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1. 发明公开

EP3383483A1 DISPOSABLE GASTROINTESTINAL IMPLANTABLE STIMULATOR 有权
公开(公告)号：EP3383483A1
公开(公告)日：2018-10-10
申请号：EP16869351.3
申请日：2016-11-28
申请人： The Regents of the University of California
发明人： LO, Yi-Kai , LIU, Wentai
IPC分类号： A61N1/36 , A61N1/378 , A61N1/372 , H02J7/02 , A61N1/08
CPC分类号： A61N1/36007 , A61B5/0031 , A61N1/36053 , A61N1/36153 , A61N1/36171 , A61N1/3727 , A61N1/375 , A61N1/3787 , H02J50/10
摘要： A disposable implant that may be positioned inside the gastrointestinal (GI) tract through laparotomy or laparoscopic surgery. The implant may be secured in place using a biodegradable glue or biodegradable suture and is naturally expelled from the body with bowel movement after a certain period of time. In one embodiment, GI implant comprises a coil that receives power from, and sends the recorded physiological information to, an external device through wireless inductive coupling.

2. 发明公开

EP4233999A3 IMPLANTABLE AND NON-INVASIVE STIMULATORS FOR GASTROINTESTINAL THERAPEUTICS 审中-实审
公开(公告)号：EP4233999A3
公开(公告)日：2023-11-22
申请号：EP23183442.5
申请日：2017-12-12
申请人： The Regents of The University of California
发明人： LO, Yi-Kai , LIU, Wentai
IPC分类号： A61N1/375 , A61N1/05 , A61N1/36 , A61N1/372 , A61N1/04
摘要： Systems and methods for implementation of a disposable miniaturized implant for treatment of PostOperative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.

3. 发明公开

EP3203903A1 REAL-TIME STIMULATION ARTIFACT SUPPRESSION FOR SIMULTANEOUS ELECTROPHYSIOLOGICAL ELECTRICAL STIMULATION AND RECORDING 审中-公开
标题翻译：实时刺激抑制同时进行的电生理电刺激和记录
公开(公告)号：EP3203903A1
公开(公告)日：2017-08-16
申请号：EP15849158.9
申请日：2015-09-25
申请人： The Regents of the University of California
发明人： LIU, Wentai , LO, Yi-Kai
IPC分类号： A61B5/04 , A61B5/00
CPC分类号： A61B5/0531 , A61B5/4238 , A61B5/4255 , A61B5/721 , A61B5/7225 , A61B5/7278 , A61B2560/0223 , A61N1/36125
摘要： A system and method of suppressing stimulation artifacts when performing electrophysiological electrical stimulation and recording. An artifact waveform is captured associated with a stimulus output, and then the artifact waveform calibrated during another stimulus output for accurately representing the actual artifact waveform received within each measured response to a stimulus. During actual stimulus generation and response recording, the calibrated artifact waveform is subtracted in at least one of the amplifier stages so that the artifacts are removed from the amplified response to the stimulus thus providing an accurate output without saturating the amplifiers.
摘要翻译：当执行电生理电刺激和记录时抑制刺激伪影的系统和方法。捕获与刺激输出相关联的伪像波形，然后在另一个刺激输出期间校准伪像波形，以准确地表示在对刺激的每个测量响应内接收到的实际伪像波形。在实际的刺激生成和响应记录期间，在至少一个放大器级中减去校准的伪影波形，使得伪像从对刺激的放大响应中移除，从而提供精确的输出而不会使放大器饱和。

