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1. 发明授权

EP0342913B1 Method for immunochromatographic analysis 失效
标题翻译：一种免疫层析分析过程。
公开(公告)号：EP0342913B1
公开(公告)日：1995-08-23
申请号：EP89304913.0
申请日：1989-05-16
申请人： SYNTEX (U.S.A.) INC.
发明人： Ghazarossian, Vartan , Shanafelt, Armen B. , Skold, Carl N. , Ullman, Edwin F.
IPC分类号： G01N33/558 , G01N33/543 , G01N33/94
CPC分类号： G01N33/54386 , G01N33/558 , Y10S435/97 , Y10S435/971 , Y10S435/972 , Y10S435/975 , Y10S436/807 , Y10S436/81 , Y10S436/815 , Y10S436/816 , Y10S436/819 , Y10S436/822

2. 发明授权

EP0264219B1 Receptors for immune complexes, their methods of production and assay methods using them 失效转让
标题翻译：受体的免疫复合物，过程为他们测试这些benutzend准备和方法。
公开(公告)号：EP0264219B1
公开(公告)日：1995-08-02
申请号：EP87308829.8
申请日：1987-10-06
申请人： SYNTEX (U.S.A.) INC.
发明人： Ullman, Edwin F. , Jelesko, John , Pirio, Marcel R. , Kempe, Thomas D.
IPC分类号： G01N33/577 , G01N33/564 , G01N33/94 , A61K39/395 , C12P21/00
CPC分类号： C07K16/42 , G01N33/564 , G01N33/948 , Y10S435/975 , Y10S436/80 , Y10S436/804 , Y10S436/805 , Y10S436/808 , Y10S436/815 , Y10S436/817 , Y10S530/808

3. 发明授权

EP0306336B1 Multiple port assay device 有权
标题翻译：与多个开口测试设备。
公开(公告)号：EP0306336B1
公开(公告)日：1994-02-23
申请号：EP88308162.2
申请日：1988-09-02
申请人： SYNTEX (U.S.A.) INC.
发明人： Dafforn, Geoffrey A. , Becker, Martin , Kurn, Nurith , Ullman, Edwin F.
IPC分类号： G01N33/543 , G01N33/52 , B01L3/00
CPC分类号： G01N33/558 , B01L3/5023 , G01N33/5302 , G01N33/54366 , Y10S435/805 , Y10S435/81 , Y10S436/81

4. 发明授权

EP0300796B1 Amplification method for polynucleotide assays 失效转让
标题翻译：扩增方法用于检测多核苷酸。
公开(公告)号：EP0300796B1
公开(公告)日：1993-10-20
申请号：EP88306717.5
申请日：1988-07-21
申请人： SYNTEX (U.S.A.) INC.
发明人： Becker, Martin , Goodman, Thomas , Rose, Samual , Ullman, Edwin F.
IPC分类号： C12Q1/68 , C07H21/00 , C12P19/34
CPC分类号： C12Q1/701 , C12Q1/6813 , C12Q1/683 , C12Q1/6844 , C12Q1/6853 , C12Q1/6858 , Y10T436/143333 , C12Q2565/537 , C12Q2537/155 , C12Q2521/301

5. 发明授权

EP0243001B1 Liquid single reagent for assays 有权
标题翻译：单液体试剂进行测试。
公开(公告)号：EP0243001B1
公开(公告)日：1993-10-20
申请号：EP87302511.8
申请日：1987-03-24
申请人： SYNTEX (U.S.A.) INC.
发明人： Gibbons, Ian , Felgner, Philip L. , Ullman, Edwin F.
IPC分类号： G01N33/546 , G01N33/549 , G01N33/555 , A61K9/50 , A61K47/00
CPC分类号： G01N33/549 , G01N33/54313

