专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP1669357A4 SUBSTANCE WHICH EXHIBITS ANTIVIRAL AND ANTIBACTERIAL ACTIVITY AND IS BASED ON DERIVATIVES OF 2,8-DITHIOXO-1H-PYRANO[ 2,3-D,6,5-D'] DIPYRIMIDINE AND 10-AZA-ANALOGUE THEREOF 审中-公开
标题翻译： SUBSTANZ MIT ANTIVIRALER UND ANTIBKTERIELLER WIRKUNG AUF DER BASIC VON DERIVATEN VON 2,8-DITHIOXO-1H-PYRANO [2,3-D 6,5-D'] DIPYRIMIDIN UND DENEN 10-AZA-ANALOGA
公开(公告)号：EP1669357A4
公开(公告)日：2006-10-25
申请号：EP03810030
申请日：2003-11-05
申请人： TETS VIKTOR VENIAMINOVICH , ASHKINAZI RIMMA ILIINICHNA
发明人： TETS VIKTOR VENIAMINOVICH , KRASNOV KONSTANTIN ANDREEVICH , ASHKINAZI RIMMA ILIINICHNA
IPC分类号： C07D491/147 , A61K31/519 , A61P31/00 , C07D211/00 , C07D239/00 , C07D309/00 , C07D471/14 , C07D491/14
CPC分类号： C07D471/14 , C07D491/14
摘要： The invention relates to organic chemistry and medicine, more specifically to synthetic pyrimidine derivatives, i.e. 2,8-dithioxo-1H-pyrano[2,3d¸6,5-d']dipyrimidyne and 10-aza-analogue thereof and to the complexes and salts thereof which exhibit antiviral and antimicrobial activity. Said invention can be used for medicine and veterinary science for treating viral diseases, bacteria-induced diseases and for cosmetology in the form of an additive for preventing and treating infections. The aim of said invention is to develop a novel more efficient substance exhibiting antiviral and antimicrobial activity. The inventive substance which exhibits antiviral and antimicrobial activity is based on derivatives of 2,8-dithioxo-1H-pyrano[2,3d¸6,5-d']dipyrimidyne and 10-aza-analogue thereof and characterised in that it comprises the derivative of said group of general formula A1 ∗ M: wherein X is selected from a group O, NH, N-Alkyl; R1 is selected from a group H, Oh, Cl, O-Alkyl, NH2, NH-Alkyl; NH-Ar, N(Alkyl)2, SH, S-Alkyl, S-Ar, S-Hetaryl; R2 is selected from a group C6H5, Aryl; R3 is selected from a group H, Cl, O-Alkyl; NH2, NH-Alkyl, NH-Ar, S-Heratyl; M is absent or selected from a group of Na, K, Li, ammonium cation or another pharmacologically acceptable cation; or said complex of pharmacologically acceptable cation with the anion of one of derivatives A1 (above-mentioned variants R1-R3).
摘要翻译：本发明涉及有机化学和医学，更具体地涉及合成的嘧啶衍生物，即2,8-二硫代-1H-吡喃并[2,3-d，6,5-d']二嘧啶及其10-氮杂 - 类似物和该络合物及其显示抗病毒和抗微生物活性的盐。本发明可用于医学和兽医科学，用于治疗病毒性疾病，细菌引起的疾病和用于预防和治疗感染的添加剂形式的美容。所述发明的目的是开发一种新的更有效的显示抗病毒和抗微生物活性的物质。显示抗病毒和抗微生物活性的本发明物质基于2,8-二硫代-1H-吡喃并[2,3-d，6,5-d']二嘧啶及其10-氮杂 - 类似物的衍生物，其特征在于它包含所述通式A1 * M的基团的衍生物：其中X选自O，NH，N-烷基; R1选自H，O，Cl，O-烷基，NH2，NH-烷基; NH-Ar，N（烷基）2，SH，S-烷基，S-Ar，S-Hetary1; R2选自C6H5，芳基; R3选自H，Cl，O-烷基; NH2，NH-烷基，NH-Ar，S-乙酰基; M不存在或选自Na，K，Li，铵阳离子或另一药理学上可接受的阳离子; 或所述药理学上可接受的阳离子与衍生物A1之一的阴离子的复合物（上述变体R1-R3）。

