专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

EP0375439A2 Geminal diphenyl derivatives and their use in immunoassays 失效转让
标题翻译： Geminale Diphenyl-Derivate und ihre Verwendung in Immunotests。
公开(公告)号：EP0375439A2
公开(公告)日：1990-06-27
申请号：EP89313464.3
申请日：1989-12-21
申请人： SYNTEX (U.S.A.) INC.
发明人： Hu, Mae Wan-Leng , Schulkamp, Kirk , Ullman, Edwin F. , Lin, Cheng-I
IPC分类号： G01N33/53 , G01N33/78 , C07C309/15 , C07C235/52
CPC分类号： G01N33/94 , C07C235/34 , C07C235/52 , C07C259/10 , C07C309/15 , G01N33/5306 , G01N33/78 , Y10S436/815 , Y10S436/825 , Y10S436/826
摘要： Methods are disclosed for inactivating interfering binding proteins in a immunoassay for a member of a specific binding pair (sbp). The method comprises including in an assay medium containing a sample suspected of containing an sbp member and an interfering binding protein an effective amount of a water soluble compound having two substituted or unsubstituted phenyl groups linked to a common atom. When the sbp member or its sbp partner has two phenyl groups linked to a common atom, the compound has a number of groups other than hydrogen attached to the phenyl groups and the atom that differs by at least two from the number of such groups on the sbp member. When the sbp member or its sbp partner has two phenyl groups linked to a common atom and the binding protein is not an antibody, the compound has only one group other than hydrogen attached to a phenyl group or the common atom. The methods have particular application in avoiding cross-reactivity of non-analyte materials in a sample with immunochemical reagents used in such assay. The methods have application also in disrupting complexes between an analyte to be determined and other materials so that one can accurately determine the amount of an analyte in a sample.
摘要翻译：公开了用于在特异性结合对（sbp）的成员的免疫测定中灭活干扰结合蛋白的方法。该方法包括在含有疑似含有sbp成员和干扰结合蛋白的样品的测定培养基中包含有效量的具有连接到共同原子的两个取代或未取代的苯基的水溶性化合物。当sbp成员或其sbp伴侣具有连接到共同原子的两个苯基时，该化合物具有除苯基之外的氢以外的多个基团，并且与该基团上的这些基团的数目不同的至少两个的原子 sbp成员。当sbp成员或其sbp伴侣具有连接到共同原子的两个苯基并且结合蛋白不是抗体时，化合物除了连接到苯基或共同原子上的氢以外仅具有一个基团。该方法特别适用于避免样品中非分析物质与这种测定中使用的免疫化学试剂的交叉反应。所述方法还可用于破坏待测定的分析物与其它材料之间的复合物，使得可以准确地确定样品中分析物的量。

2. 发明公开

EP0375439A3 Geminal diphenyl derivatives and their use in immunoassays 失效转让
标题翻译： GEMINAL DIPHENYL衍生物及其在免疫中的应用
公开(公告)号：EP0375439A3
公开(公告)日：1991-11-27
申请号：EP89313464.3
申请日：1989-12-21
申请人： SYNTEX (U.S.A.) INC.
发明人： Hu, Mae Wan-Leng , Schulkamp, Kirk , Ullman, Edwin F. , Lin, Cheng-I
IPC分类号： G01N33/53 , G01N33/78 , C07C309/15 , C07C235/52
CPC分类号： G01N33/94 , C07C235/34 , C07C235/52 , C07C259/10 , C07C309/15 , G01N33/5306 , G01N33/78 , Y10S436/815 , Y10S436/825 , Y10S436/826
摘要： Methods are disclosed for inactivating interfering binding proteins in a immunoassay for a member of a specific binding pair (sbp). The method comprises including in an assay medium containing a sample suspected of containing an sbp member and an interfering binding protein an effective amount of a water soluble compound having two substituted or unsubstituted phenyl groups linked to a common atom. When the sbp member or its sbp partner has two phenyl groups linked to a common atom, the compound has a number of groups other than hydrogen attached to the phenyl groups and the atom that differs by at least two from the number of such groups on the sbp member. When the sbp member or its sbp partner has two phenyl groups linked to a common atom and the binding protein is not an antibody, the compound has only one group other than hydrogen attached to a phenyl group or the common atom. The methods have particular application in avoiding cross-reactivity of non-analyte materials in a sample with immunochemical reagents used in such assay. The methods have application also in disrupting complexes between an analyte to be determined and other materials so that one can accurately determine the amount of an analyte in a sample.

3. 发明授权

EP0375439B1 Geminal diphenyl derivatives and their use in immunoassays 失效转让
标题翻译：偕联苯衍生物及其在免疫测定。
公开(公告)号：EP0375439B1
公开(公告)日：1995-09-06
申请号：EP89313464.3
申请日：1989-12-21
申请人： SYNTEX (U.S.A.) INC.
发明人： Hu, Mae Wan-Leng , Schulkamp, Kirk , Ullman, Edwin F. , Lin, Cheng-I
IPC分类号： G01N33/53 , G01N33/78 , C07C309/15 , C07C235/52
CPC分类号： G01N33/94 , C07C235/34 , C07C235/52 , C07C259/10 , C07C309/15 , G01N33/5306 , G01N33/78 , Y10S436/815 , Y10S436/825 , Y10S436/826

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式