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1. 发明公开

EP2356995A2 Process of preparation of formulations of the peptide Angiotensin-(1-7) and its analogues, agonists and antagonists using cyclodextrins, liposomes and biodegradable polymers and/or mixtures and products thereof 审中-公开
标题翻译：使用环糊精，脂质体和生物可降解聚合物和/或其混合物和产物制备肽血管紧张素 - （1-7）及其类似物，激动剂和拮抗剂制剂的方法
公开(公告)号：EP2356995A2
公开(公告)日：2011-08-17
申请号：EP11160834.5
申请日：2002-11-05
申请人： Universidade Federal de Minas Gerais-UFMG
发明人： Santos, Robson Augusto Souza , Nadu, Ana Paula , Frezard, Frederic Jean Georges , Sinisterra, Rubén Dario
IPC分类号： A61K38/08 , A61P9/00 , A61K9/127 , A61K9/16 , A61K47/40
CPC分类号： B82Y5/00 , A61K9/1271 , A61K9/1647 , A61K38/085 , A61K47/6951
摘要： There is no description in the state of technique of a formulation, application or product of D-Ala 7 -Angiotensin-(1-7) (A-779) and analogues and derivatives, D-Pro 7 -Angiotensin-(1-7) and analogues or derivatives or of Ang-(1-7) analogues or derivatives using cyclodextrines, liposomes, biodegradable polymers and its derivatives for the study or treatment of arterial hypertension and other cardiovascular diseases and its complications, wounds, burns, erithema, tumors, diabetes mellitus, sperm mobility, nephropathy, gastrointestinal and gynaecological disorders, angiogenesis, angioplatsy, alopecia and blood diseases in animals of warm blood, or as ligands for de G-protein-coupled receptor MAS. This characterizes the present invention as a more effective option for the study and treatment of pathologies associated or not to this receptor. The present invention is characterized by the combination of two different technologies: the molecular encapsulation of the peptide Angiotensin-(1-7) and its analogues and derivates in cyclodextrin and the microencapsulation in biodegradable polymers and liposomes. It is also characterized by the increase of this peptide and its analogues and derivatives using the formulation of the present invention.
摘要翻译：在D-Ala7-血管紧张素 - （1-7）（A-779）及其类似物和衍生物，D-Pro7-血管紧张素 - （1-7）和其衍生物的制剂，应用或产品的技术状态中没有描述用于研究或治疗动脉高血压和其他心血管疾病及其并发症，伤口，烧伤，鼻炎，肿瘤，糖尿病的使用环糊精，脂质体，生物可降解聚合物及其衍生物的类似物或衍生物或Ang-（1-7）类似物或衍生物精子活动能力，肾病，胃肠和妇科疾病，血管生成，血管扩张症，脱发和血液疾病，或作为G蛋白偶联受体MAS的配体。这将本发明表征为研究和治疗与这种受体相关或不相关病理的更有效的选择。本发明的特征在于两种不同技术的组合：肽类血管紧张素 - （1-7）及其类似物和衍生物在环糊精中的分子包封以及生物可降解聚合物和脂质体中的微囊化。其特征还在于使用本发明的制剂增加了该肽及其类似物和衍生物。

2. 发明公开

EP2356995A3 Process of preparation of formulations of the peptide Angiotensin-(1-7) and its analogues, agonists and antagonists using cyclodextrins, liposomes and biodegradable polymers and/or mixtures and products thereof 审中-公开
标题翻译：一种用于肽血管紧张素 - （1-7）和其类似物，环糊精使用激动剂和拮抗剂，脂质体和可生物降解的聚合物和/或它们的混合物及其产品的制剂的制备过程
公开(公告)号：EP2356995A3
公开(公告)日：2011-08-24
申请号：EP11160834.5
申请日：2002-11-05
申请人： Universidade Federal de Minas Gerais-UFMG
发明人： Santos, Robson Augusto Souza , Nadu, Ana Paula , Frezard, Frederic Jean Georges , Sinisterra, Rubén Dario
IPC分类号： A61K38/08 , A61P9/00 , A61K9/127 , A61K9/16 , A61K47/40 , A61P17/02 , A61P13/00 , A61P15/00 , A61P3/10 , A61P35/00
CPC分类号： B82Y5/00 , A61K9/1271 , A61K9/1647 , A61K38/085 , A61K47/6951
摘要： There is no description in the state of technique of a formulation, application or product of D-Ala 7 -Angiotensin-(1-7) (A-779) and analogues and derivatives, D-Pro 7 -Angiotensin-(1-7) and analogues or derivatives or of Ang-(1-7) analogues or derivatives using cyclodextrines, liposomes, biodegradable polymers and its derivatives for the study or treatment of arterial hypertension and other cardiovascular diseases and its complications, wounds, burns, erithema, tumors, diabetes mellitus, sperm mobility, nephropathy, gastrointestinal and gynaecological disorders, angiogenesis, angioplatsy, alopecia and blood diseases in animals of warm blood, or as ligands for de G-protein-coupled receptor MAS. This characterizes the present invention as a more effective option for the study and treatment of pathologies associated or not to this receptor. The present invention is characterized by the combination of two different technologies: the molecular encapsulation of the peptide Angiotensin-(1-7) and its analogues and derivates in cyclodextrin and the microencapsulation in biodegradable polymers and liposomes. It is also characterized by the increase of this peptide and its analogues and derivatives using the formulation of the present invention.
摘要翻译：有在制剂中，应用程序或产品的技术的状态没有描述-D-丙氨酸7 - 血管紧张素 - （1-7）（A-779）及其类似物和衍生物，D-Pro 7中 - 血管紧张素 - （1-7 ）及其类似物或衍生物或血管紧张素（1-7）类似物或使用环糊精，脂质体，生物可降解聚合物及其衍生物的研究或治疗动脉高血压和其他心血管疾病及其并发症，创伤，烧伤，erithema，肿瘤衍生物，糖尿病，精子的活动能力，肾病，胃肠道和在温血动物的妇科疾病，血管生成，angioplatsy，脱发和血液病，或作为配体进行去G-蛋白偶联的受体Mas。此本发明特征的作为病理的相关联或不该受体的研究和治疗的更有效的选择。肽血管紧张素 - （1-7）和它的类似物的分子包封和衍生物在环糊精和生物可降解聚合物和脂质体微囊化：本发明是通过两种不同技术的结合为特征。因此，通过使用本发明的制剂中的这种肽及其类似物和衍生物的增加为特征。

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