发明授权

EP3320903B1 PHARMACEUTICAL COMPOSITION CONTAINING AMLODIPINE, VALSARTAN, AND ROSUVASTATIN 有权转让
公开(公告)号：EP3320903B1
公开(公告)日：2021-05-19
申请号：EP16821693.5
申请日：2016-07-08
发明人： JUNG, Yoon Seok , LYU, Chun Seon , OH, Tack Oon , JEON, Eun Kyung , HAN, Sung Kyun , RYU, Chae Young
IPC分类号： A61K31/4422 , A61K31/41 , A61K31/505 , A61K9/20 , A61K9/24

3. 发明公开

EP3654987A1 USE OF AMINOALKYLBENZOTHIAZEPINE DERIVATIVES 有权转让
公开(公告)号：EP3654987A1
公开(公告)日：2020-05-27
申请号：EP18835549.9
申请日：2018-07-20
申请人： CJ Healthcare Corporation
发明人： JUN, Hyungjin , KI, So Young , LEE, Keunho , JUNG, Jin Woo , KIM, Dong Hyun , PARK, Chi Hye , BAK, Hyoung Rok , RYU, Shin-Young , LEE, Ju Hyun , LEE, Ho-Youl , JUNG, Won-Hyuk , KO, Dong Hyun , KIM, Seungin , BYUN, Joonseok , YOO, Jae Ho , JI, Seunghee
IPC分类号： A61K31/554

4. 发明公开

EP3305291A1 USES OF BENZIMIDAZOLE DERIVATIVE FOR NOCTURNAL ACID BREAKTHROUGH 有权转让
标题翻译：苯并咪唑衍生物用于黄嘌呤突变的用途
公开(公告)号：EP3305291A1
公开(公告)日：2018-04-11
申请号：EP16807788.1
申请日：2016-06-08
申请人： CJ Healthcare Corporation , RaQualia Pharma Inc.
发明人： LEE, Ha Jin , KIM, Bong Tae , KIM, Hyun , NAM, Ji Yeon , PARK, Jie Eun , SONG, Geun Seog , RYU, Shin Young , KOIZUMI, Shinichi , TAKAHASHI, Nobuyuki , TAJIMI, Masaomi
IPC分类号： A61K31/4184 , A61K31/352 , A61K9/20 , A61K9/28
CPC分类号： A61K31/4184 , A61K9/20 , A61K9/28 , A61P1/04
摘要： The present invention relates to a use of benzimidazole derivative compounds for improvement and treatment of nocturnal acid breakthrough (NAB). The benzimidazole derivative compounds can more effectively prevent and treat gastric acid-related diseases by effectively improving and treating nocturnal nocturnal acid breakthrough symptoms.
摘要翻译：本发明涉及苯并咪唑衍生物化合物用于改善和治疗夜间酸突破（NAB）的用途。苯并咪唑衍生物可有效改善和治疗夜间夜间酸中毒症状，从而更有效地预防和治疗胃酸相关疾病。

5. 发明公开

EP3248967A2 A NOVEL CRYSTALLINE FORM OF A BENZIMIDAZOLE DERIVATIVE AND A PREPARATION METHOD THEREOF 有权转让
标题翻译：苯并咪唑衍生物的新型结晶形式及其制备方法
公开(公告)号：EP3248967A2
公开(公告)日：2017-11-29
申请号：EP15879068.3
申请日：2015-11-18
申请人： CJ Healthcare Corporation
发明人： KIM, Young Ju , KIM, Eun Sun , LEE, Ji Yun , LEE, Hyuk Woo , KWEON, Jae Hong , LEE, Sung Ah , CHOI, Kwang Do , KO, Dong Hyun , HEO, Seung Pyeong
IPC分类号： C07D407/12 , C07D235/06 , C07D235/04
摘要： The present invention relates to a novel crystalline form of a benzimidazole derivative and a preparation method thereof.
The novel crystalline form according to the present invention is hardly changed chemically and/or physically under a long-term photo-stressed condition, has a low hygroscopicity, and has an extremely low static-electricity-inducing capability, thus being advantageous for formulation, and due to the excellent stability of the crystal form itself, it is very useful for long-term storage of the compound.
摘要翻译：本发明涉及苯并咪唑衍生物的新型结晶形式及其制备方法。根据本发明的新颖结晶形式在长期光应力条件下几乎不发生化学和/或物理变化，具有低吸湿性，并且具有极低的静电诱导能力，因此有利于配制，并且由于晶体本身的优异稳定性，它对于化合物的长期储存非常有用。

6. 发明公开

EP3207945A1 SUSTAINED RELEASE FORMULATION OF METFORMIN AND METHOD FOR PREPARING SAME 有权转让
标题翻译： METFORMIN的持续释放制剂及其制备方法
公开(公告)号：EP3207945A1
公开(公告)日：2017-08-23
申请号：EP15850079.3
申请日：2015-07-21
申请人： CJ Healthcare Corporation
发明人： PARK, Jun Hong , LEE, Ji Eun , KIM, Yu Jeong , LYU, Chun Seon , SEO, Hyuk Seong , OH, Tack Oon , JEON, Eun Kyung , HAN, Sung Kyun
IPC分类号： A61K47/38 , A61K47/30 , A61K9/22 , A61K31/155
CPC分类号： A61K9/2081 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2095 , A61K9/2893 , A61K31/155
摘要： The present invention relates to a gastric-retention type sustained-release formulation of metformin as an insulin-independent diabetic agent, and a preparation method thereof. More specifically, the present invention relates to a gastric-retention type sustained-release formulation, which can effectively control drug release even with a small amount of a polymer by forming a sustained-release granulated material, which comprises granules containing metformin or a pharmaceutically acceptable salt thereof and a swellable polymer, and a water-insoluble coated on the surface of the granules; and also can allow a tablet containing the drug to swell rapidly at an early stage by formulating via mixing of a superdisintegrant, which is capable of controlling the speed of gelation forming hydrogels, with the granulated material; and a preparation method thereof
摘要翻译：本发明涉及作为胰岛素非依赖性糖尿病药物的二甲双胍胃滞留型缓释制剂及其制备方法。更具体地说，本发明涉及一种胃滞留型缓释制剂，其通过形成缓释造粒材料即使用少量聚合物也能够有效地控制药物释放，所述缓释造粒材料包含含有二甲双胍或药学上可接受的其盐和可溶胀聚合物，以及涂覆在颗粒表面上的水不溶性物质; 并且通过将能够控制凝胶化形成水凝胶速度的超级崩解剂与粒化材料混合配制，也可以使含药物的片剂在早期迅速溶胀; 及其制备方法

