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1. 发明公开

EP3178923A1 USE OF SUSD2 PROTEIN AS MARKER 有权
标题翻译：使用SUSD2蛋白作为标记
公开(公告)号：EP3178923A1
公开(公告)日：2017-06-14
申请号：EP15829144.3
申请日：2015-08-04
申请人： Peking University , Peking University Shenzhen Graduate School , Beijing Ruipu Chenchuang Technology Co., Ltd
发明人： DENG, Hongkui , LIU, Haisong , ZHU, Dicong , YANG, Huan , LIANG, Zhen
IPC分类号： C12N5/071 , G01N33/53
CPC分类号： G01N33/507 , C12N5/0676 , C12N5/0678 , G01N33/5073 , G01N33/56966 , G01N2500/10
摘要： Disclosed is a use of a SUSD2 protein as a marker, in particular a use of the SUSD2 protein as the marker in identification, selection or separation of pancreatic internal secretion precursor cells and/or newborn pancreatic internal secretion cells; and a use of an mRNA, for encoding the SUSD2 protein, of a precursor protein as the marker in identification of the pancreatic internal secretion precursor cells and/or the newborn pancreatic internal secretion cells. Through analysis of gene expression of pancreatic endoderm cells sourced by induced directional differentiation of human pluripotent stem cells, the enrichment expression of a SUSD2 gene in the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells is found. In addition, a protein encoded by the SUSD2 gene is a receptor protein on cell membranes. Using the protein as the marker, the identification, the selection or the separation of the pancreatic internal secretion precursor cells and the newborn pancreatic internal secretion cells can be carried out, which has an important significance on research about pancreas related cells in each development stage.
摘要翻译：公开了SUSD2蛋白质作为标志物的用途，特别是SUSD2蛋白质作为胰腺内分泌前体细胞和/或新生胰腺内分泌细胞的鉴定，选择或分离中的标记的用途; 以及用于编码SUSD2蛋白的前体蛋白质作为鉴定胰内分泌前体细胞和/或新生胰腺内分泌细胞的标记的用途。通过分析由人多能干细胞的诱导定向分化产生的胰腺内胚层细胞的基因表达，发现SUSD2基因在胰内分泌前体细胞和新生胰腺内分泌细胞中的富集表达。另外，由SUSD2基因编码的蛋白质是细胞膜上的受体蛋白质。以该蛋白质作为标记物，可以进行胰内分泌前体细胞和新生胰腺内分泌细胞的鉴定，选择或分离，这对于研究每个发育阶段的胰腺相关细胞具有重要意义。

2. 发明公开

EP3931304A1 COMPOSITIONS AND METHODS FOR REPROGRAMING NON-HEPATOCYTE CELLS INTO HEPATOCYTE CELLS 审中-公开
公开(公告)号：EP3931304A1
公开(公告)日：2022-01-05
申请号：EP19917360.0
申请日：2019-02-26
申请人： Peking University
发明人： DENG, Hongkui , XIE, Bingqing , SUN, Da , DU, Yuanyuan
IPC分类号： C12N5/071

3. 发明公开

EP1871869A1 METHOD OF INDUCING EMBRYONIC STEM CELLS INTO PANCREATIC CELLS 审中-公开
标题翻译：诱导胰腺细胞中胚胎干细胞的方法
公开(公告)号：EP1871869A1
公开(公告)日：2008-01-02
申请号：EP06722332.1
申请日：2006-04-14
申请人： Peking University
发明人： DENG, Hongkui , DING, Mingxiao , SHI, Yan , JIANG, Wei , HOU, Lingling , TANG, Fuchou
IPC分类号： C12N5/00 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0676 , A61K35/12 , C12N2500/25 , C12N2500/38 , C12N2500/44 , C12N2501/115 , C12N2501/16 , C12N2501/385 , C12N2506/02 , C12N2533/52 , C12N2533/90
摘要： The present invention provided a simple three-step approach based on the combinational induction with activin A, all-trans retinoic acid and, optionally, other maturation factors which are able to induce embryonic stem cells to differentiate into insulin-producing cells. A kit used to induce embryonic stem cells to differentiate into insulin-producing cells was also provided.

