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1. 发明公开

EP3766530A1 BLOOD PURIFICATION DEVICE 审中-实审
公开(公告)号：EP3766530A1
公开(公告)日：2021-01-20
申请号：EP19792790.8
申请日：2019-04-19
申请人： Nikkiso Company Limited
发明人： AKITA Kunihiko , HASEGAWA Shinya , TOYODA Masahiro
IPC分类号： A61M1/36 , A61M1/16
摘要： The present invention provides a blood purification apparatus that includes a blood circuit including an arterial blood circuit provided with an arterial puncture needle with which an access vessel of a patient is puncturable and a venous blood circuit provided with a venous puncture needle with which the access vessel is puncturable, the blood circuit allowing blood of the patient to extracorporeally circulate; a blood purifier connected to the arterial blood circuit and to the venous blood circuit and that purifies the blood flowing through the blood circuit; a blood pump provided to the arterial blood circuit; a recirculating-blood-detecting unit capable of detecting recirculating blood when the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump, the recirculating blood being blood once returned to the patient from the venous blood circuit and reintroduced into the arterial blood circuit; and a recirculation-rate-calculating unit capable of calculating recirculation rate, the recirculation rate being a proportion of the recirculating blood in the blood flowing in the arterial blood circuit. The blood purification apparatus includes a control unit capable of executing a treatment mode in which blood purification treatment is performed with the blood purifier while the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump in a state of normal connection where an upstream part of the access vessel is punctured with the puncture needle at a distal end of the arterial blood circuit and a downstream part of the access vessel is punctured with the puncture needle at a distal end of the venous blood circuit; and a measurement mode in which the detection of recirculating blood by the recirculating-blood-detecting unit and the calculation of recirculation rate by the recirculation-rate-calculating unit are performed while the blood of the patient is caused to extracorporeally circulate through the blood circuit by activating the blood pump in a state of reverse connection where the downstream part of the access vessel is punctured with the puncture needle at the distal end of the arterial blood circuit and the upstream part of the access vessel is punctured with the puncture needle at the distal end of the venous blood circuit, the calculated recirculation rate being used in calculating blood flow rate in the access vessel that is calculable in the measurement mode.

2. 发明公开

EP3698823A1 BLOOD PURIFICATION DEVICE 有权
公开(公告)号：EP3698823A1
公开(公告)日：2020-08-26
申请号：EP18868950.9
申请日：2018-10-17
申请人： Nikkiso Company Limited
发明人： KAWARABAYASHI Satoru , HASEGAWA Shinya , MURAKAMI Tomoya , AKITA Kunihiko , TOYODA Masahiro
IPC分类号： A61M1/16
摘要： The present invention provides a blood purification apparatus to which a blood circuit that allows a patient's blood to extracorporeally circulate and a blood purifier connected to the blood circuit and that purifies the blood in extracorporeal circulation are attachable, the blood purification apparatus including a dialysate introduction line through which dialysate is introduced into the blood purifier; a dialysate drain line through which waste dialysate resulting from blood purification performed by the blood purifier is drained from the blood purifier; and a concentration-detecting unit that detects a concentration of a predetermined substance in the waste dialysate resulting from the blood purification by the blood purifier and flowing through the dialysate drain line. The blood purification apparatus includes a control unit that establishes a state of equilibrium where the concentration of the predetermined substance in the waste dialysate flowing through the dialysate drain line and a concentration of the predetermined substance in the blood flowing through the blood circuit are equal or approximate to each other; a storage unit capable of storing a value detected by the concentration-detecting unit in the state of equilibrium as an equilibrium value; and a clearance-calculating unit that calculates clearance in accordance with the value detected by the concentration-detecting unit and the equilibrium value stored in the storage unit, the clearance being a figure of merit representing a degree of solute removal by the blood purifier.