4. 发明公开

EP3200724A1 FLEXIBLE AND STRETCHABLE ELECTRODES FOR GASTROINTESTINAL IMPLANTS 审中-公开
标题翻译：用于胃肠道植入物的柔性和可拉伸电极
公开(公告)号：EP3200724A1
公开(公告)日：2017-08-09
申请号：EP15845840.6
申请日：2015-09-28
申请人： The Regents of the University of California
发明人： LIU, Wentai , DUNN, James C.Y. , WU, Benjamin M. , LO, Yi-Kai , CHANG, Chih-Wei , WAGNER, Justin
IPC分类号： A61F2/04 , A61F5/00
CPC分类号： A61N1/36007 , A61B5/4233 , A61B5/4238 , A61B5/4255 , A61F5/0026 , A61N1/0509 , A61N1/0517 , A61N1/08
摘要： A gastrointestinal stimulation apparatus and methods with an electronic controller and a flexible and stretchable electrode array with a central branch and orthogonal bilateral branches that wrap around a section of the gastrointestinal tract and can accommodate repetitive contraction and relaxation movements of the tract. Array branches have a flexible spring structure, stimulation electrodes, recording electrodes, sensors controlled by a controller and adhesion nodes that fix the branches to the tissue. The electrode array can sense the normal peristalsis from upstream tissue and produce a stimulus signal to stimulate the incapable intestine section to generate stimulation-induced contractions. Electrodes on the incapable intestine section can be used for stimulation or recording, the recorded signal from the incapable intestine section can be sent back to the electronics to form a closed loop control system. An impedance measurement using current stimulation can be used to capture low frequency contraction signals.
摘要翻译：具有电子控制器和柔性可拉伸电极阵列的胃肠刺激设备和方法，所述电极阵列具有中央分支和正交双侧分支，所述中央分支和正交双侧分支围绕胃肠道的一部分并且可以适应所述管道的重复收缩和松弛运动。阵列分支具有灵活的弹簧结构，刺激电极，记录电极，由控制器控制的传感器以及将分支固定到组织的粘合节点。电极阵列可感测来自上游组织的正常蠕动并产生刺激信号以刺激无能的肠道区段以产生刺激诱导的收缩。无能的肠段上的电极可以用于刺激或记录，来自无能的肠段的记录信号可以被发送回电子设备以形成闭环控制系统。使用电流刺激的阻抗测量可以用于捕捉低频收缩信号。

5. 发明公开

EP2956210A1 CIRCUIT ARCHITECTURE FOR HIGH CHANNEL COUNT HIGH-VOLTAGE NEURAL STIMULATOR 审中-公开
标题翻译：电路架构用于高压神经HIGH SPEED CHANNEL
公开(公告)号：EP2956210A1
公开(公告)日：2015-12-23
申请号：EP14751513.4
申请日：2014-02-10
申请人： The Regents of the University of California
发明人： LIU, Wentai , CHEN, Kuanfu , LO, Yi-Kai
IPC分类号： A61N1/08 , A61N1/36 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/36067 , A61N1/36082 , A61N1/36153 , A61N1/37223 , A61N1/3787
摘要： A high channel count high-voltage neural stimulator provides an external circuit which communicates power and data to a neural stimulator implant circuit. Data from the external device, such as image data from a camera in an epiretinal application, are communicated to the implant. Multiple pixels circuits, within each implant demultiplex the digital signals, then output separate nerve stimulator outputs from multiple outputs, each configured for connection to a nerve, by sharing a single level conversion driver circuit. In at least one example, the implant circuits can be clustered in a master-slave configuration to increase the number of available neural stimulation outputs.

6. 发明公开

EP4233999A2 IMPLANTABLE AND NON-INVASIVE STIMULATORS FOR GASTROINTESTINAL THERAPEUTICS 审中-实审
公开(公告)号：EP4233999A2
公开(公告)日：2023-08-30
申请号：EP23183442.5
申请日：2017-12-12
申请人： The Regents of The University of California
发明人： LO, Yi-Kai , LIU, Wentai
IPC分类号： A61N1/375
摘要： Systems and methods for implementation of a disposable miniaturized implant for treatment of PostOperative Ileums (POI), a miniaturized implant for treating chronic GI dysmotility (e.g., dysphagia, gastroesophageal reflux disease (GERD), nausea, functional dyspepsia, blockage of transit, and gastroparesis, inflammatory bowel disease) and obesity, by providing electrical stimulation to the part of bowel going through surgery to expedite the healing process while recording the smooth muscle activities simultaneously, or providing stimulation on a treatment location of the GI tract or the branch of the vagus nerve. Systems and methods are also provided for non-invasive, transcutaneous stimulation of anatomy within the abdomen of the patient.