5. 发明公开

EP4320223A1 CHEMICAL REPROGRAMMING OF HUMAN SOMATIC CELLS INTO PLURIPOTENT CELLS 审中-实审
公开(公告)号：EP4320223A1
公开(公告)日：2024-02-14
申请号：EP22783801.8
申请日：2022-02-21
申请人： Peking University
发明人： DENG, Hongkui , GUAN, Jingyang , WANG, Jinlin , WANG, Guan , ZHANG, Zhengyuan , FU, Yao , CHENG, Lin , MENG, Gaofan
IPC分类号： C12N5/071

6. 发明公开

EP3317405A1 COMPOSITIONS AND METHODS FOR REPROGRAMING NON-NEURONAL CELLS INTO NEURON-LIKE CELLS 审中-公开
标题翻译：将非神经元细胞重新编程为神经元样细胞的组合物和方法
公开(公告)号：EP3317405A1
公开(公告)日：2018-05-09
申请号：EP16820787.6
申请日：2016-07-01
申请人： Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd. , Peking University
发明人： DENG, Hongkui , LI, Xiang , ZUO, Xiaohan
IPC分类号： C12N5/0793 , A61K35/30 , A61P25/00 , A61P25/14 , A61P25/28
CPC分类号： A61K35/30 , A61K9/0019 , C12N5/00 , C12N5/0607 , C12N5/0619 , C12N2501/01 , C12N2501/15 , C12N2506/1307 , C12N2506/1353 , C12N2506/1369 , C12N2506/1384 , C12N2506/1392
摘要： Cocktails of chemical inducers of neuron-like properties (CINP) is provided, which includes cAMP agonists, neurogenic small molecules, glycogen synthase kinase inhibitors, TGFβ receptor inhibitors, and BET family bromodomain inhibitors and optionally, a selective inhibitor of ROCK or p38 MAPK. These cocktails are used in a method of inducing neuron-like properties in partially or completely differentiated non-neuronal cells. The method includes contacting cells of a first type (non-neuronal) with the CINPs for a sufficient period of time to result in reprogramming the cell into cells of a second type having neuron-like characteristics (CiNs). Isolated chemically induced neurons (CiNs) can be used in a number of applications, including but not limited to cell therapy.

7. 发明公开

EP3334820A1 INDUCED EXTENDED PLURIPOTENT STEM CELLS, METHODS OF MAKING AND USING 有权
公开(公告)号：EP3334820A1
公开(公告)日：2018-06-20
申请号：EP16834685.6
申请日：2016-08-12
申请人： Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd. , Peking University , Hong Guan Ltd.
发明人： DENG, Hongkui , YANG, Yang , LIU, Bei , XU, Jun
IPC分类号： C12N5/00 , C07K14/54 , C07K14/715 , C12N5/07 , C12N5/074 , C12N5/0789 , C12N5/0797 , C12N5/095 , C07K16/38 , C07K16/40
CPC分类号： C12N5/0696 , A01K67/0271 , A01K2207/12 , A01K2217/00 , A01K2227/105 , A61K35/545 , C07K16/38 , C07K16/40 , C12N5/0605 , C12N5/0606 , C12N15/873 , C12N2501/15 , C12N2501/20 , C12N2501/2306 , C12N2501/2311 , C12N2501/2327 , C12N2501/2331 , C12N2501/235 , C12N2501/237 , C12N2501/603 , C12N2501/999 , C12N2503/02 , C12N2510/00
摘要： Factors for extending the ability of isolated pluripotent stem cells to generate extraembryonic lineages in vivo, following in vitro culture, herein, chemical extenders of pluripotency (CEP). Methods of extending the ability of a pluripotent cell to generate embryonic and extraembryonic lineages. The cell to be reprogrammed is contacted with effective amounts of the CEPs for a sufficient period of time to reprogram the cell into a chemically induced extended pluripotent cell (ciEPSC). ciEPSC are identified as an extended pluripotent cell based on properties including: (i) morphologically and (ii) functionally for example, based on their ability contribute to both TE and ICM, in vivo. The ciEPSCs can be cultured or induced to differentiate into cells of a desired type, and used in a number of applications, including but not limited to cell therapy and tissue engineering.