2. 发明公开

EP1022278A4 TETRACYCLICAL DERIVATIVES FROM PYRIMIDINE 失效
标题翻译：嘧啶的TETRA环状衍生物
公开(公告)号：EP1022278A4
公开(公告)日：2000-12-27
申请号：EP97930907
申请日：1997-04-02
申请人： ASHKINAZI RIMMA ILIINICHNA
发明人： ASHKINAZI RIMMA ILIINICHNA , KRASNOV KONSTANTIN ANDREEVICH
IPC分类号： A61K31/542 , A61P31/00 , A61P31/12 , A61P33/00 , A61P37/04 , C07D513/14 , A61K31/54
CPC分类号： C07D513/14
摘要： The present invention relates to medicine, and especially to pharmacology, veterinary medicine, cosmetology and, more concretely, to synthetical biologically active compounds of a heterocyclical series having antimicrobial, antiviral, antichlamydia and immunostimulating effects: derivatives from 5-oxy-5H-(1)benzopyrano-(5,6-b)-4-oxy-4H-(1,2)-pyrimido-1,4,5,6-tetrahydro-1,3-thiazine. It is characterized by the synthesis of the new class of heterocyclical compounds, i.e. derivatives from 5-oxy-5H-(1)benzopyrano-(5,6-b)-4-oxy-4H-(1,2)-pyrimido-1,4,5,6-tetrahydro-1,3-thiazine (1) of general formula (1); (1-X) where R1 is H or halogen; R2 is H or halogen or a nitro group or a hydroxy group or a metoxy group. The above-mentioned objective can be reached with R1=R2=H (I); R1=C1 (II); R1=R2=C2 (III); R1=H and R2=Br (IV); R1=R2=Br (V); R1=H and R2=NO2 (VII); R1=Br and R2=NO2 (VIII); R1=H and R2=OCN3 (IX); R1=H and R2=OH (X). The inventive synthesis of the substances concerned is a two-step processus: 1) synthesis of 5-oxy-5H-(1)benzopyrano-(5,6-b)-4-oxy-4H-(1,2)-pyrimido-1,4,5,6-tetrahydro-1,3-thiazine (XI) from 2-thiobarbituric acid (XII) and 1,3-dihalogenpropane (XIII); 2) the compound concerned (1-X) is obtained from the intermediate substance produced during the first step and the derivative corresponding to salicylaldehyde (XIV).

3. 发明公开

EP2638900A4 DRUG FOR TREATING LIVER LESIONS CAUSED BY THE ACTION OF CHEMICAL OR BIOLOGICAL AGENTS 有权
标题翻译：肝脏病变的治疗药物由于化学或生物活性物质的影响
公开(公告)号：EP2638900A4
公开(公告)日：2014-04-02
申请号：EP11839641
申请日：2011-10-10
申请人： TETS VIKTOR VENIAMINOVICH , TETS GEORGY VIKTOROVICH
发明人： KRASNOV KONSTANTIN ANDREEVICH
IPC分类号： A61K31/03 , A61K31/505 , A61K31/506 , A61K31/513 , A61P1/16
CPC分类号： C07D239/22 , A61K31/513
摘要： The invention relates to medicine and can be used for treating liver lesions caused by chemical or biological agents. The drug for treating liver lesions caused by chemical or biological agents is embodied as 1-(4-bromophenyl)-6-hydroxy-5-nitroso-1,2,3,4-tetrahydropyrimidine-2.4-dione: (I), or salts thereof having the general formula: (II), where X is selected from Na + , K + , Li + , NH 4 + ,NH 2 CONH 3 + or another pharmacologically acceptable cation. The effectiveness of the preparation in treating liver diseases of different etiologies is increased.

4. 发明公开

EP2520605A4 METHOD FOR PRODUCING BIOCIDAL POLYGUANIDINE, AND BIOCIDAL POLYGUANIDINE 有权
标题翻译：用于生产生物杀灭聚胍和杀菌聚胍
公开(公告)号：EP2520605A4
公开(公告)日：2013-12-18
申请号：EP10822298
申请日：2010-06-04
申请人： TETS VIKTOR VENIAMINOVICH
发明人： TETS GEORGY VIKTOROVICH , KRASNOV KONSTANTIN ANDREEVICH
IPC分类号： C08G73/00 , A61K31/155 , C07C279/02
CPC分类号： A61K31/155 , A61K31/785 , C07C281/16 , C08G73/00
摘要： The inventions relate to antiseptic agents and the method for producing thereof and can be used as a broad-spectrum disinfectant in medicine, veterinary medicine, agriculture etc. The method for producing of biocidal polyguanidine that comprises condensation polymerization of hexamethylenediamine with guanine salt additionally uses hydrazine hydrate during the condensation polymerization process, at the following ratio of components, mass %: Biocidal polyguanidine obtained by means of the abovementioned method, with the following formula: or where n - the number of links A in a single unit of the polymer chain, n = 1 - 3; m - the number of links B in a single unit of the polymer chain, m = 2 - 10; z - the number of single units in the polymer chain, z=4-20; Acid - an acid. The inventions allow obtaining a biocidal polyguanidine with high level of broad-spectrum antimicrobial activity.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式