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1. 发明公开

EP0015367A3 Immobilized glucose isomerase, process for preparing it and process for separating fructose from glucose 失效
标题翻译：固定葡萄糖异构体，其制备方法和从葡萄糖分离葡萄糖的方法
公开(公告)号：EP0015367A3
公开(公告)日：1981-09-09
申请号：EP80100243
申请日：1980-01-18
申请人： TORAY INDUSTRIES, INC.
发明人： Yoshioka, Toshio , Teramoto, Kazuo , Shimamura, Masaharu
IPC分类号： C12N11/08 , C13K11/00 , C12P19/24 , C13K03/00
CPC分类号： C12P19/24 , C12N11/08
摘要： An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having β-aminopropionamidomethyl group as side chains represented by the formula I:
wherein R 1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R 2 is selected from C(1-6) alkyl, C(2-6) hydroxyalkyl,
(where X, Z, and Z 2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R, and R 2 form together with the N atom, to which R 1 and R 2 are bonded, a heterocylic structure of the formula:
where A is -CH 2 -, -O- or-NR 6 - (wherein R 6 is H or C(1-6) alkyl), and R 3 , R 4 and R s are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the β-aminopropionamidomethyl group side chain of the organic polymeric material.

2. 发明授权

EP0107119B1 Blood-treating material 有权
标题翻译：血液处理材料
公开(公告)号：EP0107119B1
公开(公告)日：1987-02-04
申请号：EP83109905.6
申请日：1983-10-04
申请人： TORAY INDUSTRIES, INC.
发明人： Kodama, Masashi , Katayama, Yutaka , Tani, Toru , Teramoto, Kazuo , Murakami, Matsuo
IPC分类号： A61K47/00 , A61K37/20 , A61M1/36
CPC分类号： A61K35/74 , A61K31/715 , G01N2400/50

3. 发明授权

EP0129786B1 Endotoxin detoxifying material 失效
标题翻译：内毒素去氧化物质
公开(公告)号：EP0129786B1
公开(公告)日：1990-02-07
申请号：EP84106810.9
申请日：1984-06-14
申请人： TORAY INDUSTRIES, INC.
发明人： Kodama, Masashi , Tani, Toru , Hanazawa, Kazuyoshi , Oka, Totaro , Teramoto, Kazuo , Nishiumi, Shiro
IPC分类号： B01J20/32 , B01D15/08
CPC分类号： B01J20/28033 , B01D15/00 , B01J20/28023 , B01J20/28028 , B01J20/28038 , B01J20/28057 , B01J20/3251 , B01J20/3253 , B01J20/3255

4. 发明公开

EP0129786A3 Endotoxin detoxifying material 失效
标题翻译：内毒素去氧化物质
公开(公告)号：EP0129786A3
公开(公告)日：1986-01-22
申请号：EP84106810
申请日：1984-06-14
申请人： TORAY INDUSTRIES, INC.
发明人： Kodama, Masashi , Tani, Toru , Hanazawa, Kazuyoshi , Oka, Totaro , Teramoto, Kazuo , Nishiumi, Shiro
IPC分类号： B01J20/32 , B01D15/08
CPC分类号： B01J20/28033 , B01D15/00 , B01J20/28023 , B01J20/28028 , B01J20/28038 , B01J20/28057 , B01J20/3251 , B01J20/3253 , B01J20/3255
摘要： The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed. The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy of endotoxemia or prophylaxis of endotoxemia.

