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1. 发明公开

EP4440541A1 COMPOSITIONS FOR PREVENTING OR TREATING SKIN AGING 审中-实审
公开(公告)号：EP4440541A1
公开(公告)日：2024-10-09
申请号：EP22823003.3
申请日：2022-11-29
申请人： Estetra SRL
发明人： GERARD, Céline , DION, Valérie
IPC分类号： A61K8/63 , A61Q19/08
CPC分类号： A61Q19/08 , A61K8/63 , A61K2800/9220130101

2. 发明公开

EP4159218A1 ESTETROL AND ITS USES FOR ALLEVIATING MENOPAUSE-ASSOCIATED SYMPTOMS 审中-实审转让
公开(公告)号：EP4159218A1
公开(公告)日：2023-04-05
申请号：EP22202086.9
申请日：2019-04-19
申请人： Estetra SRL
发明人： TAZIAUX, Melanie , RAUSIN, Glwadys , JOST, Maud , MAWET, Marie
IPC分类号： A61K31/565 , A61K31/55 , A61K31/57 , A61K31/585 , A61P5/30
摘要： The present invention relates to a hormone replacement therapy, to the associated compounds and to the associated packaging units, for alleviating menopause-associated symptoms which is based on the administration to a female mammal of estetrol monohydrate at specified daily doses, optionally in combination with a progestogenic component.
The therapy enjoys a statistically significant efficacy combined with a favourable profile for side effects compared to currently available methods for alleviating menopause-associated symptoms.

3. 发明公开

EP3079671A1 ORALLY DISINTEGRATING SOLID DOSAGE UNIT CONTAINING AN ESTETROL COMPONENT 有权转让
标题翻译：口服崩解剂，具有ESTETROLKOMPONENTE固体药物剂型
公开(公告)号：EP3079671A1
公开(公告)日：2016-10-19
申请号：EP14814804.2
申请日：2014-12-10
申请人： Donesta Bioscience B.V.
发明人： PLATTEEUW, Johannes Jan , COELINGH BENNINK, Herman Jan Tijmen
IPC分类号： A61K9/20 , A61K31/56
CPC分类号： A61K31/565 , A61K9/0056 , A61K9/1623 , A61K9/1682 , A61K31/573
摘要： The solid dosage units of the present invention are particularly suited for sublingual, buccal or sublabial administration of the estetrol component.

4. 发明公开

EP1971344A1 A METHOD OF TREATING AN ACUTE VASCULAR DISORDER 有权转让
标题翻译：方法急性血管疾病的治疗
公开(公告)号：EP1971344A1
公开(公告)日：2008-09-24
申请号：EP07709154.4
申请日：2007-01-09
申请人： Pantarhei Bioscience B.V.
发明人： BENNINK, Herman Jan Thijmen Coelingh
IPC分类号： A61K31/565 , A61P9/00 , A61P9/10 , A61K31/519 , A61K31/57 , A61K31/34 , A61K31/4045
CPC分类号： A61K31/34 , A61K31/4045 , A61K31/519 , A61K31/565 , A61K31/57
摘要： The present invention relates to a method of treating an acute vascular disorder in a mammal, said method comprising orally administering to said mammal, upon demand, an effective amount of a steroid to said mammal, said steroid being selected from the group consisting of: substances represented by formula (I), in which R1, R2, R3, R4 independent ly are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors.

5. 发明授权

EP1624878B1 USE OF COMPOSITIONS COMPRISING AN ESTROGENIC COMPONENT FOR THE TREATMENT AND PREVENTION OF MUSCULOSKELETAL PAIN 有权转让
标题翻译：包含雌激素成分的组合物用于治疗和预防肌肉骨痛的用途
公开(公告)号：EP1624878B1
公开(公告)日：2006-09-27
申请号：EP04734005.4
申请日：2004-05-19
申请人： Pantarhei Bioscience B.V.
发明人： COELINGH BENNINK, Herman, Jan Tijmen , BUNSCHOTEN, Evert, Johannes
IPC分类号： A61K31/565 , A61P19/02
CPC分类号： A61K45/06 , A61K31/565 , A61K2300/00
摘要： The present invention relates to a method of treating or preventing musculoskeletal pain in a mammal receiving administration of an estrogen. suppressant selected from the group consisting of aromatase inhibitors, GnRH analogues, cyclo-oxygenase 2 (COX-2) inhibitors, 17β-hydroxysteroid dehydrogenase type 1 inhibitors, progestogens, anti-estrogens and combinations thereof, said method comprising the administration of an effective amount of an estrogenic component, wherein the estrogenic component is selected from the group consisting of : substances represented by the following formula (I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors.
摘要翻译：本发明涉及治疗或预防接受雌激素给药的哺乳动物肌肉骨骼疼痛的方法。其选自芳香酶抑制剂，GnRH类似物，环加氧酶2（COX-2）抑制剂，17β-羟基类固醇脱氢酶1型抑制剂，孕激素，抗雌激素及其组合，所述方法包括给药有效量的雌激素成分，其中所述雌激素成分选自：由下式（I）表示的物质，其中式R 1，R 2，R 3，R 4独立地为氢原子，羟基或烷氧基与 1-5个碳原子; 当用于本方法时能够释放根据上述通式的物质的前体; 以及一种或多种上述物质和/或前体的混合物。

