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1. 发明公开

EP1816423A2 High volume hyperpolarizer for spin-polarized noble gas 失效
标题翻译：超声波发生器，旋转波纹管Edelgas Durchsatzfürspinpolarisiertes Edelgas
公开(公告)号：EP1816423A2
公开(公告)日：2007-08-08
申请号：EP07008501.4
申请日：1997-03-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Cates, Gordan D., Jr. , Driehuys, Bastiaan , Happer, William , Saam, Brian , Walter, Daniel , Middleton, Hunter , Miron, Eli
IPC分类号： F25J1/00 , A61K49/00 , A61K49/18
CPC分类号： G01R33/282 , A61K49/1815 , Y10S62/919 , Y10S62/925
摘要： A method and apparatus for accumulation of hyperpolarized 129Xe is disclosed. The method and apparatus of the invention enable the continuous or episodic accumulation of flowing hyperpolarized 129Xe in frozen form. The method also permits the accumulation of hyperpolarized 129Xe to the substantial exclusion of other gases, thereby enabling the purification of hyperpolarized 129Xe. The invention further includes 129Xe accumulation means (17) which is integrated with 129Xe hyperpolarization means in a continuous or pulsed flow arrangement. The method and apparatus enable large scale production storage, and usage of hyperpolarized 129Xe for numerous purposes, including imaging of human and animal subject through magnetic resonance imaging (MRI) techniques.
摘要翻译：一种用于超极化129 Xe的方法，包括：靶极气中的超极化129 Xe，其特征在于，所述气体包括：a）荧光猝灭气体，用于淬灭碱金属荧光; b）缓冲气体，用于对碱金属原子的光吸收光谱，以及c）至少含有同位素丰度的129 Xe的氙; 在足以通过与碱金属原子的自旋交换诱导所述129Xe的超极化的条件下，由此提供超极化的129Xe。

2. 发明公开

EP1816423A3 High volume hyperpolarizer for spin-polarized noble gas 失效
标题翻译：对于自旋极化稀有气体超极化的高通量
公开(公告)号：EP1816423A3
公开(公告)日：2011-12-21
申请号：EP07008501.4
申请日：1997-03-27
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Cates, Gordan D., Jr. , Driehuys, Bastiaan , Happer, William , Saam, Brian , Walter, Daniel , Middleton, Hunter , Miron, Eli
IPC分类号： F25J1/00 , A61K49/00 , A61K49/18 , G01R33/28
CPC分类号： G01R33/282 , A61K49/1815 , Y10S62/919 , Y10S62/925
摘要： A method for hyperpolarizing 129 Xe, comprising:
hyperpolarizing 129 Xe in a target gas, characterised in that said gas comprises:
a) a fluorescence-quenching gas, for quenching alkali-metal fluorescence,
b) a buffer gas, for pressure-broadening the optical absorption spectrum of alkali metal atoms, and
c) xenon comprising 129 Xe in at least isotopic abundance;
under conditions sufficient to induce hyperpolarization of said 129 Xe by spin exchange with alkali metal atoms, thereby providing hyperpolarized 129 Xe.

3. 发明公开

EP1873544A3 Apparatus for magnetic resonance imaging using hyperpolarized noble gases 失效
标题翻译：装置用于通过超极化惰性气体的装置成像的磁共振
公开(公告)号：EP1873544A3
公开(公告)日：2008-06-04
申请号：EP07020546.3
申请日：1995-04-04
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Balamore, Dilip , Cates, Gordon D. Jr. , Driehuys, Bastiaan , Happer, William , Saam, Brian , Wishnia, Arnold , Albert, Mitchell S.
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , A61K49/1806 , A61K49/1815 , G01R33/282 , Y10T436/24
摘要： A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of the noble gas. The noble gas is selected from noble gas isotopes having nuclear spin, preferably Xenon-129 and/or Helium-3. The noble gas is at least thermally or equilibrium polarized and is preferably hyperpolarized, most preferably hyperpolarized by optical (laser) pumping in the presence of an alkali metal or by metastability exchange. The generation of the representation of the noble gas spatial distribution includes at least one dimension, preferably 2 or 3 dimensions of the spatial distribution. The noble gas may be imaged according to the invention in chemical or biological systems, preferably in a human or animal subject or organ system or tissue thereof. Also, apparatus for nuclear magnetic resonance imaging of the spatial distribution of at least one noble gas includes means for imaging a noble gas by NMR spectrometry and means for providing and/or storing imageable quantities of a noble gas, preferably hyperpolarized Xenon-129 and/or HeJium-3. Also, a medical composition includes a medically acceptable bifunctional gas effective for in vivo anesthesiological and NMR imaging functions, including at least one noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3.

4. 发明公开

EP1873544A2 Apparatus for magnetic resonance imaging using hyperpolarized noble gases 失效
标题翻译：系统zur magnetischen Resonanzbildgebung手套超极化器Nobelgase
公开(公告)号：EP1873544A2
公开(公告)日：2008-01-02
申请号：EP07020546.3
申请日：1995-04-04
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , THE TRUSTEES OF PRINCETON UNIVERSITY
发明人： Balamore, Dilip , Cates, Gordon D. Jr. , Driehuys, Bastiaan , Happer, William , Saam, Brian , Wishnia, Arnold , Albert, Mitchell S.
IPC分类号： G01R33/28
CPC分类号： G01R33/5601 , A61K49/1806 , A61K49/1815 , G01R33/282 , Y10T436/24
摘要： A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of the noble gas. The noble gas is selected from noble gas isotopes having nuclear spin, preferably Xenon-129 and/or Helium-3. The noble gas is at least thermally or equilibrium polarized and is preferably hyperpolarized, most preferably hyperpolarized by optical (laser) pumping in the presence of an alkali metal or by metastability exchange. The generation of the representation of the noble gas spatial distribution includes at least one dimension, preferably 2 or 3 dimensions of the spatial distribution. The noble gas may be imaged according to the invention in chemical or biological systems, preferably in a human or animal subject or organ system or tissue thereof. Also, apparatus for nuclear magnetic resonance imaging of the spatial distribution of at least one noble gas includes means for imaging a noble gas by NMR spectrometry and means for providing and/or storing imageable quantities of a noble gas, preferably hyperpolarized Xenon-129 and/or HeJium-3. Also, a medical composition includes a medically acceptable bifunctional gas effective for in vivo anesthesiological and NMR imaging functions, including at least one noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3.
摘要翻译：通过核磁共振光谱法对惰性气体的空间分布进行成像的方法包括通过NMR光谱法检测至少一种惰性气体的空间分布，并产生稀有气体的所述空间分布的表示。惰性气体选自具有核自旋的惰性气体同位素，优选氙129和/或氦-3。惰性气体至少是热或平衡极化的，并且优选是超极化的，最优选通过在碱金属存在下的光学（激光）泵送或通过亚稳定性交换进行超极化。惰性气体空间分布的表示的产生包括空间分布的至少一个维度，优选2或3维度。惰性气体可以根据本发明在化学或生物系统中成像，优选在人或动物受试者或器官系统或组织中成像。此外，用于核磁共振成像至少一种惰性气体的空间分布的装置包括用于通过NMR光谱法对惰性气体进行成像的装置，以及用于提供和/或存储可成像量的惰性气体，优选超极化氙129和/ 或HeJium-3。此外，医疗组合物包括对于体内麻醉和NMR成像功能有效的医学上可接受的双功能气体，包括至少一种惰性气体，优选超极化氙129和/或氦-3。

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