8. 发明公开

EP3198004A1 TGFß SIGNALING INDEPENDENT NAÏVE INDUCED PLURIPOTENT STEM CELLS, METHODS OF MAKING AND USE 审中-公开
标题翻译： TGFβ信号独立免疫诱导多功能干细胞，制备和使用方法
公开(公告)号：EP3198004A1
公开(公告)日：2017-08-02
申请号：EP15843227.8
申请日：2015-09-18
申请人： Hong Guan Ltd. , Peking University , Beijing Vitalstar Biotechnology Co., Ltd.
发明人： DENG, Hongkui , FANG, Riguo , LIU, Kang , YANG, Weifeng
IPC分类号： C12N5/0735 , C12N5/10 , A01K67/027
CPC分类号： C12N5/0696 , A01K67/027 , A01K2207/12 , A01K2227/105 , A01K2267/025 , C12N2501/115 , C12N2501/20 , C12N2501/50 , C12N2501/727 , C12N2501/734 , C12N2506/09 , C12N2506/1307
摘要： Provided is a cocktail of factors for converting/reprogramming non-naïve pluripotent stem cells into TGFβ signaling-independent (TSI) naïve induced pluripotent stem cells (iPSCs). Also provided are methods for reprograming a non-naïve PSC into a TSI naïve iPSC by contacting the cell to be reprogrammed with effective amounts of compounds for a sufficient period of time to reprogram the cell into a TSI naïve iPSC.
摘要翻译：提供了用于将非幼稚多能干细胞转化/重编程为TGFβ信号传导依赖性（TSI）未经诱导的多能干细胞（iPSC）的因子混合物。还提供了通过使待重编程的细胞与有效量的化合物接触足够的时间段以将细胞重编程为TSI天真的iPSC来将非幼稚PSC重编程为TSI幼稚iPSC的方法。

9. 发明公开

EP3931305A1 COMPOSITIONS AND METHODS FOR LONG TERM CULTURE OF HEPATOCYTES 审中-公开
公开(公告)号：EP3931305A1
公开(公告)日：2022-01-05
申请号：EP19917487.1
申请日：2019-02-26
申请人： Peking University
发明人： DENG, Hongkui , XIANG, Chengang , DU, Yuanyuan
IPC分类号： C12N5/071 , A61K31/4427 , C12R1/93

10. 发明公开

EP3105315A1 KITS AND METHODS FOR REPROGRAMING NON-HEPATOCYTE CELLS INTO HEPATOCYTE CELLS 有权转让
标题翻译：枸杞子枸杞子UR EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP3105315A1
公开(公告)日：2016-12-21
申请号：EP15748953.5
申请日：2015-02-04
申请人： Beihao Stem Cell and Regenerative Medicine Translation Research Institute , Peking University , Beijing Vitalstar Biotechnology Co., Ltd.
发明人： DENG, Hongkui , DU, Yuanyuan , SHI, Yan , JIA, Jun , WANG, Jinlin , XIANG, Chengang , SONG, Nan , XU, Jun , YIN, Ming
IPC分类号： C12N5/0735 , C12N5/10 , C12N5/071 , A61K35/407 , A61P1/16 , A61K48/00
摘要： A method for inducing reprogramming of a cell of a first type which is not a non-hepatocyte (non-hepatocyte cell), into a cell with functional hepatic drug metabolizing and transporting capabilities, is disclosed. The non-hepatocyte is induced to express or overexpress hepatic fate conversion and maturation factors, cultured in somatic cell culture medium, hepatocyte cell culture medium and hepatocyte maturation medium for a sufficient period of time to convert the non-hepatocyte cell into a cell with hepatocyte-like properties. The iHeps induced according to the methods disclosed herein are functional induced hepatocytes (iHeps) in that they express I and II drug-metabolizing enzymes and phase III drug transporters and show superior drug metabolizing activity compared to iHeps obtained by prior art methods. The iHeps thus provide a cell resource for pharmaceutical applications.
摘要翻译：公开了将不是非肝细胞（非肝细胞）的第一类细胞重编程为具有功能性肝药物代谢和输送能力的细胞的方法。诱导非肝细胞表达或过表达肝脏转化和成熟因子，在体细胞培养基，肝细胞培养基和肝细胞成熟培养基中培养足够的时间，将非肝细胞转化为具有肝细胞的细胞类属性。根据本文公开的方法诱导的iHeps是功能性诱导的肝细胞（iHeps），因为它们表达I和II药物代谢酶和III期药物转运蛋白，并且与通过现有技术方法获得的iHeps相比显示出优异的药物代谢活性。因此，iHeps为药物应用提供了一种细胞资源。

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