6. 发明公开

EP4440706A1 COMPOSITIONS FOR PROMOTING HAIR GROWTH 审中-实审
公开(公告)号：EP4440706A1
公开(公告)日：2024-10-09
申请号：EP22823371.4
申请日：2022-11-29
申请人： Estetra SRL
发明人： GERARD, Céline , DION, Valérie
IPC分类号： A61Q7/02 , A61K8/63
CPC分类号： A61Q7/02 , A61K8/63

7. 发明公开

EP4140489A1 CONTRACEPTIVE COMPOSITION WITH REDUCED CARDIOVASCULAR EFFECTS 审中-实审转让
公开(公告)号：EP4140489A1
公开(公告)日：2023-03-01
申请号：EP22199066.6
申请日：2019-02-07
申请人： Estetra SRL
发明人： JOST, Maud , RAUSIN, Glwadys
IPC分类号： A61K31/565 , A61P15/18 , A61K9/00
摘要： The present invention relates to a contraceptive method with reduced cardiovascular effects, such as reduced thromboembolism risk, such as reduced venous thromboembolism (VTE) risk and reduced aortic thromboembolism (ATE) risk. The method of the invention comprises administering to a female mammal an effective amount of an estetrol component in combination with a progestogenic component. The method enjoys a favourable profile for thromboembolism compared to currently available methods which employs contraceptives from the so-called second, third or fourth generation.

8. 发明授权

EP2155205B1 TREATMENT OF MECONIUM ASPIRATION SYNDROME WITH ESTROGENS 有权转让
标题翻译： MEKONIUMASPIRATIONSSYNDROMS与雌激素治疗
公开(公告)号：EP2155205B1
公开(公告)日：2011-12-21
申请号：EP08766828.1
申请日：2008-06-20
申请人： Pantarhei Bioscience B.V.
发明人： COELINGH BENNINK, Herman Jan Tijmen , VISSER, Monique
IPC分类号： A61K31/565 , A61K9/02 , A61K9/08 , A61P11/00
CPC分类号： A61K31/565 , A61K9/0031 , A61K9/0053
摘要： One aspect of the present invention relates to the use of an estrogen in the treatment of Meconium Aspiration Syndrome (MAS) in a newborn infant,said treatment comprising administering an effective amount of estrogen to said newborn infant within 7 days after birth. The present treatment offers the advantage that estrogens can be administered using non-invasive modes of administration, e.g. oral or rectal administration. Other aspects of the present invention relate to a suppository for use in newborn infants comprising at least1 μg of estrogen and to an oral applicator comprising a container holding an aqueous liquid containing micronised estetrol and a metering dispenser for metering the liquid into the oral cavity of a newborn infant.

9. 发明授权

EP2170346B1 TREATMENT OR PREVENTION OF HYPERTENSIVE DISORDERS OF PREGNANCY OR FETAL GROWTH RETARDATION 有权转让
标题翻译：治疗性或高血压性障碍的预防怀孕或生长延迟胎儿
公开(公告)号：EP2170346B1
公开(公告)日：2011-11-16
申请号：EP08779024.2
申请日：2008-07-14
申请人： Pantarhei Bioscience B.V.
发明人： VISSER, Monique , COELINGH BENNINK, Herjan, Jan, Tijmen
IPC分类号： A61K31/565 , A61P15/00
CPC分类号： A61K31/565
摘要： The present invention relates to the use of a steroid in the manufacture of a pharmaceutical composition for use in the therapeutic or prophylactic treatment of a hypertensive disorder of pregnancy (HDP) or fetal growth retardation, said treatment comprising administering to a female mammal a steroid selected from the group consisting of: substances represented by the following formula (formula I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1 - 5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors of such substances; and mixtures of one or more of the aforementioned substances and/or precursors.

10. 发明公开

EP1624878A1 USE OF COMPOSITIONS COMPRISING AN ESTROGENIC COMPONENT FOR THE TREATMENT AND PREVENTION OF MUSCULOSKELETAL PAIN 有权转让
标题翻译：使用的组合物包含用于治疗和预防肌肉疼痛骨架的雌激素
公开(公告)号：EP1624878A1
公开(公告)日：2006-02-15
申请号：EP04734005.4
申请日：2004-05-19
申请人： Pantarhei Bioscience B.V.
发明人： COELINGH BENNINK, Herman, Jan Tijmen , BUNSCHOTEN, Evert, Johannes
IPC分类号： A61K31/565 , A61P19/02
CPC分类号： A61K45/06 , A61K31/565 , A61K2300/00
摘要： The present invention relates to a method of treating or preventing musculoskeletal pain in a mammal receiving administration of an estrogen. suppressant selected from the group consisting of aromatase inhibitors, GnRH analogues, cyclo-oxygenase 2 (COX-2) inhibitors, 17β-hydroxysteroid dehydrogenase type 1 inhibitors, progestogens, anti-estrogens and combinations thereof, said method comprising the administration of an effective amount of an estrogenic component, wherein the estrogenic component is selected from the group consisting of : substances represented by the following formula (I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors.

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