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1. 发明公开

EP2035584A2 NANOSENSORS AND RELATED TECHNOLOGIES 失效
标题翻译：纳米传感器和相关技术
公开(公告)号：EP2035584A2
公开(公告)日：2009-03-18
申请号：EP07861323.9
申请日：2007-06-11
申请人： President and Fellows of Harvard College
发明人： LIEBER, Charles M. , FANG, Ying , PATOLSKY, Fernando
IPC分类号： C12Q1/68 , H01L29/06
CPC分类号： G01N33/551 , B82Y10/00 , C12Q1/6825 , C12Q2600/156 , G01N27/4145 , G01N27/4146 , G01N33/553 , H01L51/0049 , H01L51/0093 , C12Q2563/155
摘要： The present invention generally relates to nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample. For example, a nanoscale wire device can be used to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between an analyte and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances.

2. 发明公开

EP1525585A2 STOCHASTIC ASSEMBLY OF SUBLITHOGRAPHIC NANOSCALE INTERFACES 审中-公开
标题翻译：随机安排亚光刻NANO区INTERFACES
公开(公告)号：EP1525585A2
公开(公告)日：2005-04-27
申请号：EP03796281.8
申请日：2003-07-24
申请人： California Institute of Technology , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , Sri International , Brown University
发明人： DEHON, Andre , LIEBER, Charles M. , LINCOLN, Patrick D. , SAVAGE, John
IPC分类号： G11C13/02 , G11C8/10
CPC分类号： H01L49/00 , B82Y10/00 , G11C8/10 , G11C13/0023 , G11C13/02 , G11C13/025 , G11C2213/71 , G11C2213/77 , G11C2213/81 , H01L23/522 , H01L27/101 , H01L29/0665 , H01L29/0673 , H01L2924/0002 , Y10S977/762 , Y10S977/943 , H01L2924/00
摘要： A method for controlling electric conduction on nanoscale wires is disclosed.The nanoscale wires are provided with controllable regions axially and/or radially distributed. Controlling those regions by means of microscale wires or additional nanoscale wires allows or prevents electric conduction on the controlled nanoscale wires. The controllable regions are of two different types.For example, a first type of controllable region can exhibit a different dopingfrom a second type of controllable region. The method allows one or more of a set of nanoscale wires, packed at sublithographic pitch, to be independentlyselected.

3. 发明授权

EP2035584B1 NANOSENSORS AND RELATED TECHNOLOGIES 失效
标题翻译：纳米传感器和相关技术
公开(公告)号：EP2035584B1
公开(公告)日：2011-01-26
申请号：EP07861323.9
申请日：2007-06-11
申请人： President and Fellows of Harvard College
发明人： LIEBER, Charles M. , FANG, Ying , PATOLSKY, Fernando
IPC分类号： C12Q1/68 , H01L29/06
CPC分类号： G01N33/551 , B82Y10/00 , C12Q1/6825 , C12Q2600/156 , G01N27/4145 , G01N27/4146 , G01N33/553 , H01L51/0049 , H01L51/0093 , C12Q2563/155
摘要： The present invention generally relates to nanoscale wire devices and methods for use in determining nucleic acids or other analytes suspected to be present in a sample. For example, a nanoscale wire device can be used to detect single base mismatches within a nucleic acid (e.g., by determining association and/or dissociation rates). In one aspect, dynamical information such as a binding constant, an association rate, and/or a dissociation rate, can be determined between an analyte and a binding partner immobilized relative to a nanoscale wire. In some cases, the nanoscale wire includes a first portion comprising a metal-semiconductor compound, and a second portion that does not include a metal-semiconductor compound. The binding partner, in some embodiments, is immobilized relative to at least the second portion of the nanoscale wire, and the size of the second portion of the nanoscale wire may be minimized and/or controlled in some instances.

4. 发明公开

EP2013611A2 NANOBIOELECTRONICS 审中-公开
公开(公告)号：EP2013611A2
公开(公告)日：2009-01-14
申请号：EP07852353.7
申请日：2007-03-15
申请人： The President and Fellows of Harvard College
发明人： PATOLSKY, Fernando , TIMKO, Brian P. , YU, Guihua , LIEBER, Charles M.
IPC分类号： G01N27/00
CPC分类号： G01N33/5058 , B82Y10/00 , H01L29/0665 , H01L29/0673 , H01L29/1606
摘要： The present invention generally relates to nanobioelectronics and, in some cases, to circuits comprising nanoelectronic elements, such as nanotubes and/or nanowires, and biological components, such as neurons. In one aspect, cells, such as neurons, are positioned in electrical communication with one or more nanoscale wires. The nanoscale wires may be used to stimulate the cells, and/or determine an electrical condition of the cells. More than one nanoscale wire may be positioned in electrical communication with the cell, for example, in distinct regions of the cell. However, the nanoscale wires may be positioned such that they are relatively close together, for example, spaced apart by no more than about 200 nm. The nanoscale wires may be disposed on a substrate, for example, between electrodes, and the cells may be adhered to the substrate, for example, using cell adhesion factors such as polylysine. Also provided in other aspects of the invention are methods for making and using such devices, kits for using the same, and the like.
摘要翻译：本发明一般涉及纳米生物电子学，并且在一些情况下涉及包含纳米电子元件（例如纳米管和/或纳米线）和生物组分（例如神经元）的电路。在一个方面，诸如神经元的细胞被定位成与一个或多个纳米级导线电连通。纳米级线可用于刺激细胞，和/或确定细胞的电状况。例如，在电池的不同区域中，可以放置多于一根的纳米级电线与电池电连通。然而，纳米级线材可以定位成使得它们相对靠近在一起，例如间隔不超过约200nm。纳米级线可以设置在例如电极之间的基板上，并且例如可以使用细胞粘附因子例如聚赖氨酸将细胞粘附到基板。在本发明的其他方面也提供了制造和使用这种装置的方法，使用它们的试剂盒等。

5. 发明公开

EP3825687A1 MULTI-NANOPORE SENSOR SYSTEM AND TRANSDUCTION ELEMENTS FOR MEASUREMENT OF LOCAL ELECTRICAL POTENTIAL AT THE NANOPORES 有权
公开(公告)号：EP3825687A1
公开(公告)日：2021-05-26
申请号：EP20216269.9
申请日：2011-04-29
申请人： President and Fellows of Harvard College
发明人： LIEBER, Charles M. , XIE, Ping
IPC分类号： G01N33/487 , C12Q1/6869 , B82Y30/00 , G01N27/414
摘要： There is provided a nanopore disposed in a support structure, with a fluidic connection between a first fluidic reservoir and an inlet to the nanopore and a second fluidic connection between a second fluidic reservoir and an outlet from the nanopore. A first ionic solution of a first buffer concentration is disposed in the first reservoir and a second ionic solution of a second buffer concentration, different than the first concentration, is disposed in the second reservoir, with the nanopore providing the sole path of fluidic communication between the first and second reservoirs. An electrical connection is disposed at a location in the nanopore sensor that develops an electrical signal indicative of electrical potential local to at least one site in the nanopore sensor as an object translocates through the nanopore between the two reservoirs.

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