专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1428528A1 Synergistic combinations of dietary fiber and NSAIDs for the treatment of cancer 审中-公开
标题翻译：用于治疗癌症和纤维的NSAID协同组合物
公开(公告)号：EP1428528A1
公开(公告)日：2004-06-16
申请号：EP02021644.6
申请日：2002-09-27
申请人： Tiense Suikerraffinaderij N.V.
发明人： Van Loo, Jan , Frippiat, Anne , Hermans, Johny
IPC分类号： A61K31/19 , A61K31/715 , A61P35/00
CPC分类号： A61K31/19 , A61K31/715
摘要： Pharmaceutical compositions are disclosed that present synergistic anti-cancer effects in humans and vertebrate animals, comprising a combination of a fermentable dietary fiber (FDF) and a non-steroidal anti-inflammatory drug (NSAID) with cyclo-oxygenase2 (COX2) inhibiting activity, the FDF being present in the FDF/ NSAID combination in a weight ratio FDF : NSAID of minimum 1:1. Typical compositions comprise a FDF/NSAID combination wherein the FDF component is chicory inulin, oligofructose or a mixture thereof, and the NSAID component is selected from a group consisting of sulindac, piroxicam or aspirin, in a weight ratio FDF : NSAID ranging from 6000 : 1 to 1:1. The synergistic anti-cancer effects of the compositions are demonstrated in aberrant crypt foci studies in rats.
The pharmaceutical compositions are useful in the prevention and inhibition of carcinogenesis or recurrence of cancer and for the treatment of cancer in humans and vertebrate animals.
The invention also relates to a method for prevention or inhibition of carcinogenesis and recurrence of cancer and for the treatment of cancer in humans and vertebrate animals involving administration of a therapeutically effective dose of said pharmaceutical compositions to a human or vertebrate animal.
摘要翻译：药物组合物是圆盘游离缺失确实在人和脊椎动物本协同的抗肿瘤效果，包含可发酵的膳食纤维（FDF）和抑制性活性的非甾体类抗炎药（NSAID）与环oxygenase2（COX2）的组合，该FDF存在于的重量比FDF的FDF / NSAID组合：最小1 NSAID：1。典型的组合物包含一个FDF / NSAID组合worin的FDF组分是菊苣菊糖，低聚果糖或它们的混合物，和所述NSAID组分选自以下一组舒林酸，吡罗昔康或阿司匹林，以重量比FDF选自：NSAID范围从6000： 1至1：1。该组合物的协同抗肿瘤作用实例阐述在隐窝病灶研究的影响。的药物组合物在癌或癌症复发的预防和抑制作用和对人类和脊椎动物治疗癌症是有用的。因此，本发明涉及一种用于预防或致癌作用和癌症复发的抑制的方法和用于治疗人类及脊椎动物涉及治疗有效剂量的所述药物组合物的人或脊椎动物施用治疗癌症。

2. 发明公开

EP0958825A1 Synergistic composition of a non-digestible carbohydrate and an anti-cancer drug for use in the treatment of cancer 失效
标题翻译：包括用于治疗癌症的协同增效组合物，其非消化性碳水化合物和抗癌剂的
公开(公告)号：EP0958825A1
公开(公告)日：1999-11-24
申请号：EP98870113.2
申请日：1998-05-18
申请人： Tiense Suikerraffinaderij N.V. (Raffinerie Tirlemontoise S.A.)
发明人： Taper, Henryk , Frippiat, Anne , Van Loo, Jan , Roberfroid, Marcel
IPC分类号： A61K31/70 , A61K31/505 , A61K31/52 , A61K31/17
CPC分类号： A61K31/7004 , A61K31/715 , A61K45/06 , A61K31/70 , A61K31/52 , A61K31/505 , A61K31/17 , A61K2300/00
摘要： The present invention provides (i) a novel pharmaceutical composition comprising a synergistic combination of a non-digestible fructan-type carbohydrate, i.e. a levan or an inulin (including inulin, oligofructose and mixtures thereof) and an anti-metabolic anti-cancer drug, (ii) said composition for use in the treatment of cancer in non-ruminating mammals, (iii) the use of said combination for the manufacture of a medicament for the treatment of cancer in non-ruminating mammals, and (iv) the use of said composition in a method for treatment of cancer in non-ruminating mammals.
摘要翻译：本发明提供了（ⅰ）的新的药物组合物，包含不易消化的果聚糖型糖的协同组合，即一万特或菊糖（包括菊糖，寡果糖和它们的混合物）和抗代谢抗癌药的，（ii）所述在非反刍哺乳动物中治疗癌症的组合物，（iii）使用所述组合的用于制备药物用于非反刍哺乳动物治疗癌症，以及（iv）使用所述组合物的方法中的用于在非反刍哺乳动物治疗癌症。

