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1. 发明授权

EP2943432B8 DEVICE FOR OPENING GLASS AMPOULES 有权转让
标题翻译： VORRICHTUNG ZUMÖFFNENVON GLASS-AMPULLEN
公开(公告)号：EP2943432B8
公开(公告)日：2017-02-15
申请号：EP14703547.1
申请日：2014-01-10
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto
IPC分类号： B67B7/92
CPC分类号： B67B7/92 , Y10T225/30
摘要： This invention relates to an ampoule opening device (1) for the opening of glass ampoules (100) of the type used in particular in the pharmaceutical field for injection substances. The device according to this invention allows opening, by rupture of the neck of the ampoule, glass ampoules of different capacities (and therefore of sizes), by generating a non irregular rupture edge and therefore minimizing the creation of glass fragments that may fall into the substance contained within the ampoule. Moreover, the device object of this invention allows avoiding contact of the user's fingers with the neck and the cap of the ampoule, thereby preventing any risk of accidental injuries. The device object of this invention allows obtaining excellent results in terms of quality of the rupture edge of the ampoule neck and of repeating the result obtained thanks to the fact that the device allows to apply to the ampoule a constant rupture bending moment for ampoules of the same type.
摘要翻译：本发明涉及用于打开特别是用于注射物质制药领域的类型的玻璃安瓿（100）的安瓿打开装置（1）。根据本发明的装置允许通过产生不规则的破裂边缘来打开安瓿颈部的玻璃安瓿，从而使可能落入物质包含在安瓿内。此外，本发明的装置的目的在于避免使用者的手指与颈部和安瓿帽的接触，从而防止意外受伤的危险。本发明的装置目的在于获得安瓿颈部破裂边缘的质量方面的优异结果，并且重复所获得的结果，这是由于该装置允许将安瓿应用于安瓿的恒定的断裂弯矩相同类型

2. 发明公开

EP3110399A1 PROCESS FOR PRODUCING A STABLE LOW CONCENTRATION, INJECTABLE SOLUTION OF NORADRENALINE 有权
标题翻译：方法产生稳定，浓集的低，注射液将去甲肾上腺素
公开(公告)号：EP3110399A1
公开(公告)日：2017-01-04
申请号：EP15712064.3
申请日：2015-02-26
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto , DONATI, Elisabetta , CARONZOLO, Nicola
IPC分类号： A61K9/00 , A61K47/02 , A61K31/135
CPC分类号： A61K31/137 , A61K9/0019 , A61K9/08 , A61K47/02 , A61L2/0023
摘要： In a first aspect, the present invention relates to a process for producing a stable, injectable solution with low content of noradrenaline, which includes dissolving noradrenaline and optionally an excipient in deoxygenated or degassed water, filtrating the resulting noradrenaline solution in a nitrogen current, distributing the solution in a nitrogen current, and sterilization, preferably hot. The invention further provides a stable, injectable solution with low content of noradrenaline, substantially free of anti-oxidizing and preservative agents, as well as uses thereof in the medical and pharmaceutical fields.
摘要翻译：在第一方面，本发明涉及一种用于生产具有去甲肾上腺素的含量低，它包括溶解的赋形剂的去甲肾上腺素和任选地在脱氧的或脱气的水，过滤在氮气流中所得的去甲肾上腺素的溶液稳定的，可注射的溶液，分发在氮气流中的溶液中，并灭菌，优选热。本发明进一步提供与去甲肾上腺素的含量低，基本上无抗氧化剂和防腐剂的一种稳定的，可注射溶液，以及在医学和药学领域及其用途。

3. 发明授权

EP2874602B1 INJECTABLE SUPERSATURATED ACETAMINOPHEN SOLUTION FOR SPINAL ADMINISTRATION 有权
标题翻译：行政注射用对乙酰氨基酚的过饱和在脊椎
公开(公告)号：EP2874602B1
公开(公告)日：2016-03-30
申请号：EP13765450.5
申请日：2013-06-27
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto , DONATI, Elisabetta , CARONZOLO, Nicola
IPC分类号： A61K9/00 , A61K31/167 , A61P29/00
CPC分类号： A61K31/167 , A61K9/0085 , A61K9/08 , A61K31/245 , A61K31/381 , A61K31/445 , A61K31/47 , A61K2300/00

4. 发明公开

EP4121008A1 OPHTHALMIC CHLOROPROCAINE GEL HAVING IMPROVED FUNCTIONALITY 审中-实审
公开(公告)号：EP4121008A1
公开(公告)日：2023-01-25
申请号：EP21771604.2
申请日：2021-03-17
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto , DONATI, Elisabetta , BIANCHI, Clara
IPC分类号： A61K9/00 , A61K9/06 , A61K9/107 , A61K31/245 , A61K47/02 , A61K47/38