3. 发明公开

EP3811989A1 BLOOD PURIFICATION DEVICE AND METHOD FOR ESTIMATING NUTRITIONAL STATE OF PATIENT USING BLOOD PURIFICATION DEVICE 审中-实审
公开(公告)号：EP3811989A1
公开(公告)日：2021-04-28
申请号：EP19823372.8
申请日：2019-06-19
申请人： Nikkiso Company Limited
发明人： HASEGAWA Shinya , KAWARABAYASHI Satoru , TOYODA Masahiro , AKITA Kunihiko
IPC分类号： A61M1/36
摘要： A blood purification apparatus that accurately calculates the colloid osmotic pressure (CP) of a patient's blood. A dialyzer (3) included in the blood purification apparatus has thereinside blood flow routes and dialysate flow routes that are separated from each other by hollow fibers (3e). An ultrafiltration pump (8) draws out water from the blood in the blood flow routes through the hollow fibers (3e) into the dialysate flow routes. Four detecting units (P1 to P4) measure the pressures of liquid flowing into the blood flow routes, the liquid discharged from the blood flow routes, dialysate flowing into the dialysate flow routes, and the dialysate discharged from the dialysate flow routes. With reference to the pressures at the four positions, the transmembrane pressure difference (TMP) can be calculated. The ultrafiltration pump (8) is stopped. The blood flow routes are filled with a priming solution, and the transmembrane pressure difference (TMPa) is measured. Subsequently, the blood flow routes are filled with the patient's blood, and the transmembrane pressure difference (TMPb) is measured. With reference to TMPa and TMPb, the colloid osmotic pressure (CP) of the patient's blood can be calculated. With reference to the colloid osmotic pressure (CP), the plasma total protein (TP) can be calculated. With reference to the plasma total protein (TP), the patient's state of nutrition can be estimated.

4. 发明公开

EP3811986A1 BLOOD PURIFICATION DEVICE, AND PLASMA FLOW RATE ACQUISITION METHOD USING BLOOD PURIFICATION DEVICE 有权
公开(公告)号：EP3811986A1
公开(公告)日：2021-04-28
申请号：EP19822015.4
申请日：2019-06-19
申请人： Nikkiso Company Limited
发明人： HASEGAWA Shinya , KAWARABAYASHI Satoru , TOYODA Masahiro , AKITA Kunihiko
IPC分类号： A61M1/34
摘要： A blood purification apparatus is provided that includes a blood circuit including an arterial blood circuit and a venous blood circuit and that allows a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purifier provided between the arterial blood circuit and the venous blood circuit and that purifies the blood flowing through the blood circuit, the blood purifier having a blood flow route through which the blood extracorporeally circulating through the blood circuit flows and a dialysate flow route through which dialysate flows, the blood flow route and the dialysate flow route being separated from each other by a blood purification membrane for purifying the blood; an ultrafiltration unit that performs ultrafiltration by filtering out water from the blood in the blood flow route through the blood purification membrane and draining the water through the dialysate flow route; and a substitution-fluid supply unit that supplies substitution fluid into the blood circuit. The blood purification apparatus includes a plasma-flow-rate-acquiring unit that acquires a plasma flow rate or a correlation value of plasma flow rate with reference to a blood concentration detected from the patient's blood and a plasma total protein detected from the blood flowing through the blood circuit.

5. 发明公开

EP3730914A1 PRESSURE DETECTOR ADJUSTING DEVICE 有权
公开(公告)号：EP3730914A1
公开(公告)日：2020-10-28
申请号：EP19740982.4
申请日：2019-01-18
申请人： Nikkiso Company Limited
发明人： MAKI Hideto , HASEGAWA Shinya , EDA Yuki
IPC分类号： G01L27/00 , A61M1/36
摘要： An adjusting device for a pressure detector that is capable of arbitrarily adjusting the initial position of a membrane member is provided. An adjusting device for a pressure detector S includes a control unit E that sequentially executes a first step in which a predetermined adjusting pressure is generated in a first zone K1 by activating a pump D with the first zone K1 being closed by the closing of an electromagnetic valve B, and a second step in which a gas-phase portion S2, the first zone K1, and a second zone K2 are combined into a closed space by disabling the closing of the electromagnetic valve B; and an adjusting-pressure-acquiring unit N that acquires the adjusting pressure to be generated in the first step, the adjusting pressure being acquired in accordance with a relationship between a pressure and a capacity of the first zone K1 in the first step and a pressure and a capacity of the combination of the gas-phase portion S2, the first zone K1, and the second zone K2 in the second step. The control unit E brings the membrane member M to a position corresponding to the adjusting pressure by executing the second step after activating the pump D in the first step in such a manner as to generate the adjusting pressure acquired by the adjusting-pressure-acquiring unit N.

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