3. 发明公开

EP0879600A1 Fructan containing composition for the prevention and treatment of colon cancer 失效
标题翻译： Fruktan-haltige Zusammensetzung zur Vorbeugung und Behandlung von Dickdarmkrebs
公开(公告)号：EP0879600A1
公开(公告)日：1998-11-25
申请号：EP97870069.8
申请日：1997-05-20
申请人： Tiense Suikerraffinaderij N.V. (Raffinerie Tirlemontoise S.A.)
发明人： Van Loo, Jan , Frippiat, Anne
IPC分类号： A61K31/715
CPC分类号： A61K31/733 , A23L29/055 , A23L29/244
摘要： The use is provided of a fructran with an average degree of polymerisation of at least 15 for the manufacture of a composition for the prevention and/or treatment of colon cancer in non-bovine mammals, particularly in human beings.
Also provided is a method of prevention and treatment of colon cancer in a non-bovine mammal, particularly in a human being, comprising administering to said mammal a composition comprising an effective dose of a fructan with an average degree of polymerisation of at least 15.
The said composition can be a medicament as well as a functional food. In a preferrred embodiment the fructan is inulin, more preferably inulin with an average degree of polymerisation of at least 20.
摘要翻译：使用平均聚合度至少为15的果聚糖，用于制造用于预防和/或治疗非牛哺乳动物，特别是人类中的结肠癌的组合物。还提供了预防和治疗非牛哺乳动物，特别是人的结肠癌的方法，包括向所述哺乳动物施用包含平均聚合度至少为15的有效剂量的果聚糖的组合物。所述组合物可以是药物以及功能性食品。在优选的实施方案中，果聚糖是菊粉，更优选菊糖，平均聚合度至少为20。

4. 发明公开

EP2386649A1 Process for the recovery of betaine from molasses 审中-公开
标题翻译： Verfahren zur Gewinnung von Betain aus Melasse
公开(公告)号：EP2386649A1
公开(公告)日：2011-11-16
申请号：EP10005025.1
申请日：2010-05-12
申请人： Tiense Suikerraffinaderij N.V.
发明人： Van Loo, Jan
IPC分类号： C12P13/00 , C12P19/16 , C12P19/18 , C12P19/20 , A23L1/09 , A23L1/308
CPC分类号： C12P13/04 , A23K20/163 , A23L29/30 , A23L33/22 , C07C227/40 , C12P13/007 , C12P19/00 , C12P19/18 , C12Y204/01099 , C12Y302/01007 , C13K13/00 , C07C229/12
摘要： The invention relates to a process for the recovery of betaine from a molasses, comprising:
- a conversion step, in which the molasses is subjected to the action of an enzyme having endo-inulinase activity and/or fructosyltransferase activity, to form a fructan-containing molasses (fructan-molasses);
- a separation step, in which the fructan-molasses is subjected to a chromatographic separation, thereby obtaining a betaine-containing fraction.
摘要翻译：本发明涉及一种从糖蜜中回收甜菜碱的方法，包括：转化步骤，其中糖蜜经受内切菊粉酶活性和/或果糖基转移酶活性的酶的作用，以形成果聚糖 - 含糖蜜（果聚糖 - 糖蜜）; - 分离步骤，其中将果聚糖 - 糖蜜进行色谱分离，从而获得含甜菜碱的级分。

5. 发明公开

EP1125507A1 Inulin products with improved nutritional properties 审中-公开
标题翻译：菊苣生产者动物点心（Nahrungseigenschaften）
公开(公告)号：EP1125507A1
公开(公告)日：2001-08-22
申请号：EP00103056.8
申请日：2000-02-15
申请人： Tiense Suikerraffinaderij N.V. (Raffinerie Tirlemontoise S.A.)
发明人： Frippiat, Anne , Van Loo, Jan , Smits, Georges
IPC分类号： A23L1/0528
CPC分类号： A61K31/733 , A23L29/244
摘要： The invention relates to novel inulin products and compositions thereof, to their manufacture and to their use for modulating the bacterial flora and the fermentation pattern of inulin in the large intestine of humans and mammals, to their use for providing improved inulin-associated nutritional effects/benefits, and to their use for the manufacture of a pharmaceutical composition for providing said effects/benefits in humans and mammals.
The novel inulin products consist of a mixture of an easily fermentable inulin (EFI) component (preferably an oligofructose, an agave inulin, or a mixture thereof) and a hardly fermentable inulin (HFI) component (preferably a long-chain inulin with a ( DP ¯ ) ≥ 20, typically chicory inulin with a ( DP ¯ ) ≥ 23), in a weight ratio ranging from 10/90 to 70/30.
The nutritional effects include improved mineral absorption, particularly calcium and magnesium, bone mineral density increase, reduction of bone mineral density loss, improvement of bone structure, modulation of lipid metabolism, stimulation of the immune system, and anti-cancer effects. The novel inulin products are particularly suitable for the manufacture of a composition or a medicament for preventing, for postponing and for treating osteoporosis in humans, particularly postmenopausal women.
摘要翻译：本发明涉及新颖的菊粉产品及其组合物，其制备及其用于调节人类和哺乳动物大肠中菊糖的细菌菌群和发酵模式的用途，用于提供改善的菊粉相关营养效应/ 益处以及用于制造用于在人类和哺乳动物中提供所述效果/益处的药物组合物的用途。新颖的菊粉产品由容易发酵的菊粉（EFI）组分（优选低聚果糖，龙舌兰菊糖或其混合物）和几乎可发酵的菊粉（HFI）组分（优选长链菊粉与（ DP）≥20，通常为（DP）≥23的菊苣菊糖），重量比为10/90至70/30。营养作用包括改善矿物质吸收，特别是钙和镁，骨矿物质密度增加，骨矿物质密度损失减少，骨结构改善，脂质代谢调节，免疫系统刺激和抗癌作用。新颖的菊粉产品特别适用于制造用于预防，延缓和治疗人类，特别是绝经后妇女的骨质疏松症的组合物或药物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式