5. 发明公开

EP2943432A1 DEVICE FOR OPENING GLASS AMPOULES 有权转让
标题翻译：用于开启玻璃安瓿
公开(公告)号：EP2943432A1
公开(公告)日：2015-11-18
申请号：EP14703547.1
申请日：2014-01-10
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto
IPC分类号： B67B7/92
CPC分类号： B67B7/92 , Y10T225/30
摘要： This invention relates to an ampoule opening device (1) for the opening of glass ampoules (100) of the type used in particular in the pharmaceutical field for injection substances. The device according to this invention allows opening, by rupture of the neck of the ampoule, glass ampoules of different capacities (and therefore of sizes), by generating a non irregular rupture edge and therefore minimizing the creation of glass fragments that may fall into the substance contained within the ampoule. Moreover, the device object of this invention allows avoiding contact of the user's fingers with the neck and the cap of the ampoule, thereby preventing any risk of accidental injuries. The device object of this invention allows obtaining excellent results in terms of quality of the rupture edge of the ampoule neck and of repeating the result obtained thanks to the fact that the device allows to apply to the ampoule a constant rupture bending moment for ampoules of the same type.

6. 发明授权

EP1931304B1 NEW USE FOR A COMPOSITION COMPRISING CHLOROPROCAINE HCL, A NEW COMPOSITION COMPRISING CHLOROPROCAINE HCL AND A METHOD FOR ITS MANUFACTURE 有权
标题翻译： WITH氯的HCl的组合物的新用途，氯普鲁卡因盐酸包含新组合物及其制造方法
公开(公告)号：EP1931304B1
公开(公告)日：2013-10-16
申请号：EP06793212.9
申请日：2006-09-05
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto , DONATI, Elisabetta
IPC分类号： A61K9/00 , A61K31/245
CPC分类号： A61K31/245 , A61K9/0019 , A61K9/0085

7. 发明公开

EP4171535A1 DRUG COMBINATIONS FOR INHIBITING INFLAMMATION AND SRC KINASE ACTIVATION FOLLOWING INVASIVE SURGICAL PROCEDURES 审中-实审
公开(公告)号：EP4171535A1
公开(公告)日：2023-05-03
申请号：EP21764572.0
申请日：2021-03-03
申请人： Sintetica S.A.
发明人： BORGEAT, Alain , MITIDIERI, Augusto , VENTURI, Miro , DONATI, Elisabetta , VOTTA-VELIS, E. Gina
IPC分类号： A61K31/167 , A61K31/485 , A61K9/00 , C07D489/00 , A61P25/00

8. 发明公开

EP4013383A1 INTRATHECAL ADMINISTRATION OF LEVETIRACETAM 审中-实审
公开(公告)号：EP4013383A1
公开(公告)日：2022-06-22
申请号：EP20757683.6
申请日：2020-08-12
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto , DONATI, Elisabetta , BIANCHI, Clara , PICCAGLI, Barbara
IPC分类号： A61K9/00 , A61K31/195 , A61K31/4015 , A61P25/08

9. 发明公开

EP3681473A1 TOPICAL FORMULATIONS OF CHLOROPROCAINE 审中-实审
公开(公告)号：EP3681473A1
公开(公告)日：2020-07-22
申请号：EP18779804.6
申请日：2018-09-14
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto , DONATI, Elisabetta , BIANCHI, Clara
IPC分类号： A61K9/00 , A61K9/06 , A61K47/38 , A61K31/245

10. 发明授权

EP2943432B1 DEVICE FOR OPENING GLASS AMPOULES 有权转让
标题翻译：用于开启玻璃安瓿
公开(公告)号：EP2943432B1
公开(公告)日：2016-12-14
申请号：EP14703547.1
申请日：2014-01-10
申请人： Sintetica S.A.
发明人： MITIDIERI, Augusto
IPC分类号： B67B7/92
CPC分类号： B67B7/92 , Y10T225/30
摘要： This invention relates to an ampoule opening device (1) for the opening of glass ampoules (100) of the type used in particular in the pharmaceutical field for injection substances. The device according to this invention allows opening, by rupture of the neck of the ampoule, glass ampoules of different capacities (and therefore of sizes), by generating a non irregular rupture edge and therefore minimizing the creation of glass fragments that may fall into the substance contained within the ampoule. Moreover, the device object of this invention allows avoiding contact of the user's fingers with the neck and the cap of the ampoule, thereby preventing any risk of accidental injuries. The device object of this invention allows obtaining excellent results in terms of quality of the rupture edge of the ampoule neck and of repeating the result obtained thanks to the fact that the device allows to apply to the ampoule a constant rupture bending moment for ampoules of the same type.

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