7. 发明公开

EP3551073A1 OPTIMAL MULTI-ELECTRODE TRANSCUTANEOUS STIMULATION WITH HIGH FOCALITY AND INTENSITY 审中-实审
公开(公告)号：EP3551073A1
公开(公告)日：2019-10-16
申请号：EP17878883.2
申请日：2017-12-06
申请人： The Regents of the University of California
发明人： LI, Ying , LIU, Wentai , LO, Yi-Kai
IPC分类号： A61B5/055 , A61B6/03 , A61N1/00 , A61N1/05 , A61N1/08 , A61N1/36 , G06F19/00

8. 发明公开

EP3331603A1 METHODS OF FABRICATING AN ELECTRODE ARRAY FOR TRANSCUTANEOUS ELECTRICAL STIMULATION OF THE SPINAL CORD 审中-公开
公开(公告)号：EP3331603A1
公开(公告)日：2018-06-13
申请号：EP16833976.0
申请日：2016-08-05
申请人： The Regents of the University of California
发明人： CHANG, Chih-Wei , LIU, Wentai , LO, Yi-Kai
IPC分类号： A61N1/05 , B29C67/00 , B23K26/38 , A61N1/04 , A61N1/36 , B33Y70/00
CPC分类号： A61N1/0502 , A61N1/0456 , A61N1/0476 , A61N1/36017 , B21D22/00 , B22F3/008 , B23K26/342 , B23K26/362 , B23K26/38 , B23K26/40 , B23K2101/20 , B23K2101/38 , B23K2103/05 , B23K2103/08 , B23K2103/42 , B23K2103/50 , B33Y10/00 , B33Y70/00 , B33Y80/00
摘要： In various embodiments, a transcutaneous needle electrode and uses thereof are provided. In certain embodiments the needle electrodes comprise a plurality of electrically conductive needles, where the needles are solid, or where the needles are hollow and have a closed tip, where the needles have an average tip diameter less than about 10 μm and an average length greater than about 20-50 μm wherein the electrically conductive needles are electrically coupled to one or more electrical leads.

9. 发明公开

EP3331602A1 ELECTRODE ARRAY FOR TRANSCUTANEOUS ELECTRICAL STIMULATION OF THE SPINAL CORD AND USES THEREOF 审中-公开
公开(公告)号：EP3331602A1
公开(公告)日：2018-06-13
申请号：EP16833973.7
申请日：2016-08-05
申请人： The Regents of the University of California
发明人： CHANG, Chih-Wei , EDGERTON, Victor Reggie , LIU, Wentai , GERASIMENKO, Yuri , GAD, Parag , LO, Yi-Kai
IPC分类号： A61N1/05 , A61N1/04 , A61N1/36 , A61L31/02 , A61N1/08
CPC分类号： A61N1/0456 , A61N1/0502
摘要： In various embodiments, a transcutaneous needle electrode and uses thereof are provided. In certain embodiments the needle electrodes comprise a plurality of electrically conductive needles, where the needles are solid, or where the needles are hollow and have a closed tip, where the needles have an average tip diameter less than about 10 µm and an average length greater than about 20-50 µm wherein the electrically conductive needles are electrically coupled to one or more electrical leads.

10. 发明公开

EP3136959A1 BIO-IMPEDANCE MEASUREMENT METHOD USING BI-PHASIC CURRENT STIMULUS EXCITATION FOR IMPLANTABLE STIMULATOR 审中-公开
标题翻译： BIOIMPEDANZMESSVERFAHREN MIT BI-PHASISCHER STROMSTIMULUSERREGUNGFÜREINEN IMPLANTIBBENEN STIMULATOR
公开(公告)号：EP3136959A1
公开(公告)日：2017-03-08
申请号：EP15786206.1
申请日：2015-04-28
申请人： The Regents of the University of California
发明人： LIU, Wentai , LO, Yi-Kai , CHANG, Chih-Wei
IPC分类号： A61B5/053 , A61B5/00
CPC分类号： A61B5/0538 , A61B5/02158 , A61B5/1107 , A61B5/1108 , A61B5/4238 , A61B5/4255 , A61B5/4836 , A61B5/4839 , A61B5/686 , A61B5/6873 , A61B5/6876 , A61B2562/0215 , A61N1/36007 , A61N1/36135
摘要： Method and apparatus for estimating bio-impedance at electrode-electrolyte interface by injecting a single low-intensity bi-phasic current stimulus having an selected inter-pulse delay first and second current pulse phases, which involves acquiring transient electrode voltage along the bi-phasic current stimulus waveform. Determining equivalent circuit parameters of an electrode, at the electrode-electrolyte/tissue interface, based on transient electrode voltage across said multiple temporal locations is also performed.
摘要翻译：用于通过注入具有选定的脉冲间延迟第一和第二电流脉冲相的单个低强度双相电流刺激来估计电极 - 电解质界面处的生物阻抗的方法和装置，其涉及沿着双相位当前刺激波形。还执行基于跨越所述多个时间位置的瞬态电极电极在电极 - 电解质/组织界面处确定电极的等效电路参数。

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