5. 发明公开

EP1532993A1 IMMUNOSUPPRESSIVE SUBSTANCE ADSORBENT, EXTRACORPOREAL CIRCULATION COLUMN AND METHOD OF TREATING CANCER 审中-公开
标题翻译：吸收剂免疫抑制剂，体外循环柱和方法治疗癌症的
公开(公告)号：EP1532993A1
公开(公告)日：2005-05-25
申请号：EP03756106.5
申请日：2003-04-03
申请人： Toray Industries, Inc.
发明人： Teramoto, Kazuo , Yoshioka, Toshio , Shimagaki, Masaaki , Matsunase, Takeo , Watanabe, Koji , Ueda, Yuji , Yamamoto, Yoshiki
IPC分类号： A61M1/36 , B01J20/26
CPC分类号： B01J20/26 , A61M1/3679 , B01J20/261 , B01J20/262 , B01J20/265 , B01J20/28014 , B01J20/28016 , B01J20/28023 , B01J20/2803 , B01J20/28033 , B01J20/28045 , B01J20/28057 , B01J20/3092 , B01J20/321 , B01J20/3212 , B01J20/3217 , B01J20/3242 , B01J20/3251 , B01J20/3272 , B01J20/3293 , B01J2220/58 , B01J2220/60
摘要： An object of this invention is to provide an adsorbent for immunosuppressive substance, which adsorbent can highly efficiently and selectively adsorb an excessive immunosuppressive substance directly from the body fluid, can carry out extracorporeal perfusion safely and can be utilized in treatment of cancer. Such an excessive immunosuppressive substance may be involved in growth of cancer cells.
An adsorbent for immunosuppressive substance of the invention includes a water-insoluble carrier and a hydrophilic amino group immobilized to the water-insoluble carrier.
An extracorporeal perfusion column of the invention contains the adsorbent of the invention.
A method for treating cancer of the invention carries out extracorporeal perfusion using the extracorporeal perfusion column of the invention.
摘要翻译：本发明的一个目的是提供一种吸附剂，免疫抑制物质，其可以吸附剂高度有效且选择性地吸附到过度免疫抑制物质直接从体液，可以安全地进行体外灌注，并且可以在治疗癌症中使用。过度免疫抑制物质的搜索可能参与了癌细胞的生长。用于本发明的免疫抑制物质的吸附剂包括不溶于水的载体和固定在水不溶性载体的亲水性氨基。本发明的体外灌注柱含有本发明的吸附剂。一种本发明治疗癌症的方法进行使用本发明的体外灌注柱体外灌注。

6. 发明公开

EP0061862A1 Method for isomerizing glucose to fructose 有权
标题翻译： Verfahren zum Isomerisieren von Glucose zu Fruktose。
公开(公告)号：EP0061862A1
公开(公告)日：1982-10-06
申请号：EP82301334.7
申请日：1982-03-16
申请人： TORAY INDUSTRIES, INC.
发明人： Yoshioka, Toshio , Teramoto, Kazuo , Shimamura, Masaharu
IPC分类号： C12P19/24 , C12N9/92 , C12N9/96
CPC分类号： C12N9/00 , C12N9/92 , C12P19/24
摘要： A deactivation inhibitor for enzymes, such as glucose isomerase, comprises a carrier on which are bonded the ions of a metal capable of assuming different states of oxidation, such as Ti, V, Cr, Mn, Fe, Co, Cu, Sn, Ce and Ag, or a mixture of such ions. The carrier may be a synthetic organic (e.g. styrene based) ion exchanger. In an enzyme reaction method, the substrate treated with the enzyme may be contacted with the enzyme deactivation inhibitor either prior to or during the course of the reaction.
摘要翻译：用于酶的失活抑制剂，例如葡萄糖异构酶，其包含与能够呈现不同氧化态的金属离子如Ti，V，Cr，Mn，Fe，Co，Cu，Sn，Ce结合的载体和Ag，或这些离子的混合物。载体可以是合成的有机（例如苯乙烯）离子交换剂。在酶反应方法中，用酶处理的底物可以在反应过程之前或期间与酶失活抑制剂接触。

7. 发明授权

EP0061862B1 Method for isomerizing glucose to fructose 有权
标题翻译：将葡萄糖与葡萄糖同位素的方法
公开(公告)号：EP0061862B1
公开(公告)日：1986-06-25
申请号：EP82301334.7
申请日：1982-03-16
申请人： TORAY INDUSTRIES, INC.
发明人： Yoshioka, Toshio , Teramoto, Kazuo , Shimamura, Masaharu
IPC分类号： C12P19/24 , C12N9/92 , C12N9/96
CPC分类号： C12N9/00 , C12N9/92 , C12P19/24

8. 发明公开

EP0129786A2 Endotoxin detoxifying material 失效
标题翻译：内毒素解毒材料。
公开(公告)号：EP0129786A2
公开(公告)日：1985-01-02
申请号：EP84106810.9
申请日：1984-06-14
申请人： TORAY INDUSTRIES, INC.
发明人： Kodama, Masashi , Tani, Toru , Hanazawa, Kazuyoshi , Oka, Totaro , Teramoto, Kazuo , Nishiumi, Shiro
IPC分类号： B01J20/32 , B01D15/08
CPC分类号： B01J20/28033 , B01D15/00 , B01J20/28023 , B01J20/28028 , B01J20/28038 , B01J20/28057 , B01J20/3251 , B01J20/3253 , B01J20/3255
摘要： The present invention provides (1) an endotoxin detoxifying material comprising a fibrous carrier to which Polymyxin is fixed, (2) an endotoxin detoxifying material comprising a carrier to which Polymyxin and a basic nitrogen atom are fixed, and (3) a method of removing endotoxin from a fluid by contacting the fluid with the endotoxin detoxifying material comprising a carrier to which Polymyxin is fixed.
The present invention makes it possible to contact blood with Polymixin directly and safely and gives a new method of therapy of endotoxemia or prophylaxis of endotoxemia.