6. 发明公开

EP0375439A3 Geminal diphenyl derivatives and their use in immunoassays 失效转让
标题翻译： GEMINAL DIPHENYL衍生物及其在免疫中的应用
公开(公告)号：EP0375439A3
公开(公告)日：1991-11-27
申请号：EP89313464.3
申请日：1989-12-21
申请人： SYNTEX (U.S.A.) INC.
发明人： Hu, Mae Wan-Leng , Schulkamp, Kirk , Ullman, Edwin F. , Lin, Cheng-I
IPC分类号： G01N33/53 , G01N33/78 , C07C309/15 , C07C235/52
CPC分类号： G01N33/94 , C07C235/34 , C07C235/52 , C07C259/10 , C07C309/15 , G01N33/5306 , G01N33/78 , Y10S436/815 , Y10S436/825 , Y10S436/826
摘要： Methods are disclosed for inactivating interfering binding proteins in a immunoassay for a member of a specific binding pair (sbp). The method comprises including in an assay medium containing a sample suspected of containing an sbp member and an interfering binding protein an effective amount of a water soluble compound having two substituted or unsubstituted phenyl groups linked to a common atom. When the sbp member or its sbp partner has two phenyl groups linked to a common atom, the compound has a number of groups other than hydrogen attached to the phenyl groups and the atom that differs by at least two from the number of such groups on the sbp member. When the sbp member or its sbp partner has two phenyl groups linked to a common atom and the binding protein is not an antibody, the compound has only one group other than hydrogen attached to a phenyl group or the common atom. The methods have particular application in avoiding cross-reactivity of non-analyte materials in a sample with immunochemical reagents used in such assay. The methods have application also in disrupting complexes between an analyte to be determined and other materials so that one can accurately determine the amount of an analyte in a sample.

7. 发明公开

EP0271204A3 Immunochromatographic method and device 失效
标题翻译：免疫色谱方法和装置
公开(公告)号：EP0271204A3
公开(公告)日：1989-10-25
申请号：EP87309724.0
申请日：1987-11-03
申请人： SYNTEX (U.S.A.) INC.
发明人： Ullman, Edwin F. , Ghazarossian, vartan , Peries, Rohan , Sizto , Ning Chung
IPC分类号： G01N33/558 , G01N33/543 , G01N33/94
CPC分类号： G01N33/948 , G01N33/558 , G01N33/9486
摘要： A method for determining the presence of an analyte in a sample suspected of containing the analyte is disclosed. The analyte is a member of a specific binding pair ("sbp member") consisting of ligand and its complementary receptor. The method comprises contacting, with a test solution containing said sample and a first sbp member analogous to said analyte, a contact portion of a piece of bibulous material capable of being traversed in at least one direction by said test solution by capillary migration. The bibulous material contains a second sbp member capable of binding the analyte and the first sbp member. The second sbp member is non-diffusively bound to the bibulous material at least at a portion thereof between the contact portion and a small situs on the piece separated from the contact portion. The surface area of the situs is substantially less than that of the piece of bibulous material. the situs is capable of binding the first sbp member not bound to said second sbp member. Next, at least a portion of the test solution is allowed to traverse the bibulous material by means of capillary migration and thereby contact the situs. The situs is examined for the presence of the first sbp member at the situs, which is usually indicated by the presence of a detectible signal. Such signal can be directly detectible, or the situs can be exposed to a signal producing means capable of interacting with the first sbp member to produce a detectible signal at the situs in relation to the amount of analyte in the sample. The signal at the situs is distinguishable from signal detectible at portions of the bibulous material other than the situs.

8. 发明公开

EP0214847A3 Squarate dye conjugate, process for making it and its use in assay methods and kits 失效转让
标题翻译：方酸盐染料结合物，其制备方法及其在测定方法和试剂盒中的用途
公开(公告)号：EP0214847A3
公开(公告)日：1988-06-01
申请号：EP86306859
申请日：1986-09-05
申请人： SYNTEX (U.S.A.) INC.
发明人： Berger, Jr. Donald E. , Tarnowski, Thomas L. , Ullman, Edwin F.
IPC分类号： G01N33/533 , C09B23/00
CPC分类号： C09B57/007 , C09B23/0066 , G01N33/533 , Y10S435/81 , Y10S436/80 , Y10S436/815
摘要： Novel assays for ligands and receptors employing novel compounds that are conjugates of squarates dyes and members of a specific binding pair (sbp) are disclosed. The sbp members are selected from the group consisting of ligand and its complementary receptor. The sbp member is covalently or non-covalently bound to the squarate dye, which usually has an absorption maximum greater than 600 nanometers. The novel conjugates are employed in assays for determining the presence or amount of an sbp member analyte in a sample suspected of containing such analyte. Kits comprising such novel conjugates are also disclosed.
摘要翻译：公开了使用作为方酸染料和特定结合对成员（sbp）的缀合物的新化合物的配体和受体的新测定法。 sbp成员选自配体及其互补受体。 sbp成员与方酸染料共价或非共价结合，其通常具有大于600纳米的吸收最大值。新型缀合物用于测定怀疑含有这种分析物的样品中sbp成员分析物的存在或量的分析。还公开了包含这种新型缀合物的试剂盒。