7. 发明公开

EP2925325A4 A STABILIZED PEMETREXED FORMULATION 有权转让
标题翻译：培美曲塞的稳定的制剂
公开(公告)号：EP2925325A4
公开(公告)日：2016-07-13
申请号：EP13858153
申请日：2013-11-29
申请人： CJ HEALTHCARE CORP
发明人： PARK YOUNG JOON , SHIN MYUNG JIN , JIN HONG CHUL , CHOI HA YONG , CHOI NAK HYUN
IPC分类号： A61K31/519 , A61K31/517 , A61P35/00
CPC分类号： A61K47/20 , A61J1/05 , A61K9/0019 , A61K31/198 , A61K31/519 , A61K47/12 , A61K47/183 , A61K2300/00

8. 发明公开

EP2925325A1 A STABILIZED PEMETREXED FORMULATION 有权转让
标题翻译： STABILISIERTE FORMULIERUNG VON PEMETREXED
公开(公告)号：EP2925325A1
公开(公告)日：2015-10-07
申请号：EP13858153.3
申请日：2013-11-29
申请人： CJ Healthcare Corporation
发明人： PARK, Young Joon , SHIN, Myung Jin , JIN, Hong Chul , CHOI, Ha Yong , CHOI, Nak Hyun
IPC分类号： A61K31/519 , A61K31/517 , A61P35/00
CPC分类号： A61K47/20 , A61J1/05 , A61K9/0019 , A61K31/198 , A61K31/519 , A61K47/12 , A61K47/183 , A61K2300/00
摘要： The present invention relates to a stabilized pemetrexed formulation, and more particularly to a stabilized pemetrexed formulation comprising acetylcysteine as antioxidant and a citrate salt as buffer.
摘要翻译：本发明涉及稳定的培美曲塞制剂，更具体地涉及一种稳定的培美曲塞制剂，其包含作为抗氧化剂的乙酰半胱氨酸和作为缓冲液的柠檬酸盐。

9. 发明公开

EP2781213A1 Method of preparing microspheres by using polymer having sol-gel transition property and microspheres prepared thereby 有权转让
标题翻译：一种用于通过具有溶胶 - 凝胶转变特性的聚合物的制备微球的过程
公开(公告)号：EP2781213A1
公开(公告)日：2014-09-24
申请号：EP14160555.0
申请日：2014-03-18
申请人： CJ Cheiljedang Corporation
发明人： Kim, Yi Mi , Park, Young Joon , Baek, Seung Hee , Lim, Sun Kyung
IPC分类号： A61K9/16 , A61K38/09
CPC分类号： A61K9/1652 , A61K9/1641 , A61K9/1647 , A61K9/1694 , A61K38/09
摘要： The present invention relates to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby, and more particularly, to a method of preparing microspheres by using a polymer having a sol-gel transition property and microspheres prepared thereby capable of preventing a solvent in a polymer solution for a carrier from being rapidly diffused to the aqueous medium before formation of the microspheres to reduce porosity of the microspheres and reduce surface roughness of the microspheres in order to obtain microspheres having a sphere shape, and increasing an encapsulation ratio of a bioactive substance, by using a polymer having a sol-gel transition property as a surfactant included in an aqueous medium into which a primary emulsion is injected and gelating a secondary emulsion formed after injecting the primary emulsion using the sol-gel transition property of the polymer used as the surfactant.
摘要翻译：本发明涉及一种通过使用具有溶胶 - 凝胶转变特性和微球从而制备，并且更具体地，涉及通过使用具有制备的溶胶 - 凝胶转变特性和微球体的聚合物制备的微球的方法的聚合物制备的微球的方法从而能够从被迅速地扩散到wässrige介质形成微球体之前，以减少微球的孔隙率和降低为了得到具有球形形状的微球的微球的表面粗糙度在聚合物溶液中防止溶剂的载体，和增加的生物活性物质的包封率，通过使用聚合物具有溶胶 - 凝胶转变特性如在wässrige介质包括在表面活性剂加入其中初级乳液注入并凝胶化使用溶胶注入初级乳液后形成的二级乳液用作表面活性剂的聚合物的凝胶转变特性。

10. 发明授权

EP3648739B8 COMPOSITION FOR INJECTION 有权转让
公开(公告)号：EP3648739B8
公开(公告)日：2023-03-01
申请号：EP18828340.2
申请日：2018-07-06
发明人： KIM, Hyo Jin , KIM, Sung Jun , LEE, Min Kyoung , LEE, Sung Ah , YOON, Mi Young
IPC分类号： A61K9/00 , A61K31/4184 , A61K31/352 , A61K47/26 , A61K9/08 , A61K9/19

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