9. 发明公开

EP0107119A1 Blood-treating material 有权
标题翻译： Mittel zur Blutbehandlung。
公开(公告)号：EP0107119A1
公开(公告)日：1984-05-02
申请号：EP83109905.6
申请日：1983-10-04
申请人： TORAY INDUSTRIES, INC.
发明人： Kodama, Masashi , Katayama, Yutaka , Tani, Toru , Teramoto, Kazuo , Murakami, Matsuo
IPC分类号： A61K47/00 , A61K37/20 , A61M1/36
CPC分类号： A61K35/74 , A61K31/715 , G01N2400/50
摘要： The present invention provides (1) a blood-treating material comprising a lipopolysaccharide derived from cell walls of Gram-negative bacteria and immobilized by an insoluble carrier containing an amino group or a carboxyl group and (2) a process for producing the blood-treating material characterized by reacting a condensing agent with a mixture of the lipopolysaccharide and the insoluble carrier.
Lipopolysaccharides have been known to have antitumor effects against malignant tumors. However, they could not be used safely, since their fatal doses are very close to the minimum effective doses in the treatment of the tumors.
The present invention makes it possible to reduce the lethal toxicity of the above-mentioned lipopolysaccharides and provide a new blood-treating material that can be used safely for therapy of cancer, because this blood-treating material has antitumor effects similar to those of the lipopolysaccharides derived from cell walls of Gram-negative bacteria but no fatal effects.
摘要翻译：本发明提供（1）一种血液处理材料，其特征在于，含有衍生自革兰氏阴性细菌的细胞壁的脂多糖并通过含有氨基或羧基的不溶性载体固定的血液处理材料和（2）其特征在于使缩合剂与脂多糖和不溶性载体的混合物反应。已知脂多糖对恶性肿瘤具有抗肿瘤作用。然而，它们不能安全使用，因为它们的致命剂量非常接近治疗肿瘤的最小有效剂量。本发明使得可以降低上述脂多糖的致死毒性，并提供可以安全地用于癌症治疗的新型血液处理材料，因为该血液处理材料具有与脂多糖类似的抗肿瘤效果衍生自革兰氏阴性细菌的细胞壁，但没有致命的影响。

10. 发明公开

EP0015367A2 Immobilized glucose isomerase, process for preparing it and process for preparing fructose from glucose 失效
标题翻译：固定化的葡萄糖异构酶，它们的从葡萄糖制备果糖制备和处理。
公开(公告)号：EP0015367A2
公开(公告)日：1980-09-17
申请号：EP80100243.7
申请日：1980-01-18
申请人： TORAY INDUSTRIES, INC.
发明人： Yoshioka, Toshio , Teramoto, Kazuo , Shimamura, Masaharu
IPC分类号： C12N11/08 , C13K11/00 , C12P19/24
CPC分类号： C12P19/24 , C12N11/08
摘要： An enzymatically active product for use in isomerization of glucose into fructose is provided. The active product comprises an organic polymeric material predominantly comprised of a monovinyl aromatic compound polymer having β-aminopropionamidomethyl group as side chains represented by the formula I:
wherein R 1 is selected from H, C(1-6) alkyl and C(2-6) hydroxyalkyl, R 2 is selected from C(1-6) alkyl, C(2-6) hydroxyalkyl,
(where X, Z, and Z 2 are selected from H and C(1-6) alkyl, and n is from 2 to 6), or R, and R 2 form together with the N atom, to which R 1 and R 2 are bonded, a heterocylic structure of the formula:
where A is -CH 2 -, -O- or-NR 6 - (wherein R 6 is H or C(1-6) alkyl), and R 3 , R 4 and R s are selected from H and methyl. The organic polymeric material has glucose isomerase immobilized with the β-aminopropionamidomethyl group side chain of the organic polymeric material.

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