9. 发明公开

EP0230768A1 Particle separation method 失效
标题翻译： Teilchentrennungsverfahren。
公开(公告)号：EP0230768A1
公开(公告)日：1987-08-05
申请号：EP86309967.7
申请日：1986-12-19
申请人： SYNTEX (U.S.A.) INC.
发明人： Ullman, Edwin F. , Kurn, Nurith , Ghazarossian, Vartan E. , Weng, Litai
IPC分类号： B03C1/00 , G01N33/553 , G01N33/538
CPC分类号： G01N33/54333 , B03C1/01 , C12Q1/24 , G01N33/538
摘要： A method is disclosed for separating a substance from a liquid medium. The method comprises combining the liquid medium containing the substance with magnetic particles under conditions for non-specific chemical binding of the magnetic particles. Thereafter, the medium is subjected to a magnetic field gradient to separate the particles from the medium. The preferred non-specific binding is achieved as the result of charge interactions between the particles usually by means of a polyionic reagent. The method of the invention has particular application to the separation of cells and microorganisms from aqueous suspensions and also to the determination of an analyte in a sample suspected of containing the analyte. The analyte is a member of a specific binding pair (sbp). The sample is combined in an assay medium with magnetic particles and a sbp member complementary to the analyte. Magnetic or non-magnetic particles capable of specific binding to the analyte or its complementary sbp member must be included in the assay medium. The combination is made under conditions for non-specifically aggregating the magnetic particles or coaggregating the magnetic and non-magnetic particles when non-magnetic particles are present. The assay medium is subjected to a magnetic field gradient to separate the aggregated particles from the medium. Then, the medium or the particles are examined for the presence or amount of the analyte or an sbp member, the binding of which is affected by the presence of the analyte.
摘要翻译：公开了一种用于从液体介质中分离物质的方法。该方法包括将含有物质的液体介质与磁性颗粒的非特异性化学结合的条件组合。此后，介质经受磁场梯度以将颗粒与介质分离。作为通常通过聚离子试剂在颗粒之间的电荷相互作用的结果，实现了优选的非特异性结合。本发明的方法特别适用于从水性悬浮液中分离细胞和微生物，并且还涉及怀疑含有分析物的样品中的分析物的测定。分析物是特异性结合对（sbp）的成员。将样品在测定介质中与磁性颗粒和与分析物互补的sbp构件组合。能够与分析物或其互补sbp成员特异性结合的磁性或非磁性颗粒必须包含在测定介质中。在存在非磁性颗粒时，在非特异性聚集磁性颗粒或共磁化磁性和非磁性颗粒的条件下进行组合。对测定介质进行磁场梯度以将聚集的颗粒与介质分离。然后，检查介质或颗粒的分析物或sbp构件的存在或量，其结合受分析物的存在的影响。

10. 发明授权

EP0375439B1 Geminal diphenyl derivatives and their use in immunoassays 失效转让
标题翻译：偕联苯衍生物及其在免疫测定。
公开(公告)号：EP0375439B1
公开(公告)日：1995-09-06
申请号：EP89313464.3
申请日：1989-12-21
申请人： SYNTEX (U.S.A.) INC.
发明人： Hu, Mae Wan-Leng , Schulkamp, Kirk , Ullman, Edwin F. , Lin, Cheng-I
IPC分类号： G01N33/53 , G01N33/78 , C07C309/15 , C07C235/52
CPC分类号： G01N33/94 , C07C235/34 , C07C235/52 , C07C259/10 , C07C309/15 , G01N33/5306 , G01N33/78 , Y10S436/815 , Y10S436/825 , Y10S436/826

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